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Collaborative Arrangements and Licensing Agreements, Roche (Details) $ in Thousands | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2022 USD ($) Indication Agreement | Jun. 30, 2022 USD ($) | Sep. 30, 2021 USD ($) | Sep. 30, 2022 USD ($) Indication Agreement | Sep. 30, 2021 USD ($) | Dec. 31, 2021 USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Revenue | $ 159,767 |  | $ 133,093 | $ 435,478 | $ 370,450 |
R&D Revenue [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Revenue | $ 87,357 |  | $ 48,273 | $ 212,599 | $ 115,321 |
Roche Collaborations [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Number of collaboration agreements | Agreement | 2 |  |  | 2 |  |
Cumulative payments received | $ 283,000 |  |  | $ 283,000 |  |
Deferred revenue | $ 23,600 |  |  | $ 23,600 |  | $ 31,600
Roche Collaborations [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Concentration percentage | 26.00% |  | 3.00% | 15.00% | 3.00% |
Roche Collaborations [Member] | R&D Revenue [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Revenue | $ 41,500 |  | $ 3,900 | $ 65,400 | $ 11,400 |
Collaboration to Develop IONIS-FB-L with Roche [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Number of collaboration agreements | Agreement | 1 |  |  | 1 |  |
Number of disease indications | Indication | 2 |  |  | 2 |  |
Maximum amount of payments receivable for development milestones | $ 145,000 |  |  | $ 145,000 |  |
Maximum amount of payments receivable for regulatory milestones | 279,000 |  |  | 279,000 |  |
Maximum amount of payments receivable for sales-related milestones | 280,000 |  |  | $ 280,000 |  |
Revenue | 35,000 | $ 13,800 |  |  |  |
Collaboration to Develop IONIS-FB-L with Roche [Member] | Maximum [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Royalty percentage received on net sales of medicine |  |  |  | 20.00% |  |
Next prospective milestone | $ 90,000 |  |  | $ 90,000 |  |
Collaboration to Develop IONIS-FB-L with Roche [Member] | GA [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Number of disease indications | Indication | 1 |  |  | 1 |  |
Collaboration to Develop IONIS-FB-L with Roche [Member] | IgAN [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Number of disease indications | Indication | 1 |  |  | 1 |  |
Collaboration to Develop Treatments for Huntington's Disease with Roche [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Number of collaboration agreements | Agreement | 1 |  |  | 1 |  |

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