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Document and Entity Information
Aug. 30, 2020
Cover [Abstract]  
Entity Registrant Name IONIS PHARMACEUTICALS INC
Amendment Flag false
Entity Central Index Key 0000874015
Document Type 8-K
Document Period End Date Aug. 30, 2020
Entity Incorporation State Country Code DE
Entity File Number 000-19125
Entity Tax Identification Number 33-0336973
Entity Address, Address Line One 2855 Gazelle Court
Entity Address, City or Town Carlsbad
Entity Address, State or Province CA
Entity Address, Postal Zip Code 92010
City Area Code (760)
Local Phone Number 931-9200
Written Communications false
Soliciting Material false
Pre Commencement Tender Offer true
Pre Commencement Issuer Tender Offer false
Security 12b Title Common Stock, $.001 Par Value
Trading Symbol IONS
Security Exchange Name NASDAQ
Entity Emerging Growth Company false