    <SEC-DOCUMENT>0001140361-20-009606-index.html : 20200424
    <SEC-HEADER>0001140361-20-009606.hdr.sgml : 20200424
    <ACCEPTANCE-DATETIME>20200424060215
    ACCESSION NUMBER:		0001140361-20-009606
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		20
    CONFORMED PERIOD OF REPORT:	20200604
    FILED AS OF DATE:		20200424
    DATE AS OF CHANGE:		20200424
    EFFECTIVENESS DATE:		20200424

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
    		CENTRAL INDEX KEY:			0000874015
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				330336973
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	000-19125
    		FILM NUMBER:		20812392

    	BUSINESS ADDRESS:
    		STREET 1:		2855 GAZELLE COURT
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92010
    		BUSINESS PHONE:		7609319200

    	MAIL ADDRESS:
    		STREET 1:		2855 GAZELLE COURT
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92010

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
    		DATE OF NAME CHANGE:	19930328
    </SEC-HEADER>
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    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>nc10007589x2_def14a.htm
    <DESCRIPTION>DEF 14A
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    Document 1 - file: nc10007589x2_def14a.htm

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    <FILENAME>nc10007589x2_barchart01.jpg
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    Document 2 - file: nc10007589x2_barchart01.jpg

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    <FILENAME>nc10007589x2_barchart02.jpg
    <TEXT>
    Document 3 - file: nc10007589x2_barchart02.jpg

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    <FILENAME>nc10007589x2_diagram01.jpg
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    Document 4 - file: nc10007589x2_diagram01.jpg

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    Document 5 - file: nc10007589x2_diagram02.jpg

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    Document 6 - file: nc10007589x2_diagram03.jpg

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    <FILENAME>nc10007589x2_pickup01.jpg
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    Document 7 - file: nc10007589x2_pickup01.jpg

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    <FILENAME>nc10007589x2_pickup02.jpg
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    Document 8 - file: nc10007589x2_pickup02.jpg

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    <FILENAME>nc10007589x2_pickup03.jpg
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    Document 9 - file: nc10007589x2_pickup03.jpg

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    <FILENAME>nc10007589x2_pickup04.jpg
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    Document 10 - file: nc10007589x2_pickup04.jpg

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    <FILENAME>nc10007589x2_pickup05.jpg
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    Document 11 - file: nc10007589x2_pickup05.jpg

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    <FILENAME>nc10007589x2_pickup06.jpg
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    Document 12 - file: nc10007589x2_pickup06.jpg

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    <FILENAME>nc10007589x2_pickup07.jpg
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    Document 13 - file: nc10007589x2_pickup07.jpg

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    <SEQUENCE>14
    <FILENAME>nc10007589x2_pickup08.jpg
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    Document 14 - file: nc10007589x2_pickup08.jpg

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    <FILENAME>nc10007589x2_pickup09.jpg
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    Document 15 - file: nc10007589x2_pickup09.jpg

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    <FILENAME>nc10007589x2_pickup10.jpg
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    Document 16 - file: nc10007589x2_pickup10.jpg

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    <FILENAME>nc10007589x2_pickup11.jpg
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    Document 17 - file: nc10007589x2_pickup11.jpg

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    <FILENAME>nc10007589x2_pickup12.jpg
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    Document 18 - file: nc10007589x2_pickup12.jpg

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    <FILENAME>nc10007589x2_proxycards01.jpg
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