    <SEC-DOCUMENT>0001140361-23-019312-index.html : 20230420
    <SEC-HEADER>0001140361-23-019312.hdr.sgml : 20230420
    <ACCEPTANCE-DATETIME>20230420102211
    ACCESSION NUMBER:		0001140361-23-019312
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20221231
    FILED AS OF DATE:		20230420
    DATE AS OF CHANGE:		20230420
    EFFECTIVENESS DATE:		20230420

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
    		CENTRAL INDEX KEY:			0000874015
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				330336973
    		STATE OF INCORPORATION:			CA
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	000-19125
    		FILM NUMBER:		23831729

    	BUSINESS ADDRESS:
    		STREET 1:		2855 GAZELLE COURT
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92010
    		BUSINESS PHONE:		7609319200

    	MAIL ADDRESS:
    		STREET 1:		2855 GAZELLE COURT
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92010

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
    		DATE OF NAME CHANGE:	19930328
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>ny20007094x4_ars.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: ny20007094x4_ars.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>