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Collaborative Arrangements and Licensing Agreements, Janssen Biotech, Inc. (Details) $ in Thousands | 1 Months Ended | 12 Months Ended | 17 Months Ended
--- | --- | --- | ---
Jan. 31, 2018 USD ($) | Nov. 30, 2017 USD ($) | Jul. 31, 2016 USD ($) | May 31, 2015 USD ($) | Dec. 31, 2014 USD ($) PerformanceObligation Program | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Nov. 30, 2017 USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Revenue |  |  |  | $ 91,200 |  | $ 599,674 | $ 514,179 | $ 372,776 |
Deferred revenue |  |  |  |  |  |  | 233,362 |  |
Licensing and Other Royalties [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  | 14,755 | 7,474 | 21,884 |
R&D [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  | 344,752 | 394,165 | $ 350,009 |
Janssen Biotech, Inc. [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Number of programs under which drugs are to be developed and commercialized | Program |  |  |  |  | 3 |  |  |  |
Upfront payment received |  |  |  |  | $ 35,000 |  |  |  |
Minimum amount of payments receivable for license fees and substantive milestones |  |  |  |  |  | 800,000 |  |  |
Maximum amount of payments receivable for development milestones |  |  |  |  |  | 175,000 |  |  |
Maximum amount of payments receivable for regulatory milestones |  |  |  |  |  | 440,000 |  |  |
Maximum amount of payments receivable for commercialization milestones |  |  |  |  |  | 180,000 |  |  |
Cumulative payments received |  |  |  |  |  | 75,000 |  |  |
Next prospective milestone |  |  |  |  |  | 5,000 |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  | 1 |  |  |  |
Transaction price |  |  |  |  | $ 35,000 |  |  |  |
Deferred revenue |  |  |  |  |  | $ 0 | $ 0 |  |
Janssen Biotech, Inc. [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Concentration percentage |  |  |  |  |  | 1.00% | 7.00% | 7.00% |
Janssen Biotech, Inc. [Member] | Licensing and Other Royalties [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | $ 15,000
Janssen Biotech, Inc. [Member] | IONIS-JBI1-2.5 [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Revenue | $ 5,000 |  | $ 10,000 |  |  |  |  |  |
Janssen Biotech, Inc. [Member] | IONIS-JBI2-2.5 [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Revenue |  | $ 5,000 |  |  |  |  |  |  |
Janssen Biotech, Inc. [Member] | R&D [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  | $ 6,600 | $ 36,000 | $ 24,800 |

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