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Organization and Significant Accounting Policies, Fair Value Measurements (Details) - Recurring Basis [Member] - USD ($)
$ in Thousands
Dec. 31, 2019
Dec. 31, 2018
Fair Value Measurements [Abstract]    
Cash equivalents [1] $ 418,406 $ 146,281
Investment in ProQR Therapeutics N.V. [2] 4,506 1,349
Total 2,258,985 2,017,298
Corporate Debt Securities [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 1,102,568 [3] 1,252,960 [4]
Corporate Debt Securities [Member] | Cash and Cash Equivalents [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 19,000 50,200
Debt Securities issued by U.S. Government Agencies [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 329,404 [5] 276,612 [6]
Debt Securities issued by U.S. Government Agencies [Member] | Cash and Cash Equivalents [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 800  
Debt Securities issued by the U.S. Treasury [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 363,694 [6] 260,154 [7]
Debt Securities issued by the U.S. Treasury [Member] | Cash and Cash Equivalents [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities   14,200
Debt Securities issued by States of the U.S. and Political Subdivisions of the States [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities [6] 40,407 79,942
Quoted Prices in Active Markets (Level 1) [Member]    
Fair Value Measurements [Abstract]    
Cash equivalents 418,406 146,281
Investment in ProQR Therapeutics N.V. 0 0
Total 782,100 406,435
Quoted Prices in Active Markets (Level 1) [Member] | Corporate Debt Securities [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 0 0
Quoted Prices in Active Markets (Level 1) [Member] | Debt Securities issued by U.S. Government Agencies [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 0 0
Quoted Prices in Active Markets (Level 1) [Member] | Debt Securities issued by the U.S. Treasury [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 363,694 260,154
Quoted Prices in Active Markets (Level 1) [Member] | Debt Securities issued by States of the U.S. and Political Subdivisions of the States [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 0 0
Significant Other Observable Inputs (Level 2) [Member]    
Fair Value Measurements [Abstract]    
Cash equivalents 0 0
Investment in ProQR Therapeutics N.V. 0 0
Total 1,472,379 1,609,514
Significant Other Observable Inputs (Level 2) [Member] | Corporate Debt Securities [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 1,102,568 1,252,960
Significant Other Observable Inputs (Level 2) [Member] | Debt Securities issued by U.S. Government Agencies [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 329,404 276,612
Significant Other Observable Inputs (Level 2) [Member] | Debt Securities issued by the U.S. Treasury [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 0 0
Significant Other Observable Inputs (Level 2) [Member] | Debt Securities issued by States of the U.S. and Political Subdivisions of the States [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 40,407 79,942
Significant Unobservable Inputs (Level 3) [Member]    
Fair Value Measurements [Abstract]    
Cash equivalents 0  
Investment in ProQR Therapeutics N.V. 4,506 1,349
Total 4,506 1,349
Significant Unobservable Inputs (Level 3) [Member] | Corporate Debt Securities [Member]    
Fair Value Measurements [Abstract]    
Cash equivalents   0
Available-for-sale securities 0 0
Significant Unobservable Inputs (Level 3) [Member] | Debt Securities issued by U.S. Government Agencies [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 0 0
Significant Unobservable Inputs (Level 3) [Member] | Debt Securities issued by the U.S. Treasury [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities 0 0
Significant Unobservable Inputs (Level 3) [Member] | Debt Securities issued by States of the U.S. and Political Subdivisions of the States [Member]    
Fair Value Measurements [Abstract]    
Available-for-sale securities $ 0 $ 0
[1] Included in cash and cash equivalents on our consolidated balance sheet.
[2] Included in other current assets on our consolidated balance sheet.
[3] $19.0 million included in cash and cash equivalents on our consolidated balance sheet, with the difference included in short-term investments on our consolidated balance sheet.
[4] $50.2 million included in cash and cash equivalents on our consolidated balance sheet, with the difference included in short-term investments on our consolidated balance sheet.
[5] $0.8 million included in cash and cash equivalents on our consolidated balance sheet, with the difference included in short-term investments on our consolidated balance sheet.
[6] Included in short-term investments.
[7] $14.2 million included in cash and cash equivalents on our consolidated balance sheet, with the difference included in short-term investments on our consolidated balance sheet.