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Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2020 | Dec. 31, 2021
Deferred Tax Assets [Abstract] |  |
Net operating loss carryovers | $ 83,681 | $ 85,600
Tax credits | 245,746 | 269,538
Deferred revenue | 124,452 | 104,330
Stock-based compensation | 80,055 | 86,611
Intangible and capital assets | 98,443 | 92,542
Convertible debt | 22,395 | 45,681
Interest expense limitation | 0 | 6,996
Other | 13,402 | 15,048
Total deferred tax assets | 668,174 | 706,346
Deferred Tax Liabilities [Abstract] |  |
Fixed assets | (3,611) | (3,303)
Other | (5,808) | (5,270)
Net deferred tax asset | 658,755 | 697,773
Valuation allowance | (658,755) | (697,773)
Total net deferred tax assets and liabilities | 0 | 0
Increase in valuation allowance | $ 341,000 | $ 39,000

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