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Organization and Significant Accounting Policies, Research, Development and Patent Expenses (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Research, Development and Patent Expenses [Abstract] |  |  |
Research and development expenses | $ 461.5 | $ 411.9 | $ 372.5
Patents [Member] |  |  |
Patents [Abstract] |  |  |
Estimated useful life | 10 years 3 months 18 days |  |
Cost | $ 34.0 | 32.7 |
Accumulated amortization | 8.3 | 8.7 |
Estimated Amortization Expense [Abstract] |  |  |
2020 | 1.8 |  |
2021 | 1.8 |  |
2022 | 1.7 |  |
2023 | 1.6 |  |
2024 | 1.4 |  |
Patent expenses | 4.2 | 2.6 | 2.1
Non-cash charges related to write-down | 2.2 | 0.8 | 0.4
Collaborative Agreements [Member] |  |  |
Research, Development and Patent Expenses [Abstract] |  |  |
Research and development expenses | $ 83.2 | $ 58.7 | $ 59.5

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