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Significant Accounting Policies, Revenue Recognition (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended
--- | --- | --- | ---
Aug. 31, 2021 USD ($) | Feb. 28, 2017 USD ($) PerformanceObligation | May 31, 2015 USD ($) | Sep. 30, 2021 USD ($) | Dec. 31, 2020 USD ($) | Sep. 30, 2020 USD ($) | Dec. 31, 2018 USD ($) | Jun. 30, 2018 Agreement | Sep. 30, 2021 USD ($) PerformanceObligation | Sep. 30, 2020 USD ($)
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  | $ 133,093 |  | $ 160,079 |  |  | $ 370,450 | $ 438,983
Number of performance obligations at inception of contract | PerformanceObligation |  |  |  |  |  |  |  |  | 1 |
Biogen [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Number of agreements | Agreement |  |  |  |  |  |  |  | 2 |  |
TEGSEDI and WAYLIVRA [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  | 15,519 |  | $ 19,040 |  |  | $ 46,901 | $ 50,562
PTC [Member] | TEGSEDI and WAYLIVRA [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  | 4,000 |  |  |  |  |  |
Novartis [Member] | Pelacarsen [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue | $ 25,000 |  |  | $ 25,000 |  |  |  |  |  |
Percentage enrollment in Lp(a) HORIZON Phase 3 cardiovascular outcome study | 50.00% |  |  | 50.00% |  |  |  |  | 50.00% |
IONIS-FB-L for Complement-Mediated Diseases [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  |  |  |  | $ 75,000 |  |  |
Biogen 2018 Strategic Neurology [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Milestone payment received and added to transaction price |  |  |  |  | $ 7,500 |  |  |  |  |
AstraZeneca [Member] | ION455 [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | $ 30,000 |  |  |  |  |
Bayer [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  | $ 100,000 |  |  |  |  |  |  |
Bayer [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Upfront payment received |  | $ 75,000 |  |  |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  | 3 |  |  |  |  |  |  |  |
Transaction price |  | $ 75,000 |  |  |  |  |  |  |  |

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