0001104659-05-006242 8-K 2 20050214 1.01 9.01 20050214 20050214 ISIS PHARMACEUTICALS INC 0000874015 2834 330336973 DE 1231 8-K 34 000-19125 05607611 2292 FARADAY AVE CARLSBAD CA 92008 7609319200 2292 FARADAY AVE CARLSBAD CA 92008 8-K 1 a05-3231_18k.htm 8-K EX-99.1 2 a05-3231_1ex99d1.htm EX-99.1