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Segment Information and Concentration of Business Risk, Segment Information (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
May 31, 2015 USD ($) | Dec. 31, 2018 USD ($) | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Sep. 30, 2017 USD ($) | Jun. 30, 2017 USD ($) | Mar. 31, 2017 USD ($) | Dec. 31, 2018 USD ($) Segment | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Jul. 31, 2017
Segment Information and Concentration of Business Risk [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Number of reportable segments | Segment |  |  |  |  |  |  |  |  |  | 2 |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue | $ 91,200 |  |  |  |  |  |  |  |  | $ 599,674 | $ 514,179 | $ 372,776 |
Total operating expenses |  | $ 181,331 | $ 163,967 | $ 168,028 | $ 147,720 | $ 173,992 | $ 107,002 | $ 105,823 | $ 96,315 | 661,046 | 483,132 | 392,936 |
Income (loss) from operations |  | 10,782 | $ (18,572) | $ (50,281) | $ (3,301) | (6,200) | $ 11,312 | $ 6,450 | $ 19,485 | (61,372) | 31,047 | (20,160) |
Total assets as of current period |  | $ 2,667,784 |  |  |  | 1,322,774 |  |  |  | 2,667,784 | 1,322,774 |  |
Commercial Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 254,922 | 120,014 | 22,767 |
SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 237,930 | 112,540 | 883 |
TEGSEDI Product Sales, Net [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 2,237 | 0 | 0 |
Licensing and Other Royalty Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 14,755 | 7,474 | 21,884 |
R&D Revenue Under Collaborative Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | $ 344,752 | 394,165 | 350,009 |
Akcea [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information and Concentration of Business Risk [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage ownership |  | 75.00% |  |  | 68.00% |  |  |  |  | 75.00% |  |  | 68.00%
Operating Segments [Member] | Ionis Core [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | $ 641,944 | 525,185 | 385,424 |
Total operating expenses |  |  |  |  |  |  |  |  |  | 380,212 | 373,788 | 322,192 |
Income (loss) from operations |  |  |  |  |  |  |  |  |  | 261,732 | 151,397 | 63,232 |
Total assets as of current period |  | $ 2,975,491 |  |  |  | 1,342,578 |  |  |  | 2,975,491 | 1,342,578 |  |
Operating Segments [Member] | Ionis Core [Member] | Commercial Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 240,685 | 120,014 | 22,767 |
Operating Segments [Member] | Ionis Core [Member] | SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 237,930 | 112,540 | 883 |
Operating Segments [Member] | Ionis Core [Member] | TEGSEDI Product Sales, Net [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 0 |  |  |
Operating Segments [Member] | Ionis Core [Member] | Licensing and Other Royalty Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 2,755 | 7,474 | 21,884 |
Operating Segments [Member] | Ionis Core [Member] | R&D Revenue Under Collaborative Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 401,259 | 405,171 | 362,657 |
Operating Segments [Member] | Akcea Therapeutics [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 64,867 | 43,401 | 0 |
Total operating expenses |  |  |  |  |  |  |  |  |  | 295,683 | 163,871 | 83,512 |
Income (loss) from operations |  |  |  |  |  |  |  |  |  | (230,816) | (120,470) | (83,512) |
Total assets as of current period |  | 365,261 |  |  |  | 268,804 |  |  |  | 365,261 | 268,804 |  |
Operating Segments [Member] | Akcea Therapeutics [Member] | Commercial Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 14,237 | 0 | 0 |
Operating Segments [Member] | Akcea Therapeutics [Member] | SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 0 | 0 | 0 |
Operating Segments [Member] | Akcea Therapeutics [Member] | TEGSEDI Product Sales, Net [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 2,237 |  |  |
Operating Segments [Member] | Akcea Therapeutics [Member] | Licensing and Other Royalty Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 12,000 | 0 | 0 |
Operating Segments [Member] | Akcea Therapeutics [Member] | R&D Revenue Under Collaborative Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 50,630 | 43,401 | 0 |
Elimination of Intercompany Activity [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | (107,137) | (54,407) | (12,648) |
Total operating expenses |  |  |  |  |  |  |  |  |  | (14,849) | (54,527) | (12,768) |
Income (loss) from operations |  |  |  |  |  |  |  |  |  | (92,288) | 120 | 120 |
Total assets as of current period |  | $ (672,968) |  |  |  | $ (288,608) |  |  |  | (672,968) | (288,608) |  |
Elimination of Intercompany Activity [Member] | Commercial Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 0 | 0 | 0 |
Elimination of Intercompany Activity [Member] | SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 0 | 0 | 0 |
Elimination of Intercompany Activity [Member] | TEGSEDI Product Sales, Net [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 0 |  |  |
Elimination of Intercompany Activity [Member] | Licensing and Other Royalty Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 0 | 0 | 0 |
Elimination of Intercompany Activity [Member] | R&D Revenue Under Collaborative Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | $ (107,137) | $ (54,407) | $ (12,648) |

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