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Segment Information and Concentration of Business Risk (Tables) | 12 Months Ended
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Dec. 31, 2018
Segment Information and Concentration of Business Risk [Abstract] |
Segment Information | The following tables show our segment revenue and income (loss) from operations for 2018, 2017 and 2016 (in thousands), respectively.
2018 |  | Ionis Core |  |  | Akcea Therapeutics |  |  | Elimination of Intercompany Activity |  |  | Total |
Revenue: |  |  |  |  |  |  |  |  |  |  |  |
Commercial revenue: |  |  |  |  |  |  |  |  |  |  |  |
SPINRAZA royalties |  | $ | 237,930 |  |  | $ | — |  |  | $ | — |  |  | $ | 237,930 |
TEGSEDI product sales, net |  |  | — |  |  |  | 2,237 |  |  |  | — |  |  |  | 2,237 |
Licensing and other royalty revenue |  |  | 2,755 |  |  |  | 12,000 |  |  |  | — |  |  |  | 14,755 |
Total commercial revenue |  |  | 240,685 |  |  |  | 14,237 |  |  |  | — |  |  |  | 254,922 |
R&D revenue under collaborative agreements |  |  | 401,259 |  |  |  | 50,630 |  |  |  | (107,137 | ) |  |  | 344,752 |
Total segment revenue |  | $ | 641,944 |  |  | $ | 64,867 |  |  | $ | (107,137 | ) |  | $ | 599,674 |
Total operating expenses |  | $ | 380,212 |  |  | $ | 295,683 |  |  | $ | (14,849 | ) |  | $ | 661,046 |
Income (loss) from operations |  | $ | 261,732 |  |  | $ | (230,816 | ) |  | $ | (92,288 | ) |  | $ | (61,372 | )
2017 (as revised) |  | Ionis Core |  |  | Akcea Therapeutics |  |  | Elimination of Intercompany Activity |  |  | Total |
Revenue: |  |  |  |  |  |  |  |  |  |  |  |
Commercial revenue: |  |  |  |  |  |  |  |  |  |  |  |
SPINRAZA royalties |  | $ | 112,540 |  |  | $ | — |  |  | $ | — |  |  | $ | 112,540 |
Licensing and other royalty revenue |  |  | 7,474 |  |  |  | — |  |  |  | — |  |  |  | 7,474 |
Total commercial revenue |  |  | 120,014 |  |  |  | — |  |  |  | — |  |  |  | 120,014 |
R&D revenue under collaborative agreements |  |  | 405,171 |  |  |  | 43,401 |  |  |  | (54,407 | ) |  |  | 394,165 |
Total segment revenue |  | $ | 525,185 |  |  | $ | 43,401 |  |  | $ | (54,407 | ) |  | $ | 514,179 |
Total operating expenses |  | $ | 373,788 |  |  | $ | 163,871 |  |  | $ | (54,527 | ) |  | $ | 483,132 |
Income (loss) from operations |  | $ | 151,397 |  |  | $ | (120,470 | ) |  | $ | 120 |  |  | $ | 31,047 |
2016 (as revised) |  | Ionis Core |  |  | Akcea Therapeutics |  |  | Elimination of Intercompany Activity |  |  | Total |
Revenue: |  |  |  |  |  |  |  |  |  |  |  |
Commercial revenue: |  |  |  |  |  |  |  |  |  |  |  |
SPINRAZA royalties |  | $ | 883 |  |  | $ | — |  |  | $ | — |  |  | $ | 883 |
Licensing and other royalty revenue |  |  | 21,884 |  |  |  | — |  |  |  | — |  |  |  | 21,884 |
Total commercial revenue |  |  | 22,767 |  |  |  | — |  |  |  | — |  |  |  | 22,767 |
R&D revenue under collaborative agreements |  |  | 362,657 |  |  |  | — |  |  |  | (12,648 | ) |  |  | 350,009 |
Total segment revenue |  | $ | 385,424 |  |  | $ | — |  |  | $ | (12,648 | ) |  | $ | 372,776 |
Total operating expenses |  | $ | 322,192 |  |  | $ | 83,512 |  |  | $ | (12,768 | ) |  | $ | 392,936 |
Income (loss) from operations |  | $ | 63,232 |  |  | $ | (83,512 | ) |  | $ | 120 |  |  | $ | (20,160 | )
The following table shows our total assets by segment at December 31, 2018 and 2017 (in thousands), respectively.
Total Assets |  | Ionis Core |  |  | Akcea Therapeutics |  |  | Elimination of Intercompany Activity |  |  | Total |
December 31, 2018 |  | $ | 2,975,491 |  |  | $ | 365,261 |  |  | $ | (672,968 | ) |  | $ | 2,667,784 |
December 31, 2017 (as revised) |  | $ | 1,342,578 |  |  | $ | 268,804 |  |  | $ | (288,608 | ) |  | $ | 1,322,774 |

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