0001104659-05-053297 8-K 2 20051108 2.02 9.01 20051108 20051108 ISIS PHARMACEUTICALS INC 0000874015 2834 330336973 DE 1231 8-K 34 000-19125 051184899 1896 RUTHERFORD ROAD CARLSBAD CA 92008 7609319200 1896 RUTHERFORD ROAD CARLSBAD CA 92008 8-K 1 a05-19832_18k.htm CURRENT REPORT OF MATERIAL EVENTS OR CORPORATE CHANGES EX-99.1 2 a05-19832_1ex99d1.htm EXHIBIT 99