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Collaborative Arrangements and Licensing Agreements, Novartis (Details) $ in Thousands, shares in Millions | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Feb. 27, 2019 USD ($) | Jul. 31, 2017 USD ($) | May 31, 2015 USD ($) | Mar. 31, 2017 USD ($) PerformanceObligation shares | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Mar. 01, 2019 USD ($) shares | Jan. 31, 2017 USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Proceeds from sale of common stock to Novartis in a private placement |  |  |  |  | $ 0 | $ 50,000 | $ 0 |  |
Revenue |  |  | $ 91,200 |  | 599,674 | 514,179 | 372,776 |  |
Deferred revenue |  |  |  |  |  | 233,362 |  |  |
Subsequent Event [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Sublicense fee to be paid in stock by Akcea for license of AKCEA-AP)(a)-L |  |  |  |  |  |  |  | $ 75,000 |
Additional shares of Akcea stock to be received for license of AKCEA-APO(a)-L (in shares) | shares |  |  |  |  |  |  |  | 2.8 |
R&D [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 344,752 | 394,165 | $ 350,009 |  |
Novartis [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Shares issued (in shares) | shares |  |  |  | 1.6 |  |  |  |  |
Proceeds from sale of common stock |  |  |  | $ 100,000 |  |  |  |  |
Additional amount of common stock required to be purchased |  |  |  |  |  |  |  |  | $ 50,000
Number of separate performance obligations | PerformanceObligation |  |  |  | 4 |  |  |  |  |
Transaction price |  |  |  | $ 108,400 |  |  |  |  |
Premium received on shares issued |  |  |  | 28,400 |  |  |  |  |
Potential premium received if common stock is purchased in the future |  |  |  | 5,000 |  |  |  |  |
Deferred revenue |  |  |  |  | $ 28,800 | $ 70,700 |  |  |
Novartis [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Concentration percentage |  |  |  |  | 8.00% | 8.00% |  |  |
Novartis [Member] | R&D Services for AKCEA-APO(a)-L [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Transaction price |  |  |  | 64,000 |  |  |  |  |
Novartis [Member] | Delivery of AKCEA-APO(a)-L [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Transaction price |  |  |  | 1,500 |  |  |  |  |
Novartis [Member] | R&D Services for AKCEA-APOCIII-L [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Transaction price |  |  |  | 40,100 |  |  |  |  |
Novartis [Member] | Delivery of AKCEA-APOCIII-L [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Transaction price |  |  |  | 2,800 |  |  |  |  |
Novartis [Member] | R&D [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | $ 50,600 | $ 43,400 |  |  |
Akcea [Member] | Novartis [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  | 75,000 |  |  |  |  |
Portion of upfront payment retained |  |  |  | 60,000 |  |  |  |  |
Portion of upfront payment paid as a sublicense fee |  |  |  | 15,000 |  |  |  |  |
License fee receivable per drug |  |  |  |  | $ 150,000 |  |  |  |
Percentage of license fees, milestone payments and royalties paid as sublicense fee |  |  |  |  | 50.00% |  |  |  |
Additional amount of common stock required to be purchased |  |  |  | $ 50,000 |  |  |  |  |
Proceeds from sale of common stock to Novartis in a private placement |  | $ 50,000 |  |  |  |  |  |  |
Akcea [Member] | Novartis [Member] | License Fees [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Revenue | $ 150,000 |  |  |  |  |  |  |  |
Akcea [Member] | Novartis [Member] | AKCEA-APO(a)-L [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Maximum amount of payments receivable for milestones |  |  |  |  | $ 675,000 |  |  |  |
Maximum amount of payments receivable for development milestones |  |  |  |  | 25,000 |  |  |  |
Maximum amount of payments receivable for regulatory milestones |  |  |  |  | 290,000 |  |  |  |
Maximum amount of payments receivable for commercialization milestones |  |  |  |  | $ 360,000 |  |  |  |
Royalty percentage received on sales of drug |  |  |  |  | 20.00% |  |  |  |
Akcea [Member] | Novartis [Member] | AKCEA-APOCIII-L [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Maximum amount of payments receivable for milestones |  |  |  |  | $ 530,000 |  |  |  |
Maximum amount of payments receivable for development milestones |  |  |  |  | 25,000 |  |  |  |
Maximum amount of payments receivable for regulatory milestones |  |  |  |  | 240,000 |  |  |  |
Maximum amount of payments receivable for commercialization milestones |  |  |  |  | $ 265,000 |  |  |  |
Royalty percentage received on sales of drug |  |  |  |  | 20.00% |  |  |  |

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