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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2022 | Jun. 30, 2021
Operating activities: |  |
Net loss | $ (170,300) | $ (170,744)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 7,484 | 7,951
Amortization of right-of-use operating lease assets | 1,300 | 781
Amortization of patents | 1,197 | 1,137
Amortization of premium on investments, net | 7,867 | 8,824
Amortization of debt issuance costs | 2,688 | 2,193
Stock-based compensation expense | 50,738 | 67,882
Loss (gain) on investments | 54 | (873)
Loss on early retirement of debt | 0 | 8,627
Non-cash losses related to disposal of property, plant and equipment | 527 | 0
Non-cash losses related to patents | 951 | 827
Changes in operating assets and liabilities: |  |
Contracts receivable | 55,145 | 52,200
Inventories | 4,995 | (2,134)
Other current and long-term assets | (39) | 9,179
Income taxes payable | (22) | 551
Accounts payable | (2,672) | (2,819)
Accrued compensation | (13,825) | (35,506)
Accrued liabilities and other current liabilities | 45,170 | (14,914)
Deferred contract revenue | (41,004) | (50,476)
Net cash used in operating activities | (49,746) | (117,314)
Investing activities: |  |
Purchases of short-term investments | (663,195) | (740,721)
Proceeds from sale of short-term investments | 380,375 | 727,859
Purchases of property, plant and equipment | (6,040) | (6,130)
Acquisition of licenses and other assets, net | (1,993) | (3,182)
Net cash used in nvesting activities | (290,853) | (22,174)
Financing activities: |  |
Proceeds from equity, net | 3,462 | 9,642
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options | (9,572) | (15,795)
Proceeds from the issuance of 0 percent convertible notes | 0 | 632,500
0 percent convertible senior notes issuance costs | 0 | (15,551)
Repurchase of $247.9 million principal amount of the 1 percent convertible senior notes | 0 | (256,963)
Proceeds from issuance of warrants | 0 | 89,752
Purchase of note hedges | 0 | (136,620)
Net cash (used in) provided by financing activities | (6,110) | 306,965
Effects of exchange rates on cash | (565) | (22)
Net (decrease) increase in cash and cash equivalents | (347,274) | 167,455
Cash and cash equivalents at beginning of period | 869,191 | 397,664
Cash and cash equivalents at end of period | 521,917 | 565,119
Supplemental disclosures of cash flow information: |  |
Interest paid | 1,544 | 2,866
Income taxes paid | 2 | 0
Supplemental disclosures of non-cash investing and financing activities: |  |
Amounts accrued for capital and patent expenditures | $ 1,121 | $ 278

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