    <SEC-DOCUMENT>0001140361-22-015118-index.html : 20220420
    <SEC-HEADER>0001140361-22-015118.hdr.sgml : 20220420
    <ACCEPTANCE-DATETIME>20220420122436
    ACCESSION NUMBER:		0001140361-22-015118
    CONFORMED SUBMISSION TYPE:	DEFA14A
    PUBLIC DOCUMENT COUNT:		3
    FILED AS OF DATE:		20220420
    DATE AS OF CHANGE:		20220420

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
    		CENTRAL INDEX KEY:			0000874015
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				330336973
    		STATE OF INCORPORATION:			CA
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEFA14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	000-19125
    		FILM NUMBER:		22837156

    	BUSINESS ADDRESS:
    		STREET 1:		2855 GAZELLE COURT
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92010
    		BUSINESS PHONE:		7609319200

    	MAIL ADDRESS:
    		STREET 1:		2855 GAZELLE COURT
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92010

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
    		DATE OF NAME CHANGE:	19930328
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEFA14A
    <SEQUENCE>1
    <FILENAME>ny20002718x2_defa14a.htm
    <DESCRIPTION>DEFA14A
    <TEXT>
    Document 1 - file: ny20002718x2_defa14a.htm

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>ny20002718x2_nc01.jpg
    <TEXT>
    Document 2 - file: ny20002718x2_nc01.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>ny20002718x2_nc02.jpg
    <TEXT>
    Document 3 - file: ny20002718x2_nc02.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>