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CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited) - USD ($) shares in Thousands, $ in Thousands | Common Stock [Member] | Additional Paid In Capital [Member] | Accumulated Other Comprehensive Loss [Member] | Accumulated Deficit [Member] | Total Ionis Stockholders' Equity [Member] | Noncontrolling Interest in Akcea Therapeutics, Inc. [Member] | Total
--- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2017 | $ 125 | $ 1,553,681 | $ (31,759) | $ (1,241,034) | $ 281,013 | $ 84,267 | $ 365,280
Balance (in shares) at Dec. 31, 2017 | 124,976 |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |
Net income (loss) | $ 0 | 0 | 0 | (1,420) | (1,420) | 0 | (1,420)
Change in unrealized gains (losses), net of tax | 0 | 0 | (1,530) | 0 | (1,530) | 0 | (1,530)
Foreign currency translation | 0 | 0 | 55 | 0 | 55 | 0 | 55
Issuance of common stock in connection with employee stock plans | $ 0 | 5,664 | 0 | 0 | 5,664 | 0 | 5,664
Issuance of common stock in connection with employee stock plans (in shares) | 473 |  |  |  |  |  |
Stock-based compensation expense | $ 0 | 28,451 | 0 | 0 | 28,451 | 0 | 28,451
Noncontrolling interest in Akcea Therapetuics, Inc. | 0 | (10,842) | 0 | 0 | (10,842) | 1,443 | (9,399)
Balance at Mar. 31, 2018 | $ 125 | 1,576,954 | (33,234) | (1,242,454) | 301,391 | 85,710 | 387,101
Balance (in shares) at Mar. 31, 2018 | 125,449 |  |  |  |  |  |
Balance at Dec. 31, 2018 | $ 138 | 2,047,250 | (32,016) | (967,293) | 1,048,079 | 139,081 | 1,187,160
Balance (in shares) at Dec. 31, 2018 | 137,929 |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |
Net income (loss) | $ 0 | 0 | 0 | 84,443 | 84,443 | 0 | 84,443
Change in unrealized gains (losses), net of tax | 0 | 0 | 4,324 | 0 | 4,324 | 0 | 4,324
Foreign currency translation | 0 | 0 | 84 | 0 | 84 | 0 | 84
Issuance of common stock in connection with employee stock plans | $ 2 | 67,057 | 0 | 0 | 67,059 | 0 | 67,059
Issuance of common stock in connection with employee stock plans (in shares) | 1,825 |  |  |  |  |  |
Stock-based compensation expense | $ 0 | 45,505 | 0 | 0 | 45,505 | 0 | 45,505
Payments of tax withholdings related to vesting of share-based awards | $ 0 | (7,597) | 0 | 0 | (7,597) | 0 | (7,597)
Payments of tax withholdings related to vesting of share-based awards (in shares) | (130) |  |  |  |  |  |
Noncontrolling interest in Akcea Therapetuics, Inc. | $ 0 | (34,246) | 0 | 0 | (34,246) | 40,688 | 6,442
Balance at Mar. 31, 2019 | $ 140 | $ 2,117,969 | $ (27,608) | $ (882,850) | $ 1,207,651 | $ 179,769 | $ 1,387,420
Balance (in shares) at Mar. 31, 2019 | 139,624 |  |  |  |  |  |

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