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v3.19.3.a.u2

Segment Information and Concentration of Business Risk, Segment Information (Details) $ in Thousands | 3 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Dec. 31, 2019 USD ($) | Sep. 30, 2019 USD ($) | Jun. 30, 2019 USD ($) | Mar. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2019 USD ($) Segment | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Jun. 30, 2017
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Number of reportable segments | Segment |  |  |  |  |  |  |  |  | 2 |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | $ 1,122,599 | $ 599,674 | $ 514,179 |
Total operating expenses | $ 233,028 | $ 165,369 | $ 182,640 | $ 175,679 | $ 181,331 | $ 163,967 | $ 168,028 | $ 147,720 | 756,716 | 661,046 | 483,132 |
Income (loss) from operations | 260,652 | $ 2,523 | $ (18,827) | $ 121,535 | 10,782 | $ (18,572) | $ (50,281) | $ (3,301) | 365,883 | (61,372) | 31,047 |
Total assets as of current period | $ 3,233,112 |  |  |  | 2,667,784 |  |  |  | 3,233,112 | 2,667,784 |  |
Commercial Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 352,450 | 254,922 | 120,014 |
SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 292,992 | 237,930 | 112,540 |
Product Sales, Net [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 42,253 | 2,237 | 0 |
Licensing and Other Royalty Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 17,205 | 14,755 | 7,474 |
R&D Revenue Under Collaborative Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | $ 770,149 | 344,752 | 394,165 |
Akcea [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Percentage ownership | 76.00% |  |  |  |  |  |  |  | 76.00% |  |  | 100.00%
Operating Segments [Member] | Ionis Core [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | $ 858,646 | 641,944 | 525,185 |
Total operating expenses |  |  |  |  |  |  |  |  | 523,207 | 380,212 | 373,788 |
Income (loss) from operations |  |  |  |  |  |  |  |  | 335,439 | 261,732 | 151,397 |
Total assets as of current period | $ 3,478,081 |  |  |  | 2,975,491 |  |  |  | 3,478,081 | 2,975,491 |  |
Operating Segments [Member] | Ionis Core [Member] | Commercial Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 305,608 | 240,685 | 120,014 |
Operating Segments [Member] | Ionis Core [Member] | SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 292,992 | 237,930 | 112,540 |
Operating Segments [Member] | Ionis Core [Member] | Product Sales, Net [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 0 | 0 |  |
Operating Segments [Member] | Ionis Core [Member] | Licensing and Other Royalty Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 12,616 | 2,755 | 7,474 |
Operating Segments [Member] | Ionis Core [Member] | R&D Revenue Under Collaborative Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 553,038 | 401,259 | 405,171 |
Operating Segments [Member] | Akcea Therapeutics [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 488,543 | 64,867 | 43,401 |
Total operating expenses |  |  |  |  |  |  |  |  | 450,469 | 295,683 | 163,871 |
Income (loss) from operations |  |  |  |  |  |  |  |  | 38,074 | (230,816) | (120,470) |
Total assets as of current period | 599,250 |  |  |  | 365,261 |  |  |  | 599,250 | 365,261 |  |
Operating Segments [Member] | Akcea Therapeutics [Member] | Commercial Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 52,425 | 14,237 | 0 |
Operating Segments [Member] | Akcea Therapeutics [Member] | SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 0 | 0 | 0 |
Operating Segments [Member] | Akcea Therapeutics [Member] | Product Sales, Net [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 42,253 | 2,237 |  |
Operating Segments [Member] | Akcea Therapeutics [Member] | Licensing and Other Royalty Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 10,172 | 12,000 | 0 |
Operating Segments [Member] | Akcea Therapeutics [Member] | R&D Revenue Under Collaborative Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 436,118 | 50,630 | 43,401 |
Elimination of Intercompany Activity [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | (224,590) | (107,137) | (54,407) |
Total operating expenses |  |  |  |  |  |  |  |  | (216,960) | (14,849) | (54,527) |
Income (loss) from operations |  |  |  |  |  |  |  |  | (7,630) | (92,288) | 120 |
Total assets as of current period | $ (844,219) |  |  |  | $ (672,968) |  |  |  | (844,219) | (672,968) |  |
Elimination of Intercompany Activity [Member] | Commercial Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | (5,583) | 0 | 0 |
Elimination of Intercompany Activity [Member] | SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 0 | 0 | 0 |
Elimination of Intercompany Activity [Member] | Product Sales, Net [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 0 | 0 |  |
Elimination of Intercompany Activity [Member] | Licensing and Other Royalty Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | (5,583) | 0 | 0 |
Elimination of Intercompany Activity [Member] | R&D Revenue Under Collaborative Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |
Segment Information [Abstract] |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | $ (219,007) | $ (107,137) | $ (54,407) |

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