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Organization and Significant Accounting Policies, Stock-Based Compensation Expense (Details) | 12 Months Ended
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Dec. 31, 2021 Period $ / shares shares | Dec. 31, 2020 $ / shares
RSUs [Member] | Employees [Member] |  |
Stock-Based Compensation Expense [Abstract] |  |
Vesting period | 4 years |
RSUs [Member] | Board of Directors [Member] | Granted Prior to June 2020 [Member] |  |
Stock-Based Compensation Expense [Abstract] |  |
Vesting period | 4 years |
RSUs [Member] | Board of Directors [Member] | Granted After June 2020 [Member] |  |
Stock-Based Compensation Expense [Abstract] |  |
Vesting period | 1 year |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] |  |
Stock-Based Compensation Expense [Abstract] |  |
Number of performance periods | Period | 3 |
Vesting period | 3 years |
Number of units guaranteed to vest | shares | 0 |
Weighted-average grant date fair value (in dollars per share) | $ / shares | $ 77.17 | $ 93.09
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Minimum [Member] |  |
Stock-Based Compensation Expense [Abstract] |  |
Percentage of units guaranteed to vest | 0.00% |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Maximum [Member] |  |
Stock-Based Compensation Expense [Abstract] |  |
Percentage of units guaranteed to vest | 150.00% |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | One-Year Period [Member] |  |
Stock-Based Compensation Expense [Abstract] |  |
Vesting percentage | 33.30% |
Vesting period | 1 year |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Two-Year Period [Member] |  |
Stock-Based Compensation Expense [Abstract] |  |
Vesting percentage | 33.30% |
Vesting period | 2 years |
PRSUs [Member] | Chief Executive Officer, Dr. Brett Monia [Member] | Three-Year Period [Member] |  |
Stock-Based Compensation Expense [Abstract] |  |
Vesting percentage | 33.30% |
Vesting period | 3 years |

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