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Collaborative Arrangements and Licensing Agreements, Bicycle License Agreement (Details) - USD ($) $ in Millions | 1 Months Ended | 12 Months Ended
--- | --- | ---
Jul. 31, 2021 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |
R&D expense |  | $ 638.2 | $ 531.0 | $ 461.5
Bicycle License Agreement [Member] |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |
Payment of license fee | $ 42.0 |  |  |
Trading restriction period under lock up agreement |  | 1 year |  |
Equity investment |  | $ 7.2 |  |
R&D expense |  | 34.8 |  |
Cumulative payments made |  | $ 46.6 |  |

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- References No definition available. + Details
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- Definition Cumulative amount of payments made under the collaboration agreement as of the end of the reporting period. + References No definition available. + Details
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- Definition Acquisition of investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI). + References No definition available. + Details
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- Definition Period after completion of initial public offering by an equity investee and restriction to sell equity holding in the investee, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. + References No definition available. + Details
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- Definition Represents the cash outflow for payments made under the collaboration agreement for the reimbursement of support received in connection with the Company's Huntington's disease program. + References No definition available. + Details
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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 912 -SubTopic 730 -Section 25 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6472174&loc=d3e58812-109433 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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