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Collaborative Arrangements and Licensing Agreements, PTC Therapeutics (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Aug. 31, 2018 USD ($) PerformanceObligation | May 31, 2015 USD ($) | Sep. 30, 2018 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Revenue |  | $ 91,200 |  | $ 599,674 | $ 514,179 | $ 372,776
Deferred revenue |  |  |  |  | 233,362 |
PTC Therapeutics [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation | 2 |  |  |  |  |
Deferred revenue |  |  |  | 0 | $ 0 |
PTC Therapeutics [Member] | Sublicense Revenue [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Revenue |  |  | $ 7,200 |  |  |
Akcea [Member] | PTC Therapeutics [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Payment receivable under license agreement |  |  |  | 26,000 |  |
Payment received under license agreement |  |  | $ 12,000 |  |  |
Payment to be received on earlier of FDA or EMA approval of WAYLIVRA |  |  |  | 6,000 |  |
Maximum amount of payments receivable per drug for regulatory milestones |  |  |  | $ 8,000 |  |
Royalty percentage received on net sales of each drug in Latin America from PTC |  |  |  | 20.00% |  |
Period before PTC pays royalties on net sales of product after first commercial sale in Brazil |  |  |  | 12 months |  |
Minimum revenue recognized in Latin America by PTC before paying royalties |  |  |  | $ 10,000 |  |
Akcea [Member] | PTC Therapeutics [Member] | License Fees [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Revenue | $ 12,000 |  |  |  |  |

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- Definition The amount of the payment receivable under the license agreement to be received on the earlier of approval by the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA) under the collaboration agreement. + References No definition available. + Details
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- Definition Period of time before collaboration partner pays royalties on net sales of product after first commercial sale in Brazil, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
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