0001104659-05-061018 8-K 2 20051213 5.02 9.01 20051215 20051215 ISIS PHARMACEUTICALS INC 0000874015 2834 330336973 DE 1231 8-K 34 000-19125 051266409 1896 RUTHERFORD ROAD CARLSBAD CA 92008 7609319200 1896 RUTHERFORD ROAD CARLSBAD CA 92008 8-K 1 a05-21748_18k.htm CURRENT REPORT OF MATERIAL EVENTS OR CORPORATE CHANGES EX-99.1 2 a05-21748_1ex99d1.htm EXHIBIT 99