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Legal Proceedings (Details) - John Makris, et al. v. Ionis Pharmaceuticals, Inc., et al. [Member] $ in Millions |  |  | 12 Months Ended
--- | --- | --- | ---
Jun. 03, 2022 USD ($) | Aug. 05, 2021 Plaintiff | Dec. 31, 2022 USD ($)
Legal Procedings [Abstract] |  |  |
Number of plaintiffs | Plaintiff |  | 4 |
Settlement agreement | $ 12.5 |  |
Other Expense [Member] |  |  |
Legal Procedings [Abstract] |  |  |
Net settlement expense |  |  | $ 7.7

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