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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2019 | Jun. 30, 2018
Operating activities: |  |
Net income (loss) | $ 80,873 | $ (67,381)
Adjustments to reconcile net loss to net cash provided by operating activities: |  |
Depreciation | 6,253 | 4,858
Amortization of right-of-use operating lease assets | 1,035 | 0
Amortization of patents | 948 | 895
Amortization of premium (discount) on investments, net | (5,163) | 1,845
Amortization of debt issuance costs | 957 | 853
Amortization of convertible senior notes discount | 17,661 | 16,364
Stock-based compensation expense | 87,437 | 62,327
Non-cash losses related to patents, licensing and property, plant and equipment | 203 | 415
Provision for deferred income taxes | 14,436 | 0
Changes in operating assets and liabilities: |  |
Contracts receivable | (16,255) | 46,193
Inventories | (5,736) | 915
Other current and long-term assets | (6,372) | (5,177)
Accounts payable | (16,104) | (14,239)
Accrued compensation | (9,219) | (10,062)
Accrued liabilities and deferred rent | 3,283 | (8,218)
Deferred contract revenue | (73,643) | 483,814
Net cash provided by operating activities | 80,594 | 513,402
Investing activities: |  |
Purchases of short-term investments | (1,049,274) | (648,902)
Proceeds from short-term investments | 877,966 | 364,048
Purchases of property, plant and equipment | (7,243) | (8,977)
Acquisition of licenses and other assets, net | (2,310) | (1,854)
Net cash used in investing activities | (180,861) | (295,685)
Financing activities: |  |
Proceeds from equity awards | 102,004 | 10,178
Payments of tax withholdings related to vesting of employee stock awards | (8,034) | 0
Proceeds from the issuance of common stock to Biogen | 0 | 447,965
Net cash provided by financing activities | 93,970 | 458,143
Net increase in cash and cash equivalents | (6,297) | 675,860
Cash and cash equivalents at beginning of period | 278,820 | 129,630
Cash and cash equivalents at end of period | 272,523 | 805,490
Supplemental disclosures of cash flow information: |  |
Interest paid | 4,776 | 4,753
Supplemental disclosures of non-cash investing and financing activities: |  |
Right-of-use assets obtained in exchange for lease obligations | 13,920 | 0
Amounts accrued for capital and patent expenditures | $ 3,073 | $ 2,645

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