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    ACCESSION NUMBER:		0001140361-22-015116
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		13
    CONFORMED PERIOD OF REPORT:	20220602
    FILED AS OF DATE:		20220420
    DATE AS OF CHANGE:		20220420

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
    		CENTRAL INDEX KEY:			0000874015
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				330336973
    		STATE OF INCORPORATION:			CA
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	000-19125
    		FILM NUMBER:		22837149

    	BUSINESS ADDRESS:
    		STREET 1:		2855 GAZELLE COURT
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92010
    		BUSINESS PHONE:		7609319200

    	MAIL ADDRESS:
    		STREET 1:		2855 GAZELLE COURT
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92010

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
    		DATE OF NAME CHANGE:	19930328
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