0001104659-05-028785 S-8 3 20050617 20050617 20050617 ISIS PHARMACEUTICALS INC 0000874015 2834 330336973 DE 1231 S-8 33 333-125911 05903334 2292 FARADAY AVE CARLSBAD CA 92008 7609319200 2292 FARADAY AVE CARLSBAD CA 92008 S-8 1 a05-10943_1s8.htm S-8 EX-5.1 2 a05-10943_1ex5d1.htm EX-5.1 EX-23.1 3 a05-10943_1ex23d1.htm EX-23.1