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Organization and Significant Accounting Policies, Research, Development and Patent Expenses (Details) - USD ($) $ in Millions | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Research, Development and Patent Expenses [Abstract] |  |  |
Patent expenses | $ 4.7 | $ 5.3 | $ 4.1

X
- Definition Includes charges for amortization and write-downs of capitalized patent costs as well as legal fees for patent litigation and patent defense. + References No definition available. + Details
Name: | ions_PatentExpenses
Namespace Prefix: | ions_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- References No definition available. + Details
Name: | us-gaap_ResearchAndDevelopmentExpenseAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration