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Income Taxes, Reconciliation of Statutory to Effective Tax Rate (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Reconciliation Between Effective and Statutory Tax Rate [Abstract] |  |  |  |
Pre-tax loss |  | $ (76,156) | $ (16,763) | $ (57,466)
Statutory rate |  | (15,993) | (5,867) | (20,113)
State income tax net of federal benefit |  | (2,202) | 820 | 95
Foreign |  | 1,735 | 4,299 | 0
Net change in valuation allowance | $ 332,100 | (277,924) | (86,296) | 46,402
Net operating loss expiration |  | 8,864 | 3,987 | 0
TEGSEDI licensing gain |  | 59,583 | 0 | 0
Tax credits |  | (73,362) | (32,769) | (26,954)
Deferred tax true-up |  | 9,947 | 4,848 | 2,591
Tax rate change |  | (1,808) | 114,832 | 0
Non-deductible compensation |  | 3,154 | 1,575 | 825
Other non-deductible items |  | (569) | 2,548 | 324
Akcea deconsolidation adjustment at IPO |  | 0 | 469 | 0
Stock-based compensation |  | (4,199) | (14,337) | 0
Other |  | 1,633 | (89) | (236)
Income tax (benefit) expense |  | $ (291,141) | $ (5,980) | $ 2,934
Reconciliation Between Effective and Statutory Tax Rate Percentage [Abstract] |  |  |  |
Statutory rate |  | 21.00% | 35.00% | 35.00%
State income tax net of federal benefit |  | 2.90% | (4.90%) | (0.20%)
Foreign |  | (2.30%) | (25.60%) | 0.00%
Net change in valuation allowance |  | 364.90% | 514.80% | (80.70%)
Net operating loss expiration |  | (11.60%) | (23.80%) | 0.00%
TEGSEDI licensing gain |  | (78.20%) | 0.00% | 0.00%
Tax credits |  | 96.30% | 195.50% | 46.90%
Deferred tax true-up |  | (13.10%) | (28.90%) | (4.50%)
Tax rate change |  | 2.40% | (685.00%) | 0.00%
Non-deductible compensation |  | (4.10%) | (9.40%) | (1.40%)
Other nondeductible items |  | 0.70% | (15.20%) | (0.60%)
Akcea deconsolidation adjustment at IPO |  | 0.00% | (2.80%) | 0.00%
Stock-based compensation |  | 5.50% | 85.50% | 0.00%
Other |  | (2.10%) | 0.50% | 0.40%
Effective rate |  | 382.30% | 35.70% | (5.10%)

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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to licensing gain on TEGSEDI. + References No definition available. + Details
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- Definition The amount of income tax expense or benefit for the period computed by applying the domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32698-109319 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(h)(2)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 + Details
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other nondeductible expenses. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32698-109319 + Details
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other adjustments. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 + Details
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