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Operating Leases (Details) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2019 USD ($) Option | Mar. 31, 2018 USD ($)
Operating Leases [Abstract] |  |  |
Right-of-use operating lease assets | [1] | $ 13,100 |
Operating lease liabilties | [2] | $ 17,960 |
Weighted average remaining lease term |  | 9 years |
Weighted average discount rate |  | 7.60% |
Current portion of operating lease liabilties |  | $ 2,000 |
Operating lease cash payments |  | 1,000 |
Annual Future Minimum Payments Under Operating Leases [Abstract] |  |  |
Remainder of 2019 |  | 2,341 |
2020 |  | 3,008 |
2021 |  | 2,725 |
2022 |  | 2,539 |
2023 |  | 2,505 |
Thereafter |  | 11,862 |
Total minimum payments |  | 24,980 |
Imputed interest |  | (7,020) |
Total lease liabilities | [2] | 17,960 |
Rent expense |  | $ 900 | $ 0
Office and Laboratory Space Adjacent to Manufacturing Facility [Member] |  |  |
Operating Leases [Abstract] |  |  |
Number of options to extend lease | Option |  | 2 |
Term of lease extension |  | 5 years |
Office Space Subleased to Akcea [Member] |  |  |
Operating Leases [Abstract] |  |  |
Number of options to extend lease | Option |  | 1 |
Term of lease extension |  | 5 years |
Akcea [Member] | Office Space for Corporate Headquarters [Member] |  |  |
Operating Leases [Abstract] |  |  |
Term of lease extension |  | 5 years |
Term of lease |  | 123 months |
Period of free rent under lease |  | 3 months |
Tenant improvement allowance |  | $ 3,800 |
Initial amount of letter of credit |  | 2,400 |
Letter of credit on third anniversary of rent commencement date |  | 1,800 |
Letter of credit on fifth anniversary of rent commencement date |  | $ 1,200 |
[1] | Included in deposits and other assets on our condensed consolidated balance sheet.
[2] | Current portion of $2.0 million was included in current portion of long-term obligations on our condensed consolidated balance sheet, with the difference included in long-term obligations.

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- Definition Letter of credit provided to lessor to secure lease obligation under lessee's operating lease on the fifth anniversary of the rent commencement date. + References No definition available. + Details
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- Definition Letter of credit provided to lessor to secure lease obligation under lessee's operating lease on the third anniversary of the rent commencement date. + References No definition available. + Details
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- Definition Period of time in which the rent is free under operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. + References No definition available. + Details
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- Definition Amount of lessee's undiscounted obligation for lease payments for operating lease. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=77888426&loc=SL77918701-209980 + Details
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