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Long-Term Obligations and Commitments, Operating Leases (Details) $ in Thousands | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2018 USD ($) Option | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Aug. 15, 2018 USD ($) | Apr. 05, 2018
Office and Laboratory Space Adjacent to Manufacturing Facility [Member] |  |  |  |  |
Operating Leases [Abstract] |  |  |  |  |
Number of options to extend lease | Option | 2 |  |  |  |
Term of lease extension | 5 years |  |  |  |
Annual Future Minimum Payments Under Operating Leases [Abstract] |  |  |  |  |
2019 | $ 3,129 |  |  |  |
2020 | 3,008 |  |  |  |
2021 | 2,725 |  |  |  |
2022 | 2,539 |  |  |  |
2023 | 2,505 |  |  |  |
Thereafter | 11,862 |  |  |  |
Total minimum payments | 25,768 |  |  |  |
Rent expense | 2,600 | $ 1,700 | $ 2,000 |  |
Deferred rent | $ 5,000 | $ 100 |  |  |
Office Space Subleased to Akcea [Member] |  |  |  |  |
Operating Leases [Abstract] |  |  |  |  |
Number of options to extend lease | Option | 1 |  |  |  |
Term of lease extension | 5 years |  |  |  |
Akcea [Member] | Office Space for Corporate Headquarters [Member] |  |  |  |  |
Operating Leases [Abstract] |  |  |  |  |
Term of lease extension |  |  |  |  | 5 years
Term of lease |  |  |  |  | 123 months
Period of free rent under lease | 3 months |  |  |  |
Tenant improvement allowance |  |  |  | $ 3,800 |
Initial amount of letter of credit |  |  |  | 2,400 |
Letter of credit on third anniversary of rent commencement date |  |  |  | 1,800 |
Letter of credit on fifth anniversary of rent commencement date |  |  |  | $ 1,200 |

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- Definition Allowance for tenant improvements to the office space included in the lessee's operating lease. + References No definition available. + Details
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- Definition Initial letter of credit provided to lessor to secure lease obligation under lessee's operating lease. + References No definition available. + Details
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- Definition Letter of credit provided to lessor to secure lease obligation under lessee's operating lease on the fifth anniversary of the rent commencement date. + References No definition available. + Details
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- Definition Letter of credit provided to lessor to secure lease obligation under lessee's operating lease on the third anniversary of the rent commencement date. + References No definition available. + Details
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- Definition Period of time in which the rent is free under operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. + References No definition available. + Details
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- Definition The cumulative difference between the rental payments required by a lease agreement and the rental income or expense recognized on a straight-line basis, or other systematic and rational basis more representative of the time pattern in which use or benefit is granted or derived from the leased property, expected to be recognized in income or expense over the term of the leased property by the lessor or lessee, respectively. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 20 -Section 25 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=77902458&loc=d3e39896-112707 + Details
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- Definition Amount of required minimum rental payments for operating leases having an initial or remaining non-cancelable lease term in excess of one year due in the fifth fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 20 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=77902758&loc=d3e41502-112717 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 10 -Section 55 -Paragraph 40 -Subparagraph (Note 3) -URI http://asc.fasb.org/extlink&oid=82846649&loc=d3e38371-112697 + Details
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- Definition Amount of required minimum rental payments for operating leases having an initial or remaining non-cancelable lease term in excess of one year due in the fourth fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 10 -Section 55 -Paragraph 40 -Subparagraph (Note 3) -URI http://asc.fasb.org/extlink&oid=82846649&loc=d3e38371-112697 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 20 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=77902758&loc=d3e41502-112717 + Details
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- Definition Amount of required minimum rental payments for operating leases having an initial or remaining non-cancelable lease term in excess of one year due in the second fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 10 -Section 55 -Paragraph 40 -Subparagraph (Note 3) -URI http://asc.fasb.org/extlink&oid=82846649&loc=d3e38371-112697 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 20 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=77902758&loc=d3e41502-112717 + Details
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- Definition This element represents the payments that the lessee is obligated to make or can be required to make in connection with a property under the terms of an agreement classified as an operating lease, excluding contingent rentals and a guarantee by the lessee of the lessor's debt and the lessee's obligation to pay (apart from the rental payments) executory costs such as insurance, maintenance, and taxes. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=77902758&loc=d3e41499-112717 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 10 -Section 25 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=77910348&loc=d3e34039-112682 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 10 -Section 55 -Paragraph 40 -Subparagraph (Note 3) -URI http://asc.fasb.org/extlink&oid=82846649&loc=d3e38371-112697 + Details
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