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Significant Accounting Policies, Cost of Products Sold (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Cost of Products Sold [Abstract]
Previously expensed costs to produce TEGSEDI related to TEGSEDI commercial revenue	$ 0.6	$ 0.3

X

- Definition

The costs related to goods produced and sold that were previously recognized as expense and are related to the commercial revenue recognized during the period.

+ References

No definition available.

+ Details

Name:	ions_CostOfProductsSoldPreviouslyRecognized
Namespace Prefix:	ions_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- References

No definition available.

+ Details

Name:	us-gaap_CostOfGoodsAndServicesSoldAbstract
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration