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v3.21.1

Significant Accounting Policies, Convertible Debt (Details) $ / shares in Units, $ in Thousands | 3 Months Ended |  |
--- | --- | --- | ---
Mar. 31, 2021 USD ($) Note $ / shares | Mar. 31, 2020 USD ($) $ / shares | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Convertible Debt [Abstract] |  |  |  |
Number of outstanding convertible notes | Note | 2 |  |  |
Condensed Consolidated Balance Sheet [Abstract] |  |  |  |
1 percent convertible senior notes, net | $ 61,816 |  | $ 308,809 |
Additional paid-in capital | 1,925,801 |  | 1,895,519 |
Accumulated deficit | (1,221,175) |  | (1,131,306) |
Condensed Consolidated Statement of Operations [Abstract] |  |  |  |
Interest expense | (2,414) | $ (2,207) |  |
Loss before income tax (expense) benefit | (89,739) | (52,954) |  |
Income tax (expense) benefit | (130) | 3,072 |  |
Net loss | (89,869) | (49,882) |  |
Net loss attributable to Ionis Pharmaceuticals, Inc. common stockholders | $ (89,869) | $ (39,628) |  |
Basic net loss per share (in dollars per share) | $ / shares | $ (0.64) | $ (0.28) |  |
Diluted net loss per share (in dollars per share) | $ / shares | $ (0.64) | $ (0.28) |  |
Condensed Consolidated Statements of Stockholders' Equity [Abstract] |  |  |  |
Balance | $ 680,564 | $ 1,471,920 | 743,282 | $ 1,577,458
Additional Paid In Capital [Member] |  |  |  |
Condensed Consolidated Statement of Operations [Abstract] |  |  |  |
Net loss attributable to Ionis Pharmaceuticals, Inc. common stockholders | 0 | 0 |  |
Condensed Consolidated Statements of Stockholders' Equity [Abstract] |  |  |  |
Balance | 1,925,801 | 2,015,516 | 1,895,519 | 1,985,650
Accumulated Deficit [Member] |  |  |  |
Condensed Consolidated Statement of Operations [Abstract] |  |  |  |
Net loss attributable to Ionis Pharmaceuticals, Inc. common stockholders | (89,869) | (39,628) |  |
Condensed Consolidated Statements of Stockholders' Equity [Abstract] |  |  |  |
Balance | (1,221,175) | (726,672) | (1,131,306) | (596,495)
Total Ionis Stockholders' Equity [Member] |  |  |  |
Condensed Consolidated Statement of Operations [Abstract] |  |  |  |
Net loss attributable to Ionis Pharmaceuticals, Inc. common stockholders | (89,869) | (39,628) |  |
Condensed Consolidated Statements of Stockholders' Equity [Abstract] |  |  |  |
Balance | $ 680,564 | 1,261,748 | $ 743,282 | 1,364,005
0.125 Percent Convertible Senior Notes [Member] |  |  |  |
Convertible Debt [Abstract] |  |  |  |
Interest rate on convertible senior notes | 0.125% |  | 0.125% |
Condensed Consolidated Balance Sheet [Abstract] |  |  |  |
Convertible senior notes | $ 540,679 |  | $ 540,136 |
Condensed Consolidated Statement of Operations [Abstract] |  |  |  |
Effective interest rate | 0.50% |  |  |
1 Percent Convertible Senior Notes [Member] |  |  |  |
Convertible Debt [Abstract] |  |  |  |
Interest rate on convertible senior notes | 1.00% |  | 1.00% |
Condensed Consolidated Balance Sheet [Abstract] |  |  |  |
Convertible senior notes | $ 247,292 |  | $ 0 |
Condensed Consolidated Statement of Operations [Abstract] |  |  |  |
Effective interest rate | 1.40% |  |  |
As Previously Reported [Member] |  |  |  |
Condensed Consolidated Balance Sheet [Abstract] |  |  |  |
1 percent convertible senior notes, net |  |  | 293,161 |
Additional paid-in capital |  |  | 2,113,646 |
Accumulated deficit |  |  | (1,249,368) |
Condensed Consolidated Statement of Operations [Abstract] |  |  |  |
Interest expense |  | (10,990) |  |
Loss before income tax (expense) benefit |  | (61,737) |  |
Income tax (expense) benefit |  | 3,257 |  |
Net loss |  | (58,480) |  |
Net loss attributable to Ionis Pharmaceuticals, Inc. common stockholders |  | $ (48,226) |  |
Basic net loss per share (in dollars per share) | $ / shares |  | $ (0.35) |  |
Diluted net loss per share (in dollars per share) | $ / shares |  | $ (0.35) |  |
Condensed Consolidated Statements of Stockholders' Equity [Abstract] |  |  |  |
Balance |  |  | 843,347 | 1,684,547
As Previously Reported [Member] | Additional Paid In Capital [Member] |  |  |  |
Condensed Consolidated Statements of Stockholders' Equity [Abstract] |  |  |  |
Balance |  |  | 2,113,646 | 2,203,778
As Previously Reported [Member] | Accumulated Deficit [Member] |  |  |  |
Condensed Consolidated Statements of Stockholders' Equity [Abstract] |  |  |  |
Balance |  |  | (1,249,368) | (707,534)
As Previously Reported [Member] | 0.125 Percent Convertible Senior Notes [Member] |  |  |  |
Condensed Consolidated Balance Sheet [Abstract] |  |  |  |
Convertible senior notes |  |  | 455,719 |
Adjustment [Member] | ASU 2020-06 [Member] |  |  |  |
Condensed Consolidated Balance Sheet [Abstract] |  |  |  |
1 percent convertible senior notes, net |  |  | 15,648 |
Additional paid-in capital |  |  | (218,127) |
Accumulated deficit |  |  | 118,062 |
Net deferred tax assets |  |  | 0 |
Condensed Consolidated Statement of Operations [Abstract] |  |  |  |
Interest expense |  | $ 8,783 |  |
Loss before income tax (expense) benefit |  | 8,783 |  |
Income tax (expense) benefit |  | (185) |  |
Net loss |  | 8,598 |  |
Net loss attributable to Ionis Pharmaceuticals, Inc. common stockholders |  | $ 8,598 |  |
Basic net loss per share (in dollars per share) | $ / shares |  | $ 0.07 |  |
Diluted net loss per share (in dollars per share) | $ / shares |  | $ 0.07 |  |
Condensed Consolidated Statements of Stockholders' Equity [Abstract] |  |  |  |
Balance |  |  | (100,065) | (107,089)
Adjustment [Member] | ASU 2020-06 [Member] | Additional Paid In Capital [Member] |  |  |  |
Condensed Consolidated Statements of Stockholders' Equity [Abstract] |  |  |  |
Balance |  |  | (218,127) | (218,128)
Adjustment [Member] | ASU 2020-06 [Member] | Accumulated Deficit [Member] |  |  |  |
Condensed Consolidated Statements of Stockholders' Equity [Abstract] |  |  |  |
Balance |  |  | 118,062 | $ 111,039
Adjustment [Member] | ASU 2020-06 [Member] | 0.125 Percent Convertible Senior Notes [Member] |  |  |  |
Condensed Consolidated Balance Sheet [Abstract] |  |  |  |
Convertible senior notes |  |  | $ 84,417 |

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