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Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Deferred Tax Assets [Abstract] |  |  |  |
Net operating loss carryovers | $ 89,717 | $ 89,717 | $ 153,575 |
R&D credits | 313,652 | 313,652 | 240,290 |
Deferred revenue | 27,381 | 27,381 | 54,302 |
Stock-based compensation | 61,027 | 61,027 | 40,090 |
Intangible and capital assets | 49,007 | 49,007 | 672 |
Other | 8,275 | 8,275 | 12,164 |
Total deferred tax assets | 549,059 | 549,059 | 501,093 |
Deferred Tax Liabilities [Abstract] |  |  |  |
Convertible debt | (24,018) | (24,018) | (32,391) |
Net deferred tax asset | 525,041 | 525,041 | 468,702 |
Valuation allowance | (234,245) | (234,245) | (468,702) |
Total net deferred tax assets and liabilities | 290,796 | 290,796 | 0 |
One-time non-cash tax benefit related to reversal of valuation allowance | $ 332,100 | $ (277,924) | $ (86,296) | $ 46,402
Utilization period for net operating loss carryforwards and tax credit carryforwards |  | 3 years |  |
Decrease in valuation allowance |  | $ (234,500) |  |

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