# Filing Detail

Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405]:
SEC Accession No. 0000874015-22-000079
Filing Date
2022-02-25
Accepted
2022-02-24 17:38:52
Documents
122
Period of Report
2021-12-31

Document Format Files

Seq | Description | Document | Type | Size
--- | --- | --- | --- | ---
1 | IONIS PHARMACEUTICALS, INC. 10-K 12-31-2021 | form10k.htm iXBRL | 10-K | 4128050
2 | EXHIBIT 4.11 | exhibit4-11.htm | EX-4.11 | 24552
3 | EXHIBIT 10.19 | exhibit10-19.htm | EX-10.19 | 86819
4 | EXHIBIT 10.60 | exhibit10-60.htm | EX-10.60 | 46272
5 | EXHIBIT 10.83 | exhibit10-83.htm | EX-10.83 | 32094
6 | EXHIBIT 10.84 | exhibit10-84.htm | EX-10.84 | 1557190
7 | EXHIBIT 21.1 | exhibit21-1.htm | EX-21.1 | 3707
8 | EXHIBIT 23.1 | exhibit23-1.htm | EX-23.1 | 3047
9 | EXHIBIT 31.1 | exhibit31-1.htm | EX-31.1 | 13081
10 | EXHIBIT 31.2 | exhibit31-2.htm | EX-31.2 | 13090
11 | EXHIBIT 32.1 | exhibit32-1.htm | EX-32 | 7653
17 |  | image01.jpg | GRAPHIC | 167230
18 |  | image02.jpg | GRAPHIC | 24762
19 |  | image03.jpg | GRAPHIC | 32540
20 |  | image04.jpg | GRAPHIC | 46106
21 |  | image05.jpg | GRAPHIC | 40315
22 |  | image06.jpg | GRAPHIC | 67530
23 |  | image07.jpg | GRAPHIC | 105188
24 |  | image08.jpg | GRAPHIC | 49803
25 |  | image09.jpg | GRAPHIC | 86992
26 |  | image10.jpg | GRAPHIC | 31669
27 |  | image11.jpg | GRAPHIC | 25608
28 |  | image12.jpg | GRAPHIC | 112488
29 |  | image13.jpg | GRAPHIC | 73717
30 |  | image14.jpg | GRAPHIC | 58301
| Complete submission text file | 0000874015-22-000079.txt |  | 23722666

Data Files

Seq | Description | Document | Type | Size
--- | --- | --- | --- | ---
12 | XBRL TAXONOMY EXTENSION SCHEMA | ions-20211231.xsd | EX-101.SCH | 113077
13 | XBRL TAXONOMY EXTENSION CALCULATION LINKBASE | ions-20211231_cal.xml | EX-101.CAL | 138477
14 | XBRL TAXONOMY EXTENSION DEFINITION LINKBASE | ions-20211231_def.xml | EX-101.DEF | 795734
15 | XBRL TAXONOMY EXTENSION LABEL LINKBASE | ions-20211231_lab.xml | EX-101.LAB | 1676801
16 | XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE | ions-20211231_pre.xml | EX-101.PRE | 1025948
116 | EXTRACTED XBRL INSTANCE DOCUMENT | form10k_htm.xml | XML | 3753112

Mailing Address 2855 GAZELLE COURT CARLSBAD CA 92010
Business Address 2855 GAZELLE COURT CARLSBAD CA 92010 7609319200
IONIS PHARMACEUTICALS INC (Filer) CIK: 0000874015 (see all company filings)

EIN.: 330336973 | State of Incorp.: CA | Fiscal Year End: 1231
Type: 10-K | Act: 34 | File No.: 000-19125 | Film No.: 22673044
SIC: 2834 Pharmaceutical Preparations