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Organization and Significant Accounting Policies, Accrued Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
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Accrued Liabilities [Abstract] |  |
Clincial expenses | $ 65,730 | $ 39,477
In-licensing expenses | 8,044 | 8,264
Commercial expenses | 2,471 | 11,559
Other miscellaneous expenses | 12,315 | 30,861
Total accrued liabilities | $ 88,560 | $ 90,161

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