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Organization and Significant Accounting Policies, Property, Plant and Equipment (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2021 | Dec. 31, 2020
Property, Plant and Equipment [Abstract] |  |
Less accumulated depreciation | $ (102,653) | $ (87,379)
Property, plant and equipment, net | 178,069 | 181,077
Property, Plant and Equipment, Excluding Land [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Property, plant and equipment | 257,660 | 245,394
Property, plant and equipment, net | 155,007 | 158,015
Computer Software, Laboratory, Manufacturing and Other Equipment [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Property, plant and equipment | $ 72,802 | 68,990
Computer Software, Laboratory, Manufacturing and Other Equipment [Member] | Minimum [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Estimated useful lives | 3 years |
Computer Software, Laboratory, Manufacturing and Other Equipment [Member] | Maximum [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Estimated useful lives | 10 years |
Building, Building Improvements and Building Systems [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Property, plant and equipment | $ 144,046 | 137,879
Building, Building Improvements and Building Systems [Member] | Minimum [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Estimated useful lives | 15 years |
Building, Building Improvements and Building Systems [Member] | Maximum [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Estimated useful lives | 40 years |
Land Improvements [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Property, plant and equipment | $ 10,077 | 8,391
Estimated useful lives | 20 years |
Leasehold Improvements [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Property, plant and equipment | $ 20,144 | 17,263
Leasehold Improvements [Member] | Minimum [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Estimated useful lives | 5 years |
Leasehold Improvements [Member] | Maximum [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Estimated useful lives | 15 years |
Furniture and Fixtures [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Property, plant and equipment | $ 10,591 | 12,871
Furniture and Fixtures [Member] | Minimum [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Estimated useful lives | 5 years |
Furniture and Fixtures [Member] | Maximum [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Estimated useful lives | 10 years |
Land [Member] |  |
Property, Plant and Equipment [Abstract] |  |
Property, plant and equipment | $ 23,062 | $ 23,062

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