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Collaborative Arrangements and Licensing Agreements, AstraZeneca (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Jul. 31, 2015 USD ($) PerformanceObligation | May 31, 2015 USD ($) | Dec. 31, 2012 USD ($) PerformanceObligation | Dec. 31, 2018 USD ($) Drug Program | Sep. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2018 USD ($) Drug | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Mar. 31, 2014 PerformanceObligation
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  | $ 91,200 |  |  |  |  | $ 599,674 | $ 514,179 | $ 372,776 |
Deferred revenue |  |  |  |  |  |  |  | 233,362 |  |
R&D [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  | 344,752 | 394,165 | $ 350,009 |
AstraZeneca [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  |  | $ 40,100 |  |  | $ 40,100 | $ 57,700 |  |
AstraZeneca [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Concentration percentage |  |  |  |  |  |  | 20.00% | 4.00% | 11.00% |
AstraZeneca [Member] | R&D [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  | $ 120,700 | $ 21,600 | $ 41,300 |
Cardiac, Renal and Metabolic Diseases [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Number of drugs that can be licensed under option in collaboration agreements | Drug |  |  |  | 3 |  |  | 3 |  |  |
Upfront payment received | $ 65,000 |  |  |  |  |  |  |  |  |
Minimum amount of payments receivable for license fees and substantive milestones |  |  |  | $ 4,000,000 |  |  | $ 4,000,000 |  |  |
Maximum amount of payments receivable for development milestones |  |  |  | 1,100,000 |  |  | 1,100,000 |  |  |
Maximum amount of payments receivable for regulatory milestones |  |  |  | 2,900,000 |  |  | 2,900,000 |  |  |
Cumulative payments received |  |  |  | 165,000 |  |  | 165,000 |  |  |
Next prospective payment |  |  |  | 10,000 |  |  | 10,000 |  |  |
Number of separate performance obligations | PerformanceObligation | 1 |  |  |  |  |  |  |  |  |
Transaction price | $ 65,000 |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | $ 10,000 |  |  |  |  |
Cardiac, Renal and Metabolic Diseases [Member] | IONIS-AZ5-2.5 [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  | $ 30,000 |  |  |  |
Cardiac, Renal and Metabolic Diseases [Member] | IONIS-AZ6-2.5 [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  | $ 30,000 |  |  |  |
Cardiac, Renal and Metabolic Diseases [Member] | R&D [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Payments included in transaction price for performance obligation |  |  |  | 90,000 |  |  | 90,000 |  |  |
Revenue |  |  |  |  | $ 10,000 |  |  |  |  |
Oncology [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  | $ 31,000 |  |  |  |  |  |  |
Minimum amount of payments receivable for license fees and substantive milestones |  |  |  | 450,000 |  |  | 450,000 |  |  |
Maximum amount of payments receivable for development milestones |  |  |  | 152,000 |  |  | 152,000 |  |  |
Maximum amount of payments receivable for regulatory milestones |  |  |  | 275,000 |  |  | 275,000 |  |  |
Cumulative payments received |  |  |  | 125,000 |  |  | 125,000 |  |  |
Next prospective payment |  |  |  | $ 25,000 |  |  | $ 25,000 |  |  |
Number of programs advanced | Program |  |  |  | 2 |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  | 4 |  |  |  |  |  |  |
Transaction price |  |  | $ 31,000 |  |  |  |  |  |  |
Number of obligations fully satisfied | PerformanceObligation |  |  |  |  |  |  |  |  |  | 3
Revenue |  |  |  | $ 30,000 |  |  |  |  |  |
Oncology [Member] | Danvatirsen [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  | 17,500 |  |  |  |  |  |
Oncology [Member] | Undisclosed Program [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  | $ 10,000 |  |  |  |  |  |
Oncology [Member] | R&D [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Transaction price |  |  | $ 7,600 |  |  |  |  |  |  |

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