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v3.19.3.a.u2

Organization and Significant Accounting Policies, Cost of Products Sold (Details) - USD ($) $ in Millions | 12 Months Ended
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Dec. 31, 2019 | Dec. 31, 2018
Cost of Products Sold [Abstract] |  |
Previously expensed costs to produce TEGSEDI related to TEGSEDI commercial revenue | $ 0.7 | $ 0.1

X
- Definition The costs related to goods produced and sold that were previously recognized as expense and are related to the commercial revenue recognized during the period. + References No definition available. + Details
Name: | ions_CostOfProductsSoldPreviouslyRecognized
Namespace Prefix: | ions_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- References No definition available. + Details
Name: | us-gaap_CostOfGoodsAndServicesSoldAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration