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Collaborative Arrangements and Licensing Agreements, Novartis (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended
--- | --- | --- | ---
Aug. 31, 2021 | Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |
Revenue |  | $ 133,093 | $ 160,079 | $ 370,450 | $ 438,983
Novartis [Member] |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |
Cumulative payments received |  | 425,000 |  | 425,000 |
Novartis [Member] | Maximum [Member] |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |
Next prospective milestone |  | 75,000 |  | $ 75,000 |
Novartis [Member] | Pelacarsen [Member] |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |
Revenue | $ 25,000 | $ 25,000 |  |  |
Percentage enrollment in Lp(a) HORIZON Phase 3 cardiovascular outcome study | 50.00% | 50.00% |  | 50.00% |

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