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v3.21.1

Significant Accounting Policies, Stock-Based Compensation Expense (Details) $ / shares in Units, $ in Thousands | 3 Months Ended
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Mar. 31, 2021 USD ($) Period $ / shares shares | Mar. 31, 2020 USD ($) shares
Stock-based Compensation Expense [Abstract] |  |
Stock-based compensation expense | $ 37,861 | $ 40,790
Cost of Sales [Member] |  |
Stock-based Compensation Expense [Abstract] |  |
Stock-based compensation expense | 182 | 237
Research, Development and Patent Expense [Member] |  |
Stock-based Compensation Expense [Abstract] |  |
Stock-based compensation expense | 25,899 | 25,556
Selling, General and Administrative Expense [Member] |  |
Stock-based Compensation Expense [Abstract] |  |
Stock-based compensation expense | 11,780 | $ 14,997
Stock Options [Member] |  |
Unrecognized Compensation Expense [Abstract] |  |
Unrecognized compensation expense related to non-vested stock options | $ 101,800 |
Weighted average period for recognition | 1 year 4 months 24 days |
Stock Options [Member] | Board of Directors [Member] |  |
Stock-based Compensation Expense [Abstract] |  |
Stock options granted (in shares) | shares | 0 | 0
Stock Options [Member] | Employees [Member] |  |
Weighted-Average Assumptions [Abstract] |  |
Risk-free interest rate | 0.50% | 1.60%
Dividend yield | 0.00% | 0.00%
Volatility | 55.10% | 58.90%
Expected life | 4 years 10 months 24 days | 4 years 8 months 12 days
ESPP [Member] |  |
Weighted-Average Assumptions [Abstract] |  |
Risk-free interest rate | 0.10% | 1.10%
Dividend yield | 0.00% | 0.00%
Volatility | 39.10% | 47.20%
Expected life | 6 months | 6 months
RSUs [Member] |  |
Unrecognized Compensation Expense [Abstract] |  |
Unrecognized compensation cost related to non-vested units | $ 109,600 |
Weighted average period for recognition | 1 year 9 months 18 days |
RSUs [Member] | Board of Directors [Member] |  |
Stock-based Compensation Expense [Abstract] |  |
Units granted (in shares) | shares | 0 | 0
RSUs [Member] | Board of Directors [Member] | Maximum [Member] |  |
RSUs and PRSUs [Abstract] |  |
Vesting period | 4 years |
RSUs [Member] | Board of Directors [Member] | Minimum [Member] |  |
RSUs and PRSUs [Abstract] |  |
Vesting period | 1 year |
RSUs [Member] | Employees [Member] |  |
RSUs and PRSUs [Abstract] |  |
Vesting period | 4 years |
Weighted-average grant date fair value (in dollars per share) | $ / shares | $ 62.02 |
PRSUs [Member] |  |
Unrecognized Compensation Expense [Abstract] |  |
Unrecognized compensation cost related to non-vested units | $ 3,800 |
Weighted average period for recognition | 1 year 8 months 12 days |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] |  |
RSUs and PRSUs [Abstract] |  |
Number of performance periods | Period | 3 |
Vesting period | 3 years |
Number of units guaranteed to vest | shares | 0 |
Weighted-average grant date fair value (in dollars per share) | $ / shares | $ 77.17 |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Maximum [Member] |  |
RSUs and PRSUs [Abstract] |  |
Percentage of units guaranteed to vest | 150.00% |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Minimum [Member] |  |
RSUs and PRSUs [Abstract] |  |
Percentage of units guaranteed to vest | 0.00% |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | One-Year Period [Member] |  |
RSUs and PRSUs [Abstract] |  |
Vesting percentage | 33.30% |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Two-Year Period [Member] |  |
RSUs and PRSUs [Abstract] |  |
Vesting percentage | 33.30% |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Three-Year Period [Member] |  |
RSUs and PRSUs [Abstract] |  |
Vesting percentage | 33.30% |

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