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Organization and Significant Accounting Policies, Basis of Presentation (Details) - Akcea [Member] | Dec. 31, 2022 | Oct. 31, 2020 | Jun. 30, 2017
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Basis of Presentation [Abstract] |  |  |
Percentage ownership | 100.00% |  |
Maximum [Member] |  |  |
Basis of Presentation [Abstract] |  |  |
Percentage ownership |  | 77.00% | 100.00%

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- Definition The parent entity's interest in net assets of the subsidiary, expressed as a percentage. + References No definition available. + Details
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- Details
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