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v3.21.2

Significant Accounting Policies, Stock-Based Compensation Expense (Details) $ / shares in Units, $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2021 USD ($) | Sep. 30, 2020 USD ($) | Sep. 30, 2021 USD ($) Period $ / shares shares | Sep. 30, 2020 USD ($)
Stock-based Compensation Expense [Abstract] |  |  |  |
Non-cash stock-based compensation expense | $ 30,537 | $ 45,845 | $ 98,419 | $ 135,077
Cost of Sales [Member] |  |  |  |
Stock-based Compensation Expense [Abstract] |  |  |  |
Non-cash stock-based compensation expense | 111 | 315 | 293 | 902
Research, Development and Patent Expense [Member] |  |  |  |
Stock-based Compensation Expense [Abstract] |  |  |  |
Non-cash stock-based compensation expense | 23,332 | 25,359 | 71,979 | 76,931
Selling, General and Administrative Expense [Member] |  |  |  |
Stock-based Compensation Expense [Abstract] |  |  |  |
Non-cash stock-based compensation expense | 7,094 | $ 20,171 | 26,147 | $ 57,244
Stock Options [Member] |  |  |  |
Unrecognized Compensation Expense [Abstract] |  |  |  |
Unrecognized compensation expense related to non-vested stock options | 65,300 |  | $ 65,300 |
Weighted average period for recognition |  |  | 1 year 2 months 12 days |
Stock Options [Member] | Board of Directors [Member] |  |  |  |
Weighted-Average Assumptions [Abstract] |  |  |  |
Risk-free interest rate |  |  | 1.20% | 0.50%
Dividend yield |  |  | 0.00% | 0.00%
Volatility |  |  | 55.90% | 57.60%
Expected life |  |  | 7 years 3 months 18 days | 6 years 8 months 12 days
Stock Options [Member] | Employees [Member] |  |  |  |
Weighted-Average Assumptions [Abstract] |  |  |  |
Risk-free interest rate |  |  | 0.50% | 1.50%
Dividend yield |  |  | 0.00% | 0.00%
Volatility |  |  | 54.30% | 58.80%
Expected life |  |  | 4 years 10 months 24 days | 4 years 8 months 12 days
ESPP [Member] |  |  |  |
Weighted-Average Assumptions [Abstract] |  |  |  |
Risk-free interest rate |  |  | 0.10% | 0.80%
Dividend yield |  |  | 0.00% | 0.00%
Volatility |  |  | 42.40% | 47.90%
Expected life |  |  | 6 months | 6 months
RSUs [Member] |  |  |  |
Unrecognized Compensation Expense [Abstract] |  |  |  |
Unrecognized compensation cost related to non-vested units | 72,200 |  | $ 72,200 |
Weighted average period for recognition |  |  | 1 year 4 months 24 days |
RSUs [Member] | Board of Directors [Member] |  |  |  |
RSUs and PRSUs [Abstract] |  |  |  |
Weighted-average grant date fair value (in dollars per share) | $ / shares |  |  | $ 39.42 |
RSUs [Member] | Board of Directors [Member] | Maximum [Member] |  |  |  |
RSUs and PRSUs [Abstract] |  |  |  |
Vesting period |  |  | 4 years |
RSUs [Member] | Board of Directors [Member] | Minimum [Member] |  |  |  |
RSUs and PRSUs [Abstract] |  |  |  |
Vesting period |  |  | 1 year |
RSUs [Member] | Employees [Member] |  |  |  |
RSUs and PRSUs [Abstract] |  |  |  |
Vesting period |  |  | 4 years |
Weighted-average grant date fair value (in dollars per share) | $ / shares |  |  | $ 59.15 |
PRSUs [Member] |  |  |  |
Unrecognized Compensation Expense [Abstract] |  |  |  |
Unrecognized compensation cost related to non-vested units | $ 2,500 |  | $ 2,500 |
Weighted average period for recognition |  |  | 1 year 2 months 12 days |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] |  |  |  |
RSUs and PRSUs [Abstract] |  |  |  |
Number of performance periods | Period |  |  | 3 |
Vesting period |  |  | 3 years |
Number of units guaranteed to vest | shares |  |  | 0 |
Weighted-average grant date fair value (in dollars per share) | $ / shares |  |  | $ 77.17 |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Maximum [Member] |  |  |  |
RSUs and PRSUs [Abstract] |  |  |  |
Percentage of units guaranteed to vest |  |  | 150.00% |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Minimum [Member] |  |  |  |
RSUs and PRSUs [Abstract] |  |  |  |
Percentage of units guaranteed to vest |  |  | 0.00% |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | One-Year Period [Member] |  |  |  |
RSUs and PRSUs [Abstract] |  |  |  |
Vesting percentage |  |  | 33.30% |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Two-Year Period [Member] |  |  |  |
RSUs and PRSUs [Abstract] |  |  |  |
Vesting percentage |  |  | 33.30% |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Three-Year Period [Member] |  |  |  |
RSUs and PRSUs [Abstract] |  |  |  |
Vesting percentage |  |  | 33.30% |

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