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Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2018 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Deferred Tax Assets [Abstract] |  |  |  |
Net operating loss carryovers | $ 89,717 | $ 20,191 | $ 89,717 |
R&D credits | 313,652 | 210,455 | 313,652 |
Deferred revenue | 27,381 | 127,763 | 27,381 |
Stock-based compensation | 61,027 | 65,703 | 61,027 |
Intangible and capital assets | 49,007 | 77,861 | 49,007 |
Other | 8,275 | 12,510 | 8,275 |
Total deferred tax assets | 549,059 | 514,483 | 549,059 |
Deferred Tax Liabilities [Abstract] |  |  |  |
Convertible debt | (24,018) | (6,110) | (24,018) |
Fixed assets | 0 | (1,958) | 0 |
Other | 0 | (3,884) | 0 |
Net deferred tax asset | 525,041 | 502,531 | 525,041 |
Valuation allowance | (234,245) | (196,974) | (234,245) |
Total net deferred tax assets and liabilities | 290,796 | 305,557 | 290,796 |
One-time non-cash tax benefit related to reversal of valuation allowance | $ 332,100 | (37,765) | $ (277,924) | $ (86,296)
Decrease in valuation allowance |  | (37,300) |  |
Decrease in combined state tax liability |  | $ (59,100) |  |

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