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Collaborative Arrangements and Licensing Agreements, Biogen (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Dec. 31, 2017 USD ($) PerformanceObligation | Jul. 31, 2016 USD ($) | May 31, 2015 USD ($) | Sep. 30, 2013 USD ($) PerformanceObligation | Dec. 31, 2012 USD ($) PerformanceObligation Target Program | Dec. 31, 2018 USD ($) Drug Country Target | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) | Sep. 30, 2017 USD ($) | Dec. 31, 2018 USD ($) Drug Country Target | Dec. 31, 2017 USD ($) PerformanceObligation | Dec. 31, 2016 USD ($) PerformanceObligation | Apr. 30, 2018 USD ($) PerformanceObligation
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  | $ 91,200 |  |  |  |  |  |  | $ 599,674 | $ 514,179 | $ 372,776 |
Deferred revenue | $ 233,362 |  |  |  |  |  |  |  |  |  | 233,362 |  |
SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 237,930 | 112,540 | 883 |
Licensing and Other Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 14,755 | 7,474 | 21,884 |
R&D [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | $ 344,752 | 394,165 | 350,009 |
Biogen [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Number of additional drugs in clinical development to treat neurodegenerative diseases | Drug |  |  |  |  |  | 6 |  |  |  | 6 |  |  |
Cumulative payments received |  |  |  |  |  | $ 2,000,000 |  |  |  | $ 2,000,000 |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 375,000 | 263,100 | $ 249,700 |
Deferred revenue | $ 93,600 |  |  |  |  | 580,900 |  |  |  | $ 580,900 | $ 93,600 |  |
Biogen [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration percentage |  |  |  |  |  |  |  |  |  | 63.00% | 51.00% | 67.00% |
Biogen [Member] | SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | $ 237,900 | $ 112,500 | $ 900 |
Biogen [Member] | R&D [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 137,100 | 150,600 | $ 248,800 |
SPINRAZA [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative revenue earned |  |  |  |  |  | $ 785,000 |  |  |  | $ 785,000 |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  |  |  |  |  |  |  |  | 2 |
SPINRAZA [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Number of countries where SPINRAZA is approved for use | Country |  |  |  |  |  | 40 |  |  |  | 40 |  |  |
Royalty percentage received on net sales of drug |  |  |  |  |  |  |  |  |  | 11.00% |  |  |
SPINRAZA [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty percentage received on net sales of drug |  |  |  |  |  |  |  |  |  | 15.00% |  |  |
SPINRAZA [Member] | SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative revenue earned |  |  |  |  |  | $ 350,000 |  |  |  | $ 350,000 |  |  |
SPINRAZA [Member] | Licensing and Other Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  | $ 75,000 |  |  |  |  |  |  |  |  |  |  |
SPINRAZA [Member] | R&D [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative revenue earned |  |  |  |  |  | 435,000 |  |  |  | $ 435,000 |  |  |
Revenue |  |  |  |  |  |  |  |  |  |  | $ 90,000 |  |
New Antisense Drugs for the Treatment of SMA [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty percentage received on net sales of drug |  |  |  |  |  |  |  |  |  | 20.00% |  |  |
Number of separate performance obligations | PerformanceObligation | 1 |  |  |  |  |  |  |  |  |  | 1 |  |
Upfront payment received | $ 25,000 |  |  |  |  |  |  |  |  |  |  |  |
Maximum amount of payments receivable for license fees and substantive milestones |  |  |  |  |  | 1,200,000 |  |  |  | $ 1,200,000 |  |  |
Maximum amount of payments receivable for development milestones |  |  |  |  |  | 80,000 |  |  |  | 80,000 |  |  |
Maximum amount of payments receivable for commercialization milestones |  |  |  |  |  | 180,000 |  |  |  | 180,000 |  |  |
Maximum amount of payments receivable for sales milestones |  |  |  |  |  | 800,000 |  |  |  | 800,000 |  |  |
Next prospective payment |  |  |  |  |  | 60,000 |  |  |  | 60,000 |  |  |
Transaction price | $ 25,000 |  |  |  |  |  |  |  |  |  | $ 25,000 |  |
2018 Strategic Neurology [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  |  |  |  | $ 1,000,000 |  |  |  | $ 1,000,000 |  |  |
Royalty percentage received on net sales of drug |  |  |  |  |  |  |  |  |  | 20.00% |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  |  |  |  |  |  |  |  |  | 1
Number of targets | Target |  |  |  |  |  | 2 |  |  |  | 2 |  |  |
Upfront payment received |  |  |  |  |  |  |  | $ 375,000 |  |  |  |  |
Next prospective payment |  |  |  |  |  | $ 7,500 |  |  |  | $ 7,500 |  |  |
Transaction price |  |  |  |  |  |  |  |  |  |  |  |  | $ 552,000
Maximum amount of payments receivable per drug for substantive milestone payments |  |  |  |  |  | 270,000 |  |  |  | $ 270,000 |  |  |
Term of collaboration agreement |  |  |  |  |  |  |  |  |  | 10 years |  |  |
Upfront payment received, including purchase of stock |  |  |  |  |  |  |  | 1,000,000 |  |  |  |  |
Proceeds from issuance of common stock |  |  |  |  |  |  |  | $ 625,000 |  |  |  |  |
Percentage cash premium paid on shares purchased |  |  |  |  |  |  |  | 25.00% |  |  |  |  |
Premium paid on shares purchased |  |  |  |  |  |  |  | $ 177,000 |  |  |  |  |
Milestone payments received and added to transaction price |  |  |  |  |  | 15,000 |  |  |  |  |  |  |
2013 Strategic Neurology [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  |  |  |  | 210,000 |  |  |  | $ 210,000 |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  | 1 |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  | $ 100,000 |  |  |  |  |  |  |  |  |
Next prospective payment |  |  |  |  |  | $ 10,000 |  |  |  | $ 10,000 |  |  |
Transaction price |  |  |  | $ 100,000 |  |  |  |  |  |  |  |  |
Number of drugs currently being advanced | Drug |  |  |  |  |  | 5 |  |  |  | 5 |  |  |
Revenue |  |  |  |  |  |  | $ 10,000 |  |  |  |  |  |
2013 Strategic Neurology [Member] | Licensing and Other Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  | $ 35,000 |  |  |  |  |  |  |
2013 Strategic Neurology [Member] | R&D [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Payments included in transaction price for performance obligation |  |  |  |  |  | 145,000 |  |  |  | $ 145,000 |  |  |
Revenue |  |  |  |  |  | 5,000 |  |  |  |  |  |  |
2013 Strategic Neurology [Member] | Antisense Molecule [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum amount of payments receivable for license fees and substantive milestones |  |  |  |  |  | 260,000 |  |  |  | 260,000 |  |  |
Maximum amount of payments receivable for development milestones |  |  |  |  |  | 60,000 |  |  |  | 60,000 |  |  |
Maximum amount of payments receivable for regulatory milestones |  |  |  |  |  | 130,000 |  |  |  | 130,000 |  |  |
Neurology [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  |  |  |  | 58,000 |  |  |  | 58,000 |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  | 1 |  |  |  |  |  |  |  |
Number of targets | Target |  |  |  |  | 3 |  |  |  |  |  |  |  |
Number of programs under which drugs are to be developed and commercialized | Program |  |  |  |  | 3 |  |  |  |  |  |  |  |
Upfront payment received |  |  |  |  | $ 30,000 |  |  |  |  |  |  |  |
Next prospective payment |  |  |  |  |  | 7,500 |  |  |  | 7,500 |  |  |
Transaction price |  |  |  |  | $ 30,000 |  |  |  |  |  |  |  |
Maximum amount of payments receivable per program for license fee and substantive milestone payments |  |  |  |  |  | 210,000 |  |  |  | 210,000 |  |  |
Maximum amount of payments receivable per program for development milestones |  |  |  |  |  | 10,000 |  |  |  | 10,000 |  |  |
Maximum amount of payments receivable per program for regulatory milestones |  |  |  |  |  | 130,000 |  |  |  | 130,000 |  |  |
Milestone payments received and added to transaction price |  |  |  |  |  |  |  |  | $ 10,000 |  |  |  |
Neurology [Member] | R&D [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Payments included in transaction price for performance obligation |  |  |  |  |  | $ 40,000 |  |  |  | $ 40,000 |  |  |

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