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Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2022 | Dec. 31, 2021
Deferred Tax Assets [Abstract] |  |
Net operating loss carryovers | $ 87,802 | $ 85,600
Tax credits | 277,436 | 269,538
Deferred revenue | 85,700 | 104,330
Stock-based compensation | 86,983 | 86,611
Intangible and capital assets | 104,649 | 92,542
Convertible debt | 34,384 | 45,681
Interest expense limitation | 0 | 6,996
Capitalized research and development expenses | 119,635 | 0
Long-term lease liabilities | 45,612 | 5,119
Other | 15,813 | 9,929
Total deferred tax assets | 858,014 | 706,346
Deferred Tax Liabilities [Abstract] |  |
Fixed assets | (4,475) | (3,303)
Right-of-use assets | (44,504) | (4,159)
Other | (313) | (1,111)
Net deferred tax asset | 808,722 | 697,773
Valuation allowance | (808,722) | (697,773)
Total net deferred tax assets and liabilities | 0 | $ 0
Increase in valuation allowance | $ 111,000 |

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