<SEC-DOCUMENT>0001140361-22-015116-index.html : 20220420
<SEC-HEADER>0001140361-22-015116.hdr.sgml : 20220420
<ACCEPTANCE-DATETIME>20220420122243
ACCESSION NUMBER:		0001140361-22-015116
CONFORMED SUBMISSION TYPE:	DEF 14A
PUBLIC DOCUMENT COUNT:		13
CONFORMED PERIOD OF REPORT:	20220602
FILED AS OF DATE:		20220420
DATE AS OF CHANGE:		20220420

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEF 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		22837149

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEF 14A
<SEQUENCE>1
<FILENAME>ny20002718x1_def14a.htm
<DESCRIPTION>DEF 14A
<TEXT>
Document 1 - file: ny20002718x1_def14a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>ny20002718x1_def14aimg001.jpg
<TEXT>
Document 2 - file: ny20002718x1_def14aimg001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>ny20002718x1_def14aimg002.jpg
<TEXT>
Document 3 - file: ny20002718x1_def14aimg002.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>ny20002718x1_def14aimg003.jpg
<TEXT>
Document 4 - file: ny20002718x1_def14aimg003.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>ny20002718x1_def14aimg005.jpg
<TEXT>
Document 5 - file: ny20002718x1_def14aimg005.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>ny20002718x1_def14aimg006.jpg
<TEXT>
Document 6 - file: ny20002718x1_def14aimg006.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>ny20002718x1_def14aimg007.jpg
<TEXT>
Document 7 - file: ny20002718x1_def14aimg007.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>ny20002718x1_def14aimg008.jpg
<TEXT>
Document 8 - file: ny20002718x1_def14aimg008.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>ny20002718x1_def14aimg009.jpg
<TEXT>
Document 9 - file: ny20002718x1_def14aimg009.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>10
<FILENAME>ny20002718x1_def14aimg010.jpg
<TEXT>
Document 10 - file: ny20002718x1_def14aimg010.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>11
<FILENAME>ny20002718x1_def14aimg011.jpg
<TEXT>
Document 11 - file: ny20002718x1_def14aimg011.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>12
<FILENAME>ny20002718x1_def14aimg012.jpg
<TEXT>
Document 12 - file: ny20002718x1_def14aimg012.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>13
<FILENAME>ny20002718x1_def14aimg013.jpg
<TEXT>
Document 13 - file: ny20002718x1_def14aimg013.jpg

</DOCUMENT>
</SEC-DOCUMENT>