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Collaborative Arrangements and Licensing Agreements, Bayer (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Feb. 28, 2017 USD ($) PerformanceObligation | May 31, 2015 USD ($) PerformanceObligation | Dec. 31, 2019 USD ($) | Jun. 30, 2015 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  |  |  |  | $ 1,122,599 | $ 599,674 | $ 514,179
R&D Revenue [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  |  |  |  | 770,149 | 344,752 | $ 394,165
Bayer [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation | 3 |  |  |  |  |  |
Revenue |  |  | $ 10,000 |  |  |  |
Deferred revenue |  |  | 2,400 |  | $ 2,400 | $ 4,300 |
Bayer [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Concentration percentage |  |  |  |  | 1.00% | 1.00% | 13.00%
Bayer [Member] | R&D Revenue [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  |  |  |  | $ 14,300 | $ 5,000 | $ 67,100
Bayer [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Upfront payment received |  | $ 100,000 |  | $ 100,000 |  |  |
Maximum amount of payments receivable for license fees and milestones |  |  | 385,000 |  | 385,000 |  |
Maximum amount of payments receivable for development milestones |  |  | 125,000 |  | 125,000 |  |
Maximum amount of payments receivable for commercialization milestones |  |  | 110,000 |  | $ 110,000 |  |
Royalty percentage received on gross margins of both drugs combined |  |  |  |  | 20.00% |  |
Cumulative payments received |  |  | 185,000 |  | $ 185,000 |  |
Next prospective milestone |  |  | $ 20,000 |  | $ 20,000 |  |
Number of separate performance obligations | PerformanceObligation |  | 3 |  |  |  |  |
Bayer [Member] | R&D Services for IONIS-FXI-L [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Transaction price | $ 10,100 |  |  |  |  |  |
Bayer [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Upfront payment received | 75,000 |  |  |  |  |  |
Payment received for advancing programs | $ 75,000 |  |  |  |  |  |
Number of new performance obligations | PerformanceObligation | 2 |  |  |  |  |  |
Transaction price | $ 75,000 |  |  |  |  |  |
Bayer [Member] | IONIS-FXI-L [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Number of new performance obligations | PerformanceObligation | 1 |  |  |  |  |  |
Transaction price | $ 64,900 |  |  |  |  |  |
Bayer [Member] | R&D Services for IONIS-FXI-L [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Number of new performance obligations | PerformanceObligation | 1 |  |  |  |  |  |

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