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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2023 | Sep. 30, 2022
Operating activities: |  |
Net loss | $ (357,023) | $ (217,292)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 7,748 | 11,301
Amortization of right-of-use operating lease assets | 7,234 | 1,970
Amortization of other assets | 1,904 | 1,805
Amortization of premium (discount) on investments, net | (20,396) | 9,072
Amortization of debt issuance costs | 4,666 | 4,035
Non-cash royalty revenue related to sale of royalties | (27,814) | 0
Non-cash interest related to sale of future royalties | 50,541 | 0
Stock-based compensation expense | 79,473 | 74,575
Loss on investments | 1,429 | 228
Gain on early retirement of debt | (13,389) | 0
Non-cash losses related to disposal of property, plant and equipment | 14,646 | 528
Non-cash losses related to other assets | 849 | 1,155
Changes in operating assets and liabilities: |  |
Contracts receivable | (116,814) | 55,251
Inventories | (3,601) | 4,161
Other current and long-term assets | (18,325) | (988)
Income taxes payable | 24,821 | (20)
Accounts payable | (12,462) | 5,607
Accrued compensation | (15,397) | (8,400)
Accrued liabilities and other current liabilities | (24,219) | 38,263
Deferred contract revenue | 75,751 | (55,426)
Net cash used in operating activities | (340,378) | (74,175)
Investing activities: |  |
Purchases of short-term investments | (1,353,100) | (1,223,791)
Proceeds from sale of short-term investments | 1,193,724 | 764,101
Purchases of property, plant and equipment | (24,624) | (11,582)
Acquisition of licenses and other assets, net | (3,414) | (3,511)
Net cash used in investing activities | (187,414) | (474,783)
Financing activities: |  |
Proceeds from equity, net | 8,680 | 6,030
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options | 0 | (10,217)
Proceeds from issuance of 1.75 percent convertible senior notes | 575,000 | 0
1.75 percent convertible senior notes issuance costs | (14,175) | 0
Repurchase of $504.4 million principal amount of 0.125 percent convertible senior notes | (487,943) | 0
Proceeds from sale of future royalties | 500,000 | 0
Payments of transaction costs related to sale of future royalties | (10,434) | 0
Proceeds from real estate transaction | 32,352 | 0
Principal payments on mortgage debt | (122) | (89)
Net cash provided by (used in) financing activities | 603,358 | (4,276)
Effects of exchange rates on cash | 22 | (964)
Net increase (decrease) in cash and cash equivalents | 75,588 | (554,198)
Cash and cash equivalents at beginning of period | 276,472 | 869,191
Cash and cash equivalents at end of period | 352,060 | 314,993
Supplemental disclosures of cash flow information: |  |
Interest paid | 952 | 2,204
Income taxes paid | 714 | 2
Supplemental disclosures of non-cash investing and financing activities: |  |
Amounts accrued for capital and patent expenditures | 341 | 3,032
Right-of-use assets obtained in exchange for lease liabilities | $ 0 | $ 657

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