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Organization and Significant Accounting Policies, Revenue Recognition (Details) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) PerformanceObligation Component | Dec. 31, 2020 USD ($)
Revenue Recognition [Abstract] |  |  |
Revenue | $ 587,367 | $ 810,456 | $ 729,264
Eplontersen Collaboration with AstraZeneca [Member] |  |  |
Revenue Recognition [Abstract] |  |  |
Revenue |  | $ 200,000 |
Number of material components | Component |  | 4 |
Number of separate performance obligations | PerformanceObligation |  | 1 |
Transaction price |  | $ 200,000 |
Percentage of costs associated with ongoing global Phase 3 development program paid by AstraZeneca | 55.00% |  |

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