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Collaborative Arrangements and Licensing Agreements, Novartis (Details) $ in Thousands, shares in Millions | 3 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Sep. 30, 2021 USD ($) | Mar. 31, 2019 USD ($) | Mar. 31, 2017 USD ($) PerformanceObligation shares | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Aug. 31, 2021
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  |  |  | $ 810,456 | $ 729,264 | $ 1,122,599 |
Licensing and Other Royalties [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  |  |  | 19,119 | 8,117 | 17,205 |
R&D Revenue [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  |  |  | 468,061 | 364,565 | $ 770,149 |
Novartis [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Upfront payment received |  |  | $ 75,000 |  |  |  |
Maximum amount of payments receivable for milestones |  |  |  | 675,000 |  |  |
Maximum amount of payments receivable for development milestones |  |  |  | 25,000 |  |  |
Maximum amount of payments receivable for regulatory milestones |  |  |  | 290,000 |  |  |
Maximum amount of payments receivable for sales milestones |  |  |  | 360,000 |  |  |
Cumulative payments received |  |  |  | 425,000 |  |  |
Next prospective payment |  |  |  | 75,000 |  |  |
Shares issued (in shares) | shares |  |  | 1.6 |  |  |  |
Proceeds from sale of common stock |  |  | $ 100,000 |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  | 4 |  |  |  |
Transaction price |  |  | $ 108,400 |  |  |  |
Premium received on shares issued |  |  | 28,400 |  |  |  |
Potential premium received if common stock is purchased in the future |  |  | 5,000 |  |  |  |
Deferred revenue |  |  |  | $ 0 | $ 0 |  |
Novartis [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Concentration percentage |  |  |  | 3.00% | 0.00% | 17.00% |
Novartis [Member] | Licensing and Other Royalties [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  | $ 150,000 |  |  |  |  |
Novartis [Member] | R&D Services for Pelacarsen [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Transaction price |  |  | 64,000 |  |  |  |
Novartis [Member] | R&D Services for Olezarsen [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Transaction price |  |  | 40,100 |  |  |  |
Novartis [Member] | Pelacarsen API [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Royalty percentage received on sales of medicine |  |  |  | 20.00% |  |  |
Percentage enrollment in Lp(a) HORIZON Phase 3 cardiovascular outcome study |  |  |  |  |  |  | 50.00%
Transaction price |  |  | 1,500 |  |  |  |
Revenue | $ 25,000 |  |  |  |  |  |
Novartis [Member] | Olezarsen API [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Transaction price |  |  | $ 2,800 |  |  |  |
Novartis [Member] | R&D Revenue [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  |  |  | $ 25,500 | $ 1,000 | $ 187,400 |

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