XML 93 R57.htm IDEA: XBRL DOCUMENT
v3.22.4

Stockholders' Equity, Stock Plans (Details) | 1 Months Ended | 12 Months Ended |  |  |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jun. 30, 2009 shares | Dec. 31, 2022 Officer $ / shares shares | Dec. 31, 2021 shares | Jun. 30, 2021 shares | Dec. 31, 2020 shares | Jun. 30, 2020 shares | Jun. 30, 2019 shares | May 31, 2017 shares | Jun. 30, 2015 shares | May 31, 2015 shares
Stock Options [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Number of options outstanding (in shares) |  | 14,970,000 | 14,089,000 |  |  |  |  |  |  |
Number of options exercisable (in shares) |  | 10,285,000 |  |  |  |  |  |  |  |
1989 Stock Option Plan [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Number of shares authorized for issuance under the Plan (in shares) |  | 20,000,000 |  |  |  |  |  |  |  |
Number of options outstanding (in shares) |  | 12,000 |  |  |  |  |  |  |  |
Number of options exercisable (in shares) |  | 12,000 |  |  |  |  |  |  |  |
Number of shares available for grant (in shares) |  | 65,000 |  |  |  |  |  |  |  |
1989 Stock Option Plan [Member] | Stock Options [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Vesting period |  | 4 years |  |  |  |  |  |  |  |
Award term |  | 7 years |  |  |  |  |  |  |  |
1989 Stock Option Plan [Member] | Stock Options [Member] | One Year from Date of Grant [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Vesting percentage |  | 25.00% |  |  |  |  |  |  |  |
Period before options are exercisable |  | 1 year |  |  |  |  |  |  |  |
2011 Equity Incentive Plan [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Number of shares authorized for issuance under the Plan (in shares) |  |  |  | 29,700,000 |  |  | 23,000,000 | 16,000,000 | 11,000,000 | 5,500,000
Reduction in fungible share reserve for each share issued pursuant to full value award (n shares) |  |  |  | (1.7) |  |  |  |  |  |
Increase in fungible share reserve for each share returning from a full value award (in shares) |  |  |  | 1.7 |  |  |  |  |  |
Number of options outstanding (in shares) |  | 13,700,000 |  |  |  |  |  |  |  |
Number of options exercisable (in shares) |  | 9,400,000 |  |  |  |  |  |  |  |
Number of shares available for grant (in shares) |  | 5,800,000 |  |  |  |  |  |  |  |
Number of executive officers terminated before change in control when vesting will accelerate for executive officers | Officer |  | 1 |  |  |  |  |  |  |  |
Period before change in control when vesting will accelerate for executive officers |  | 3 months |  |  |  |  |  |  |  |
Period after change in control when vesting will accelerate for executive officers |  | 12 months |  |  |  |  |  |  |  |
2011 Equity Incentive Plan [Member] | Stock Options [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Vesting period |  | 4 years |  |  |  |  |  |  |  |
Award term |  | 7 years |  |  |  |  |  |  |  |
2011 Equity Incentive Plan [Member] | Stock Options [Member] | Issued after December 31, 2021 [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Award term |  | 10 years |  |  |  |  |  |  |  |
2011 Equity Incentive Plan [Member] | Stock Options [Member] | One Year from Date of Grant [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Vesting percentage |  | 25.00% |  |  |  |  |  |  |  |
Period before options are exercisable |  | 1 year |  |  |  |  |  |  |  |
2011 Equity Incentive Plan [Member] | Restricted Stock Units [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Vesting period |  | 4 years |  |  |  |  |  |  |  |
Number of awards outstanding (in shares) |  | 2,700,000 |  |  |  |  |  |  |  |
2020 Equity Incentive Plan [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Number of shares authorized for issuance under the Plan (in shares) |  |  |  | 1,600,000 | 2,600,000 |  |  |  |  |
Number of options outstanding (in shares) |  | 300,000 |  |  |  |  |  |  |  |
Number of options exercisable (in shares) |  | 61,000 |  |  |  |  |  |  |  |
Number of shares available for grant (in shares) |  | 1,200,000 |  |  |  |  |  |  |  |
2020 Equity Incentive Plan [Member] | Stock Options [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Vesting period |  | 4 years |  |  |  |  |  |  |  |
Award term |  | 7 years |  |  |  |  |  |  |  |
2020 Equity Incentive Plan [Member] | Stock Options [Member] | Issued after December 31, 2021 [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Award term |  | 10 years |  |  |  |  |  |  |  |
2020 Equity Incentive Plan [Member] | Stock Options [Member] | One Year from Date of Grant [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Vesting percentage |  | 25.00% |  |  |  |  |  |  |  |
Period before options are exercisable |  | 1 year |  |  |  |  |  |  |  |
2020 Equity Incentive Plan [Member] | Restricted Stock Units [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Vesting period |  | 4 years |  |  |  |  |  |  |  |
Number of awards outstanding (in shares) |  | 100,000 |  |  |  |  |  |  |  |
2002 Non-Employee Directors' Stock Option Plan [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Number of shares authorized for issuance under the Plan (in shares) |  |  |  |  |  | 2,800,000 |  |  | 2,000,000 | 1,200,000
Number of options outstanding (in shares) |  | 900,000 |  |  |  |  |  |  |  |
Number of options exercisable (in shares) |  | 800,000 |  |  |  |  |  |  |  |
Number of shares available for grant (in shares) |  | 600,000 |  |  |  |  |  |  |  |
2002 Non-Employee Directors' Stock Option Plan [Member] | Stock Options [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Award term |  | 10 years |  |  |  |  |  |  |  |
2002 Non-Employee Directors' Stock Option Plan [Member] | Restricted Stock Units [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Number of awards outstanding (in shares) |  | 100,000 |  |  |  |  |  |  |  |
Employee Stock Purchase Plan [Member] |  |  |  |  |  |  |  |  |  |
Stock Plans [Abstract] |  |  |  |  |  |  |  |  |  |
Number of shares authorized for issuance under the Plan (in shares) |  | 3,200,000 |  |  |  |  |  |  |  |
Number of additional shares reserved for issuance (in shares) | 150,000 | 150,000 |  |  |  |  |  |  |  |
Maximum percentage of employee compensation used to purchase shares |  | 10.00% |  |  |  |  |  |  |  |
Percentage of fair market value used to determine purchase price of stock |  | 85.00% |  |  |  |  |  |  |  |
Holding period for purchased stock |  | 6 months |  |  |  |  |  |  |  |
Shares purchased and issued under ESPP (in shares) |  | 100,000 |  |  |  |  |  |  |  |
Weighted average purchase price (in dollars per share) | $ / shares |  | $ 28.57 |  |  |  |  |  |  |  |
Shares available for purchase under ESPP (in shares) |  | 500,000 |  |  |  |  |  |  |  |

X
- Definition The number of shares available for purchase under an employee stock purchase plan. + References No definition available. + Details
Name: | ions_EmployeeStockPurchasePlanSharesAvailableForPurchase
Namespace Prefix: | ions_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition Weighted average sales price of shares purchased through an employee stock purchase plan. + References No definition available. + Details
Name: | ions_EmployeeStockPurchasePlanWeightedAverageSalesPriceOfSharesPurchased
Namespace Prefix: | ions_
Data Type: | dtr-types:perShareItemType
Balance Type: | na
Period Type: | duration

X
- Definition Increase (decrease) in the number of shares in the "fungible" share reserve for each share issued pursuant to full value award. + References No definition available. + Details
Name: | ions_IncreaseDecreaseInFungibleShareReserveForEachShareIssuedPursuantToFullValueAward
Namespace Prefix: | ions_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition Increase (decrease) in the number of shares in the "fungible" share reserve for each share of common stock returning from a full value award. + References No definition available. + Details
Name: | ions_IncreaseDecreaseInFungibleShareReserveForEachShareReturningFromFullValueAward
Namespace Prefix: | ions_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition The number of executive officers terminated by the Company during the period that begins three months before and ends twelve months following a change in control of the Company when vesting will accelerate for options and RSUs outstanding as of the termination date for executive officers + References No definition available. + Details
Name: | ions_NumberOfExecutiveOfficersTerminatedBeforeChangeInControlWhenVestingWillAccelerateForExecutiveOfficers
Namespace Prefix: | ions_
Data Type: | xbrli:integerItemType
Balance Type: | na
Period Type: | duration

X
- Definition Period of time after a change in control of the Company when vesting will accelerate for options and RSUs outstanding as of the termination date for executive officers, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
Name: | ions_PeriodAfterChangeInControlWhenVestingWillAccelerateForExecutiveOfficers
Namespace Prefix: | ions_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- Definition Period of time before a change in control of the Company when vesting will accelerate for options and RSUs outstanding as of the termination date for executive officers, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
Name: | ions_PeriodBeforeChangeInControlWhenVestingWillAccelerateForExecutiveOfficers
Namespace Prefix: | ions_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- Definition Represents the holding period from the date of purchase for stock purchased under the plan. + References No definition available. + Details
Name: | ions_ShareBasedCompensationArrangementByShareBasedPaymentAwardHoldingPeriod
Namespace Prefix: | ions_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- References No definition available. + Details
Name: | us-gaap_ShareBasedArrangementsToObtainGoodsAndServicesAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Estimated period over which an employee is required to provide service in exchange for the equity-based payment award, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
Name: | us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1
Namespace Prefix: | us-gaap_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- Definition Period over which grantee's right to exercise award under share-based payment arrangement is no longer contingent on satisfaction of service or performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, combination of market, performance or service condition. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
Name: | us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1
Namespace Prefix: | us-gaap_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- Definition The highest percentage of annual salary that an employee is permitted to utilize with respect to the plan. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
Name: | us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionRate
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | instant

X
- Definition Number of equity instruments other than options outstanding, including both vested and non-vested instruments. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(ii) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
Name: | us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition Number of additional shares authorized for issuance under share-based payment arrangement. + References No definition available. + Details
Name: | us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | duration

X
- Definition Number of shares authorized for issuance under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(3) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
Name: | us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
Name: | us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iii) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
Name: | us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition Number of options outstanding, including both vested and non-vested options. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(ii) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
Name: | us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- Definition Percentage of vesting of award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
Name: | us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | duration

X
- Definition Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
Name: | us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod
Namespace Prefix: | us-gaap_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- Definition Purchase price of common stock expressed as a percentage of its fair value. + References No definition available. + Details
Name: | us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | duration

X
- Definition Number of shares issued during the period as a result of an employee stock purchase plan. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=126973232&loc=d3e21463-112644 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.3-04) -URI https://asc.fasb.org/extlink&oid=120397183&loc=d3e187085-122770 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(28)) -URI https://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682 Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(29)) -URI https://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682 + Details
Name: | us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | duration

X
- Details
Name: | us-gaap_AwardTypeAxis=us-gaap_StockOptionMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_PlanNameAxis=ions_StockOptionPlan1989Member
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_VestingAxis=us-gaap_ShareBasedCompensationAwardTrancheOneMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_PlanNameAxis=ions_EquityIncentivePlan2011Member
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_AwardDateAxis=ions_IssuedAfterDecember312021Member
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_AwardTypeAxis=us-gaap_RestrictedStockUnitsRSUMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_PlanNameAxis=ions_EquityIncentivePlan2020Member
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_PlanNameAxis=ions_NonemployeeDirectorsStockOptionPlan2002Member
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_PlanNameAxis=ions_EmployeeStockPurchasePlanMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |