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Segment Information and Concentration of Business Risk | 12 Months Ended
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Dec. 31, 2018
Segment Information and Concentration of Business Risk [Abstract] |
Segment Information and Concentration of Business Risk | 7. Segment Information and Concentration of Business Risk We have two reportable segments Ionis Core and Akcea Therapeutics. At December 31, 2018, we owned approximately 75 percent of Akcea. Segment income (loss) from operations includes revenue less operating expenses attributable to each segment. In our Ionis Core segment we are exploiting our antisense technology to generate a broad pipeline of first-in-class and/or best-in-class medicines for us and our partners. Our Ionis Core segment generates revenue from a multifaceted partnering strategy. Akcea is a biopharmaceutical company focused on developing and commercializing medicines to treat patients with rare and serious diseases. The following tables show our segment revenue and income (loss) from operations for 2018, 2017 and 2016 (in thousands), respectively.
2018 |  | Ionis Core |  |  | Akcea Therapeutics |  |  | Elimination of Intercompany Activity |  |  | Total |
Revenue: |  |  |  |  |  |  |  |  |  |  |  |
Commercial revenue: |  |  |  |  |  |  |  |  |  |  |  |
SPINRAZA royalties |  | $ | 237,930 |  |  | $ | — |  |  | $ | — |  |  | $ | 237,930 |
TEGSEDI product sales, net |  |  | — |  |  |  | 2,237 |  |  |  | — |  |  |  | 2,237 |
Licensing and other royalty revenue |  |  | 2,755 |  |  |  | 12,000 |  |  |  | — |  |  |  | 14,755 |
Total commercial revenue |  |  | 240,685 |  |  |  | 14,237 |  |  |  | — |  |  |  | 254,922 |
R&D revenue under collaborative agreements |  |  | 401,259 |  |  |  | 50,630 |  |  |  | (107,137 | ) |  |  | 344,752 |
Total segment revenue |  | $ | 641,944 |  |  | $ | 64,867 |  |  | $ | (107,137 | ) |  | $ | 599,674 |
Total operating expenses |  | $ | 380,212 |  |  | $ | 295,683 |  |  | $ | (14,849 | ) |  | $ | 661,046 |
Income (loss) from operations |  | $ | 261,732 |  |  | $ | (230,816 | ) |  | $ | (92,288 | ) |  | $ | (61,372 | )
2017 (as revised) |  | Ionis Core |  |  | Akcea Therapeutics |  |  | Elimination of Intercompany Activity |  |  | Total |
Revenue: |  |  |  |  |  |  |  |  |  |  |  |
Commercial revenue: |  |  |  |  |  |  |  |  |  |  |  |
SPINRAZA royalties |  | $ | 112,540 |  |  | $ | — |  |  | $ | — |  |  | $ | 112,540 |
Licensing and other royalty revenue |  |  | 7,474 |  |  |  | — |  |  |  | — |  |  |  | 7,474 |
Total commercial revenue |  |  | 120,014 |  |  |  | — |  |  |  | — |  |  |  | 120,014 |
R&D revenue under collaborative agreements |  |  | 405,171 |  |  |  | 43,401 |  |  |  | (54,407 | ) |  |  | 394,165 |
Total segment revenue |  | $ | 525,185 |  |  | $ | 43,401 |  |  | $ | (54,407 | ) |  | $ | 514,179 |
Total operating expenses |  | $ | 373,788 |  |  | $ | 163,871 |  |  | $ | (54,527 | ) |  | $ | 483,132 |
Income (loss) from operations |  | $ | 151,397 |  |  | $ | (120,470 | ) |  | $ | 120 |  |  | $ | 31,047 |
2016 (as revised) |  | Ionis Core |  |  | Akcea Therapeutics |  |  | Elimination of Intercompany Activity |  |  | Total |
Revenue: |  |  |  |  |  |  |  |  |  |  |  |
Commercial revenue: |  |  |  |  |  |  |  |  |  |  |  |
SPINRAZA royalties |  | $ | 883 |  |  | $ | — |  |  | $ | — |  |  | $ | 883 |
Licensing and other royalty revenue |  |  | 21,884 |  |  |  | — |  |  |  | — |  |  |  | 21,884 |
Total commercial revenue |  |  | 22,767 |  |  |  | — |  |  |  | — |  |  |  | 22,767 |
R&D revenue under collaborative agreements |  |  | 362,657 |  |  |  | — |  |  |  | (12,648 | ) |  |  | 350,009 |
Total segment revenue |  | $ | 385,424 |  |  | $ | — |  |  | $ | (12,648 | ) |  | $ | 372,776 |
Total operating expenses |  | $ | 322,192 |  |  | $ | 83,512 |  |  | $ | (12,768 | ) |  | $ | 392,936 |
Income (loss) from operations |  | $ | 63,232 |  |  | $ | (83,512 | ) |  | $ | 120 |  |  | $ | (20,160 | )
The following table shows our total assets by segment at December 31, 2018 and 2017 (in thousands), respectively.
Total Assets |  | Ionis Core |  |  | Akcea Therapeutics |  |  | Elimination of Intercompany Activity |  |  | Total |
December 31, 2018 |  | $ | 2,975,491 |  |  | $ | 365,261 |  |  | $ | (672,968 | ) |  | $ | 2,667,784 |
December 31, 2017 (as revised) |  | $ | 1,342,578 |  |  | $ | 268,804 |  |  | $ | (288,608 | ) |  | $ | 1,322,774 |
Contracts receivables at December 31, 2018 and December 31, 2017 were comprised of approximately 99 percent and 84 percent for each year from four and two significant partners, respectively.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -URI http://asc.fasb.org/topic&trid=2134510 + Details
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