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Organization and Significant Accounting Policies, Revenue Recognition - Deferred Revenue (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017
Deferred Revenue [Abstract] |  |
Revenue recognized | $ 105,300 | $ 95,100
Current portion of deferred contract revenue | 160,256 | 125,336
Long-term deferred contract revenue | $ 567,359 | 108,026
Total deferred revenue |  | 233,362
As Previously Reported Under Topic 605 [Member] | Topic 606 [Member] |  |
Deferred Revenue [Abstract] |  |
Current portion of deferred contract revenue |  | 106,465
Long-term deferred contract revenue |  | 72,708
Total deferred revenue |  | 179,173
Topic 606 Adjustment [Member] | Topic 606 [Member] |  |
Deferred Revenue [Abstract] |  |
Current portion of deferred contract revenue |  | 18,871
Long-term deferred contract revenue |  | 35,318
Total deferred revenue |  | 54,189
Topic 606 Adjustment [Member] | Topic 606 [Member] | Biogen [Member] |  |
Deferred Revenue [Abstract] |  |
Total deferred revenue |  | 24,200
Topic 606 Adjustment [Member] | Topic 606 [Member] | AstraZeneca [Member] |  |
Deferred Revenue [Abstract] |  |
Total deferred revenue |  | 15,900
Topic 606 Adjustment [Member] | Topic 606 [Member] | Novartis [Member] |  |
Deferred Revenue [Abstract] |  |
Total deferred revenue |  | 11,800
Topic 606 Adjustment [Member] | Topic 606 [Member] | Other Partners [Member] |  |
Deferred Revenue [Abstract] |  |
Total deferred revenue |  | $ 2,300

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