0001140361-15-022745 DEFA14A 4 20150602 20150602 20150602 ISIS PHARMACEUTICALS INC 0000874015 2834 330336973 DE 1231 DEFA14A 34 000-19125 15905476 2855 GAZELLE COURT CARLSBAD CA 92010 7609319200 2855 GAZELLE COURT CARLSBAD CA 92010 DEFA14A 1 formdefa14a.htm ISIS PHARMACEUTICALS INC. DEFA14A 6-30-2015 GRAPHIC 2 image00001.jpg GRAPHIC 3 image00002.jpg GRAPHIC 4 image00003.jpg