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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Operating activities: |  |
Net loss | $ (253,210) | $ (124,056)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 11,665 | 9,713
Amortization of right-of-use operating lease assets | 1,171 | 1,356
Amortization of patents | 1,740 | 1,526
Amortization of premium on investments, net | 13,515 | 7,812
Amortization of debt issuance costs | 3,586 | 2,388
Stock-based compensation expense | 98,419 | 135,077
Gain on investments | (933) | (10,722)
Loss on early retirement of debt | 8,627 | 0
Non-cash losses related to patents | 1,150 | 616
Provision for deferred income taxes | 0 | 1,649
Changes in operating assets and liabilities: |  |
Contracts receivable | 67,136 | 24,057
Inventories | (965) | (1,468)
Other current and long-term assets | 10,358 | (5,647)
Income taxes (payable) receivable | 134 | (23,674)
Accounts payable | (10,737) | (10,970)
Accrued compensation | (33,408) | (8,967)
Accrued liabilities and other current liabilities | (19,526) | 13,195
Deferred contract revenue | (71,610) | (73,970)
Net cash used in operating activities | (172,888) | (62,085)
Investing activities: |  |
Purchases of short-term investments | (930,963) | (1,376,631)
Proceeds from sale of short-term investments | 1,051,857 | 1,497,433
Purchases of property, plant and equipment | (9,453) | (29,971)
Acquisition of patents, net | (4,459) | (4,203)
Purchase of Bicycle Therapeutics plc common stock | (7,185) | 0
Net cash provided by investing activities | 99,797 | 86,628
Financing activities: |  |
Proceeds from equity, net | 11,564 | 29,450
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options | (16,285) | (12,960)
Proceeds from issuance of 0 percent convertible senior notes | 632,500 | 0
0 percent convertible senior notes issuance costs | (15,525) | 0
Repurchase of $247.9 million principal amount of 1 percent convertible senior notes | (256,963) | 0
Proceeds from issuance of warrants | 89,752 | 0
Purchase of note hedges | (136,620) | 0
Repurchases and retirements of common stock | 0 | (90,548)
Payments of transaction costs for Akcea merger | 0 | (1,071)
Net cash provided by (used in) financing activities | 308,423 | (75,129)
Effects of exchange rates on cash | (43) | 358
Net increase (decrease) in cash and cash equivalents | 235,289 | (50,228)
Cash and cash equivalents at beginning of period | 397,664 | 683,287
Cash and cash equivalents at end of period | 632,953 | 633,059
Supplemental disclosures of cash flow information: |  |
Interest paid | 3,527 | 3,700
Income taxes paid | 3 | 23,532
Supplemental disclosures of non-cash investing and financing activities: |  |
Amounts accrued for capital and patent expenditures | 1,811 | 6,576
Amounts accrued for Akcea merger transaction costs | $ 0 | $ 8,103

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- Definition Amount of amortization expense for right-of-use asset from operating lease. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3602-108585 + Details
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- Definition The cash outflow for a financial contract that meets the hedge criteria as either cash flow hedge, fair value hedge or hedge of net investment in foreign operations. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3291-108585 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 27 -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3581-108585 + Details
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- Definition The cash outflow to reacquire common stock during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3291-108585 + Details
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- Definition The cash outflow paid to third parties in connection with debt origination, which will be amortized over the remaining maturity period of the associated long-term debt. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3291-108585 + Details
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- Definition The cash outflow for financing costs associated with business combinations. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3291-108585 + Details
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- Definition Amount of cash outflow to satisfy grantee's tax withholding obligation for award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3291-108585 + Details
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- Definition Amount of cash outflow to acquire investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3213-108585 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3151-108585 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=124260329&loc=d3e26853-111562 + Details
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- Definition Amount of cash outflow to acquire investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI), classified as investing activity. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 321 -SubTopic 10 -Section 45 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=123583714&loc=SL75117360-209713 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3444-108585 + Details
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- Definition The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the issuance of a long-term debt instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3255-108585 + Details
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