0001104659-05-062396 S-3 3 20051222 20051222 ISIS PHARMACEUTICALS INC 0000874015 2834 330336973 DE 1231 S-3 33 333-130639 051282793 1896 RUTHERFORD ROAD CARLSBAD CA 92008 7609319200 1896 RUTHERFORD ROAD CARLSBAD CA 92008 S-3 1 a05-22096_1s3.htm REGISTRATION STATEMENT FOR FACE-AMOUNT CERTIFICATE COMPANIES EX-5.1 2 a05-22096_1ex5d1.htm OPINION REGARDING LEGALITY EX-23.1 3 a05-22096_1ex23d1.htm CONSENTS OF EXPERTS AND COUNSEL