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Collaborative Arrangements and Licensing Agreements, PTC Therapeutics (Details) $ in Thousands | 3 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Dec. 31, 2019 USD ($) | Jun. 30, 2019 USD ($) | Sep. 30, 2018 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Aug. 31, 2018 PerformanceObligation
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  |  |  | $ 1,122,599 | $ 599,674 | $ 514,179 |
Licensing and Other Royalty Revenue [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  |  |  | 17,205 | 14,755 | $ 7,474 |
PTC Therapeutics [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  |  |  | 2
Deferred revenue | $ 0 |  |  | 0 | $ 0 |  |
Akcea [Member] | PTC Therapeutics [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Maximum payment receivable under license agreement | 26,000 |  |  | 26,000 |  |  |
Payment received under license agreement | 4,000 | $ 6,000 | $ 12,000 |  |  |  |
Maximum amount of payments receivable per drug for regulatory milestones | 4,000 |  |  | $ 4,000 |  |  |
Royalty percentage received on net sales of each drug in Latin America from PTC |  |  |  | 20.00% |  |  |
Period before PTC pays royalties on net sales of product after first commercial sale in Brazil |  |  |  | 12 months |  |  |
Minimum revenue recognized in Latin America by PTC before paying royalties |  |  |  | $ 10,000 |  |  |
Akcea [Member] | PTC Therapeutics [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Concentration percentage |  |  |  | 1.00% | 2.00% |  |
Akcea [Member] | PTC Therapeutics [Member] | Licensing and Other Royalty Revenue [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  |  |  | $ 10,200 | $ 12,000 |  |
Akcea [Member] | PTC Therapeutics [Member] | License Fees [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  |  | $ 12,000 |  |  |  |
Akcea [Member] | PTC Therapeutics [Member] | WAYLIVRA [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  | $ 6,000 |  |  |  |  |
Akcea [Member] | PTC Therapeutics [Member] | TEGSEDI [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue | $ 4,000 |  |  |  |  |  |

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