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Collaborative Arrangements and Licensing Agreements, AstraZeneca (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Dec. 31, 2021 USD ($) PerformanceObligation Component | Jul. 31, 2015 USD ($) PerformanceObligation | Dec. 31, 2021 USD ($) PerformanceObligation Component | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) PerformanceObligation Component | Dec. 31, 2020 USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Revenue |  |  |  | $ 587,367 | $ 810,456 | $ 729,264
R&D Revenue [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Revenue |  |  |  | 284,009 | 468,061 | $ 364,565
AstraZeneca [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Deferred revenue | $ 0 |  | $ 0 | $ 0 | $ 0 |
AstraZeneca [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Concentration percentage |  |  |  | 13.00% | 31.00% | 12.00%
AstraZeneca [Member] | R&D Revenue [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Revenue |  |  |  | $ 79,200 | $ 254,600 | $ 88,000
Eplontersen Collaboration [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Maximum amount of payments receivable over term of collaboration |  |  |  | 3,600,000 |  |
Upfront payment received | $ 200,000 |  |  |  |  |
Maximum amount of development milestone payments over term of collaboration |  |  |  | 485,000 |  |
Maximum amount of sales milestone payments over term of collaboration |  |  |  | $ 2,900,000 |  |
Royalty percentage received on sales of medicine in U.S. |  |  |  | 20.00% |  |
Number of material components | Component | 4 |  | 4 |  | 4 |
Number of separate performance obligations | PerformanceObligation | 1 |  | 1 |  | 1 |
Transaction price | $ 200,000 |  | $ 200,000 |  | $ 200,000 |
Percentage of costs associated with ongoing global Phase 3 development program paid by AstraZeneca |  |  |  | 55.00% |  |
Next payment to be achieved |  |  |  | $ 50,000 |  |
Revenue |  |  |  |  | $ 200,000 |
Eplontersen Collaboration [Member] | Maximum [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Cumulative payments received |  |  |  | 260,000 |  |
Cardiovascular, Renal and Metabolic Diseases Collaboration [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Maximum amount of payments receivable over term of collaboration |  |  |  | 5,800,000 |  |
Upfront payment received |  | $ 65,000 |  |  |  |
Maximum amount of license fees over term of collaboration |  |  |  | 290,000 |  |
Maximum amount of development milestone payments over term of collaboration |  |  |  | 1,100,000 |  |
Maximum amount of regulatory milestone payments over term of collaboration |  |  |  | 2,900,000 |  |
Maximum amount of sales milestone payments over term of collaboration |  |  |  | 1,500,000 |  |
Number of separate performance obligations | PerformanceObligation |  | 1 |  |  |  |
Transaction price |  | $ 65,000 |  |  |  |
Next payment to be achieved |  |  |  | 10,000 |  |
Revenue |  |  | $ 30,000 |  |  |
Cardiovascular, Renal and Metabolic Diseases Collaboration [Member] | Minimum [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Cumulative payments received |  |  |  | 280,000 |  |
Cardiovascular, Renal and Metabolic Diseases Collaboration [Member] | R&D Revenue [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Cumulative payments included in transaction price for performance obligation |  |  |  | $ 90,000 |  |

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