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Organization and Significant Accounting Policies, Research, Development and Patent Expenses (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Research, Development and Patent Expenses [Abstract] |  |  |
Research and development expenses | $ 411.9 | $ 372.5 | $ 340.4
Patents [Member] |  |  |
Patents [Abstract] |  |  |
Estimated useful life | 10 years 1 month 6 days |  |
Cost | $ 32.7 | 30.8 |
Accumulated amortization | 8.7 | 8.8 |
Estimated Amortization Expense [Abstract] |  |  |
2019 | 1.7 |  |
2020 | 1.6 |  |
2021 | 1.5 |  |
2022 | 1.4 |  |
2023 | 1.3 |  |
Patent expenses | 2.6 | 2.1 | 3.9
Non-cash charges related to write-down | 0.8 | 0.4 | 2.3
Collaborative Agreements [Member] |  |  |
Research, Development and Patent Expenses [Abstract] |  |  |
Research and development expenses | $ 58.7 | $ 59.5 | $ 187.1

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