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Stockholders' Equity, Stock-based Compensation Expense (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Oct. 31, 2020
Stock-Based Compensation [Abstract] |  |  |  |
Stock-based compensation expense | $ 100,264 | $ 120,678 | $ 230,117 |
Cost of Sales [Member] |  |  |  |
Stock-Based Compensation [Abstract] |  |  |  |
Stock-based compensation expense | 533 | 456 | 1,991 |
Research, Development and Patent [Member] |  |  |  |
Stock-Based Compensation [Abstract] |  |  |  |
Stock-based compensation expense | 73,704 | 87,522 | 115,584 |
Selling, General and Administrative [Member] |  |  |  |
Stock-Based Compensation [Abstract] |  |  |  |
Stock-based compensation expense | $ 26,027 | $ 32,700 | $ 112,542 |
Akcea [Member] |  |  |  |
Stock-Based Compensation [Abstract] |  |  |  |
Unrecognized compensation cost related to non-vested units |  |  |  | $ 59,300

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