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Significant Accounting Policies, Revenue Recognition (Details) $ in Thousands | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | ---
Sep. 30, 2022 USD ($) Target | Jun. 30, 2022 USD ($) | Mar. 31, 2022 USD ($) | Sep. 30, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2018 USD ($) | Jun. 30, 2018 Agreement | Sep. 30, 2022 USD ($) | Sep. 30, 2021 USD ($) | Dec. 31, 2021 USD ($) Component PerformanceObligation
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue | $ 159,767 |  |  | $ 133,093 |  |  |  | $ 435,478 | $ 370,450 |
Biogen [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Number of agreements | Agreement |  |  |  |  |  |  | 2 |  |  |
2013 Strategic Neurology Collaboration with Biogen [Member] | ION859 [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  | $ 10,000 |  |  |  |  |  |  |
Collaboration to Develop IONIS-FB-L with Roche [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue | 35,000 | $ 13,800 |  |  |  |  |  |  |  |
Upfront payment received |  |  |  |  |  | $ 75,000 |  |  |  |
Milestone payment received and added to transaction price |  | $ 20,000 |  |  |  |  |  |  |  |
Neurology Collaborations with Biogen [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue | $ 13,000 |  |  |  |  |  |  |  |  |
Number of targets advanced | Target | 2 |  |  |  |  |  |  |  |  |
Alnylam [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | $ 41,200 |  |  |  |  |
Eplontersen Collaboration with AstraZeneca [Member] |  |  |  |  |  |  |  |  |  |
Revenue Recognition [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | $ 200,000
Number of material components | Component |  |  |  |  |  |  |  |  |  | 4
Number of separate performance obligations | PerformanceObligation |  |  |  |  |  |  |  |  |  | 1
Transaction price |  |  |  |  |  |  |  |  |  | $ 200,000
Percentage of costs associated with ongoing global Phase 3 development program paid by AstraZeneca |  |  |  |  |  |  |  | 55.00% |  |

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