XML 60 R30.htm IDEA: XBRL DOCUMENT
v3.22.0.1

Organization and Significant Accounting Policies, Basis of Presentation (Details) - Akcea [Member] | Dec. 31, 2021 | Oct. 31, 2020 | Sep. 30, 2020 | Jun. 30, 2017
--- | --- | --- | --- | ---
Basis of Presentation [Abstract] |  |  |  |
Percentage ownership | 100.00% | 100.00% | 76.00% |
Maximum [Member] |  |  |  |
Basis of Presentation [Abstract] |  |  |  |
Percentage ownership |  | 77.00% |  | 100.00%

X
- Definition The parent entity's interest in net assets of the subsidiary, expressed as a percentage. + References No definition available. + Details
Name: | us-gaap_MinorityInterestOwnershipPercentageByParent
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | instant

X
- References No definition available. + Details
Name: | us-gaap_ProceedsFromIssuanceOrSaleOfEquityAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Details
Name: | srt_OwnershipAxis=ions_AkceaTherapeuticsIncMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_RangeAxis=srt_MaximumMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |