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Organization and Significant Accounting Policies, Fair Value Measurements - Novartis Future Stock Purchase (Details) - USD ($) $ in Thousands | 12 Months Ended |
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Dec. 31, 2017 | Jan. 31, 2017
Novartis [Member] |  |
Novartis Future Stock Purchase [Abstract] |  |
Additional amount of common stock required to be purchased |  | $ 50,000
Fair value of potential future premium |  | $ 5,000
Potential Future Premium [Member] |  |
Unobservable Inputs (Level 3) [Roll Forward] |  |
Beginning balance of Level 3 instruments | $ 0 |
Value of the potential premium we will receive from Novartis at inception of the SPA (January 2017) | 5,035 |
Write-off of premium to other expenses | (5,035) |
Ending balance of Level 3 instruments | $ 0 |

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- Definition The additional amount of common stock the collaboration partner is required to purchase under a Stock Purchase Agreement (SPA) in conjunction with the collaboration agreement. + References No definition available. + Details
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- References No definition available. + Details
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- Definition The fair value of the potential future premium the Company will receive if Novartis purchases its common stock under a Stock Purchase Agreement (SPA) entered into in January 2017. + References No definition available. + Details
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- Definition A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period. + References No definition available. + Details
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- Definition Amount of gain (loss) recognized in the income statement for financial instrument classified as an asset measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258 + Details
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- Definition Amount of transfer of financial instrument classified as an asset into level 3 of the fair value hierarchy. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(3) -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258 + Details
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