0001104659-05-037061 8-K 2 20050808 2.02 9.01 20050808 20050808 ISIS PHARMACEUTICALS INC 0000874015 2834 330336973 DE 1231 8-K 34 000-19125 051004618 1896 RUTHERFORD ROAD CARLSBAD CA 92008 7609319200 1896 RUTHERFORD ROAD CARLSBAD CA 92008 8-K 1 a05-14363_18k.htm 8-K EX-99.1 2 a05-14363_1ex99d1.htm EX-99.1