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Collaborative Arrangements and Licensing Agreements, AstraZeneca (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Jul. 31, 2015 USD ($) PerformanceObligation | Dec. 31, 2012 USD ($) PerformanceObligation | Dec. 31, 2019 USD ($) Drug | Dec. 31, 2018 USD ($) Program | Sep. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) LicenseFee | Dec. 31, 2019 USD ($) Drug | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Mar. 31, 2014 PerformanceObligation
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  | $ 1,122,599 | $ 599,674 | $ 514,179 |
R&D Revenue [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  | 770,149 | 344,752 | $ 394,165 |
AstraZeneca [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  | $ 25,000 | $ 40,100 |  |  | $ 25,000 | $ 40,100 |  |
AstraZeneca [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Concentration percentage |  |  |  |  |  |  | 3.00% | 20.00% | 4.00% |
AstraZeneca [Member] | R&D Revenue [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  | $ 28,100 | $ 120,700 | $ 21,600 |
Cardiovascular, Renal and Metabolic Diseases [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Number of licensed drugs | Drug |  |  | 3 |  |  |  | 3 |  |  |
Upfront payment received | $ 65,000 |  |  |  |  |  |  |  |  |
Minimum amount of payments receivable for license fees and milestones |  |  | $ 4,000,000 |  |  |  | $ 4,000,000 |  |  |
Maximum amount of payments receivable for development milestones |  |  | 1,100,000 |  |  |  | 1,100,000 |  |  |
Maximum amount of payments receivable for regulatory milestones |  |  | 2,900,000 |  |  |  | 2,900,000 |  |  |
Next prospective payment |  |  | 10,000 |  |  |  | 10,000 |  |  |
Cumulative payments received |  |  | 175,000 |  |  |  | 175,000 |  |  |
Number of separate performance obligations | PerformanceObligation | 1 |  |  |  |  |  |  |  |  |
Transaction price | $ 65,000 |  |  |  |  |  |  |  |  |
Number of license fees earned | LicenseFee |  |  |  |  |  | 2 |  |  |  |
Revenue |  |  |  | $ 10,000 | $ 10,000 |  |  |  |  |
Cardiovascular, Renal and Metabolic Diseases [Member] | ION532 [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  | $ 30,000 |  |  |  |
Cardiovascular, Renal and Metabolic Diseases [Member] | IOIN839 [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  | $ 30,000 |  |  |  |
Cardiovascular, Renal and Metabolic Diseases [Member] | R&D Revenue [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments included in transaction price for performance obligation |  |  | 90,000 |  |  |  | 90,000 |  |  |
Oncology [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Upfront payment received |  | $ 31,000 | 10,000 |  |  |  |  |  |  |
Minimum amount of payments receivable for license fees and milestones |  |  | 450,000 |  |  |  | 450,000 |  |  |
Maximum amount of payments receivable for development milestones |  |  | 152,000 |  |  |  | 152,000 |  |  |
Maximum amount of payments receivable for regulatory milestones |  |  | 275,000 |  |  |  | 275,000 |  |  |
Cumulative payments received |  |  | 125,000 |  |  |  | 125,000 |  |  |
Number of separate performance obligations | PerformanceObligation |  | 4 |  |  |  |  |  |  |  |
Number of performance obligations completed | PerformanceObligation |  |  |  |  |  |  |  |  |  | 3
Number of programs advanced | Program |  |  |  | 2 |  |  |  |  |  |
Revenue |  |  |  | $ 30,000 |  |  |  |  |  |
Oncology [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Next prospective payment |  |  | $ 25,000 |  |  |  | $ 25,000 |  |  |
Oncology [Member] | Danvatirsen [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  | 17,500 |  |  |  |  |  |
Oncology [Member] | ION736 [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  | $ 10,000 |  |  |  |  |  |

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