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Collaborative Arrangements and Licensing Agreements (Tables) | 12 Months Ended
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Dec. 31, 2022
Biogen [Member] |
Collaborative Arrangements and Licensing Agreements [Abstract] |
Revenue from Collaborative Relationship | During the years ended December 31, 2022, 2021 and 2020, we earned the following revenue from our relationship with Biogen (in millions, except percentage amounts):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |  |  | 2020 |
SPINRAZA royalties (commercial revenue) |  | $ | 242.3 |  |  | $ | 267.8 |  |  | $ | 286.6 |
R&D revenue |  |  | 124.4 |  |  |  | 161.0 |  |  |  | 122.0 |
Total revenue from our relationship with Biogen |  | $ | 366.7 |  |  | $ | 428.8 |  |  | $ | 408.6 |
Percentage of total revenue |  |  | 62 | % |  |  | 53 | % |  |  | 56 | %
AstraZeneca [Member] |
Collaborative Arrangements and Licensing Agreements [Abstract] |
Revenue from Collaborative Relationship | During the years ended December 31, 2022, 2021 and 2020, we earned the following revenue from our relationship with AstraZeneca (in millions, except percentage amounts):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |  |  | 2020 |
R&D revenue |  | $ | 79.2 |  |  | $ | 254.6 |  |  | $ | 88.0 |
Percentage of total revenue |  |  | 13 | % |  |  | 31 | % |  |  | 12 | %
GSK [Member] |
Collaborative Arrangements and Licensing Agreements [Abstract] |
Revenue from Collaborative Relationship | During the years ended December 31, 2022, 2021 and 2020, we earned the following revenue from our relationship with GSK (in millions, except percentage amounts):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |  |  | 2020 |
R&D revenue |  | $ | — |  |  | $ | — |  |  | $ | 0.2 |
Percentage of total revenue |  |  | — |  |  |  | — |  |  |  | — |
Novartis [Member] |
Collaborative Arrangements and Licensing Agreements [Abstract] |
Revenue from Collaborative Relationship | During the years ended December 31, 2022, 2021 and 2020, we earned the following revenue from our relationship with Novartis (in millions, except percentage amounts):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |  |  | 2020 |
R&D revenue |  | $ | 0.2 |  |  | $ | 25.5 |  |  | $ | 1.0 |
Percentage of total revenue |  |  | — |  |  |  | 3 | % |  |  | — |
Roche [Member] |
Collaborative Arrangements and Licensing Agreements [Abstract] |
Revenue from Collaborative Relationship | During the years ended December 31, 2022, 2021 and 2020, we earned the following revenue from our relationship with Roche (in millions, except percentage amounts):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |  |  | 2020 |
R&D revenue |  | $ | 67.2 |  |  | $ | 17.2 |  |  | $ | 5.9 |
Percentage of total revenue |  |  | 11 | % |  |  | 2 | % |  |  | 1 | %
Alnylam [Member] |
Collaborative Arrangements and Licensing Agreements [Abstract] |
Revenue from Collaborative Relationship | During the years ended December 31, 2022, 2021 and 2020, we earned the following revenue from our relationship with Alnylam (in millions, except percentage amounts):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |  |  | 2020 |
R&D revenue |  | $ | 21.4 |  |  | $ | — |  |  | $ | 47.9 |
Percentage of total revenue |  |  | 4 | % |  |  | — |  |  |  | 7 | %

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