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Organization and Significant Accounting Policies, Revenue Recognition (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Dec. 31, 2021 USD ($) PerformanceObligation | Feb. 28, 2017 USD ($) PerformanceObligation | Jul. 31, 2015 USD ($) PerformanceObligation | May 31, 2015 USD ($) PerformanceObligation | Dec. 31, 2021 USD ($) Target PerformanceObligation | Sep. 30, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Jun. 30, 2018 USD ($) Agreement | Dec. 31, 2017 USD ($) PerformanceObligation | Jun. 30, 2015 USD ($) | Dec. 31, 2021 USD ($) PerformanceObligation | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Oct. 31, 2018 USD ($) PerformanceObligation | Apr. 30, 2018 USD ($) PerformanceObligation
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  |  |  |  | $ 810,456 | $ 729,264 | $ 1,122,599 |  |
Biogen [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of agreements | Agreement |  |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |
TEGSEDI and WAYLIVRA [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  |  |  |  | $ 55,500 | $ 69,999 | $ 42,253 |  |
PTC Therapeutics [Member] | TEGSEDI and WAYLIVRA [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  | $ 4,000 |  |  |  |  |  |  |  |  |  |  |
AstraZeneca [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue | $ 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received | $ 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation | 1 |  |  |  | 1 |  |  |  |  |  |  |  | 1 |  |  |  |
Transaction price | $ 200,000 |  |  |  | $ 200,000 |  |  |  |  |  |  |  | $ 200,000 |  |  |  |
AstraZeneca [Member] | Eplontersen [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 200,000 |  |  |  |  |  |  |  |  |  |  |  |
AstraZeneca [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 10,000 |  |  |  |  |  |  |  | $ 10,000 |  |  |  |
Upfront payment received |  |  | $ 65,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price |  |  | $ 65,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Roche IONIS-FB-L for Complement-Mediated Diseases [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  | $ (9,200) |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  |  |  |  |  |  | $ 75,000 |  |  |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |
Transaction price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 75,000 |
Biogen 2018 Strategic Neurology [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 15,000 |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  |  |  |  |  |  |  | $ 375,000 |  |  |  |  |  |  |
Milestone payment received and added to transaction price |  |  |  |  | $ 7,500 |  |  |  |  |  |  |  |  |  |  |  |
Number of new targets advanced | Target |  |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1
Transaction price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 552,000
Biogen Treatment of SMA [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  | $ 8,300 |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  |  |  |  |  |  |  |  | $ 25,000 |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |
Transaction price |  |  |  |  |  |  |  |  |  |  | $ 25,000 |  |  |  |  |  |
Biogen Treatment of SMA [Member] | ION306 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue | $ 60,000 |  |  |  | $ 60,000 |  |  |  |  |  |  |  |  |  |  |  |
Alnylam [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  | $ 41,200 |  |  |  |  |  |  |  |  |  |
Bayer [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  | $ 100,000 |  |  |  |  |  |  |  | $ 100,000 |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  | 3 |  |  |  |  |  |  |  |  |  |  |  |  |
Bayer [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received |  | $ 75,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  | 3 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price |  | $ 75,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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