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Stockholders' Equity, Stock-based Compensation Expense (Details) $ in Thousands | 3 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Sep. 30, 2019 USD ($) Officer | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Oct. 31, 2020 USD ($)
Stock-Based Compensation [Abstract] |  |  |  |  |
Stock-based compensation expense |  | $ 120,678 | $ 230,117 | $ 146,574 |
Cost of Sales [Member] |  |  |  |  |
Stock-Based Compensation [Abstract] |  |  |  |  |
Stock-based compensation expense |  | 456 | 1,991 | 438 |
Research, Development and Patent [Member] |  |  |  |  |
Stock-Based Compensation [Abstract] |  |  |  |  |
Stock-based compensation expense |  | 87,522 | 115,584 | 95,348 |
Selling, General and Administrative [Member] |  |  |  |  |
Stock-Based Compensation [Abstract] |  |  |  |  |
Stock-based compensation expense |  | $ 32,700 | $ 112,542 | $ 50,788 |
Akcea [Member] |  |  |  |  |
Stock-Based Compensation [Abstract] |  |  |  |  |
Stock-based compensation expense | $ (19,100) |  |  |  |
Unrecognized compensation cost related to non-vested units |  |  |  |  | $ 59,300
Number of executive officers terminating employment | Officer | 3 |  |  |  |

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