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Collaborative Arrangements and Licensing Agreements, AstraZeneca (Details) $ in Thousands	1 Months Ended			3 Months Ended			9 Months Ended
	Nov. 06, 2018 USD ($) Program	Jul. 31, 2015 USD ($) PerformanceObligation Drug	Dec. 31, 2012 USD ($) PerformanceObligation	Sep. 30, 2018 USD ($)	Mar. 31, 2018 USD ($)	Sep. 30, 2017 USD ($)	Sep. 30, 2018 USD ($)	Sep. 30, 2017 USD ($)	Dec. 31, 2017 USD ($)	Mar. 31, 2014 PerformanceObligation
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue				$ 145,395		$ 118,314	$ 407,559	$ 346,387
Deferred revenue									$ 233,362
R&D [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue				62,639		$ 83,697	225,584	$ 280,281
AstraZeneca [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Deferred revenue				$ 44,900			$ 44,900		$ 57,700
AstraZeneca [Member] | Revenue [Member] | Strategic Partner [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Concentration percentage				10.00%		4.00%	21.00%	4.00%
AstraZeneca [Member] | R&D [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue				$ 14,200		$ 4,800	$ 86,500	$ 14,800
Cardiac, Renal and Metabolic Diseases [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of drugs that can be licensed under option in collaboration agreements | Drug		3
Upfront payment received		$ 65,000
Minimum amount of payments receivable for license fees and substantive milestones				4,000,000			4,000,000
Maximum amount of payments receivable for development milestones				1,100,000			1,100,000
Maximum amount of payments receivable for regulatory milestones				2,900,000			2,900,000
Cumulative payments received				165,000			165,000
Next prospective payment				10,000			10,000
Number of separate performance obligations | PerformanceObligation		1
Transaction price		$ 65,000
Revenue				10,000
Cardiac, Renal and Metabolic Diseases [Member] | IONIS-AZ5-2.5 [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue					$ 30,000
Cardiac, Renal and Metabolic Diseases [Member] | IONIS-AZ6-2.5 [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue					$ 30,000
Cardiac, Renal and Metabolic Diseases [Member] | R&D [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Payments included in transaction price for performance obligation				90,000			90,000
Oncology [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Upfront payment received			$ 31,000
Minimum amount of payments receivable for license fees and substantive milestones				450,000			450,000
Maximum amount of payments receivable for development milestones				152,000			152,000
Maximum amount of payments receivable for regulatory milestones				275,000			275,000
Cumulative payments received				97,800			97,800
Next prospective payment				$ 25,000			$ 25,000
Number of separate performance obligations | PerformanceObligation			4
Transaction price			$ 31,000
Number of obligations fully satisfied | PerformanceObligation										3
Oncology [Member] | Subsequent Event [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of programs advanced | Program	2
Revenue	$ 30,000
Oncology [Member] | R&D [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Transaction price			$ 7,600

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