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Organization and Significant Accounting Policies, Research, Development and Patent Expenses (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Research, Development and Patent Expenses [Abstract] |  |  |
Research and development expenses | $ 638,200 | $ 531,000 | $ 461,500
Estimated Amortization Expense [Abstract] |  |  |
Non-cash charges related to write-down | 2,707 | 1,948 | 2,226
Patents [Member] |  |  |
Research, Development and Patent Expenses [Abstract] |  |  |
Research and development expenses | $ 5,300 | 4,100 | 4,200
Estimated useful life | 10 years 2 months 12 days |  |
Cost | $ 38,400 | 37,000 |
Accumulated amortization | 9,400 | 9,100 |
Estimated Amortization Expense [Abstract] |  |  |
2022 | 2,200 |  |
2023 | 2,100 |  |
2024 | 1,900 |  |
2025 | 1,800 |  |
2026 | 1,800 |  |
Non-cash charges related to write-down | $ 2,700 | $ 1,900 | $ 2,200

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