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Income Taxes, Reconciliation of Statutory to Effective Tax Rate (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2018 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Reconciliation Between Effective and Statutory Tax Rate [Abstract] |  |  |  |
Pre-tax income (loss) |  | $ 346,769 | $ (76,156) | $ (16,763)
Statutory rate |  | 72,822 | (15,993) | (5,867)
State income tax net of federal benefit |  | 49,119 | (2,202) | 820
Foreign |  | 340 | 1,735 | 4,299
Net change in valuation allowance | $ 332,100 | (37,765) | (277,924) | (86,296)
Net operating loss expiration |  | 0 | 8,864 | 3,987
TEGSEDI licensing gain |  | 0 | 59,583 | 0
Impact from outside basis differences |  | (16,344) | 0 | 0
Tax credits |  | (22,296) | (73,362) | (32,769)
Deferred tax true-up |  | 646 | 9,947 | 4,848
Tax rate change |  | 1,811 | (1,808) | 114,832
Non-deductible compensation |  | 3,361 | 3,154 | 1,575
Other non-deductible items |  | 329 | (569) | 2,548
Akcea deconsolidation adjustment at IPO |  | 0 | 0 | 469
Stock-based compensation |  | (4,837) | (4,199) | (14,337)
Foreign-derived intangible income benefit |  | (2,071) | 0 | 0
Other |  | (1,608) | 1,633 | (89)
Income tax expense (benefit) |  | $ 43,507 | $ (291,141) | $ (5,980)
Reconciliation Between Effective and Statutory Tax Rate Percentage [Abstract] |  |  |  |
Statutory rate |  | 21.00% | 21.00% | 35.00%
State income tax net of federal benefit |  | 14.20% | 2.90% | (4.90%)
Foreign |  | 0.10% | (2.30%) | (25.60%)
Net change in valuation allowance |  | (10.90%) | 364.90% | 514.80%
Net operating loss expiration |  | 0.00% | (11.60%) | (23.80%)
TEGSEDI licensing gain |  | 0.00% | (78.20%) | 0.00%
Impact from outside basis differences |  | (4.70%) | 0.00% | 0.00%
Tax credits |  | (6.40%) | 96.30% | 195.50%
Deferred tax true-up |  | 0.20% | (13.10%) | (28.90%)
Tax rate change |  | 0.50% | 2.40% | (685.00%)
Non-deductible compensation |  | 1.00% | (4.10%) | (9.40%)
Other nondeductible items |  | 0.10% | 0.70% | (15.20%)
Akcea deconsolidation adjustment at IPO |  | 0.00% | 0.00% | (2.80%)
Stock-based compensation |  | (1.40%) | 5.50% | 85.50%
Foreign-derived intangible income benefit |  | (0.60%) | 0.00% | 0.00%
Other |  | (0.50%) | (2.10%) | 0.50%
Effective rate |  | 12.60% | 382.30% | 35.70%

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