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Collaborative Arrangements and Licensing Agreements, Biogen (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Sep. 30, 2013 USD ($) PerformanceObligation | Dec. 31, 2012 USD ($) Program | Dec. 31, 2022 USD ($) Medicine | Sep. 30, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2019 USD ($) | Jun. 30, 2018 USD ($) | Dec. 31, 2017 USD ($) PerformanceObligation | Dec. 31, 2022 USD ($) Medicine | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2018 USD ($) | Jan. 31, 2023 USD ($) | Apr. 30, 2018 USD ($) PerformanceObligation
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | $ 587,367 | $ 810,456 | $ 729,264 |  |  |
SPINRAZA [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum amount of annual sales on which royalty payments are paid |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,500,000 |
SPINRAZA [Member] | Minimum [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of royalty payments paid to Royalty Pharma on annual sales of medicine |  |  |  |  |  |  |  |  |  |  |  |  | 25.00% |
Maximum royalty payments made before royalty interest reverts back |  |  |  |  |  |  |  |  |  |  |  |  | $ 475,000 |
SPINRAZA [Member] | Maximum [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of royalty payments paid to Royalty Pharma on annual sales of medicine |  |  |  |  |  |  |  |  |  |  |  |  | 45.00% |
Maximum royalty payments made before royalty interest reverts back |  |  |  |  |  |  |  |  |  |  |  |  | $ 550,000 |
SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 242,314 | 267,776 | 286,583 |  |  |
R&D Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 284,009 | 468,061 | 364,565 |  |  |
Biogen [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 366,700 | 428,800 | $ 408,600 |  |  |
Deferred revenue |  |  | $ 351,200 |  | $ 407,500 |  |  |  | $ 351,200 | $ 407,500 |  |  |  |
Biogen [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration percentage |  |  |  |  |  |  |  |  | 62.00% | 53.00% | 56.00% |  |  |
Biogen [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | 3,400,000 |  |  |  |  |  | $ 3,400,000 |  |  |  |  |
Biogen [Member] | SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 242,300 | $ 267,800 | $ 286,600 |  |  |
Biogen [Member] | R&D Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | 124,400 | 161,000 | 122,000 |  |  |
SPINRAZA [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative revenue earned |  |  | 1,800,000 |  |  |  |  |  | $ 1,800,000 |  |  |  |  |
Royalty percentage received on net sales of medicine |  |  |  |  |  |  |  |  | 11.00% |  |  |  |  |
SPINRAZA [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty percentage received on net sales of medicine |  |  |  |  |  |  |  |  | 15.00% |  |  |  |  |
SPINRAZA [Member] | SPINRAZA Royalties [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative revenue earned |  |  | 1,400,000 |  |  |  |  |  | $ 1,400,000 |  |  |  |  |
SPINRAZA [Member] | R&D Revenue [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative revenue earned |  |  | 425,000 |  |  |  |  |  | 425,000 |  |  |  |  |
New Antisense Medicines for the Treatment of SMA [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | 85,000 |  |  |  |  |  | $ 85,000 |  |  |  |  |
Royalty percentage received on net sales of medicine |  |  |  |  |  |  |  |  | 20.00% |  |  |  |  |
Upfront payment received |  |  |  |  |  |  |  | $ 25,000 |  |  |  |  |  |
Maximum amount of payments receivable over term of collaboration |  |  | 1,200,000 |  |  |  |  |  | $ 1,200,000 |  |  |  |  |
Maximum amount of upfront payments over term of collaboration |  |  | 25,000 |  |  |  |  |  | 25,000 |  |  |  |  |
Maximum amount of license fees over term of collaboration |  |  | 110,000 |  |  |  |  |  | 110,000 |  |  |  |  |
Maximum amount of development milestone payments over term of collaboration |  |  | 80,000 |  |  |  |  |  | 80,000 |  |  |  |  |
Maximum amount of regulatory milestone payments over term of collaboration |  |  | 180,000 |  |  |  |  |  | 180,000 |  |  |  |  |
Maximum amount of sales milestone payments over term of collaboration |  |  | 800,000 |  |  |  |  |  | 800,000 |  |  |  |  |
Next payment to be achieved |  |  | 45,000 |  |  |  |  |  | 45,000 |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  |  |  |  | 1 |  |  |  |  |  |
Transaction price |  |  |  |  |  |  |  | $ 25,000 |  |  |  |  |  |
New Antisense Medicines for the Treatment of SMA [Member] | ION306 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum amount of payments receivable over term of collaboration |  |  | 555,000 |  |  |  |  |  | 555,000 |  |  |  |  |
Maximum amount of development milestone payments over term of collaboration |  |  | 45,000 |  |  |  |  |  | 45,000 |  |  |  |  |
Maximum amount of regulatory milestone payments over term of collaboration |  |  | 110,000 |  |  |  |  |  | 110,000 |  |  |  |  |
Maximum amount of sales milestone payments over term of collaboration |  |  | 400,000 |  |  |  |  |  | 400,000 |  |  |  |  |
Revenue |  |  |  |  | $ 60,000 |  |  |  |  |  |  |  |  |
2018 Strategic Neurology [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | 1,100,000 |  |  |  |  |  | $ 1,100,000 |  |  |  |  |
Royalty percentage received on net sales of medicine |  |  |  |  |  |  |  |  | 20.00% |  |  |  |  |
Upfront payment received |  |  |  |  |  |  | $ 375,000 |  |  |  |  |  |  |
Next payment to be achieved |  |  | 7,500 |  |  |  |  |  | $ 7,500 |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  |  |  |  |  |  |  |  |  |  | 1
Transaction price |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 552,000
Term of collaboration agreement |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |
Upfront payment received, including purchase of stock |  |  |  |  |  |  | 1,000,000 |  |  |  |  |  |  |
Proceeds from issuance of common stock |  |  |  |  |  |  | $ 625,000 |  |  |  |  |  |  |
Percentage cash premium paid on shares purchased |  |  |  |  |  |  | 25.00% |  |  |  |  |  |  |
Maximum amount of payments receivable per medicine over term of collaboration |  |  | 270,000 |  |  |  |  |  | $ 270,000 |  |  |  |  |
Maximum amount of license fees per medicine over term of collaboration |  |  | 15,000 |  |  |  |  |  | 15,000 |  |  |  |  |
Maximum amount of development milestone payments per medicine over term of collaboration |  |  | 105,000 |  |  |  |  |  | 105,000 |  |  |  |  |
Maximum amount of regulatory milestone payments per medicine over term of collaboration |  |  | 150,000 |  |  |  |  |  | 150,000 |  |  |  |  |
Premium paid on shares purchased |  |  |  |  |  |  | $ 177,000 |  |  |  |  |  |  |
Cumulative payments included in transaction price for performance obligation |  |  | 616,000 |  |  |  |  |  | 616,000 |  |  |  |  |
Milestone payments achieved and included in transaction price for performance obligation |  |  |  |  |  |  |  |  |  | $ 23,000 | 11,000 |  |  |
2013 Strategic Neurology [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | 300,000 |  |  |  |  |  | 300,000 |  |  |  |  |
Upfront payment received | $ 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Next payment to be achieved |  |  | $ 16,000 |  |  |  |  |  | $ 16,000 |  |  |  |  |
Number of separate performance obligations | PerformanceObligation | 1 |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price | $ 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Number of medicines currently being advanced | Medicine |  |  | 5 |  |  |  |  |  | 5 |  |  |  |  |
Maximum amount of payments receivable per antisense molecule over term of collaboration |  |  | $ 260,000 |  |  |  |  |  | $ 260,000 |  |  |  |  |
Maximum amount of license fees per antisense molecule over term of collaboration |  |  | 70,000 |  |  |  |  |  | 70,000 |  |  |  |  |
Maximum amount of development milestone payments per antisense molecule over term of collaboration |  |  | 60,000 |  |  |  |  |  | 60,000 |  |  |  |  |
Maximum amount of regulatory milestone payments per antisense molecule over term of collaboration |  |  | $ 130,000 |  |  |  |  |  | $ 130,000 |  |  |  |  |
Revenue |  |  |  | $ 9,000 |  |  |  |  |  |  |  | $ 35,000 |  |
2013 Strategic Neurology [Member] | R&D Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative payments included in transaction price for performance obligation |  |  |  |  |  |  |  |  |  |  | 145,000 |  |  |
2013 Strategic Neurology [Member] | Medicines for Parkinson's Disease [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of medicines currently being advanced | Medicine |  |  | 1 |  |  |  |  |  | 1 |  |  |  |  |
2013 Strategic Neurology [Member] | Medicines for ALS [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of medicines currently being advanced | Medicine |  |  | 2 |  |  |  |  |  | 2 |  |  |  |  |
2013 Strategic Neurology [Member] | Medicines for Multiple System Atrophy [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of medicines currently being advanced | Medicine |  |  | 1 |  |  |  |  |  | 1 |  |  |  |  |
2013 Strategic Neurology [Member] | Medicines for Undisclosed Targets [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of medicines currently being advanced | Medicine |  |  | 1 |  |  |  |  |  | 1 |  |  |  |  |
2013 Strategic Neurology [Member] | Tofersen [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum amount of payments receivable over term of collaboration |  |  | $ 110,000 |  |  |  |  |  | $ 110,000 |  |  |  |  |
Maximum amount of license fees over term of collaboration |  |  | 35,000 |  |  |  |  |  | 35,000 |  |  |  |  |
Maximum amount of development milestone payments over term of collaboration |  |  | 18,000 |  |  |  |  |  | 18,000 |  |  |  |  |
Maximum amount of regulatory milestone payments over term of collaboration |  |  | 55,000 |  |  |  |  |  | 55,000 |  |  |  |  |
2012 Neurology [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | 170,000 |  |  |  |  |  | 170,000 |  |  |  |  |
Upfront payment received |  | $ 30,000 |  |  |  |  |  |  |  |  |  |  |  |
Maximum amount of payments receivable over term of collaboration |  |  | 210,000 |  |  |  |  |  | 210,000 |  |  |  |  |
Maximum amount of license fees over term of collaboration |  |  | 70,000 |  |  |  |  |  | 70,000 |  |  |  |  |
Maximum amount of development milestone payments over term of collaboration |  |  | 10,000 |  |  |  |  |  | 10,000 |  |  |  |  |
Maximum amount of regulatory milestone payments over term of collaboration |  |  | 130,000 |  |  |  |  |  | 130,000 |  |  |  |  |
Next payment to be achieved |  |  | 25,000 |  |  |  |  |  | 25,000 |  |  |  |  |
Number of programs under which medicines are to be developed and commercialized | Program |  | 2 |  |  |  |  |  |  |  |  |  |  |  |
2012 Neurology [Member] | R&D Revenue [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative payments included in transaction price for performance obligation |  |  | 40,000 |  |  |  |  |  | 40,000 |  |  |  |  |
2012 Neurology [Member] | IONIS-MAPT [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative payments included in transaction price for performance obligation |  |  | 57,000 |  |  |  |  |  | 57,000 |  |  |  |  |
Milestone payments achieved and included in transaction price for performance obligation |  |  |  |  |  |  |  |  |  |  | $ 19,500 |  |  |
Revenue |  |  |  |  |  | $ 45,000 |  |  | 10,000 |  |  |  |  |
2012 Neurology [Member] | ION582 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments achieved and included in transaction price for performance obligation |  |  | $ 14,500 |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | $ 20,000 |  |  |  |  |

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- Definition The maximum amount of payments the Company is eligible to receive for each antisense molecule that is chosen for drug discovery and development over the term of the collaboration. + References No definition available. + Details
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