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Stockholders' Equity, Stock Plans (Details) | 1 Months Ended | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jun. 30, 2009 shares | Dec. 31, 2018 Installment $ / shares shares | Dec. 31, 2017 shares | May 31, 2017 shares | Apr. 30, 2017 shares | Jun. 30, 2015 shares | May 31, 2015 shares
Stock Options [Member] |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |
Number of options outstanding (in shares) |  | 11,311,000 | 9,397,000 |  |  |  |
Number of options exercisable (in shares) |  | 6,071,000 |  |  |  |  |
Restricted Stock Units [Member] |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |
Vesting period |  | 4 years |  |  |  |  |
1989 Stock Option Plan [Member] |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |
Number of shares authorized (in shares) |  | 20,000,000 |  |  |  |  |
Vesting period |  | 4 years |  |  |  |  |
Award term |  | 7 years |  |  |  |  |
Number of options outstanding (in shares) |  | 848,753 |  |  |  |  |
Number of options exercisable (in shares) |  | 831,656 |  |  |  |  |
Number of shares available for grant (in shares) |  | 42,925 |  |  |  |  |
1989 Stock Option Plan [Member] | One Year from Date of Grant [Member] |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |
Vesting percentage |  | 25.00% |  |  |  |  |
2011 Equity Incentive Plan [Member] |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |
Number of shares authorized (in shares) |  |  |  | 16,000,000 | 11,000,000 | 11,000,000 | 5,500,000
Number of options outstanding (in shares) |  | 9,705,441 |  |  |  |  |
Number of options exercisable (in shares) |  | 4,801,904 |  |  |  |  |
Number of shares available for grant (in shares) |  | 3,340,351 |  |  |  |  |
Period before change of control when vesting will accelerate for executive officers |  | 3 months |  |  |  |  |
Period after change of control when vesting will accelerate for executive officers |  | 12 months |  |  |  |  |
Number of awards outstanding (in shares) |  | 1,183,154 |  |  |  |  |
2011 Equity Incentive Plan [Member] | Stock Options [Member] | Minimum [Member] |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |
Vesting period |  | 2 years |  |  |  |  |
2011 Equity Incentive Plan [Member] | Restricted Stock Units [Member] |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |
Vesting period |  | 4 years |  |  |  |  |
2011 Equity Incentive Plan [Member] | Restricted Stock Units [Member] | Minimum [Member] |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |
Vesting period |  | 3 years |  |  |  |  |
2002 Non-Employee Directors' Stock Option Plan [Member] |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |
Number of shares authorized (in shares) |  |  |  |  |  | 2,000,000 | 1,200,000
Award term |  | 10 years |  |  |  |  |
Number of options outstanding (in shares) |  | 757,750 |  |  |  |  |
Number of options exercisable (in shares) |  | 437,750 |  |  |  |  |
Number of shares available for grant (in shares) |  | 420,762 |  |  |  |  |
Number of awards outstanding (in shares) |  | 63,099 |  |  |  |  |
2002 Non-Employee Directors' Stock Option Plan [Member] | One Year from Date of Grant [Member] |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |
Number of equal annual installments over which options become exercisable | Installment |  | 4 |  |  |  |  |
Employee Stock Purchase Plan [Member] |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |
Number of shares authorized (in shares) |  | 3,674,596 |  |  |  |  |
Number of shares available for grant (in shares) |  | 774,816 |  |  |  |  |
Number of additional shares reserved for issuance (in shares) | 150,000 | 150,000 |  |  |  |  |
Maximum percentage of employee compensation used to purchase shares |  | 10.00% |  |  |  |  |
Percentage of fair market value used to determine purchase price of stock |  | 85.00% |  |  |  |  |
Purchase period |  | 6 months |  |  |  |  |
Holding period for purchased stock |  | 6 months |  |  |  |  |
Shares purchased and issued under ESPP (in shares) |  | 43,416 |  |  |  |  |
Purchase price (in dollars per share) | $ / shares |  | $ 39.03 |  |  |  |  |

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