<SEC-DOCUMENT>0001140361-23-019309.txt : 20230420
<SEC-HEADER>0001140361-23-019309.hdr.sgml : 20230420
<ACCEPTANCE-DATETIME>20230420101846
ACCESSION NUMBER:		0001140361-23-019309
CONFORMED SUBMISSION TYPE:	DEF 14A
PUBLIC DOCUMENT COUNT:		38
FILED AS OF DATE:		20230420
DATE AS OF CHANGE:		20230420

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEF 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		23831724

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEF 14A
<SEQUENCE>1
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<DESCRIPTION>DEF 14A
<TEXT>
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    <td>Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))</td>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: #A20067"><img alt="" src="ny20007094x2_def14aimg001.jpg" /></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 16pt"><b>NOTICE OF 2023
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #231F20">Dear Stockholders,</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0.25in"><span style="color: #231F20">I am pleased to invite you to Ionis Pharmaceuticals, Inc.&#8217;s 2023 Annual
      Meeting of Stockholders to be held on June 1, 2023. </span>The Annual Meeting will be held in a virtual meeting format only, via live webcast on the Internet, with no physical in-person meeting. You can attend and participate in the Annual Meeting
    online by visiting <span style="text-decoration: underline;">www.virtualshareholdermeeting.com/IONS2023</span>, where you will be able to listen to the meeting live, submit questions and vote<span style="color: #231F20">. As always, we encourage you to vote your shares prior to the Annual
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0.25in"><span style="color: #231F20">This document includes the agenda for this year&#8217;s Annual Meeting and the Proxy
      Statement. We will cover the formal items on the agenda during the Annual Meeting. Following the formal Annual Meeting, we will review the major developments of the past year and our plans for 2023 via webcast. You can find information regarding how
      to join the webcast on our website at <span style="text-decoration: underline;">ir.ionispharma.com</span></span>. <span style="color: #231F20">The Proxy Statement explains the matters we will discuss in the meeting and provides additional information about us.</span></p>
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    to vote your shares as soon as possible to ensure your representation at the meeting. We are distributing our proxy materials under a Securities and Exchange Commission rule that allows us to furnish proxy materials to our stockholders over the
    Internet rather than in paper form. We believe this method of distribution reduces our environmental impact and costs without hindering our stockholders&#8217; timely access to such important material. As a result, if you are a stockholder of record (that
    is, if your stock is registered with us in your own name) you will receive a Notice Regarding the Availability of Proxy Materials in the mail, which contains instructions on how to access our proxy materials and vote electronically through the Internet
    or to request printed proxy materials so you may vote by telephone or mail.</p>
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    forward the Notice Regarding the Availability of Proxy Materials to you and you can direct that nominee to vote your shares. Alternatively, if your nominee participates in a program provided through Broadridge Financial Solutions, Inc. that allows you
    to vote by telephone or through the Internet, your nominee will send you a voting form with telephone and Internet voting instructions.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0.25in; color: #231F20">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0.25in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0.25in; color: #231F20"><b>PLEASE NOTE, HOWEVER, THAT IF A BROKER, BANK OR OTHER NOMINEE HOLDS YOUR SHARES OF
      RECORD AND YOU WISH TO VOTE AT THE MEETING, <i><span style="text-decoration: underline;">YOU MUST OBTAIN A PROXY ISSUED IN YOUR NAME</span></i> FROM THE BROKER, BANK OR OTHER NOMINEE.</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0.25in; color: #231F20">In this document, unless the context requires otherwise, the words &#8220;Ionis,&#8221; &#8220;Company,&#8221;
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    <td style="width: 65%">&#160;</td>

    <td style="width: 35%">Sincerely,</td>

  </tr>

  <tr style="vertical-align: top; text-align: left">

    <td>&#160;</td>

    <td><i>Patrick R. O&#8217;Neil</i></td>

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  <tr style="vertical-align: top; text-align: left">

    <td>&#160;</td>

    <td>Corporate Secretary</td>

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    <div style="TEXT-ALIGN: center">&#160;</div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: #CE0F69"><b>NOTICE OF 2023 ANNUAL MEETING OF STOCKHOLDERS</b></p>
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  <tr style="vertical-align: top">

    <td style="text-align: left; width: 30%"><span style="color: #E57200">Date:</span></td>

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    <td style="text-align: left; width: 68%">June 1, 2023</td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
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  <tr style="vertical-align: top">

    <td style="text-align: left; width: 30%"><span style="color: #E57200">Time:</span> </td>

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    <td style="text-align: left; width: 68%">2:00 p.m. Pacific Time</td>

  </tr>


</table>
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  <tr style="vertical-align: top">

    <td style="text-align: left; width: 30%"><span style="color: #E57200">Place:</span></td>

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    <td style="text-align: left; width: 68%">Online only: <span style="text-decoration: underline;">www.virtualshareholdermeeting.com/IONS2023</span></td>

  </tr>


</table>
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  <tr style="vertical-align: top">

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    <td style="text-align: left; width: 68%">April 3, 2023. <span style="color: #231F20">If you were an Ionis stockholder of record at the close of business on April 3, 2023, you may vote at the Annual Meeting.</span></td>

  </tr>


</table>
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  <tr style="vertical-align: top">

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    <td style="text-align: left; width: 68%">We are holding the Annual Meeting for the following purposes, as more fully described in the accompanying Proxy Statement:</td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1.5in; text-align: left; text-indent: -1.5in">&#160;</p>
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  <tr style="vertical-align: top">

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    <td style="width: 3%">1.</td>

    <td style="text-align: left; padding-right: 0; width: 65%">To elect our nominees, Spencer R. Berthelsen, Joan E. Herman, B. Lynne Parshall, and Joseph H. Wender, to our Board of Directors to serve as Directors for a three-year term;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top; text-align: justify">

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    <td style="width: 3%; text-align: left">2.</td>

    <td style="width: 65%;">To make an advisory vote on executive compensation;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top">

    <td style="width: 32%"></td>

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    <td style="text-align: left; width: 65%">To make an advisory vote on the frequency of future advisory votes on executive compensation;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top">

    <td style="width: 32%"></td>

    <td style="width: 3%">4.</td>

    <td style="text-align: left; width: 65%">To approve an amendment of the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan to increase the aggregate number of shares of common stock authorized for issuance under such plan by 5,500,000 shares to
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  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top">

    <td style="width: 32%"></td>

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    <td style="text-align: left; width: 65%">To ratify increasing the vesting of future initial stock option and restricted stock unit awards to new non-employee Directors from one year to three years;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20">


  <tr style="vertical-align: top">

    <td style="width: 32%"></td>

    <td style="width: 3%">6.</td>

    <td style="text-align: left; width: 65%">To ratify the Audit Committee&#8217;s selection of Ernst &amp; Young LLP as independent auditors for our 2023 fiscal year; and</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top">

    <td style="width: 32%"></td>

    <td style="width: 3%">7.</td>

    <td style="text-align: left; width: 65%">To transact any other business that may be properly presented at the Annual Meeting.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top">

    <td style="text-align: left; width: 30%"><span style="color: #E57200">Virtual Meeting:</span></td>

    <td style="width: 2%">&#160;</td>

    <td style="text-align: left; width: 68%"><span style="color: #231F20">To participate in the Annual Meeting, please visit <span style="text-decoration: underline;">www.virtualshareholdermeeting.com/IONS2023</span>. You will need the 16-digit control number included on your Notice of
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  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 1.5in; text-align: left; text-indent: -1.5in">&#160;</p>
  <table cellspacing="0" cellpadding="0" border="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif">


  <tr style="vertical-align: top">

    <td style="text-align: justify; width: 30%"><span style="color: #E57200">Voting:</span></td>

    <td style="width: 2%">&#160;</td>

    <td style="text-align: left; width: 68%"><span style="color: #231F20">WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE VOTE BY TELEPHONE OR INTERNET BY FOLLOWING THE INSTRUCTIONS INCLUDED IN THIS PROXY STATEMENT AND YOUR NOTICE REGARDING THE
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  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top; text-align: left">

    <td style="width: 65%">&#160;</td>

    <td style="width: 35%"><span style="color: #231F20">By order of the Board of Directors,</span></td>

  </tr>

  <tr style="vertical-align: top; text-align: left">

    <td>&#160;</td>

    <td><span style="color: #231F20"><i>Patrick R. O&#8217;Neil</i></span></td>

  </tr>

  <tr style="vertical-align: top; text-align: left">

    <td>&#160;</td>

    <td>Corporate Secretary</td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #231F20">Carlsbad, California<br />
    April 20, 2023</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 22.3pt; text-align: left; text-indent: 0in; color: #231F20">&#160;</p>
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  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: #231F20">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
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    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
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  <!--PROfilePageNumberReset%Num%1%%%-->
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0; color: #231F20"><b>IONIS PHARMACEUTICALS, INC.<br />
      2855 Gazelle Court<br />
      Carlsbad, CA 92010 </b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 225.5pt; text-align: center; text-indent: -0.05pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: #231F20"><b>PROXY STATEMENT<br />
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: #231F20"><b>To Be Held on June 1, 2023</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><b>QUESTIONS AND ANSWERS ABOUT THESE PROXY MATERIALS AND VOTING</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">The Board of Directors (the &#8220;<b><i>Board</i></b>&#8221;) of Ionis Pharmaceuticals, Inc. (the &#8220;<b><i>Company</i></b>&#8221;)






















    is soliciting your proxy to vote at the 2023 Annual Meeting of Stockholders, including at any adjournments or postponements of the meeting. We are distributing our Notice of Annual Meeting and Proxy Materials (the &#8220;<b><i>Notice</i></b>&#8221;) by mail using
    the Notice and Access procedures established by the United States Securities and Exchange Commission (the &#8220;<b><i>SEC</i></b>&#8221;). The Notice is important because it contains a control number and instructions that will allow you to access our proxy
    materials and vote electronically through the Internet or to request printed proxy materials so you may vote by telephone or mail. Your vote is very important. Whether or not you plan to attend the meeting, please be sure to vote your shares as soon as
    possible to ensure your representation at the meeting. All stockholders will have the ability to access the proxy materials on the website referred to in the Notice or request to receive a printed set of the proxy materials. You can find instructions
    on how to access the proxy materials over the Internet or to request a printed copy in the Notice.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">We intend to mail the Notice on April 21, 2023 to all stockholders of record entitled to vote
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
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  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">Where and when is the Annual Meeting?</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">If you cannot attend, please note that we will make a webcast of the presentation that follows
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067"><b>How do I attend the Annual Meeting?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">We will be hosting the Annual Meeting via live webcast on the Internet.&#160;<b>You will not be able to attend the
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    <b>The webcast will begin at 2:00 p.m. Pacific Time on June 1, 2023. Stockholders may vote and submit questions while connected to the Annual Meeting on the Internet.</b> <span style="color: #231F20">A summary of the information you need to attend the
      Annual Meeting online is provided below.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&#160;</p>
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      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067"><b>What do I need in order to be able to participate in the Annual Meeting online?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 24pt">You will need the 16-digit control number included on your Notice of Internet Availability of Proxy Materials,
    proxy card or voting instruction form that accompanied your proxy materials to be able to vote your shares or submit questions during the virtual Annual Meeting.&#160; <b>Instructions on how to connect and participate in the Annual Meeting via the
      internet, including how to demonstrate proof of stock ownership, are posted at&#160;<span style="text-decoration: underline;">www.virtualshareholdermeeting.com/IONS2023</span>.</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 24pt">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">What if I have technical difficulties or trouble accessing the live webcast of the Annual
    Meeting?</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 24pt">If you encounter any difficulties accessing the live webcast of the Annual Meeting or during the Annual Meeting,
    please call the telephone number that is listed at <span style="text-decoration: underline;">www.virtualshareholdermeeting.com/IONS2023</span> for assistance. If you misplace the 16-digit control number that is required to enter the Annual Meeting webcast and are a stockholder of record,
    operators providing assistance at this telephone number will be able to provide it to you. However, if you need your 16-digit control number and hold your shares in an account at a brokerage firm, bank, dealer, or other similar organization, you must
    contact that organization to obtain your 16-digit control number prior to the Annual Meeting.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 24pt">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">Who can attend and vote at the Annual Meeting?</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">Only stockholders at the close of business on April 3, 2023 may attend and vote at the Annual
    Meeting. On this record date, there were 143,023,414 shares of common stock outstanding and entitled to vote.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #CE0F69"><i>Stockholder of Record: Shares Registered in Your Name</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">If on April 3, 2023 your shares were registered directly in your name with our transfer agent,
    American Stock Transfer &amp; Trust Company, then you are a stockholder of record. As a stockholder of record, you may vote online at the virtual meeting or vote by proxy over the telephone, by mail, or the Internet as instructed under the section
    below titled &#8220;How do I vote?&#8221; Whether or not you plan to attend the meeting, we urge you to fill out and return the proxy card or vote over the telephone or Internet to ensure your vote is counted.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #CE0F69"><i>Beneficial Owner: Shares Registered in the Name of a Broker or Bank</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">If on April 3, 2023 you did not own shares in your name, but rather in an account at a
    brokerage firm, bank, dealer or other similar organization, then you are the beneficial owner of shares held in &#8220;street name&#8221; and that organization is forwarding the Notice to you. The organization holding your account is the stockholder of record for
    purposes of voting at the Annual Meeting. As a beneficial owner, you may direct your broker or other agent regarding how to vote the shares in your account. If your shares are registered in the name of a broker or other nominee, your nominee may be
    participating in a program provided through Broadridge Financial Solutions, Inc. (&#8220;<b><i>Broadridge</i></b>&#8221;) that also allows you to vote by telephone or through the Internet. If so, the voting form your nominee sends you will provide telephone and
    Internet instructions. You are also invited to attend the virtual Annual Meeting via live webcast.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20"><b>PLEASE NOTE, HOWEVER, THAT IF A BROKER, BANK OR OTHER NOMINEE HOLDS YOUR SHARES OF RECORD
      AND YOU WISH TO VOTE AT THE MEETING, <i><span style="text-decoration: underline;">YOU MUST OBTAIN A PROXY ISSUED IN YOUR NAME</span></i> FROM THE BROKER, BANK OR OTHER NOMINEE.</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #231F20"><b>What am I voting on?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">The following matters are scheduled for a vote:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 0.5in"><span style="color: #231F20">1.</span></td>

    <td style="text-align: left; padding-right: 0; width: 1in"><span style="color: #E57200"><span style="text-decoration: underline;">Proposal 1:</span></span></td>

    <td style="text-align: left; padding-right: 52.1pt"><span style="color: #231F20">elect our nominees, Spencer R. Berthelsen, Joan E. Herman, B. Lynne Parshall, and Joseph H. Wender, to our Board of Directors to serve as Directors for a three-year
            term;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 0.5in"><span style="color: #231F20">2.</span></td>

    <td style="text-align: left; width: 1in"><span style="color: #E57200"><span style="text-decoration: underline;">Proposal 2:</span></span></td>

    <td style="text-align: left; padding-right: 52.1pt"><span style="color: #231F20">make an advisory vote on executive compensation;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 0.5in"><span style="color: #231F20">3.</span></td>

    <td style="text-align: left; width: 1in"><span style="color: #E57200"><span style="text-decoration: underline;">Proposal 3:</span></span></td>

    <td style="text-align: left; padding-right: 52.1pt">make an advisory vote on the frequency of future advisory votes on executive compensation;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 0.5in"><span style="color: #231F20">4.</span></td>

    <td style="text-align: left; width: 1in"><span style="color: #E57200"><span style="text-decoration: underline;">Proposal 4</span>:</span></td>

    <td style="text-align: left; padding-right: 52.1pt">approve an amendment of the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan to increase the aggregate number of shares of common stock authorized for issuance under such plan by 5,500,000
          shares to an aggregate of <span style="color: #231F20">35,200,000 </span>shares;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&#160;</p>
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    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">2</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 0.5in"><span style="color: #231F20">5.</span></td>

    <td style="text-align: left; width: 1in"><span style="color: #E57200"><span style="text-decoration: underline;">Proposal 5</span>:</span></td>

    <td style="text-align: left; padding-right: 52.1pt"><span style="color: #231F20">ratify increasing the vesting of future initial stock option and restricted stock unit awards to new non-employee Directors from one year to three years; and </span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 0.5in"><span style="color: #231F20">6.</span></td>

    <td style="text-align: left; width: 1in"><span style="color: #E57200"><span style="text-decoration: underline;">Proposal 6:</span></span></td>

    <td style="text-align: left; padding-right: 10pt"><span style="color: #231F20">ratify the Audit Committee&#8217;s selection of Ernst &amp; Young LLP as independent auditors for our 2023 fiscal year.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">What if another matter is properly brought before the meeting?</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; color: #231F20; text-align: left; text-indent: 22.5pt"><span style="font-weight: normal">The Board knows of no other matters that will be presented
      for consideration at the Annual Meeting. If any other matters are properly brought before the meeting, the persons named in the accompanying proxy intend to vote on those matters in accordance with their best judgment.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; color: #231F20; text-align: left; text-indent: 22.5pt">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in"><span style="color: #A20067">How do I vote?</span><span style="color: #231F20"> </span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 22.5pt; color: #231F20; text-align: left; text-indent: 0in"><span style="font-weight: normal">You may vote in one of the following ways:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 22.5pt; color: #231F20; text-align: left; text-indent: 0in">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 22.5pt">1.</td>

    <td style="text-align: left">vote through the Internet by following the instructions included with your Notice or proxy card;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 22.5pt">2.</td>

    <td style="text-align: left">vote by telephone by following the instructions included with your proxy card if you have received proxy materials electronically or by mail;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 22.5pt">3.</td>

    <td style="text-align: left">vote by mail by completing, signing, dating, and returning your proxy card in the postage paid envelope provided; or</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 22.5pt">4.</td>

    <td style="text-align: left">vote during the virtual Annual Meeting by following the instructions posted at <span style="text-decoration: underline;">www.virtualshareholdermeeting.com/IONS2023</span>.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.35in; text-align: left; text-indent: 0in; color: #231F20">The procedures for voting are fairly simple:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.35in; text-align: left; text-indent: 0in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.35in; text-align: left; text-indent: 0in; color: #CE0F69"><i>For Shares Registered in Your Name:</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.35in; text-align: left; text-indent: 0in; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">If you are a stockholder of record, you may go to <span style="text-decoration: underline;">www.proxyvote.com</span> to vote your
    shares through the Internet up until 11:59 p.m. Eastern Time on May 31, 2023. The votes represented by your proxy will be displayed on the computer screen and you will be prompted to submit or revise your votes as desired.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">To vote your shares by telephone, you must first request that we send proxy materials to you
    by following the instructions included in your Notice. Once you have received your proxy materials, you may vote using a touch-tone telephone by calling 1-800-690-6903 up until 11:59 p.m. Eastern Time on May 31, 2023 and following the recorded
    instructions. Please have your proxy card available at the time you vote.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">To vote using the proxy card, simply complete, sign and date the proxy card that may be
    delivered to you and return it promptly in the envelope provided. If we receive your signed proxy card before the Annual Meeting, we will vote your shares as you direct.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #CE0F69"><i>For Shares Registered in the Name of a Broker or Bank:</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">If your broker or bank holds your shares in &#8220;street name,&#8221; you will need to obtain a proxy
    form from the institution that holds your shares and follow the instructions included on that form regarding how to instruct your broker to vote your shares. If you do not give instructions to your broker, your broker can vote your shares with respect
    to &#8220;discretionary&#8221; items, but not with respect to &#8220;non-discretionary&#8221; items. Discretionary items are proposals considered routine under the rules of the New York Stock Exchange (&#8220;<b><i>NYSE</i></b>&#8221;) on which a broker may vote shares held in street
    name in the absence of your voting instructions. While Ionis is listed with the Nasdaq Stock Market (&#8220;<b><i>Nasdaq</i></b>&#8221;), NYSE rules affect how brokers licensed by the NYSE can vote in a director election of any company, including companies listed
    with Nasdaq. The proposal to ratify Ernst &amp; Young LLP as independent auditors is a discretionary item. Proposals 1 through 5 regarding (1) the election of Directors, (2) approval, on an advisory basis, of our executive compensation, (3) approval,
    on an advisory basis, of the frequency of future advisory votes on executive compensation, (4) approval of an amendment of the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan to increase the aggregate number of shares of common stock authorized
    for issuance under such plan by 5,500,000 shares to an aggregate of 35,200,000 shares, and (5) ratification of increasing the vesting of future initial stock option and restricted stock unit awards to new non-employee Directors from one year to three
    years are non-discretionary items. If you do not give your broker instructions for a non-discretionary item your broker cannot vote your shares, which will result in what is commonly referred to as a &#8220;broker non-vote.&#8221; Broker non-votes will have no
    effect.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">3</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">A number of brokers and banks are participating in a program provided by Broadridge that
    allows proxies to vote shares by means of the telephone and Internet. If your shares are held in an account with a broker or bank participating in the Broadridge program, you may vote your shares by telephone or through the Internet by having the
    voting form in hand and calling the number or going to the website indicated on the form and following the instructions.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>What if I return a proxy card or otherwise vote but do not make specific choices?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">If you return a signed and dated proxy card or otherwise vote without marking voting
    selections, one of the individuals named on your proxy card will vote your shares as follows:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 13.5pt"><span style="color: #231F20">1.</span></td>

    <td style="text-align: left"><span style="color: #231F20">&#8220;</span><span style="color: #CE0F69">For</span><span style="color: #231F20">&#8221; the election of the nominees for Director named in the Proxy Statement;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 13.5pt"><span style="color: #231F20">2.</span></td>

    <td style="text-align: left"><span style="color: #231F20">&#8220;</span><span style="color: #CE0F69">For</span><span style="color: #231F20">&#8221; the approval, on an advisory basis, of executive compensation; </span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 13.5pt"><span style="color: #231F20">3.</span></td>

    <td style="text-align: left"><span style="color: #231F20">&#8220;</span><span style="color: #CE0F69">For</span><span style="color: #231F20">&#8221; every year as the preferred frequency of future advisory votes on executive compensation;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 13.5pt"><span style="color: #231F20">4.</span></td>

    <td style="text-align: left"><span style="color: #231F20">&#8220;</span><span style="color: #CE0F69">For</span><span style="color: #231F20">&#8221;</span> the approval of an amendment of the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan to increase
          the aggregate number of shares of common stock authorized for issuance under such plan by 5,500,000 shares to an aggregate of 35,200,000 shares;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 13.5pt"><span style="color: #231F20">5.</span></td>

    <td style="text-align: left; padding-right: 10pt"><span style="color: #231F20">&#8220;</span><span style="color: #CE0F69">For</span><span style="color: #231F20">&#8221; ratification of increasing the vesting of future initial stock option and restricted stock
            unit awards to new non-employee Directors from one year to three years; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 22.5pt"></td>

    <td style="width: 13.5pt"><span style="color: #231F20">6.</span></td>

    <td style="text-align: left; padding-right: 10pt"><span style="color: #231F20">&#8220;</span><span style="color: #CE0F69">For</span><span style="color: #231F20">&#8221; the ratification of the Audit Committee&#8217;s selection of Ernst &amp; Young LLP as independent
            auditors for our 2023 fiscal year.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">If any other matter is properly presented at the meeting, one of the individuals named on your
    proxy card will vote your shares using his or her best judgment.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>Who is paying for this proxy solicitation?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">Our Board is soliciting your proxy to vote at the Annual Meeting. We will bear the entire cost
    of soliciting proxies, including preparing, assembling, making available on the Internet and printing and mailing this Proxy Statement, the proxy card and any additional information furnished to stockholders. We will furnish copies of solicitation
    materials to banks, brokerage houses, fiduciaries and custodians holding our common stock in &#8220;street name&#8221; on behalf of beneficial owners of such shares. We may reimburse persons representing beneficial owners of our common stock for their costs of
    forwarding solicitation materials to such beneficial owners. Our Directors, officers or other employees may supplement original solicitation of proxies by telephone, electronic mail, or personal solicitation. We will not pay our Directors, officers, or
    employees any additional compensation for soliciting proxies. However, please be aware that you must bear any costs associated with your Internet service, such as usage charges from Internet access providers or telephone companies.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>What does it mean if I receive more than one Notice?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">If you receive more than one Notice or proxy card, your shares are registered in more than one
    name or are registered in different accounts. Please complete, sign, date and return <i>each </i>separate proxy card or vote by telephone or through the Internet by following the instructions included with <i>each </i>Notice or proxy card to
    properly vote your shares.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>Can I change my vote after submitting my proxy?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">Yes. Once you have submitted your proxy by mail, Internet, or telephone, you may revoke it at
    any time before we exercise it at the Annual Meeting. You may revoke your proxy by any one of the following four ways:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in; color: #231F20">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 22.5pt">1.</td>

    <td style="text-align: left">you may mail another proxy marked with a later date;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 22.5pt">2.</td>

    <td style="text-align: left">you may revoke it through the Internet;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 22.5pt">3.</td>

    <td style="text-align: left; padding-right: 10pt">you may notify our corporate secretary in writing sent to 2855 Gazelle Court, Carlsbad, California 92010 that you wish to revoke your proxy before the Annual Meeting takes place; or</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 22.5pt">4.</td>

    <td style="text-align: left; padding-right: 10pt">you may vote during the virtual Annual Meeting. <i>Attending</i> the meeting <i>will not</i>, by itself, revoke a proxy.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">4</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in">If your shares are held by your broker, bank, or other agent, you should follow the instructions provided by
    your broker, bank, or other agent.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.35in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 4.5pt; color: #A20067"><b>When are stockholder proposals due for next year&#8217;s Annual Meeting?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 4.5pt; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 27pt"><span style="color: #231F20">If you have a proposal that you would like us to include in our proxy materials for
      next year&#8217;s Annual Meeting of Stockholders, you must send the proposal to us in writing by no later than December 22, 2023 and comply with all applicable requirements of Rule 14a-8 promulgated under the Securities Exchange Act of 1934, as amended (&#8220;<b><i>Rule





















          14a-8</i></b>&#8221;). Stockholders wishing to submit proposals or Director nominations that are not to be included in such proxy</span> <span style="font-family: Times New Roman, Times, Serif">materials</span> <span style="color: #231F20">for next
      year&#8217;s Annual Meeting of Stockholders pursuant to Rule 14a-8 must do so no later than the close of business on February 2, 2024, as required by our bylaws. Stockholders should also review our bylaws, which contain additional requirements with respect
      to advance notice of stockholder proposals and Director nominations. In addition to satisfying the foregoing requirements under our bylaws, stockholders who intend to solicit proxies in support of director nominees other than the Company&#8217;s nominees
      must also comply with the additional requirements of Rule 14a-19(b).</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 27pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>What is the quorum requirement?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 27pt; color: #231F20">A quorum of stockholders is necessary to hold a valid meeting. A quorum will be present at the
    meeting if at least a majority of the outstanding shares entitled to vote are represented at the meeting or by proxy. We will count your shares towards the quorum only if you submit a valid proxy vote (or one is submitted on your behalf by your broker,
    bank, or other nominee) or vote at the meeting. We will count abstentions and broker non-votes towards the quorum requirement.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 27pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 27pt; color: #231F20">If there is no quorum, the holders of a majority of shares present at the meeting or represented
    by proxy may adjourn the meeting to another date.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 27pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>How are votes counted?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 27pt; color: #231F20">Each share of our common stock you own entitles you to one vote. Your Notice and proxy card
    indicates the number of shares of our common stock you owned at the close of business on April 3, 2023. The inspector of elections will count votes for the meeting and will separately count &#8220;For&#8221; and &#8220;Against&#8221; votes, abstentions, and broker non-votes.
    With respect to Proposal 1, the election of Directors, stockholders do not affirmatively vote &#8220;Against&#8221; nominees. Instead, if you do not want to elect a particular nominee, you should choose to &#8220;Withhold&#8221; a vote in favor of the applicable nominee for
    Director and the inspector of elections will count each &#8220;Withhold&#8221; for each nominee. Abstentions will have no effect on Proposal 1 or Proposal 3. Abstentions will count towards the vote total for Proposal 2, Proposal 4, Proposal 5 and Proposal 6 and
    will have the same effect as &#8220;Against&#8221; votes. Broker non-votes have no effect and the inspector of elections will not count them towards the vote total for any proposal.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 27pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>What are &#8220;broker non-votes&#8221;?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 27pt; color: #231F20">Broker non-votes occur when a beneficial owner of shares held in &#8220;street name&#8221; does not give
    instructions to the broker or nominee holding the shares as to how to vote on matters deemed &#8220;non-routine.&#8221; If your broker holds your shares in &#8220;street name,&#8221; and you do not give instructions to your broker, your broker can vote your shares with
    respect to &#8220;discretionary&#8221; items, but not with respect to &#8220;non-discretionary&#8221; items. The proposal to ratify Ernst &amp; Young LLP as independent auditors is a discretionary item. Proposals 1 through 5 regarding (1) the election of Directors, (2)
    approval, on an advisory basis, of our executive compensation, (3) the advisory vote on the frequency of future advisory votes on executive compensation, (4) approval of an amendment of the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan to
    increase the aggregate number of shares of common stock authorized for issuance under such plan by 5,500,000 shares to an aggregate of 35,200,000 shares, and (5) ratification of increasing the vesting of future initial stock option and restricted stock
    unit awards to new non-employee Directors from one year to three years, are all non-discretionary items.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 27pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>How many votes are needed to approve each proposal?</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 18pt"><span style="color: #231F20">1.</span></td>

    <td style="text-align: left; padding-right: 10.1pt"><span style="color: #CE0F69">Proposal 1</span><span style="color: #231F20">: For the election of Directors in an uncontested election, a Director nominee must receive a majority of the votes cast
            in the election such that the number of shares voted &#8220;For&#8221; the nominee must exceed 50% of the votes cast with respect to that Director. Only &#8220;For&#8221; and &#8220;Withhold&#8221; votes will affect the outcome. Abstentions and broker non-votes, if any, will have
            no effect.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">5</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 18pt"><span style="color: #231F20">2.</span></td>

    <td style="text-align: left; padding-right: 10.1pt"><span style="color: #CE0F69">Proposal 2: </span><span style="color: #231F20">We will consider the advisory approval of the compensation of our executive officers to be approved if it receives
            &#8220;For&#8221; votes from a majority of the holders of shares present or represented by proxy and entitled to vote on the matter. If you &#8220;Abstain&#8221; from voting, it will have the same effect as an &#8220;Against&#8221; vote. Broker non-votes, if any, will have no
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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 18pt"><span style="color: #231F20">3.</span></td>

    <td style="text-align: left; padding-right: 10.1pt"><span style="color: #CE0F69">Proposal 3: </span>For the advisory vote on the frequency of stockholder advisory votes on executive compensation, we will consider the frequency receiving the most
          &#8220;For&#8221; votes from the holders of shares present or represented by proxy and entitled to vote as the frequency preferred by the stockholders. Abstentions and broker non-votes, if any, will have no effect<span style="color: #CE0F69">.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 18pt"><span style="color: #231F20">4.</span></td>

    <td style="text-align: left; padding-right: 10.1pt"><span style="color: #CE0F69">Proposal 4:</span> To be approved, the amendment of the 2011 Equity Incentive Plan must receive &#8220;For&#8221; votes from the holders of a majority of shares present or
          represented by proxy and entitled to vote on the matter. If you &#8220;Abstain&#8221; from voting, it will have the same effect as an &#8220;Against&#8221; vote. Broker non-votes will have no effect.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 18pt"><span style="color: #231F20">5.</span></td>

    <td style="text-align: left; padding-right: 10.1pt"><span style="color: #CE0F69">Proposal 5:</span> To be approved, ratification of increasing <span style="color: #231F20">the vesting of future initial stock option and restricted stock unit awards
            to new non-employee Directors from one year to three years</span> must receive &#8220;For&#8221; votes from a majority of shares present or represented by proxy and entitled to vote on the matter. If you &#8220;Abstain&#8221; from voting, it will have the same effect
          as an &#8220;Against&#8221; vote. Broker non-votes will have no effect.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 18pt"><span style="color: #231F20">6.</span></td>

    <td style="text-align: left; padding-right: 10pt"><span style="color: #CE0F69">Proposal 6:</span> <span style="color: #231F20">To be approved, the ratification of the selection of Ernst &amp; Young LLP as our independent auditors for our 2023
            fiscal year must receive &#8220;For&#8221; votes from a majority of the holders of shares present or represented by proxy and entitled to vote on the matter. If you &#8220;Abstain&#8221; from voting, it will have the same effect as an &#8220;Against&#8221; vote. Because brokers
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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">How can I find out the results of the voting at the Annual Meeting?</p>
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      Meeting. In addition, we will publish final voting results in a current report on Form 8-K that we expect to file within four business days after the Annual Meeting. If final voting results are not available to us in time to file as part of a Form
      8-K within four business days after the Annual Meeting, we intend to file a Form 8-K to publish preliminary results and, within four business days after we know the final results, file an additional Form 8-K to publish final results.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; color: #231F20; text-align: left; text-indent: 27.35pt">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">How can I elect to receive materials for future Annual Meetings electronically?</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; color: #231F20; text-align: left; text-indent: 27.35pt">&#160;</p>
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  <tr style="vertical-align: top">

    <td style="width: 26.9pt"></td>

    <td style="width: 18.1pt">1.</td>

    <td style="text-align: left; padding-right: 10.1pt">delivering the Proxy Statement, Annual Report on Form 10-K, and related materials by email to our stockholders;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 26.9pt"></td>

    <td style="width: 18.1pt">2.</td>

    <td style="text-align: left; padding-right: 10pt">stockholder voting online;</td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 26.9pt"></td>

    <td style="width: 18.1pt">3.</td>

    <td style="text-align: left; padding-right: 10pt">helping the environment by decreasing the use of paper documents;</td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 26.9pt"></td>

    <td style="width: 18.1pt">4.</td>

    <td style="text-align: left; padding-right: 10pt">reducing the number of bulky documents stockholders receive; and</td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 26.9pt"></td>

    <td style="width: 18.1pt">5.</td>

    <td style="text-align: left; padding-right: 10pt">reducing our printing and mailing costs associated with more traditional delivery methods.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; color: #231F20; text-align: left; text-indent: 27.35pt">We encourage you to conserve natural resources and to reduce printing and mailing costs by
    signing up for electronic delivery of our stockholder communications after you place your current vote at <span style="text-decoration: underline;">www.proxyvote.com</span>.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; background-color: white; color: #A20067"><b>List of Shareholders</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; background-color: white; color: #A20067">&#160;</p>
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      will be available for examination at our principal executive offices at the address listed above for a period of 10 days prior to the Annual Meeting, and </span>will be available during the virtual Annual Meeting for examination at <span style="text-decoration: underline;">www.virtualshareholdermeeting.com/IONS2023</span>.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067"><b>Environmental, Social and Governance Initiatives</b></p>
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  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: left; text-indent: 22.5pt;">At Ionis, we work with a sense of urgency to discover, develop and deliver breakthrough medicines to create a
    better future for people with devastating diseases. We believe operating responsibly and sustainably creates value for the Company and our stakeholders. We consider the long-term impact we can make across five key areas:</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.5pt"><img alt="" src="ny20007094x2_def14aimg004.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.5pt">&#160;</p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: left; text-indent: 22.5pt;">We continue to build our corporate responsibility program and environmental, social and governance (&#8220;<b><i>ESG</i></b>&#8221;)





















    framework to support our ongoing commitment to operate our business responsibly and sustainably. In 2022, we established a formal Corporate Responsibility Steering Committee (the &#8220;<b><i>Steering Committee</i></b>&#8221;) to guide us as we develop the right
    programs and policies to continue to integrate ESG across our organization. Our corporate responsibility initiatives, policies and programs are reviewed on a regular basis by the Steering Committee and its recommendations are key to driving efforts to
    advance our corporate responsibility strategy to support our growth. The Steering Committee reports to our Chief Executive Officer (&#8220;<b><i>CEO</i></b>&#8221; or &#8220;<b><i>PEO</i></b>&#8221;) and consists of senior leaders in key functions across the Company,
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    Quality Steering Committee oversees our quality programs including our formal Quality Management System (&#8220;<b><i>QMS</i></b>&#8221;). In addition, our team of researchers and developers receive training according to internationally recognized current Good
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.5pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.3pt; color: #CE0F69"><i>Safety of Clinical Trial Participants</i></p>
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    no other therapeutic approaches have proven effective. We require adherence to GCP guidance and regional laws and regulations for designing and conducting clinical trials and reporting trial results. Additionally, Independent Review Boards (&#8220;<b><i>IRBs</i></b>&#8221;)





















    monitor the ethical conduct of our trials and have the authority to approve, modify or stop trials. Independent ethics committees, IRBs and health authorities review and approve essential clinical trial documents, such as protocols and informed consent
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.3pt">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">At Ionis, we believe the goal of making life-changing medicines available to patients in need is achieved
    through rigorous science, innovation and well-designed clinical studies, followed by regulatory approval. We also recognize that to fulfill this goal, we need to get our medicines to those who need them most. We work closely with patient advocacy
    organizations and communities around the world to identify and understand the needs of the people we serve. We also have an Expanded Access Policy that aims to provide access to investigational products based on select criteria and to support those
    patients with a serious or immediately life-threatening condition who have exhausted all available medical options and are unable to enroll in any ongoing clinical study.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
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    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">7</span>&#160;</div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.5pt; color: #CE0F69"><i>Human Resources Management</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.5pt; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">Our pursuit of excellence begins with our talent recruitment process. Whether we are hiring entry-level,
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">In addition to our supportive and inclusive culture, we offer employees a combination of robust and meaningful
    benefits, compensation and well-being programs. Our compensation is awarded based on individual and Company performance. We recognize achievements with salary increases, equity awards, promotions and bonus opportunities. We offer highly competitive
    benefits to all regular employees who work at least 20 hours per week and a range of industry-leading wellness and stress management initiatives and programs.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">Beginning with our employees&#8217; first day, we aim to provide them with tools and trainings necessary to succeed
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt"><img alt="" src="ny20007094x2_def14aimg005.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #CE0F69"><i>Diversity, Equity and Inclusion</i></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">Diversity, equity and inclusion (&#8220;<b><i>DEI</i></b>&#8221;) is embedded within our culture at Ionis. We have a
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    oversees our DEI programs through semi-annual reporting and discussion. We offer a three-part diversity training series, which focuses on unconscious bias, inclusion and belonging, and allyship and advocacy. We also provide mandatory
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">To promote DEI within our organization, we have employee-led, executive-sponsored Employee Resource Groups (&#8220;<b><i>ERGs</i></b>&#8221;).






















    Our ERGs are designed to build cultural awareness, promote an inclusive and supportive culture and support our business goals. Many of our ERG employee leaders also serve on the CEO&#8217;s DEI Advisory Council. Our ERGs include:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
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    <td style="text-align: justify">LGBTQIA+: supports our LGBTQIA+ community;</td>

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    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify">empowHer: empowers women at Ionis;</td>

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    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify">DEI Advocates: champions DEI initiatives and programs across the organization;</td>

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    <td style="text-align: justify">Mental Health &amp; Wellness: promotes employee mental health and wellness;</td>

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    <td style="text-align: justify">The Parent Network: connects our employees who are parenting young children;</td>

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    <td style="text-align: justify">Ionis NEXT: engages with middle- and high-school students to nurture the NEXT generation of minority science leaders;</td>

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    <td style="text-align: justify">New Employee Opportunity Network: creates community for new employees as they integrate into the Company; and</td>

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    <td style="text-align: justify">Veterans: supports our veteran and military family community.</td>

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    <td style="text-align: justify; padding: 25pt 15pt; width: 100%">
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          </td>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">We strive to protect the health and safety of all employees, contractors and visitors. We are also committed
    to providing an injury-free workplace. We have implemented a safety management system that uses monitoring, auditing and target setting to continuously improve our occupational health and workplace safety. Regular safety training is provided to all
    laboratory and manufacturing employees, and health and safety compliance is audited routinely.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
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    characteristics. To achieve our objective, we benchmark and evaluate pay based on market data and consider factors such as an employee&#8217;s role, experience, performance as well as internal equity. We also regularly review our compensation practices, both
    in terms of our overall workforce and in terms of individual employees. In 2021, we engaged an independent third-party expert to perform a pay equity analysis that reviewed pay equity by gender, race and age. The results of this analysis did not reveal
    any pay gaps based on gender, race or age. In 2022, we performed an internal analysis, leveraging our biostatistics team. The analysis showed similar results to the analysis performed in 2021. In addition, we implemented a comprehensive plan to comply
    with the new California pay transparency law that went into effect on January 1, 2023.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #CE0F69"><i>Commitment to Our Communities</i></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">Every year we provide support&#8212;from financial assistance to employee volunteerism and beyond&#8212;to various
    organizations that have a positive impact in our communities. We seek sustainable partnerships and initiatives that encourage scientific innovation and help address unmet patient needs, including disease awareness, education and support. In 2022, we
    donated approximately $2.9 million to charitable groups. We also coordinated volunteering days and provided in-kind support to a range of organizations, including:</p>
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    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left; padding-right: 1pt">ALS Association, Greater San Diego Chapter: dedicated to finding a cure for ALS and to improving the lives of those living with and affected by ALS;</td>

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    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left; padding-right: 1pt">ADAPT Functional Movement Center: providing a complete integrative recovery experience for individuals with chronic neurological conditions; and</td>

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    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left; padding-right: 1pt">Life Science Cares: leveraging the influence of the life science industry to address issues of poverty and inequality in Boston, San Diego, Philadelphia, and the San Francisco Bay Area and through
          virtual options.</td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">In addition, we have implemented the Adapt X Ionis Hope Scholarship grant program in collaboration with Adapt
    Functional Movement Center. This program provides fully sponsored care services, rehabilitation programs and education to individuals impacted by ALS. Scholarship grants under this program support ALS patients&#8217; participation in group classes, massage
    therapy, meditation and functional movement therapy offered by Adapt Functional Movement Center located in Carlsbad, California.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&#160;</p>
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    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">9</span>&#160;</div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.5pt; color: #CE0F69"><i>Environmental Sustainability</i></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">We are committed to conducting our operations in an environmentally responsible manner to protect our
    employees, the environment and the communities in which we operate. We have established an environmental management system (&#8220;<b><i>EMS</i></b>&#8221;) that establishes policies and procedures, outlines processes for identifying risk and implementing
    preventative measures, assigns roles and responsibilities and sets performance standards to improve our environmental performance.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">Our Carlsbad, California, headquarters was designed and built to meet energy-efficient Leadership in Energy
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    are in the process of constructing a new research and development facility and we recently began work on a new state-of-the-art manufacturing facility, both of which will include sustainability and environmental protection features. We have several
    solar photovoltaic systems in place for our current buildings and electric vehicle charging stations at our Carlsbad headquarters that are available to all employees and visitors.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #CE0F69"><i>Governance and Integrity</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">We are guided by our Code of Ethics and Business Conduct (&#8220;<b><i>Code</i></b>&#8221;) that applies to all
    employees, including executive officers and all members of our Board of Directors. We are committed to upholding a comprehensive and rigorous ethics program, including anti-bribery and anti-corruption commitments as detailed in our Code and our
    anti-bribery and anti-corruption policy. We maintain the Ionis Helpline, a confidential 24/7 helpline, hosted through a third-party provider, which is available by phone or web and provided in local languages. We proactively communicate the
    availability of the Ionis Helpline on our external website, on our internal intranet site and on posters in our buildings.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">We encourage you to view our <i>2022 Corporate Responsibility Report</i> published on our website for more
    detailed information regarding our ESG initiatives. Nothing in the report or on our website shall be deemed incorporated by reference into this Proxy Statement.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&#160;</p>
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    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">10</span>&#160;</div>

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  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">PROPOSAL 1</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">ELECTION OF DIRECTORS</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Information about our Board</b></span></p>
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      Presently, the Board has nine members with two classes consisting of four Directors each and one class consisting of one Director. Each class serves a three-year term and we hold elections each year at the Annual Meeting to elect the Directors whose
      terms are expiring. Our Nominating, Governance and Review Committee of the Board reviews the Company&#8217;s classified Board structure every year to evaluate whether it continues to be the appropriate structure for the Company. Following such evaluation,
      we believe maintaining this structure is critical at this time given the Company&#8217;s recent CEO transition and to enable us to execute on our new commercial strategy, which we believe will generate long-term sustainable value for stockholders.</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">In addition, the Board may elect a new
      Director to fill any vacant spot, including a vacancy caused by an increase in the size of the Board. However, the Board believes it is important for our stockholders to ratify any member of the Board whom the Board appoints. As a result, whenever
      the Board appoints a new member, the Board will submit such new member&#8217;s directorship for ratification or election at the next regularly scheduled Annual Meeting of Stockholders.</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board represents the interests of our
      stockholders by overseeing the Chief Executive Officer and other members of senior management in our operations. The Board&#8217;s goal is to optimize long-term value by providing guidance and strategic oversight to Ionis&#8217; management on our stockholders&#8217;
      behalf.</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Information about the 2023 Elections</b></span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board has nominated four individuals for
      election at the Annual Meeting. Each of the nominees currently serves as one of our Directors. Spencer R. Berthelsen, Joan E. Herman, B. Lynne Parshall, and Joseph H. Wender have each served as a Director for the periods set forth in the table below.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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    <td style="width: 25%; border: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 10.1pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: white"><b>Name</b></span></td>

    <td style="width: 40%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 10.1pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: white"><b>Commencement of Ionis Directorship</b></span></td>

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    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 10.1pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">Spencer R. Berthelsen</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: -4.5pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">May 2002</span></td>

  </tr>

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    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 10.1pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Joan E. Herman</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: -4.5pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">June 2019</span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 10.1pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">B. Lynne Parshall</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: -4.5pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">September 2000</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 10.1pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Joseph H. Wender</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: -4.5pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">January 1994</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dr. Berthelsen, Ms. Herman, Ms. Parshall, and
      Mr. Wender have each been previously re-elected by our stockholders. If re-elected, Dr. Berthelsen, Ms. Herman, Ms. Parshall, and Mr. Wender will serve until the 2026 Annual Meeting or, in each case, until his or her successor is elected and has
      qualified, or until his or her earlier death, resignation or removal.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Our bylaws provide a majority vote standard
      for the election of directors in uncontested elections. In an uncontested election, the majority vote standard means that to be elected, a Director nominee must receive a majority of the votes cast in the election such that the number of shares voted
      &#8220;For&#8221; the nominee must exceed 50% of the votes cast with respect to that Director. The number of votes cast with respect to a Director&#8217;s election excludes abstentions and broker non-votes. In contested elections where the number of nominees exceeds
      the number of Directors to be elected, the vote standard will be a plurality of the shares present or represented by proxy and entitled to vote.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">If a nominee who already serves as a Director
      is not elected, and no successor is elected, the Director will offer to tender his or her resignation to the Board. The Nominating, Governance and Review Committee will make a recommendation to the Board on whether to accept or reject the
      resignation, or whether to take other action. The Board will act on the Nominating, Governance and Review Committee&#8217;s recommendation and publicly disclose its decision and the rationale behind it within 90 days from the date of the certification of
      the election results. The Director who tenders his or her resignation will not participate in the recommendation of the Nominating, Governance and Review Committee or in the Board&#8217;s decision. If a nominee&#8217;s failure to be elected at the Annual Meeting
      results in a vacancy on the Board, then the Board can fill the vacancy.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">On March 13, 2023, the Nominating, Governance and Review
      Committee provided its recommendations to the Board for Director nominees to stand for election at the Annual Meeting. Following such recommendations, the Board determined it would be in the best interests of Ionis and its stockholders to nominate
      Dr. Berthelsen, Ms. Herman, Ms. Parshall, and Mr. Wender to be elected as Directors at the Annual Meeting. We provide below a short biography for each nominee. Dr. Berthelsen, Ms. Herman, Ms. Parshall, and Mr. Wender have agreed to serve if elected,
      and we have no reason to believe that they cannot serve. However, if they cannot serve, we may vote your proxy for another nominee proposed by the Board, or the Board may reduce the number of authorized Directors.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">11</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Board Skills Matrix</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The following tables illustrate (i) the core skills the Nominating,
      Governance and Review Committee considers to be the most relevant to the Board&#8217;s oversight role with respect to our business, and (ii) each of our Director&#8217;s skills in such areas indicated by check mark. The lack of a check mark for a particular item
      for a Director does not mean the Director lacks that skill; rather, a check mark indicates a specific area of focus or expertise for which the Board relies on such Director. Additional information about each Director&#8217;s background, business experience
      and other matters, including a description of how each individual&#8217;s experience qualifies the Director to serve on the Board, is provided below beginning on the following page of this Proxy Statement.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 31%; border: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Industry























              Experience</b></span></td>

    <td style="width: 69%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Relevant to an industry understanding and oversight of and contribution to our business and strategy </span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Executive/Leadership Experience</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Allows our Directors to successfully advise on and oversee the Company&#8217;s performance and represent stockholders&#8217; interests</span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Corporate Governance and Public Company Board Experience</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Ensures Directors have the background and knowledge to perform oversight and governance roles</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Accounting, Financial or Investment Experience</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Enables our Directors to analyze our financial statements, oversee our capital structure and consider financial transactions</span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Scientific, Research or Development Experience</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Facilitates the continual improvement of our science and technology and supports our vision of becoming the leader in genetic medicine </span></td>

  </tr>

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    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Commercial, Marketing, Reimbursement or Sales Experience</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Ensures we have appropriate Board expertise to advance <span style="color: #231F20">our commercial strategy</span></span></td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">

    <td style="width: 28%; border: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; white-space: nowrap;"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Director























              Skills and Qualifications</b></span></td>

    <td style="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 8%; padding-right: 5.65pt; padding-left: 5.65pt; text-indent: 0in; white-space: nowrap;"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Spencer R.<br />
              Berthelsen</b></span></td>

    <td style="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 8%; padding-right: 5.65pt; padding-left: 5.65pt; text-indent: 0in; white-space: nowrap;"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Allene M. <br />
              Diaz</b></span></td>

    <td style="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 8%; padding-right: 5.65pt; padding-left: 5.65pt; text-indent: 0in; white-space: nowrap;"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Michael <br />
              Hayden</b></span></td>

    <td style="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 8%; padding-right: 5.65pt; padding-left: 5.65pt; text-indent: 0in; white-space: nowrap;"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Joan E.<br />
              Herman</b></span></td>

    <td style="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 8%; padding-right: 5.65pt; padding-left: 5.65pt; text-indent: 0in; white-space: nowrap;"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Joseph <br />
              Klein III</b></span></td>

    <td style="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 8%; padding-right: 5.65pt; padding-left: 5.65pt; text-indent: 0in; white-space: nowrap;"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Joseph<br />
              Loscalzo</b></span></td>

    <td style="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 8%; padding-right: 5.65pt; padding-left: 5.65pt; text-indent: 0in; white-space: nowrap;"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Brett <br />
              Monia</b></span></td>

    <td style="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 8%; padding-right: 5.65pt; padding-left: 5.65pt; text-indent: 0in; white-space: nowrap;"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>B. Lynne <br />
              Parshall</b></span></td>

    <td style="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 8%; padding-right: 5.65pt; padding-left: 5.65pt; text-indent: 0in; white-space: nowrap;"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Joseph H. <br />
              Wender</b></span></td>

  </tr>

  <tr style="background-color: white; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Industry Experience</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017.jpg" /></span></td>

  </tr>

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    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Executive/Leadership Experience</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017a.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017a.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017a.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017a.jpg" /></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #C00000"><img alt="" src="ny20007094x2_def14aimg017a.jpg" /></span></td>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Biographies of the Nominees for Election for a Three-Year
        Term Expiring at the 2026 Annual Meeting</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b><i>Spencer R. Berthelsen, M.D.</i></b></span><b><i><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">, </span></i></b><span style="font: 10pt Times New Roman, Times, Serif; color: #231F20">age 70<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">2</sup>, has served as a Director of Ionis since May 2002. Dr. Berthelsen practiced Internal Medicine with the Kelsey Seybold Clinic, a 400-physician medical group based in the Texas Medical Center in Houston, until March 2017. Dr.
      Berthelsen began at Kelsey Seybold in 1980 and served in various senior leadership positions throughout his nearly four-decade career at the clinic, including Chairman of the Department of Internal Medicine, Medical Director and Managing Director. He
      also served as Chairman of its board of directors from October 2001 through April 2016. He has served as Clinical Professor of Medicine at both Baylor College of Medicine and The University of Texas Health Science Center. Previously, Dr. Berthelsen
      served on the boards of the Texas Academy of Internal Medicine and the Caremark National Pharmacy and Therapeutics Committee from 1999 through 2005.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board believes Dr. Berthelsen is uniquely suited to serve
      on the Board because of his experience advising a large multispecialty group practice and almost 40 years of experience as a practicing physician.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b><i>Joan E. Herman</i></b></span><b><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">, </span></b><span style="font: 10pt Times New Roman, Times, Serif; color: #231F20">age 69, has served as a Director of Ionis since June 2019. Since 2008, Ms.
      Herman has served as President and Chief Executive Officer of Herman &amp; Associates, a management consulting firm that specializes in advising private equity firms investing in healthcare. She has experience leading healthcare and payor companies,
      serving in several executive positions at Elevance (formerly Anthem, which was formerly WellPoint), including as President and Chief Executive Officer of several different business units. Ms. Herman also served as a Senior Vice President of Phoenix
      Life Insurance Company. Since January 2013, Ms. Herman has served on the board of directors of Encompass Health (formerly HealthSouth). Ms. Herman also serves on the board of managers of Fifth Avenue Private Equity 17. She previously served on the
      boards of both Convergys and AARP Services, Inc.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board believes Ms. Herman is uniquely suited to serve on
      the Board because of her experience leading healthcare and payor companies. Ms. Herman also brings valuable cybersecurity experience to the Board through her cybersecurity certification from the National Association of Corporate Directors (&#8220;<b><i>NACD</i></b>&#8221;).</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b><i>B. Lynne Parshall</i></b></span><b><i><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">, </span></i></b><span style="font: 10pt Times New Roman, Times, Serif; color: #231F20">age 68, has served as a Director of Ionis since September 2000. Ms.
      Parshall is CEO of Lyme Pinnacle Consulting, which provides strategic advisory services to biotechnology companies. Ms. Parshall was a Senior Strategic Advisor to Ionis from January 2018 to December 2022. Previously she served as our Chief Operating
      Officer from December 2007 through January 2018 and as our Chief Financial Officer from June 1994 through December 2012. She also served as our Corporate Secretary through 2014 and has served with the Company in various executive roles since November
      1991. Prior to joining Ionis, Ms. Parshall practiced law at Cooley LLP, outside counsel to Ionis, where she was a partner from 1986 to 1991. Ms. Parshall is a member of the American and California bar associations. Ms. Parshall has served on the
      boards of directors of Foghorn Therapeutics Inc, a public biopharmaceutical company, since August 2022, Cytokinetics, Inc., a public biopharmaceutical company, since February 2013, and Akcea Therapeutics, Inc., from January 2015 until the completion
      of the Company&#8217;s merger with Akcea Therapeutics, Inc. (the &#8220;<b><i>Akcea Merger</i></b>&#8221;). Ms. Parshall also serves on the Board of Directors of several private biotechnology companies.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board believes Ms. Parshall is uniquely suited to serve
      on the Board primarily because, as the former Chief Operating Officer and former executive of the Company for over 26 years, she has valuable Company-specific experience and expertise. In addition, Ms. Parshall has over 35 years of experience
      structuring and negotiating strategic licensing and financing transactions in the life sciences field. She has also sat on the Boards of Directors of numerous biotechnology companies. Ms. Parshall recently received a directorship certification from
      the NACD for completion of a director education program designed as a framework for continuous learning. Ms. Parshall is also in the process of obtaining a cybersecurity certification from the NACD.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b><i>Joseph H. Wender</i></b></span><b><i><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">, </span></i></b><span style="font: 10pt Times New Roman, Times, Serif; color: #231F20">age 78, has served as a Director of Ionis since January 1994 and our
      Independent Lead Director since December 2020. Mr. Wender began with Goldman, Sachs &amp; Co. in 1971 and became a General Partner of that firm in 1982, where he headed the Financial Institutions Group for over a decade. Since January 2022 he has
      been a Senior Consultant to Goldman Sachs &amp; Co., from January 2019 to December 2021 he was an Advisory Director to Goldman Sachs &amp; Co. and from January 2008 to December 2018 was a Senior Consultant to Goldman Sachs &amp; Co. He is a former
      Independent Trustee of the Schwab Family of Funds and Director of Grandpoint Capital, a bank holding company. Mr. Wender also is co-CEO and partner of Colgin Cellars. Since March 2014, Mr. Wender has been a Director of Outfront Media, a lessor of
      advertising space on out-of-home advertising structures, and has served as its Lead Independent Director since 2016.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board believes Mr. Wender is uniquely suited to serve on
      the Board and as our Independent Lead Director primarily because, with over 50 years of experience as an investment banker with Goldman, Sachs &amp; Co., he provides Ionis important advice regarding our financial reporting, corporate finance,
      strategic transactions, and compensation matters. He also has a deep understanding of our Company due to his tenure on the Board and provides invaluable advice as we grow and diversify our business.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">2 </sup>The ages of all our Directors are as of March 1, 2023.&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font: 9pt Times New Roman, Times, Serif">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font: 9pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"></p>
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    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">13</span>&#160;</div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>THE BOARD UNANIMOUSLY RECOMMENDS A VOTE &#8220;FOR&#8221; THE
        ELECTION OF THE ABOVE NOMINEES.</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Biography of the Director Whose Term Expires at the 2024
        Annual Meeting</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b><i>Brett P. Monia</i></b></span><b><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">, </span></b><span style="font: 10pt Times New Roman, Times, Serif; color: #231F20">Ph.D., age 61, has served as a Director of Ionis since March 2019. Dr. Monia
      was promoted to Chief Executive Officer in January 2020. From January 2018 to December 2019, Dr. Monia served as our Chief Operating Officer, from January 2012 to January 2018, as our Senior Vice President, Drug Discovery, from February 2009 to
      January 2012, as our Vice President, Drug Discovery, and from October 2000 to February 2009, as our Vice President, Preclinical Drug Discovery. From October 1989 to October 2000, he held various positions within our Molecular Pharmacology department.
      Following the Akcea Merger, Dr. Monia became the President of Akcea. Dr. Monia has served on the board of directors of Cognition Therapeutics, Inc., a public clinical stage neuroscience company, since October 2020.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board believes Dr. Monia is uniquely suited to serve on
      the Board primarily because, as an executive officer of the Company since 2012 and a founder of Ionis, he has dedicated more than 33 years to discovering and developing antisense-based drugs. Dr. Monia is the inventor on over 100 issued patents and
      has directly supervised programs resulting in the clinical development of more than 40 antisense-based drugs across a broad range of therapeutic areas.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Biographies of the Directors Whose Terms Expire at the
        2025 Annual Meeting</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b><i>Allene M. Diaz</i></b></span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">, age 58, has served as a Director of Ionis since June 2021. Since 2020 Ms. Diaz has led AMD Consulting, a new product strategy and portfolio management consulting practice based in
      Boston, MA. Previously, Ms. Diaz served as Senior Vice President, Research and Development Portfolio Management at GlaxoSmithKline, a global pharmaceutical company based in Brentwood, UK, from September 2019 through June 2020 and as Senior Vice
      President, Global Commercial Development and Program Strategy at TESARO Inc., a biotechnology company based in Waltham, MA, from May 2015 through August 2019. Prior to that she held a variety of commercial leadership roles in the Merck Serono and EMD
      Serono divisions of Merck KGaA. Earlier in her career, Ms. Diaz held management, operating, sales, and medical affairs roles at various biopharmaceutical companies, including Pfizer, Parke-Davis, Biogen, and Amylin Pharmaceuticals. She has
      contributed to the global development, launch or commercialization of multiple transformative products across several therapeutic areas. Ms. Diaz has served on the board of directors of Mersana Therapeutics since March 2021. Ms. Diaz served on the
      board of directors of Allena Pharmaceuticals from April 2019 to September 2022, BCLS Acquisition Corporation from October 2020 to October 2022, and Erytech Pharma SA from September 2016 to September 2019.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board believes Ms. Diaz is uniquely suited to serve on
      the Board primarily because of her deep expertise in product development, commercial strategy, market access, and portfolio management.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b><i>Michael Hayden</i></b></span><b><i><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">, </span></i></b><span style="font: 10pt Times New Roman, Times, Serif; color: #231F20">CM, OBC, MB, ChB, Ph.D., FRCP(C), FRSC, age 71, has served as a Director
      of Ionis since September 2018. Dr. Hayden has been Chief Executive Officer </span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #444444">and Director </span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">of Prilenia Therapeutics, a private clinical stage biotech company, since September 2018. Dr. Hayden is also a Killam Professor at the University of British Columbia, the highest honor UBC can confer on any faculty
      member. In addition, he is an accomplished scientist and physician. He was the President of Global R&amp;D and Chief Scientific Officer at Teva Pharmaceuticals from 2012 to 2017. During this time approximately 35 new products were approved in major
      markets with many for diseases of the central nervous system. In 2015 Teva R&amp;D was recognized as one of the 100 most exciting innovators in the pharmaceutical industry by IDEA Pharma and in 2017 Teva R&amp;D ranked top of the industry for central
      nervous system development and clinical trial success rate by Pharma Intelligence. Dr. Hayden has founded three biotechnology companies and has been the recipient of numerous prestigious honors and awards, including being inducted into the Canadian
      Medical Hall of Fame and receiving the July 2012 Diamond Jubilee Medal on behalf of HRH Queen Elisabeth II. He has also received the Canada Gairdner Wightman award. Dr. Hayden was awarded the Order of Canada, the Order of British Columbia, named
      Canada&#8217;s Health Researcher of the Year by Canadian Institutes of Health Research, and received the Prix Galien Award in 2007. Dr. Hayden served on the board of Aurinia Pharmaceuticals, Inc. until August 2021 and Xenon Pharmaceuticals until June 2022,
      and currently serves on the boards of, 89Bio, AbCellera Biologics and Oxford Biomedica. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board believes Dr. Hayden is uniquely suited to serve on
      the Board because he has significant expertise in pharmaceutical research and development, both in academia and in commercial settings. In addition, Dr. Hayden has made substantial research contributions to advance treatments for brain diseases,
      which is particularly valuable as we grow our neurologic disease franchise, a key focus of ours. Dr. Hayden also serves as the Chair of our Science/Medical Committee, providing invaluable guidance on the key scientific and development issues facing
      our technology and medicines in development.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b><i>Joseph &#8220;Skip&#8221; Klein, III</i></b></span><b><i><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">, </span></i></b><span style="font: 10pt Times New Roman, Times, Serif; color: #231F20">age 61, has served as a Director of Ionis since December 2005 and is
      Chairman of the Audit Committee. Mr. Klein is currently Managing Director of Gauss Capital Advisors, LLC, a financial consulting and investment advisory firm focused on biopharmaceuticals, which he founded in March 1998. From September 2003 to
      December 2008, Mr. Klein also served as a Venture Partner of Red Abbey Venture Partners, L.P., a life science private equity fund. From September 2001 to September 2002, Mr. Klein was a Venture Partner of MPM Capital, a healthcare venture capital
      firm. From June 1999 to September 2000 when it merged with WebMD Corporation, Mr. Klein served as Vice President, Strategy, for Medical Manager Corporation, a leading developer of physician office management information systems. For over nine years
      from 1989 to 1998, Mr. Klein was a health care investment analyst at T. Rowe Price Associates, Inc., where he was the founding portfolio manager of the T. Rowe Price Health Sciences Fund. Mr. Klein has served on the boards of directors of The
      Prospector Funds, Inc., an SEC Registered Investment Company that manages two no-load mutual funds, since September 2007, and Akcea Therapeutics, Inc., from September 2019 until the completion of the Akcea Merger. Mr. Klein also serves on the boards
      of private and non-profit entities. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board believes Mr. Klein is uniquely suited to serve on
      the Board and as Chairman of the Audit Committee because he is a Chartered Financial Analyst and has extensive public company, venture investment, board, and financial advisory expertise in the life sciences industry, including previously serving as
      Chairman of the Audit Committee at several public biopharmaceutical companies.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b><i>Joseph Loscalzo</i></b></span><b><i><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">, </span></i></b><span style="font: 10pt Times New Roman, Times, Serif; color: #231F20">M.D., Ph.D., age 71, has served as a Director of Ionis since February
      2014 and as Chairman of the Board since June 2021. Dr. Loscalzo is the Hersey </span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #444444">Distinguished </span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">Professor of the Theory and Practice of Medicine,</span> <span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #444444">the Samuel A. Levine Professor of Medicine </span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">at Harvard Medical School and Physician-in-Chief </span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #444444">Emeritus </span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">at Brigham and Women&#8217;s Hospital. Dr. Loscalzo is also a co-founder and member of the Scientific Advisory Board of Scipher Medicine, a private network medicine-based
      company matching patients with their most effective therapy. Dr. Loscalzo received his A.B. degree, <i>summa cum laude</i>, his Ph.D. in biochemistry, and his M.D. from the University of Pennsylvania. He completed his clinical training at Brigham
      and Women&#8217;s Hospital and Harvard Medical School, where he served as Resident and Chief Resident in medicine and Fellow in cardiovascular medicine. Post-training, Dr. Loscalzo joined the Harvard faculty and staff at Brigham and Women&#8217;s Hospital in
      1984. He rose to the rank of Associate Professor of Medicine, Chief of Cardiology at the West Roxbury Veterans Administration Medical Center, and Director of the Center for Research in Thrombolysis at Brigham and Women&#8217;s Hospital. He joined the
      faculty of Boston University in 1994, first as Chief of Cardiology and, in 1997, Wade Professor and Chair of Medicine, Professor of Biochemistry, and Director of the Whitaker Cardiovascular Institute. He returned to Harvard and Brigham and Women&#8217;s
      Hospital in 2005. Since January 2016, Dr. Loscalzo has served on the board of directors of Leap Therapeutics, Inc., a public biopharmaceutical company. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board believes Dr. Loscalzo is uniquely suited to serve
      on the Board and as our Chairman primarily because of his extensive scientific expertise, including 32 years of research in the areas of vascular biology, thrombosis, and atherosclerosis, and practical knowledge as a practicing physician. Dr.
      Loscalzo&#8217;s expertise and role as a leading cardiologist is particularly valuable as we advance and grow our cardiovascular franchise.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
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  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">INFORMATION REGARDING THE BOARD AND CORPORATE GOVERNANCE</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 91.05pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Independence of the Board of Directors</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">As required under Nasdaq listing standards, a
      majority of the members of a listed company&#8217;s board of directors must qualify as &#8220;independent,&#8221; as evaluated by our Nominating, Governance and Review Committee and affirmatively determined by our Board. Our Nominating, Governance and Review Committee
      consults with our legal counsel to ensure that the Committee&#8217;s determinations are consistent with all relevant securities and other laws and regulations regarding the definition of &#8220;independent,&#8221; including those set forth in the applicable Nasdaq
      listing standards and applicable SEC rules and regulations, as in effect from time to time.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Consistent with these considerations, after
      review of all relevant transactions or relationships between each Director, or any of his or her family members, and Ionis, its senior management and its independent auditors, the Board affirmatively has determined that all of our Directors are
      independent Directors within the meaning of the applicable Nasdaq listing standards and SEC rules and regulations, except for Ms. Parshall and Dr. Monia, our former Chief Operating Officer, and current Chief Executive Officer, respectively. In making
      this determination, the Board found that none of these independent Directors has a material or other disqualifying relationship with us., Notably, although the Company does business with Goldman Sachs &amp; Co. and Brigham and Women&#8217;s Hospital,
      neither Mr. Wender nor Dr. Loscalzo, respectively, receives any personal compensation directly from revenue received from Ionis.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 47.5pt 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Information Regarding the Board and its
        Committees</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 47.5pt 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Leadership Structure</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">Mr. Wender has served as our Independent Lead
      Director since December 2020 and Dr. Loscalzo has served as Chairman of our Board</span> <span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">since June 2021. The Board believes that the appointment of an Independent Lead
      Director and the separated roles of Chairman of the Board and Chief Executive Officer reinforce the independence of the Board in its oversight of the business and affairs of the Company. In addition, <span style="color: #231F20">following the
        Board&#8217;s dissolution of the Agenda Committee of the Board in March 2021, Mr. Wender, Dr. Loscalzo and Dr. Monia have worked together to set the agenda for each Board meeting. We will continue to rely on our Chairman of the Board, Independent Lead
        Director and CEO to set the agendas for future Board meetings and believe this is the appropriate structure to ensure the Board focuses on the most important matters facing our business at each meeting.</span></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Risk Oversight</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Our Board administers its risk oversight
      function directly and through all of its current committees. We provide a complete description of each committee and its respective roles and responsibilities on pages 18 through 23 of this Proxy Statement. While each of these committees is
      responsible for evaluating certain risks and overseeing how we manage risk, these committees inform the entire Board about such risks through committee reports.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">The Audit Committee oversees management of financial
      risks and related party transactions. In 2019, the Audit Committee authorized the formation of an internal audit function known as &#8220;Advisory Services&#8221; that reports to the Audit Committee. </span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Advisory Services strives to accomplish its mission of adding value to and improving the Company&#8217;s operations through sustaining a systematic, disciplined, and transparent approach to evaluating the effectiveness of
      governance, risk management, and control processes. The scope of Advisory Services is to determine if the control environment and internal control structure, as designed and represented by Company management, are adequate and functioning in a manner
      to enable the Company to meet its business objectives and satisfy its responsibilities. The Audit Committee is also responsible for reviewing and discussing the Company&#8217;s cybersecurity risks.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Nominating, Governance and Review
      Committee manages risks associated with the independence of the Board and potential conflicts of interests at the Board level, and periodically reviews our policies and procedures and makes recommendations when appropriate. The Compensation Committee
      reviews risks to the Company related to our executive compensation program and our general compensation philosophies. The Finance Committee evaluates risks to the Company associated with our corporate finance matters. The Science/Medical Committee
      identifies risks to the Company related to our technology platform. The Compliance Committee is responsible for evaluating risks to the Company in connection with the commercialization of our medicines and good practice guidelines and regulations.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">In addition to the formal compliance program,
      the Board and its committees encourage management to promote a corporate culture that understands risk management and incorporates it into the overall corporate strategy and day-to-day business operations. Our risk management structure also includes
      an ongoing effort to assess and analyze the most likely areas of future risk for Ionis. As a result, the Board and most of its committees periodically ask our executives to discuss the most likely sources of material future risks and how we are
      addressing any significant potential vulnerability.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">16</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Board Committees</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board has six committees: an Audit
      Committee, a Compensation Committee, a Nominating, Governance and Review Committee, a Science/Medical Committee, a Finance Committee, and a Compliance Committee. Below is a description of each committee of our Board. Each of the committees has
      authority to engage legal counsel or other experts or consultants as it deems appropriate to carry out its responsibilities. The Board has determined that each member of our Audit Committee, Compensation Committee, and Nominating, Governance and
      Review Committee:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 38.15pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">meets the applicable rules and regulations regarding
            &#8220;independence,&#8221; including, but not limited to, Rule 5605(a)(2) of the Nasdaq listing standards and applicable SEC rules and regulations;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 38.15pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">is not an officer or employee of Ionis; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 38.15pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">is free of any relationship that would interfere with his or her
            individual exercise of independent judgment with regard to Ionis.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Meetings and Attendance; Committee Members</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board met six times in 2022. Each Director
      serving as of December 31, 2022 attended 75% or more of the aggregate number of meetings of the Board and the committees on which such Director served during 2022. We encourage each member of the Board to attend the Annual Meeting of Stockholders.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 214.9pt; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Board Committee Members</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 214.9pt; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The table below provides membership and meeting information
      for each of the Board committees until September 2022.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">

    <td style="font: 10pt Times New Roman, Times, Serif; width: 32%; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69"><b>Name</b></span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; width: 8%; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69"><b>Audit</b></span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; width: 11%; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69"><b>Compensation</b></span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-indent: 4.2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69"><b>Compliance</b></span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69"><b>Finance</b></span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69"><b>Nominating,<br />
              Governance<br />
              and Review</b></span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; width: 9%">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Science/</b></span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Medical**</b></span></p>
        </td>

    <td style="font: 10pt Times New Roman, Times, Serif; width: 9%; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69"><b>Attended <br />
              2022 <br />
              Annual<br />
              Meeting</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dr. Spencer R.
            Berthelsen</span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; background-color: #D9D9D9; text-align: center; text-indent: 0in; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; background-color: #D9D9D9; text-align: center; text-indent: 0in; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>&#160;&#160;X*</b></span></td>

    <td style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; background-color: #DDDDDD; text-align: center; text-indent: 0in; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; background-color: #DDDDDD; text-align: center; text-indent: 0in; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; background-color: #DDDDDD; text-align: center; text-indent: 0in; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; background-color: #DDDDDD; text-align: center; text-indent: 0in; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; background-color: #DDDDDD; text-align: center; text-indent: 0in; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Ms. Allene M. Diaz</span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dr. Michael Hayden</span></td>

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X*</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Ms. Joan E. Herman</span></td>

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Mr. Joseph Klein, III</span></td>

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>&#160;&#160;X*</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dr. Joseph Loscalzo</span></td>

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dr. Brett P. Monia</span></td>

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Mr. Frederick T. Muto<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">***</sup></span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Ms. B. Lynne Parshall</span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X*</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Mr. Joseph H. Wender</span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="background-color: white; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--























            </b></span></td>

    <td style="background-color: white; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="background-color: white; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: white; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>&#160;&#160;X*</b></span></td>

    <td style="background-color: white; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>&#160;&#160;X*</b></span></td>

    <td style="background-color: white; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: white; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total meetings in fiscal year 2022</span></td>

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>9</b></span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>10</b></span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>5</b></span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>4</b></span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>3</b></span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>3</b></span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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    <td style="width: 0.3in; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">*</span></td>

    <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Committee Chairperson</span></td>

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</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"></p>
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    <td style="width: 0.3in; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">**</span></td>

    <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dr. Frank Bennett, the Company&#8217;s EVP and Chief Scientific Officer, is the executive sponsor of the committee.</span></td>

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    <td style="width: 0.3in; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">***</span></td>

    <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Mr. Muto resigned from the Board in July 2022.</span></td>

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</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">17</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The table below identifies our current Board and committee
      members as of September 2022.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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              Governance<br />
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    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

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    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

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    <td style="font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

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    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dr. Michael Hayden</span></td>

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X*</b></span></td>

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  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Ms. Joan E. Herman</span></td>

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

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    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Mr. Joseph Klein, III</span></td>

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>&#160;&#160;X*</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

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    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dr. Joseph Loscalzo</span></td>

    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

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    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

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    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Ms. B. Lynne Parshall</span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X*</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

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    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Mr. Joseph H. Wender</span></td>

    <td style="font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="background-color: #D9D9D9; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--























            </b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>X</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>&#160;&#160;X*</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>&#160;&#160;X*</b></span></td>

    <td style="background-color: #DDDDDD; text-align: center; text-indent: 0in; font: 10pt Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200"><b>--</b></span></td>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <!-- Field: Rule-Page -->
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    <td style="width: 0.3in; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">*</span></td>

    <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Committee Chairperson</span></td>

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    <td style="width: 0.3in; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">**</span></td>

    <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dr. Frank Bennett, the Company&#8217;s EVP and Chief Scientific Officer, is the executive sponsor of the committee.</span></td>

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</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Audit Committee</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Audit Committee:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">reviews the annual and quarterly financial statements, including
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            employees and management are not present;</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">selects and hires our independent auditors;</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">oversees the independence of our independent auditors;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">evaluates our independent auditors&#8217; performance; and</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.5pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">has the authority to hire its own outside consultants and
            advisors, if necessary.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0.25in; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">In addition to the responsibilities listed
      above, the Audit Committee has the following functions:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0.25in; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">receiving and considering our independent auditors&#8217; comments as to the audit of
            the financial statements and internal controls, adequacy of staff and management performance and procedures in connection with internal controls;</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">reviewing and, if appropriate, approving related party transactions;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">establishing and enforcing procedures for the receipt, retention, and treatment of
            complaints regarding accounting or auditing improprieties;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20">


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    <td style="width: 22.5pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">pre-approving all audit and non-audit services provided by our independent
            auditors that are not prohibited by law;</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20">


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    <td style="width: 22.5pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">reviewing and discussing the Company&#8217;s cybersecurity risks; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20">


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    <td style="width: 22.5pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">meeting regularly with members of the internal audit/Advisory Services team.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 22.5pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Our Audit Committee utilizes an Audit Committee
      calendar to manage and track its key duties and responsibilities throughout each year.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 22.5pt; color: #231F20"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">18</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Our Audit Committee charter requires that each
      member must be independent. We consider the members to be independent as long as they:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">do not accept any consulting, advisory or other compensatory fee
            from us, except in connection with their service as a Director;</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">are not an affiliate of Ionis or one of its subsidiaries; and</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 22.5pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">meet all of the other Nasdaq independence requirements.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">In addition, all Audit Committee members must be
      financially literate and at least one member must be a &#8220;financial expert,&#8221; as defined by SEC regulations. Our Board has determined that the Audit Committee&#8217;s financial expert is Mr. Klein based on, among other things, his status as a Chartered
      Financial Analyst and his extensive public company, venture investment, board, and financial advisory expertise in the life sciences industry, including previously serving as Chairman of the Audit Committee at several public biopharmaceutical
      companies. We provide the Audit Committee with the funding it needs to perform its duties.</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Audit Committee is responsible for reviewing
      and discussing the Company&#8217;s cybersecurity risks. The Audit Committee periodically meets with the Company&#8217;s informatics management and with the Company&#8217;s independent auditors regarding their annual audit procedures, which include information
      technology. Ms. Herman has obtained a cybersecurity certification from the NACD and Ms. Parshall is in the process of obtaining such cybersecurity certification. In addition, we utilize an information security awareness training program that is
      available to all employees. We are not aware of any breaches of our information security systems in the last three years.</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Audit Committee typically meets twice each
      quarter: once face-to-face in connection with quarterly Board of Directors meetings, and once by teleconference to review quarterly financial results and Form 10-Q or annual financial results and Form 10-K. In 2022, the Audit Committee met nine
      times. The Board has adopted a written Audit Committee charter, which you can find on our corporate website at <span style="text-decoration: underline;">www.ionispharma.com</span>.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">3</sup> Each member meets the
      membership criteria set forth in the Audit Committee charter and as stated above.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Compensation Committee</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The primary function of the Compensation
      Committee of the Board is to review, modify (as needed) and approve our overall compensation strategy and policies for our executive officers and recommend that the Board approve the compensation and other terms of employment for our Chief Executive
      Officer. We include a full list of the Compensation Committee&#8217;s responsibilities as part of the Compensation Discussion and Analysis (&#8220;<b><i>CD&amp;A</i></b>&#8221;) set forth on pages 48 through 75 of this Proxy Statement. The charter of the Compensation
      Committee grants the Compensation Committee full access to all of our books, records, facilities and personnel, and authority to obtain, at our expense, advice and assistance from internal and external legal, accounting or other advisors and
      consultants and other external resources that the Compensation Committee considers necessary or appropriate in the performance of its duties. In particular, the Compensation Committee has the sole authority to retain independent compensation
      consultants to help the Compensation Committee evaluate executive and Director compensation, including the authority to approve the consultants&#8217; reasonable fees and other retention terms.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We also have a Non-Management Stock Option
      Committee that, as delegated by the Compensation Committee, may award stock options and RSUs to employees who are below director level in accordance with guidelines adopted by the Compensation Committee. The Non-Management Stock Option Committee has
      one member, Dr. Monia.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Compensation Committee met ten times in
      2022. The Compensation Committee acted by unanimous written consent (&#8220;<b><i>UWC</i></b>&#8221;) 17 times, which number has increased in recent years due to separate UWCs for grants made pursuant to our 2020 Equity Incentive Plan for legacy Akcea employees.
      The Board has adopted a written Compensation Committee charter, which you can find on our corporate website at <span style="text-decoration: underline;">www.ionispharma.com</span>.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">4</sup></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">3 </sup>Any information that is included on or linked to our website is not part of this Proxy Statement or any registration statement or report that incorporates this Proxy Statement by reference.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">4 </sup>Any information that is included on or linked to our website is not part of this Proxy Statement or any registration statement or report that incorporates this Proxy Statement by reference.&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"></p>
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    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">19</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Compensation Committee reviews with
      management Ionis&#8217; CD&amp;A to consider whether to recommend that we include the CD&amp;A in our Proxy Statements and other filings.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Compensation Committee Interlocks and Insider
      Participation</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">As noted above, during the fiscal year ended
      December 31, 2022, our Compensation Committee was composed of Dr. Berthelsen, Mr. Wender, Mr. Muto (until July 2022) and Ms. Herman (beginning in September 2022). In each case, none of the members of the Compensation Committee has ever been an
      employee or officer of Ionis. None of our executive officers serves as a member of the board of directors or compensation committee of any other entity that has one or more executive officers serving as a member of our Board or Compensation
      Committee.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Nominating, Governance and Review Committee</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0.25in; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Nominating, Governance and Review Committee
      of the Board is responsible for:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0.25in; text-align: left; text-indent: 0in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">interviewing, evaluating, nominating, and recommending individuals
            for membership on our Board, and considering proposed changes to the Board for approval;</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">managing risks associated with the independence of the Board and
            potential conflicts of interests at the Board and executive level, and periodically reviewing our policies and procedures and making recommendations when appropriate; and</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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    <td style="width: 22.5pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">performing such other functions as may be necessary or convenient
            for the efficient discharge of the foregoing.</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Nominating, Governance and Review
      Committee met three times during 2022. You can find our Nominating, Governance and Review Committee charter on our corporate website at www.ionispharma.com.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">5</sup></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 22.3pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Director Nominations - Minimum
        Qualifications</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 22.3pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Nominating, Governance and Review
      Committee believes that candidates for Director should have certain minimum qualifications. As a result, the Board adopted membership standards (that may be revised from time to time) and believes that the Board members should meet the minimum
      membership requirements listed below.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The minimum membership requirements are as
      follows:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">members must be able to read and understand basic financial
            statements;</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">members must demonstrate high personal integrity and ethics;</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">members cannot serve as a director on the boards of more than
            five total publicly traded companies (including Ionis);</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">members cannot serve more than ten consecutive three-year terms
            on the Board; and</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.5pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">members cannot run for re-election to the Board once they have
            reached the age of 80.</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">In addition to these minimum standards, the
      Nominating, Governance and Review Committee will consider such factors as:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">possessing relevant expertise to offer advice and guidance to
            management;</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">having sufficient time to devote to Ionis&#8217; affairs;</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">demonstrating excellence in his or her field;</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">having sound business judgment;</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 22.5pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">being committed to vigorously representing the long-term
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.5pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">contributing to the diversity of the Board.</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">5 </sup>Any
      information that is included on or linked to our website is not part of this Proxy Statement or any registration statement or report that incorporates this Proxy Statement by reference.</span></p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font: 10pt Times New Roman, Times, Serif">&#160;</span></p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif; text-align: center"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">20</span>&#160;</div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Director Nominations - Diversity </i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">In considering Director nominations, the
      Nominating, Governance and Review Committee considers the total mix of competencies represented on the Board as a whole, as well as the competencies each member, or nominee, brings to the Board. In general, our Board members&#8217; experience falls into
      three large categories: (1) investment banking, financial accounting, and corporate governance experience; (2) medical and scientific expertise; and (3) experience with the commercialization of pharmaceutical products. By selecting individuals who
      have investment banking, financial accounting, and corporate governance backgrounds, we gain valuable experience that ensures we are managing our financial resources appropriately, reporting our financial results fairly and accurately, and generally
      running our business consistent with current good corporate practices. As a cutting-edge drug discovery and development company, we also greatly benefit from Board members who themselves are scientists and medical doctors and can help set and adjust
      our strategy and objectives based on the results we generate from our research and development efforts. In addition, as we advance our commercial strategy, we will benefit from Board members with backgrounds in the commercialization of pharmaceutical
      products. In different ways, these categories allow us to effectively manage our cash and make prudent investments in our technology to achieve the greatest likelihood of success. </span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We have historically <span style="color: #231F20">tried to evenly balance the Board members across the first two categories and are increasing our focus on the third category as we advance our commercial strategy.</span></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We also value diversity on our Board and do
      not discriminate against nominees on the basis of gender, race, religion, national origin, sexual orientation, disability, or any other basis. Recognizing the importance of diversity on our Board, in December 2020, the Nominating, Governance and
      Review Committee approved authorizing the Company to begin a search for qualified Director candidates who are diverse and have commercial experience. As a result of such search, Ms. Allene Diaz joined our Board in June 2021. We will continue to
      strive to add Directors to our Board who will provide relevant and valuable expertise while contributing to its diversity.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Board Diversity Matrix </i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 80%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: auto; margin-right: auto;">


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    <td style="border: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 8pt 5.4pt; text-align: center; text-indent: 0in" colspan="5"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: white"><b>Board
              Diversity Matrix (as of February 8, 2023)</b></span></td>

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  <tr style="background-color: #CE0F69; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: white"><b>Total Number of Directors</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in" colspan="4"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: white"><b>9</b></span></td>

  </tr>

  <tr style="background-color: white; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 35%; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">&#160;</span></td>

    <td style="width: 10%; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; border-right: Black 1pt solid; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>Female</b></span></td>

    <td style="width: 10%; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; border-right: Black 1pt solid; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>Male</b></span></td>

    <td style="width: 10%; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; border-right: Black 1pt solid; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>Non-Binary</b></span></td>

    <td style="width: 15%; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; border-right: Black 1pt solid; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>Did Not Disclose</b></span><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><br />
            <span style="color: #E57200"><b>Gender</b></span></span></td>

  </tr>

  <tr style="background-color: #CE0F69; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: white"><b>Part I: Gender Identity</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: white"><b>3</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: white"><b>6</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: white"><b>0</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: white"><b>0</b></span></td>

  </tr>

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    <td style="border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">&#160;</span></td>

    <td style="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">&#160;</span></td>

    <td style="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">&#160;</span></td>

    <td style="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">&#160;</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">&#160;</span></td>

  </tr>

  <tr style="background-color: #CE0F69; font: 10pt Times New Roman, Times, Serif">

    <td style="border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: white"><b>Part II: Demographic Self-Identification</b></span></td>

    <td style="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">&#160;</span></td>

    <td style="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">&#160;</span></td>

    <td style="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">&#160;</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">&#160;</span></td>

  </tr>

  <tr style="background-color: white; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>African American or Black</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

  </tr>

  <tr style="background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>Alaskan Native or Native American</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

  </tr>

  <tr style="background-color: white; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>Asian </b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

  </tr>

  <tr style="background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>Hispanic or Latinx</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>1</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

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    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>Native Hawaiian or Pacific Islander</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

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  <tr style="background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>White</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>3</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>6</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">&#160;</span></td>

  </tr>

  <tr style="background-color: white; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>Two or More Races/Ethnicities</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>1</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

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    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>LGBTQ+</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>1</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

  </tr>

  <tr style="background-color: white; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>Did not disclose demographic background</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt; color: #E57200"><b>--</b></span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font: 10pt Times New Roman, Times, Serif"><i>Director Nominations &#8211; Tenure</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Our drug technology is a &#8220;platform
      technology,&#8221; which means the more knowledge and experience an individual has with our technology platform, the better equipped that individual is to create value at Ionis. This is no different for our non-employee Directors. While we believe it&#8217;s
      important to add new non-employee Directors that will bring fresh ideas and perspectives, given the uniqueness and complexity of our technology, it is also critical to retain the knowledge and experience of an appropriate number of outstanding long
      service non-employee Directors who can contribute to our future business decisions while understanding our history.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">21</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in"><span style="font: 10pt Times New Roman, Times, Serif">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Director Nominations - Process</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Nominating, Governance and Review
      Committee will consider Director candidates our stockholders recommend. The Nominating, Governance and Review Committee does not intend to alter the manner in which it evaluates candidates, including the minimum criteria set forth above, based on
      whether or not a stockholder recommended the candidate.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Nominating, Governance and Review
      Committee reviews new candidates for Director in the context of the Board&#8217;s composition, our operating requirements, and our stockholders&#8217; long-term interests. In conducting this assessment, the Nominating, Governance and Review Committee considers
      diversity, maturity, skills, the minimum membership requirements discussed above, and such other factors as it deems appropriate given the current needs of the Board and Ionis, to maintain a balance of knowledge, experience and capability. The
      Nominating, Governance and Review Committee then uses its network of contacts to compile a list of potential candidates, but may also engage, if it deems appropriate, a paid professional search firm. The Nominating, Governance and Review Committee
      conducts any appropriate and necessary inquiries into the backgrounds and qualifications of possible candidates after considering the function and needs of the Board. In the case of incumbent Directors whose terms of office are set to expire, the
      Nominating, Governance and Review Committee reviews such Directors&#8217; overall service to Ionis during their term, including the number of meetings attended, level of participation, quality of performance, and any other relationships and transactions
      that might impair such Directors&#8217; independence.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Nominating, Governance and Review Committee
      meets to discuss and consider the candidates&#8217; qualifications and determines whether each candidate is independent based upon applicable Nasdaq listing standards, SEC rules and regulations, and the advice of counsel, if necessary. Finally, the
      Nominating, Governance and Review Committee then selects a nominee for recommendation to the Board by majority vote.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Stockholder Recommendations for Directors</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Stockholders who wish to recommend individuals
      for consideration by the Nominating, Governance and Review Committee to become nominees for election to the Board may do so by delivering a written recommendation to Ionis&#8217; corporate secretary at the following address: 2855 Gazelle Court, Carlsbad,
      California 92010. Submissions must include:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">the name, age, business address and residence address of the
            nominee;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">the principal occupation or employment of the nominee;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">the stock ownership in Ionis of the nominee;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">the stock ownership in Ionis of the stockholder making the
            nomination, including any trading in derivative securities that may disguise ownership occurring within the last 12 months;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">the information relating to the nominee that is required to be
            disclosed in solicitations of proxies under applicable securities laws;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">the nominee&#8217;s written consent to being named in the Proxy
            Statement as a nominee and to serving as a Director if elected;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 22.3pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">other information as we may reasonably require to determine the
            eligibility of the proposed nominee to serve as an independent Director or that could be material to a reasonable stockholder&#8217;s understanding of the independence of the proposed nominee; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 22.5pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">any voting commitments the nominee has to third parties.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">In addition, the nominee will need to complete
      a written questionnaire regarding the background and qualifications of the nominee, and the background of any other person or entity on whose behalf the nomination is being made. The nominee must also agree to comply with all of our applicable
      publicly disclosed corporate governance, conflict of interest, confidentiality and stock ownership and trading policies and guidelines. The description of the requirements for Director nomination set forth above is qualified in its entirety by
      reference to our full and complete bylaws, which is an exhibit to our Current Report on Form 8-K filed with the SEC on March 29, 2021, a copy of which is available by contacting our corporate secretary. To date, the Board has not received or rejected
      a timely Director nominee for election at the upcoming stockholder meeting from a stockholder or stockholders holding more than 5% of our voting stock.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">22</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Science/Medical Committee</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: justify; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The primary functions of the
      Science/Medical Committee of the Board are to focus on the key scientific and development issues facing our technology and medicines in development and help set our strategy in such areas. The Science/Medical Committee met three times in 2022.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: justify; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: justify; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Finance Committee</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: justify; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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      Committee of the Board is to advise the Board and management on certain corporate finance matters for the Company and its subsidiaries, including capital structures, financings, investments, and share repurchase activities. The Finance Committee met
      four times in 2022.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: justify; text-indent: 0.25in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: justify; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Compliance Committee</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: justify; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 0.25in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Compliance Committee met five times in
      2022. The Compliance Committee is primarily responsible for overseeing and reviewing the Company&#8217;s healthcare compliance program and the status of the Company&#8217;s compliance with laws, regulations (including good practice guidelines and regulations),
      industry standards, and internal procedures. The primary function of the Committee is to oversee the development and implementation of compliance and ethics policies and practices at the Company; however, management is responsible to design and
      implement such policies and practices.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 0.25in; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: justify; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Stockholder Communications with the Board</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: justify; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We make every effort to ensure that our Board
      or individual Directors, as applicable, hear our stockholders&#8217; views, and provide appropriate responses to stockholders in a timely manner. Stockholders who wish to communicate with the Board, or individual Directors, may do so by sending written
      communications addressed to Ionis&#8217; corporate secretary at 2855 Gazelle Court, Carlsbad, California 92010. If you wish to communicate with the independent Directors about your concerns or issues, you may address correspondence to a particular Director
      or to the independent Directors generally. If you do not name a particular Director, depending on the subject matter, we will forward the letter to the Chair of the appropriate committee of the Board. One or more of our employees designated by the
      Board will review these communications and will determine whether to present the materials to the Board. The purpose of this screening is to allow the Board to avoid having to consider irrelevant or inappropriate communications, such as
      advertisements, commercial solicitations, and hostile communications. In accordance with our Code of Ethics and Business Conduct, all communications that relate to questionable accounting or auditing matters involving Ionis will be promptly and
      directly forwarded to the Audit Committee. Other than the processes described above, our Board has not adopted a formal written process for stockholder communications with the Board. We believe our Board&#8217;s responsiveness to stockholder communications
      has been excellent.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Code of Ethics and Business Conduct</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">We have adopted a Code of Ethics and Business
      Conduct that applies to all officers, Directors, and employees. We have posted our Code of Ethics and Business Conduct on our website. If we make any substantive amendments to the Code of Ethics and Business Conduct or grant any waiver from a
      provision of the Code of Ethics and Business Conduct to any executive officer or Director, we will promptly disclose the nature of the amendment or waiver</span> <span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">via an 8-K
      filing with the SEC or on our <span style="color: #231F20">website at <span style="text-decoration: underline;">www.ionispharma.com</span>.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">6</sup></span></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Corporate Governance Guidelines</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board has adopted corporate governance
      guidelines to ensure that the Board will have the necessary authority and practices in place to review and evaluate our business operations as needed and to make decisions that are independent of our management. The guidelines are also intended to
      align our Directors&#8217; and management&#8217;s interests with those of our stockholders. The corporate governance guidelines set forth the practices the Board intends to follow with respect to board composition and selection, board meetings and involvement of
      senior management, Chief Executive Officer performance evaluation, succession planning for Board committees and compensation, &#8220;clawbacks&#8221; of executive compensation, and share retention guidelines for our executive officers and Directors. The Board
      adopted the corporate governance guidelines to, among other things, reflect changes to the Nasdaq listing standards and SEC rules adopted to implement provisions of the Sarbanes-Oxley Act of 2002. You may view our corporate governance guidelines, as
      well as the charters for the Audit, Compensation, Nominating, Governance and Review, Finance and Compliance committees at <span style="text-decoration: underline;">www.ionispharma.com</span>.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">7</sup></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">6 </sup>Any information that is included on or linked to our website is not part of this Proxy Statement or any registration statement or report that incorporates this Proxy Statement by reference.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif">&#160;<img alt="" src="ny20007094x2_def14aimg003.jpg" /></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">23</span>&#160;</div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Anti-Hedging Policy and Anti-Pledging Policy</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">All Directors and employees, including our named executive officers, are
      prohibited from taking a &#8220;short&#8221; position in our stock and otherwise hedging their position in our stock against a future drop in our stock price including short sales and derivatives such as put or call options, swaps, forwards, and futures, or
      other inherently speculative transactions with respect to Ionis&#8217; securities at any time.&#160; In addition, we also prohibit all Directors and employees, including our named executive officers, from pledging our stock as collateral.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">7 </sup>Any





















      information that is included on or linked to our website is not part of this Proxy Statement or any registration statement or report that incorporates this Proxy Statement by reference.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0"><span style="font: 10pt Times New Roman, Times, Serif">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /><span style="font: 10pt Times New Roman, Times, Serif">&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">24</span>&#160;</div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>PROPOSAL 2</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>ADVISORY VOTE ON EXECUTIVE COMPENSATION</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 150.4pt; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Dodd-Frank Wall Street Reform and Consumer
      Protection Act of 2010, called the &#8220;Dodd-Frank Act,&#8221; entitles Ionis&#8217; stockholders to vote to approve, on an advisory (nonbinding) basis, the compensation of our Chief Executive Officer, Chief Financial Officer and our three other most highly
      compensated executive officers (at December 31, 2022), called our &#8220;named executive officers&#8221; as disclosed in this Proxy Statement in accordance with Section 14A of the Exchange Act.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We are asking our stockholders to indicate
      their support for our named executive officers&#8217; compensation as described in this Proxy Statement. This Proposal 2, commonly known as a &#8220;say on pay&#8221; proposal, gives our stockholders the opportunity to express their views on the compensation paid to
      our named executive officers. This vote is not intended to address any specific item of compensation, but rather the overall compensation of our named executive officers and the philosophy, policies and practices described in this Proxy Statement.
      Accordingly, we are asking our stockholders to vote &#8220;FOR&#8221; the following resolution at the Annual Meeting:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#8220;RESOLVED, that Ionis&#8217; stockholders
      approve, on an advisory basis, the compensation of the named executive officers, as disclosed in this Proxy Statement for the 2023 Annual Meeting of Stockholders pursuant to the compensation disclosure rules of the Securities and Exchange
      Commission.&#8221;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We recommend you carefully review the
      EXECUTIVE COMPENSATION section of this Proxy Statement located on pages 48 through 75. Below is a high-level summary of some of our compensation practices. This summary is qualified by the detailed disclosure contained in the EXECUTIVE COMPENSATION
      section of this Proxy Statement.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Unless the Board decides to modify its policy regarding the
      frequency of soliciting advisory votes on the compensation of our named executives, the next scheduled &#8220;say on pay&#8221; vote will be at the 2024 Annual Meeting of Stockholders.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">25</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The table below summarizes some of our
      executive compensation practices, both the practices we implement because we believe they are consistent with our vision and long-term stockholder value, and those that we choose not to implement as we believe they are counter to our vision and
      long-term stockholder value:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 85%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: auto; margin-right: auto;">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 30%; border: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 13.5pt; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #A20067"><img alt="" src="ny20007094x2_def14aimg018.jpg" /></span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">General compensation principles</span></td>

    <td style="width: 55%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 4.45pt; text-align: left; text-indent: -1.6pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We design our compensation structure to drive the
              creation of long-term stockholder value and mitigate unnecessary or imprudent business risk taking. Specifically, we:</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 38.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;&#160;&#160;&#160;&#160; Use a combination of compensation vehicles that
              provide a balanced mix of fixed and variable cash incentives, and long-term stock incentives;</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 38.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;&#160;&#160;&#160;&#160; Require a 12-month minimum vesting period for
              equity awards;</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 38.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;&#160;&#160;&#160;&#160; Set explicit and demanding objectives at the
              beginning of each year from which we measure performance for the year;</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 38.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;&#160;&#160;&#160;&#160; Set a strict budget for equity awards and salary
              increases;</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 38.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;&#160;&#160;&#160;&#160; Do <i><span style="text-decoration: underline;">not</span></i> provide perquisites for
              any employees; and</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 38.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;&#160;&#160;&#160;&#160; Do <i><span style="text-decoration: underline;">not</span></i> provide &#8220;gross-up&#8221;
              payments, other than for relocation.</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 13.5pt; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #A20067"><img alt="" src="ny20007094x2_def14aimg018a.jpg" /></span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">Align executive compensation with Company performance and design performance based awards to drive creation of long-term stockholder value</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 4.75pt; text-align: left; text-indent: -1.85pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We tie a significant portion of our executive
              officers&#8217; compensation to Company performance and design performance-based awards to drive the creation of long-term stockholder value. For example, we:</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 38.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;&#160;&#160;&#160;&#160; Allocated 65% of our Chief Executive Officer&#8217;s
              2022 compensation in the form of performance-based compensation, which we consider to consist of cash bonuses, stock options and PRSUs;</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 38.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;&#160;&#160;&#160;&#160; Revised our PRSU structure for grants made in
              2023 and going forward such that:</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 74.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9675;&#160;&#160;&#160;&#160; awards will have a single vesting period at the
              end of three years; and</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 74.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9675;&#160;&#160;&#160;&#160; the relative TSR percentile rank for maximum
              payout of the awards increased from the 75<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile to the 90<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th </sup>percentile.</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 38.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;&#160;&#160;&#160;&#160; Place a maximum limit on cash bonuses and do not
              guarantee a cash bonus &#8211; cash bonuses can be, and have been, zero; and</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 38.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;&#160;&#160;&#160;&#160; <span style="color: #231F20">Empower our
                Compensation Committee with the ability to exercise downward discretion with respect to the Company Performance Factor (used to determine cash bonuses) for our executive officers based on Company performance, which occurred in 2021. </span></span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 13.5pt; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #A20067"><img alt="" src="ny20007094x2_def14aimg018.jpg" /></span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">Stock ownership and holding guidelines</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-left: 4.75pt; text-align: left; text-indent: -1.85pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We maintain stock ownership and holding guidelines that require our executive officers and non-employee Directors to meet certain ownership thresholds. We increased such ownership requirements for non-employee Directors in 2023.</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 13.5pt; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #A20067"><img alt="" src="ny20007094x2_def14aimg018a.jpg" /></span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #E57200">&#160;&#160;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Clawback policy</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-left: 4.75pt; text-align: left; text-indent: -1.85pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We use an executive &#8220;clawback&#8221; policy that applies to all Section 16 officers.</span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 13.5pt; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #A20067"><img alt="" src="ny20007094x2_def14aimg018.jpg" /></span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Disallow hedging and pledging</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-left: 5.4pt; text-align: left; text-indent: -2.5pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We do not allow pledging, shorting, or hedging against our stock by Directors or employees.</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 13.5pt; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #A20067"><img alt="" src="ny20007094x2_def14aimg018a.jpg" /></span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">No option re-pricing or cash buyouts</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-left: 4.45pt; text-align: left; text-indent: -1.55pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We do not reprice or &#8220;cash-out&#8221; stock options without stockholder approval.</span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 13.5pt; padding-left: 17.35pt; text-align: left; text-indent: -13.5pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #A20067"><img alt="" src="ny20007094x2_def14aimg018.jpg" /></span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Engage an independent compensation consultant</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 4.45pt; text-align: left; text-indent: -1.55pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Compensation Committee has retained a compensation
              consultant whose relationship with the Company was confirmed to be independent for 2022.</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 4.45pt; text-align: left; text-indent: -1.55pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 4.45pt; text-align: left; text-indent: -1.6pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The compensation consultant, among other things,
              assists us in selecting an appropriate peer group and annually reviewing our compensation levels, policies, practices, and procedures for our employees and non-employee Directors compared to our peer group.</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 13.5pt; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #A20067"><img alt="" src="ny20007094x2_def14aimg018a.jpg" /></span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #231F20">Use a &#8220;double trigger&#8221; for change of control for our executive officers</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 4.75pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We use a &#8220;double trigger&#8221; for cash payments and equity
              acceleration for change of control for our executive officers.</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 13.7pt; padding-left: 0.25in; text-align: left; text-indent: -13.7pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: #A20067"><img alt="" src="ny20007094x2_def14aimg018.jpg" />&#160; </span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Hold a &#8220;say on pay&#8221; vote annually </span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-left: 4.75pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Provides























            an effective way for us to obtain information on stockholder sentiment about our executive compensation program each year.</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">26</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font: 10pt Times New Roman, Times, Serif">The affirmative vote of a majority of the holders of shares
      present or represented by proxy at the Annual Meeting and entitled to vote on the matter is required to adopt the resolution. If you indicate on your proxy to &#8220;Abstain&#8221; from voting, it will have the same effect as a vote &#8220;Against&#8221; this Proposal 2.
      Brokers do not have discretion to vote uninstructed shares with respect to this Proposal 2. Accordingly, if brokers do not receive voting instructions from beneficial owners of the shares, they cannot vote the shares. Therefore, broker non-votes will
      not affect the outcome of the voting on this Proposal 2.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The &#8220;say on pay&#8221; vote is advisory, and
      therefore is not binding on Ionis, the Compensation Committee or the Board. However, Ionis&#8217; management, the Board and the Compensation Committee value the opinions of the stockholders. As such, if there is any significant vote against the named
      executive officers&#8217; compensation as disclosed in this Proxy Statement, the Board will consider the stockholders&#8217; concerns and the Board and Compensation Committee will evaluate whether any actions are necessary to address those concerns.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>THE BOARD UNANIMOUSLY RECOMMENDS A VOTE &#8220;FOR&#8221;
        APPROVAL OF PROPOSAL 2.</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #A20067"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">27</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">PROPOSAL 3</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">ADVISORY VOTE ON THE FREQUENCY OF THE VOTE
      ON EXECUTIVE COMPENSATION</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Dodd-Frank Act and Section 14A of the
      Exchange Act enable our stockholders to indicate their preference at least once every six years regarding how frequently we should solicit a non-binding advisory vote on the compensation of our named executive officers as disclosed in our proxy
      statement. Accordingly, consistent with the preference expressed by our stockholders at the 2017 Annual Meeting of Stockholders, as required by these rules, we are presenting this proposal, commonly known as a &#8220;say-on-frequency vote,&#8221; which gives you
      as a stockholder the opportunity to inform us regarding how often you wish us to include a &#8220;say-on-pay&#8221; proposal, similar to Proposal 2, in our Proxy Statement.&#160; Please note that as a stockholder you have the choice to vote for one of the following
      choices, as indicated on the proxy card: to hold the advisory vote on executive compensation every year, every two years, every three years, or to abstain from voting.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Board Recommendation</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board of Directors values constructive
      dialogue on executive compensation and other important governance topics with our stockholders.&#160; The Board believes an advisory vote every year will provide an effective way to obtain information on stockholder sentiment about our executive
      compensation program.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Required Vote of Stockholders</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We will consider the frequency with the highest
      number of votes from the holders of shares present or represented by proxy at the Annual Meeting and entitled to vote as the frequency preferred by the stockholders.<b>&#160;&#160;</b>If you indicate on your proxy to &#8220;Abstain&#8221; from voting, it will not have an
      effect on this Proposal 3. Brokers do not have discretion to vote uninstructed shares with respect to this Proposal 3. Accordingly, if brokers do not receive voting instructions from beneficial owners of the shares, they cannot vote the shares.
      Therefore, broker non-votes will not affect the outcome of the voting on this Proposal 3.<b>&#160;&#160;</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">While this say-on-frequency vote is advisory in
      nature and therefore will not bind us to adopt any particular frequency, our Board of Directors intends to carefully consider the stockholder vote resulting from the proposal in determining how frequently we will hold &#8220;say-on-pay&#8221; votes.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in; background-color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in; background-color: white; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>THE BOARD OF DIRECTORS
        RECOMMENDS THAT STOCKHOLDERS VOTE FOR &#8220;EVERY YEAR.&#8221;</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; background-color: white; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; background-color: white; color: #A20067"><img alt="" src="ny20007094x2_def14aimg003.jpg" /><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">28</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">PROPOSAL 4</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: center; text-indent: -0.65pt; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">APPROVAL OF AN AMENDMENT OF OUR 2011
      EQUITY INCENTIVE PLAN</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: center; text-indent: -0.65pt; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">In March 2011, the Compensation
      Committee of the Board, and the Board, adopted the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan (the &#8220;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>2011 Plan</i><span style="font-weight: normal">&#8221;) and
        the stockholders approved the Plan on June 16, 2011. The stockholders have approved amendments to the 2011 Plan to increase the aggregate number of shares of common stock authorized for issuance under the 2011 Plan as follows: on June 30, 2015, an
        increase of 5,500,000 to an aggregate of 11,000,000 shares; on May 24, 2017, an increase of 5,000,000 to an aggregate of 16,000,000 shares; on June 6, 2019, an increase of 7,000,000 to an aggregate of 23,000,000 shares; and in March 2021, an
        increase of 6,700,000 shares to an aggregate of 29,700,000 shares.</span></span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">In this Proposal 4, we are requesting
      stockholders to approve an amendment of the 2011 Plan to increase the aggregate number of shares of common stock authorized for issuance under the 2011 Plan by 5,500,000 shares to an aggregate of 35,200,000 shares. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">Our management, Board and
      Compensation Committee believe that stock options, restricted stock units (&#8220;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>RSUs</i><span style="font-weight: normal">&#8221;) and performance-based restricted stock units
        (&#8220;</span><i>PRSUs</i><span style="font-weight: normal">&#8221;) are a key aspect of our ability to attract and retain qualified personnel in the face of intense competition for experienced scientists and other personnel among many pharmaceutical and
        health care companies. On March 14, 2023, the Board, upon the recommendation of the Compensation Committee, approved an amendment to the 2011 Plan to increase the aggregate number of shares of common stock authorized for issuance under the 2011
        Plan by 5,500,000 to an aggregate of 35,200,000 shares, to ensure that for a period of at least one year, based on our current business plans, we can continue to grant stock options, RSUs and PRSUs to employees at appropriate levels as determined
        by the Compensation Committee. If the stockholders do not approve this Proposal 4, and as a consequence, we cannot continue to grant options, RSUs and PRSUs at competitive levels, we believe that it will negatively affect our ability to recruit and
        retain highly qualified personnel and our ability to manage future growth. Without these additional shares, management expects that the current shares available for grant under the 2011 Plan will not be sufficient to maintain our stock award
        practices for new employees or for promotions or merit awards for current employees. </span></span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">Each year the Compensation Committee
      approves a budget that sets the number of stock options, RSUs and PRSUs we can grant our employees for annual merit awards. We do not grant options, RSUs or PRSUs that exceed this budget without the Compensation Committee&#8217;s approval. Over the past
      three years, the average merit award stock budget set by the Compensation Committee has been approximately 2.2% of our outstanding common stock on an issued and outstanding basis. This stock compensation budget, and therefore our equity compensation
      burn rate, is well below the ISS-adjusted 4.4% average of our peers.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">The 2011 Plan was adopted to
      ultimately replace the Ionis Pharmaceuticals, Inc. 1989 Stock Option Plan (the &#8220;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>89 Plan</i><span style="font-weight: normal">&#8221;). There were only approximately 65,000
        shares available as of March 31, 2023 for grant under the 89 Plan; however our practice is not to issue grants under this plan. </span></span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">The 2011 Plan is our primary means of
      offering stock options, RSUs and PRSUs to our employees. There were only approximately 3.2 million shares available as of March 31, 2023 for grant under the 2011 Plan. The 2011 Plan also allows us to utilize a broad array of equity incentives and
      performance cash incentives to secure and retain the services of our employees and to provide long-term incentives that align the interests of our employees with the interests of our stockholders.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">We also have the Ionis
      Pharmaceuticals, Inc. 2020 Equity Incentive Plan (the &#8220;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>2020 Plan</i><span style="font-weight: normal">&#8221;) that we assumed in connection with the Akcea Merger. Equity
        awards granted under the 2020 Plan are reserved solely for legacy employees of Akcea who were employed as of October 12, 2020, which was the completion date of the merger. As of March 31, 2023 we had only 40 employees eligible to receive stock
        awards under the 2020 Plan. There were approximately 1.0 million shares available as of March 31, 2023 for grant under the 2020 Plan. </span></span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">The table below provides certain
      information regarding the 2020 Plan, 2011 Plan and the 89 Plan. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">29</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font: 10pt Times New Roman, Times, Serif">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="background-color: #A20067; font: 10pt Times New Roman, Times, Serif">

    <td style="border-top: Black 1pt solid; border-right: black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: center; text-indent: 0in" colspan="4"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: white"><b>Employee Equity Incentive Plans</b></span></td>

  </tr>

  <tr style="background-color: #A20067; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: center; text-indent: 0in" colspan="4"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: white"><b>(as of March 31, 2023)</b></span></td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="width: 68%; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="width: 10%; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; border-right: Black 1pt solid; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2011 Plan</b></span></td>

    <td style="width: 8%; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; border-right: Black 1pt solid; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2020<br />
              Plan</b></span></td>

    <td style="width: 14%; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; border-right: Black 1pt solid; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>89 Plan</b></span></td>

  </tr>

  <tr style="background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total number of shares of common stock subject to outstanding stock options</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">14,006,213</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">412,681</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">11,824</span></td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Weighted-average exercise price of outstanding stock options</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$48.72</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$41.27</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$36.33</span></td>

  </tr>

  <tr style="background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Weighted-average remaining term in years of outstanding stock options</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.59</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">7.85</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">0.14</span></td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total number of shares of common stock subject to outstanding full value awards</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,112,666</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">185,366</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">--</span></td>

  </tr>

  <tr style="background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total number of shares of common stock available for grant under the plan</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,215,980</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">978,223</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">64,997</span></td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in" colspan="2"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total number of shares of common stock available for grant to non-employee Directors under the Non-Employee Director Plan<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></span></td>

    <td style="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">606,333</span></td>

  </tr>

  <tr style="background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in" colspan="2"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total number of shares of common stock available for grant under other equity incentive plans</span></td>

    <td style="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">--</span></td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in" colspan="2"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total number of shares of common stock outstanding</span></td>

    <td style="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">143,022,539</span></td>

  </tr>

  <tr style="background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in" colspan="2"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Per-share closing price of common stock as reported on Nasdaq Capital Market</span></td>

    <td style="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 2pt 5.4pt; text-align: right; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$35.74</span></td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 0.25in; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 0.25in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">(1)</span></td>

    <td style="text-align: left; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">This amount reflects the number of shares of common stock available as of March
            31, 2023 for grant under our 2002 Amended and Restated Non-Employee Directors&#8217; Stock Option Plan, which we use <i>solely</i> to offer equity awards to our non-employee Directors. With respect to the Non-Employee Directors&#8217; Stock Option Plan,
            the total number of shares of common stock subject to outstanding stock options is 927,000, the weighted-average exercise price of outstanding stock options is $47.74, the weighted-average remaining term in years of outstanding stock options is
            4.98, the total number of shares of common stock subject to outstanding full value awards is 58,658, and the total number of shares of common stock available for grant under the Non-Employee Directors&#8217; Stock Option Plan 606,333. We have no
            equity incentive plans other than the 2020 Plan, 2011 Plan, 89 Plan and the Non-Employee Directors&#8217; Stock Option Plan. </span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: -0.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Required Vote and Board of Directors Recommendation</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: -0.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">Approval of this Proposal 4 requires the
      affirmative vote of a majority of the holders of shares present or represented by proxy at the Annual Meeting and entitled to vote on the matter. If you indicate on your proxy to &#8220;Abstain&#8221; from voting, it will have the same effect as an &#8220;Against&#8221;
      vote for this Proposal 4. Broker non-votes will have no effect on the outcome of the vote. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">Our Board believes that approval of
      Proposal 4 is in our best interests and the best interests of our stockholders for the reasons stated above. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>THE BOARD UNANIMOUSLY RECOMMENDS A VOTE &#8220;FOR&#8221; APPROVAL
        OF PROPOSAL</b><i>&#160;</i><b>4.</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: -0.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">DESCRIPTION OF THE IONIS PHARMACEUTICALS, INC. 2011
      EQUITY INCENTIVE PLAN</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: -0.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">Below is a high-level summary of the
      terms of the 2011 Plan. This summary is qualified in its entirety by reference to the complete text of the 2011 Plan. We encourage our stockholders to read the actual text of the 2011 Plan, as amended, in its entirety, a copy of which we filed with
      this Proxy Statement as Appendix A. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">The 2011 Plan: </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 45.35pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">is administered by our Compensation Committee, which is composed entirely of
            independent Directors;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 45.35pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">has a term ending on June 15, 2031; </span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 45.35pt"></td>

    <td style="width: 18pt; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">contains a &#8220;fungible share counting&#8221; structure, whereby the number of shares of our common stock available for issuance
            under the 2011 Plan is reduced by (i) one share for each share issued pursuant to a stock option or stock appreciation right with an exercise price that is at least 100% of the fair market value of our common stock on the date of grant (an &#8220;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><i>Appreciation Award</i></b><span style="font-weight: normal">&#8221;) granted under the 2011 Plan, and (ii) 1.7 shares for each share issued pursuant to a stock award that is
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              increased by (i) one share for each share that becomes available again for issuance under the terms of the 2011 Plan subject to an Appreciation Award, and (ii) 1.7 shares for each share that is granted after June 2, 2021 under the 2011 Plan
              that becomes available again for issuance under the terms of the 2011 Plan subject to a Full Value Award;</span></span></td>

  </tr>


</table>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63.35pt; text-align: left; text-indent: -0.25in"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">30</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 45.35pt; text-align: left"></td>

    <td style="width: 18pt; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">prohibits the repricing of any option or stock appreciation rights outstanding under the 2011 Plan, or &#8220;cashing out&#8221;
            underwater awards unless approved by our stockholders;</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63.35pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 45.35pt; text-align: left"></td>

    <td style="width: 18pt; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">is limited to the granting of stock options, SARs, restricted stock awards, RSUs, PRSUs, and performance cash awards;</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63.35pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 45.35pt; text-align: left"></td>

    <td style="width: 18pt; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">prohibits the payment of dividends and dividend equivalents with respect to shares subject to an award until such shares
            have vested in accordance with the terms of the corresponding award agreement;</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63.35pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 45.35pt; text-align: left"></td>

    <td style="width: 18pt; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">prohibits the recycling of shares forfeited to cover the exercise price or withholding taxes for stock options and SARs;</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63.35pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 45.35pt; font: 10pt Times New Roman, Times, Serif; text-align: left"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">requires that each newly granted stock option, restricted stock award, RSU, SAR
            and PRSU award not become fully vested until a date at least one year after the date of grant, except in the case of (1) a sale of all or substantially all of the assets of the Company, (2) a disposition of at least 90% of the Company&#8217;s
            securities, a merger or other similar transaction after which the Company is not the surviving corporation, (3) a merger or other similar transaction after which the Company is the surviving corporation but the shares of common stock
            immediately preceding the transaction are exchanged into other property, (4) an award granted in exchange for previously granted awards of a company acquired by the Company and (5) awards to non-employee directors that vest on the earlier of
            the one-year anniversary of the date of grant or the next annual meeting of stockholders, provided that such vesting period may not be less than 50 weeks; and Ionis may grant up to 1,485,000 shares worth of stock options, restricted stock
            awards, RSUs, SARs or PRSU awards that vest earlier than the minimum period described above; </span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 45.35pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">provides that if any stock awards held by participants who haven&#8217;t terminated
            service prior to a corporate transaction are not assumed, continued or substituted for by the acquiror (or its parent) in the transaction, then, contingent on the closing of the transaction, the vesting (and exercisability, if applicable) of
            such awards will be accelerated in full, and with respect to any awards subject to performance-based vesting conditions, vesting will be deemed satisfied at the greater of actual performance or target level; and </span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 45.35pt"></td>

    <td style="width: 18pt; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">requires all options and SARs outstanding under the 2011 Plan to have an exercise or strike price of not less than 100% of the fair market value of
            our common stock on the date of grant.</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Purpose</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">The main purpose of the 2011 Plan is to
      allow us to give our employees (including officers), Directors and consultants an opportunity to benefit from increases in value of our common stock through the granting of a combination of stock options and RSUs. We believe providing our employees a
      combination of stock options and RSUs allows us to: </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 45.35pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">retain the highest quality employees while motivating all employees to achieve key
            drivers of stock value;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 45.35pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">issue fewer shares, thereby reducing dilution; </span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 45.35pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td style="text-align: left; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">better align employee and stockholder interests; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 45.35pt"></td>

    <td style="width: 18pt; text-align: left"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">&#9679;</span></td>

    <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">encourage long-term holding by executive employees because stock settlement for RSUs does not necessarily require a same-day-sale.</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">In 2022, we granted our employees a
      combination of stock options and RSUs under our 2011 Plan, where we allocated 50% of the grant date dollar value to stock options and allocated 50% of the value to RSUs; and assumed that each share subject to an RSU was worth two shares subject to a
      stock option. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">31</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Background</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">The terms of the 2011 Plan provide for the
      grant of stock options, SARs, restricted stock awards, RSUs, PRSU awards and performance cash awards that may be settled in cash, stock, or other property.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shares Available for Awards</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">If this Proposal 4 is approved, there
      will be a total of 35,200,000 shares of our common stock authorized for issuance under the 2011 Plan. If this Proposal 4 is not approved, there will only be approximately 3.2 million shares available for issuance under the 2011 Plan as of March 31,
      2023, which, given our future hiring projections, we expect will not be sufficient to maintain our stock award practices for new employees or for promotions or merit awards for current employees.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">The following table summarizes the equity
      awards granted over the last three years, and through March 31, 2023, to our employees under our equity plans. We grant most of our equity awards for each year in January of such year as part of the annual merit compensation process. We have not
      attempted to forecast our future grant activity due to the number of assumptions that would be necessary to do so and the potential unpredictability of such underlying assumptions and estimates. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="vertical-align: bottom; background-color: #A20067; font: 10pt Times New Roman, Times, Serif">

    <td style="white-space: nowrap; border-top: Black 1pt solid; border-right: black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt" colspan="5">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Equity Award Grant History Under Employee Equity
                Plans<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></p>
        </td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="width: 33%; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: left; text-indent: 0in" rowspan="2"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="width: 16%; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; border-right: Black 1pt solid; text-align: center; text-indent: 0in" rowspan="2"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: black"><b>2020</b></span></td>

    <td style="width: 17%; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; border-right: Black 1pt solid; text-align: center; text-indent: 0in" rowspan="2"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: black"><b>2021</b></span></td>

    <td style="width: 15%; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in" rowspan="2"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: black"><b>2022</b></span></td>

    <td style="width: 19%; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; border-right: Black 1pt solid; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: black"><b>2023</b></span></td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: black"><b>(through March 31st)</b></span></td>

  </tr>

  <tr style="background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: black">Shares subject to equity awards granted</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">3,892,931&#160; </span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">4,888,667&#160; </span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">5,245,896&#160; </span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">4,240,416</span></td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: black">Shares subject to equity awards canceled</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">(712,131)</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">(2,103,394)</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">(2,464,566)</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">(1,356,954)</span></td>

  </tr>

  <tr style="background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: black">Net shares subject to equity awards<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">3,180,800&#160; </span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">2,785,273&#160; </span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">2,781,330&#160; </span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 6pt 5.4pt; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: black;">2,883,462</span></td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 27.35pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">(1)</span></td>

    <td style="text-align: left; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">Amounts shown reflect grants under our 2020 Plan, 2011 Plan and 89 Plan. We
            currently grant equity awards to our non-employee Directors separately under our Non-Employee Directors Stock Option Plan.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 27.35pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">(2)</span></td>

    <td style="text-align: left; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">Shares subject to equity awards that are canceled, forfeited, or withheld for
            taxes (except shares withheld for taxes for options and SARs) become available for re-issuance under the applicable equity plan. Therefore, net shares for any year is the total shares subject to awards granted in that year less the shares
            subject to awards canceled, forfeited, or withheld for taxes in such year.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; color: #CE0F69; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal"><i>Limited Recycling of
        Shares Related to Options and SARs</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; color: #CE0F69; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">We prohibit the recycling of shares we
      reacquire pursuant to our withholding obligations in connection with a stock option or SAR or as consideration for the exercise of a stock option or SAR and such reacquired shares will <i>not </i>become available for issuance under the 2011 Plan. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Eligibility</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">All of our employees in the United States
      and our Directors and consultants are eligible to participate in the 2011 Plan. Our practice, however, is not to grant awards to consultants or non-employee Directors under the 2011 Plan. As of March 31, 2023, we had a total of 758 employees who were
      eligible to participate in the 2011 Plan.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.65pt"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">32</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Administration</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Our Board administers the 2011 Plan. The Board may delegate authority to
      administer the 2011 Plan to a committee but may retain the authority to concurrently administer the 2011 Plan with the committee and may, at any time, revest in itself some or all of the powers previously delegated to the committee. Our Board has
      delegated administration of the 2011 Plan to the Compensation Committee.&#160; Subject to the terms of the 2011 Plan, the Compensation Committee may determine the recipients, numbers, and types of stock awards to be granted, and terms and conditions of
      the stock awards, including the period of their exercisability and vesting. Subject to the limitations set forth below, the Compensation Committee also determines the fair market value applicable to a stock award and the exercise price of stock
      options and SARs granted under the 2011 Plan.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">At the discretion of the Board, the
      Compensation Committee may consist solely of two or more &#8220;non-employee directors&#8221; within the meaning of Rule 16b-3 of the Securities Exchange Act of 1934, as amended (the &#8220;</span><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Exchange Act</i><span style="font-weight: normal">&#8221;).&#160; We also have a Non-Management Stock Award Committee that, as delegated by the Compensation Committee, awards stock awards to employees who are below director level in accordance with
        guidelines adopted by the Compensation Committee.&#160; The Non-Management Stock Award Committee has one member, Dr. Monia.&#160; As used herein, except as explicitly stated otherwise, with respect to the 2011 Plan, the &#8220;Board&#8221; refers to any committee the
        Board appoints or, if applicable, any subcommittee, as well as to the Board itself.</span></span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>No Repricing, &#8220;Cash-Out,&#8221; or Cancellation and Re-Grant of
        Stock Awards without Stockholder Approval</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">Under the 2011 Plan, the Board cannot
      reprice any outstanding options or SARs by reducing the exercise price of the stock award or cancel any outstanding options or SARs in exchange for cash or other stock awards without obtaining the approval of our stockholders within 12 months prior
      to the repricing or cancellation and re-grant event.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: -0.7pt; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Minimum Vesting; Restrictions on
      Accelerated Vesting</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: -0.7pt; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Under the 2011 Plan, no stock award granted to an employee or member of
      the Board will become 100% vested in a period of less than one year after the grant of such award, <i>except that </i>the vesting of a stock award may accelerate (or may be accelerated by the Board or Compensation Committee) in the case of (1) a
      sale of all or substantially all of the assets of the Company, (2) a disposition of at least 90% of the Company&#8217;s securities, a merger or other similar transaction after which the Company is not the surviving corporation, (3) a merger or other
      similar transaction after which the Company is the surviving corporation but the shares of common stock immediately preceding the transaction are exchanged into other property, (4) an award granted in exchange for previously granted awards of a
      company acquired by the Company and (5) awards to non-employee directors that vest on the earlier of the one-year anniversary of the date of grant or the next annual meeting of stockholders, provided in such case that such vesting period may not be
      less than 50 weeks; and Ionis may grant up to 1,485,000 shares worth of stock options, restricted stock awards, RSUs, SARs or PRSU awards that vest earlier than the minimum period described above.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Dividends and Dividend Equivalents</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The 2011 Plan prohibits the payment of dividends and dividend equivalents
      with respect to shares subject to an award until such shares have vested in accordance with the terms of the corresponding award agreement.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>No Evergreen</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The 2011 Plan does not include an automatic share reserve increase
      provision (i.e., an evergreen provision).</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Stock Options</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board grants stock options under the 2011 Plan pursuant to stock
      option agreements.&#160; The 2011 Plan permits the grant of stock options that qualify as nonstatutory stock options (&#8220;<b><i>NSOs</i></b>&#8221;).&#160; Individual stock option agreements may be more restrictive as to any or all of the permissible terms described in
      this section.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Exercise Price; Payment</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The exercise price of stock options may not be less than 100% of the fair
      market value of the common stock subject to the stock option on the date of grant.&#160; As of March 31, 2023, the closing price of our common stock as reported on the Nasdaq Global Select Market was $35.74 per share.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">33</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Vesting</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Stock options granted under the 2011 Plan may become exercisable in
      cumulative increments, or &#8220;vest,&#8221; as determined by our Board at the rate specified in the stock option agreement, subject to the minimum vesting requirements described above.&#160; Shares covered by different stock options granted under the 2011 Plan may
      be subject to different vesting schedules as our Board may determine.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Term</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">In general, the term of stock options granted under the 2011 Plan was
      previously seven years, which we increased to ten years beginning with grants made in January 2022. The 2011 Plan does not allow stock options to have a term that exceeds ten years.&#160; Unless the terms of an option holder&#8217;s stock option agreement or
      other agreement with the Company provides for earlier or later termination:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif">

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    <td style="vertical-align: top; width: 3%; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="vertical-align: top; width: 94%; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">if an option holder&#8217;s service relationship with us,
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  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

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    <td style="vertical-align: top; width: 3%; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

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    <td style="font: 10pt Times New Roman, Times, Serif">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

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    <td style="vertical-align: top; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">if an option holder&#8217;s service relationship with us, or any
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    <td style="text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif">&#160;</td>

    <td style="vertical-align: top; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif">&#160;</td>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Under the 2011 Plan, the stock option term may be extended in the event
      that exercise of the stock option following termination of service is prohibited by applicable securities laws or if the sale of stock received upon exercise of a stock option would violate the Company&#8217;s insider trading policy. In no event may a
      stock option be exercised after its expiration date.</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Consideration</i></span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Our Board determines the acceptable forms of consideration for the
      purchase of our common stock pursuant to the exercise of a stock option under the 2011 Plan, which may include cash, check, bank draft or money order made payable to us, shares of our common stock, payment pursuant to a program developed under
      Regulation T as promulgated by the Federal Reserve Board, or a net exercise feature.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Transferability</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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      will or the laws of descent and distribution or a domestic relations order.&#160; However, to the extent permitted under the terms of the applicable stock option agreement, an option holder may designate a beneficiary who may exercise the stock option
      following the option holder&#8217;s death.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Restricted Stock Unit Awards</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">RSUs are granted under the 2011 Plan pursuant to restricted stock unit
      award agreements.&#160; Payment of any purchase price is made in any legal form acceptable to the Board.&#160; We settle a payment due to a recipient of a restricted stock unit award by delivery of shares of our common stock, by cash, by a combination of cash
      and stock, or in any other form of consideration determined by our Board and set forth in the restricted stock unit award agreement.&#160; We may credit dividend equivalents in respect of shares of our common stock covered by a restricted stock unit
      award; however, no dividend equivalents may be paid with respect to such shares before the date such shares have vested in accordance with the terms of the corresponding award agreement. RSUs are subject to vesting in accordance with a vesting
      schedule determined by our Board, subject to the minimum vesting requirements described earlier.&#160; Except as otherwise provided in the applicable RSU award agreement, RSUs that have not vested will be forfeited upon the participant&#8217;s termination of
      continuous service for any reason.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Restricted Stock Awards</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board may grant restricted stock awards under the 2011 Plan pursuant
      to restricted stock award agreements.&#160; The Board may grant a restricted stock award in consideration for cash, check, bank draft or money order payable to us, the recipient&#8217;s services performed for us or our affiliate, or any other form of legal
      consideration acceptable to the Board.&#160; Shares of our common stock acquired under a restricted stock award are subject to forfeiture to us in accordance with a vesting schedule determined by our Board.&#160; Holders of awards may only transfer their
      rights to acquire shares of our common stock under a restricted stock award upon such terms and conditions as are set forth in the restricted stock award agreement.&#160; We may credit dividend equivalents in respect of shares of our common stock covered
      by a restricted stock award; however, no dividend equivalents may be paid with respect to such shares before the date such shares have vested in accordance with the terms of the corresponding award agreement. Except as otherwise provided in the
      applicable restricted stock award agreement, restricted stock awards that have not vested will be forfeited upon the participant&#8217;s termination of continuous service for any reason.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">34</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Stock Appreciation Rights</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board may grant SARs under the 2011 Plan pursuant to SAR agreements.
      Each SAR is denominated in common stock share equivalents.&#160; The Board will determine the strike price of each stock appreciation right but the strike price cannot be less than 100% of the fair market value of the stock subject to the SAR at the time
      of grant.&#160; Our Board may also impose restrictions or conditions upon the vesting of SARs that it deems appropriate, subject to the minimum vesting requirements described earlier.&#160; We may settle SARs in our common stock, in cash, in a combination of
      cash and stock, or in any other form of legal consideration approved by our Board and set forth in the stock appreciation right agreement.&#160; SARs will be subject to the same conditions upon termination and restrictions on transfer as stock options
      under the 2011 Plan.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Performance Awards</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The 2011 Plan provides for the grant of two types of performance awards:
      PRSU awards and performance cash awards.&#160; The Board may grant, vest, or settle performance awards based upon the attainment of specified performance goals during a specified period of time.&#160; The Compensation Committee will determine the length of any
      performance period, the performance goals to be achieved during the performance period, and the measure of whether and to what degree such performance goals have been attained.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">In granting a performance award, the Compensation
      Committee will set a period of time, called a performance period, over which the attainment of one or more performance goals will be measured for the purpose of determining whether the award recipient has a vested right in or to such award. The
      Compensation Committee will establish the performance goals, based upon one or more criteria, called performance criteria enumerated in the 2011 Plan. As soon as administratively practicable following the end of the performance period, the
      Compensation Committee will determine whether the performance goals have been satisfied.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.7pt; text-align: left; text-indent: 26.65pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The Board is authorized to determine whether, when calculating the
      attainment of performance goals for a performance period, as follows:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="vertical-align: top; width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">to exclude restructuring and/or other nonrecurring charges;</span></td>

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  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

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    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="vertical-align: top; width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">to exclude exchange rate effects, as applicable, for non-U.S.
            dollar denominated performance goals;</span></td>

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  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

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    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="vertical-align: top; width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">to exclude the effects of changes to generally accepted
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  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

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    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="vertical-align: top; width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">to exclude the effects of any statutory adjustments to corporate
            tax rates;</span></td>

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  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

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    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="vertical-align: top; width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">to exclude the effects of items that are &#8220;unusual&#8221; in nature or
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    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

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    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="vertical-align: top; width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">to exclude accounting expenses relating to share-based
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  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Changes to Capital Structure</b></span></p>
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  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


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    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

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    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">the class(es) and maximum number of securities subject to the
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  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

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  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


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    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

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    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">the class(es) and number of securities and price per share of
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  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

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</table>
  <p style="margin-top: 0; margin-bottom: 0; text-align: center">&#160;<img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="margin-top: 0; margin-bottom: 0"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
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    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Corporate Transactions</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Unless otherwise provided in the stock award agreement, any other written
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      awards under the 2011 Plan will be assumed, continued or substituted for by any surviving or acquiring entity (or its parent company). If the surviving or acquiring entity (or its parent company) elects not to assume, continue or substitute for such
      stock awards, then (i) with respect to any such stock awards that are held by individuals whose continuous service with us or an affiliate has not terminated prior to the effective date of the corporate transaction, the vesting and exercisability
      provisions of such stock awards will be accelerated in full (and with respect to any performance stock awards, vesting will be deemed satisfied at the greater of actual performance or target level) and such awards will terminate if not exercised
      prior to the effective date of the corporate transaction, and (ii) with respect to any stock awards that are held by individuals whose continuous service with the Company or an affiliate of the Company has terminated prior to the effective date of
      the corporate transaction, the vesting and exercisability provisions of such stock awards will not be accelerated and such awards will terminate if not exercised prior to the effective date of the corporate transaction (except that any reacquisition
      or repurchase rights held by the Company with respect to such stock awards will not terminate and may continue to be exercised notwithstanding the corporate transaction).</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="vertical-align: top; width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">a sale of all or substantially all of our consolidated assets;</span></td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

  </tr>


</table>
  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="vertical-align: top; width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">a sale of at least 90% of our outstanding securities;</span></td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

  </tr>


</table>
  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="vertical-align: top; width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">a merger or consolidation in which we are not the surviving
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  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

  </tr>


</table>
  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

    <td style="vertical-align: top; width: 20.15pt; text-align: left; text-indent: 0in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9679;</span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">a merger or consolidation in which we are the surviving
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  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0in">&#160;</td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The acceleration of vesting of an award in the event of a corporate
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Change in Control</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">A stock award will not be subject to additional acceleration of vesting
      and exercisability in connection with a change in control (as defined in the 2011 Plan), except upon certain termination events that are in connection with a change in control as provided in the stock award agreement for such stock award or as
      otherwise may be provided in any other written agreement between us or any affiliate and the participant. In such a case, the stock award agreement or other written agreement may provide that vesting (and, if applicable, exercisability) of time-based
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; font-weight: normal">The acceleration of vesting of an award in the event
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Plan Amendments</b></span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Our Board has the authority to amend or terminate the 2011 Plan.&#160;
      However, no amendment or termination of the plan will adversely affect any rights under awards already granted to a participant unless agreed to by the affected participant. We will obtain stockholder approval of any amendment to the 2011 Plan as
      required by applicable law and listing requirements.&#160; We will not seek to amend the prohibition on option repricing or &#8220;cashing-out&#8221; without obtaining such stockholder approval.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Plan Termination</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Unless sooner terminated by our Board, the 2011 Plan will automatically
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">36</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Federal Income Tax Information </b></span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The information set forth below is a summary only and does not purport to
      be complete.&#160; The information is based upon current federal income tax rules and therefore is subject to change when those rules change.&#160; Because the tax consequences to any recipient may depend on his or her particular situation, each recipient
      should consult the recipient&#8217;s tax adviser regarding the federal, state, local, and other tax consequences of the grant or exercise of an award or the disposition of stock acquired as a result of an award.&#160; The 2011 Plan is not qualified under the
      provisions of Section 401(a) of the Code and is not subject to any of the provisions of the Employee Retirement Income Security Act of 1974.&#160; Our ability to realize the benefit of any tax deductions described below depends on our generation of
      taxable income, as well as the requirement of reasonableness and the satisfaction of our tax reporting obligations.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Nonstatutory Stock Options</i></span></p>
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      option is granted with an exercise price equal to the fair market value of the underlying stock on the grant date.&#160; On exercise, an option holder will recognize ordinary income equal to the excess, if any, of the fair market value of the underlying
      stock on the date of exercise of the stock option over the exercise price.&#160; If the option holder is employed by us or one of our affiliates, that income will be subject to withholding taxes.&#160; The option holder&#8217;s tax basis in those shares will be
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Subject to the requirement of reasonableness, the provisions of Section
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Restricted Stock Unit Awards</i></span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Generally, the recipient of a restricted stock unit award structured to
      comply with the requirements of Section 409A of the Code or an exemption to Section 409A of the Code will recognize ordinary income at the time the stock is delivered equal to the excess, if any, of the fair market value of the shares of our common
      stock received over any amount paid by the recipient in exchange for the shares of our common stock.&#160; To comply with the requirements of Section 409A of the Code, the shares of our common stock subject to a restricted stock unit award may generally
      only be delivered upon one of the following events: a fixed calendar date (or dates), separation from service, death, disability or a change in control.&#160; If delivery occurs on another date, unless the restricted stock unit award otherwise complies
      with or qualifies for an exemption to the requirements of Section 409A of the Code, in addition to the tax treatment described above, the recipient will owe an additional 20% federal tax and interest on any taxes owed.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The recipient&#8217;s basis for the determination of gain or loss upon the
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Subject to the requirement of reasonableness, the provisions of Section
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Restricted Stock Awards</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Generally, the recipient of a restricted stock award will recognize
      ordinary income at the time the stock is received equal to the excess, if any, of the fair market value of the stock received over any amount paid by the recipient in exchange for the stock.&#160; If, however, the stock is not vested when it is received
      (for example, if the employee is required to work for a period of time in order to have the right to sell the stock), the recipient generally will not recognize income until the stock becomes vested, at which time the recipient will recognize
      ordinary income equal to the excess, if any, of the fair market value of the stock on the date it becomes vested over any amount paid by the recipient in exchange for the stock.&#160; A recipient may, however, file an election with the Internal Revenue
      Service, within 30 days following his or her receipt of the stock award, to recognize ordinary income, as of the date the recipient receives the award, equal to the excess, if any, of the fair market value of the stock on the date the award is
      granted over any amount paid by the recipient for the stock.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The recipient&#8217;s basis for the determination of gain or loss upon the
      subsequent disposition of shares acquired from a restricted stock award will be the amount paid for such shares plus any ordinary income recognized either when the stock is received or when the stock becomes vested.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 37.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><span style="font: 10pt Times New Roman, Times, Serif"><img alt="" src="ny20007094x2_def14aimg003.jpg" />&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 37.8pt"></p>
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    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">37</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
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  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Subject to the requirement of reasonableness, the provisions of Section
      162(m) of the Code, and the satisfaction of our tax reporting obligation, we will generally be entitled to a tax deduction equal to the taxable ordinary income realized by the recipient of the restricted stock award.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Stock Appreciation Rights</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">We may grant stock appreciation rights under the Amended 2011 Plan
      separate from any other award or together with other awards under the 2011 Plan.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Generally, if a stock appreciation right is granted with an exercise
      price equal to the fair market value of the underlying stock on the grant date, the recipient will recognize ordinary income equal to the fair market value of the stock or cash received upon such exercise.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 20.15pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Subject to the requirement of reasonableness, the provisions of Section
      162(m), and the satisfaction of our tax reporting obligation, we will generally be entitled to a tax deduction equal to the taxable ordinary income realized by the recipient of the stock appreciation right.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Section 162(m) Limitations</i></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 19.8pt; color: #CE0F69"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Section 162(m) disallows a deduction to any publicly held corporation and
      its affiliates for certain compensation paid to &#8220;covered employees&#8221; in a taxable year to the extent that compensation paid to a covered employee exceeds $1 million. The exemption from Section 162(m)&#8217;s deduction limit for performance-based
      compensation has been repealed, effective for taxable years beginning after December 31, 2017, such that compensation paid to our covered employees in excess of $1 million will not be deductible unless it qualifies for transition relief applicable to
      certain arrangements in place as of November 2, 2017, and not modified in any material respect on or after such date. As a result, compensation (including compensation pursuant to awards granted under the 2011 Plan) paid to any of our &#8220;covered
      employees&#8221; under Section 162(m) in excess of $1 million per taxable year generally will not be deductible.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>New Plan Benefits</b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;Awards granted under the 2011 Plan to our executive officers and other
      employees are discretionary and are not subject to set benefits or amounts under the terms of the 2011 Plan, and our Board and our Compensation Committee have not granted any awards under the 2011 Plan subject to stockholder approval of this Proposal
      2. Accordingly, the future benefits or amounts that will be received by or allocated to our executive officers and other employees under the 2011 Plan are not determinable.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 19.8pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Plan Benefits </b></span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 22.5pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The following table sets forth, for each of the individuals indicated, the
      total number of shares subject to awards that have been granted under the 2011 Plan as of March 31, 2023.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="vertical-align: top; background-color: #A20067; font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; border-top: Black 1pt solid; padding-top: 2pt; padding-bottom: 6pt" colspan="4">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 84.95pt; color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>PLAN BENEFITS</b></span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 84.95pt; color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2011 PLAN</b></span></p>
        </td>

    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; border-top: Black 1pt solid; padding-top: 2pt; padding-bottom: 6pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="width: 44%; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: black"><b>Name and Position</b></span></td>

    <td style="width: 18%; font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Total Number of</b></span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Shares</b></span></p>
        </td>

    <td style="width: 13%; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Options</b></span></td>

    <td style="width: 13%; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>RSUs</b></span></td>

    <td style="width: 12%; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>PRSUs</b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></span></td>

  </tr>

  <tr style="background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Brett Monia</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 7.7pt; text-align: left; text-indent: -7.7pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Executive Officer</span></p>
        </td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;1,205,292 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;757,513 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;272,339 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;175,440 </span></td>

  </tr>

  <tr style="background-color: white; font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Elizabeth L. Hougen</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 7.7pt; text-align: left; text-indent: -7.7pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Executive Vice President and Chief Financial Officer</span></p>
        </td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;436,383 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;330,048 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;89,948 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;16,387 </span></td>

  </tr>

  <tr style="background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Joseph T. Baroldi</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 7.7pt; text-align: left; text-indent: -7.7pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Executive Vice President, Chief Business Officer</span></p>
        </td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;170,609 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;106,365 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;58,099 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;6,145 </span></td>

  </tr>

  <tr style="background-color: white; font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Onaiza Cadoret-Manier</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 7.7pt; text-align: left; text-indent: -7.7pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Executive Vice President, Chief Global Product Strategy
              and Operations Officer</span></p>
        </td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;263,878 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;164,577 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;82,914 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;16,387 </span></td>

  </tr>

  <tr style="background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Richard S. Geary</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 7.7pt; text-align: left; text-indent: -7.7pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Executive Vice President, Chief Development Officer</span></p>
        </td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;414,548 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;320,327 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;79,410 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;14,811 </span></td>

  </tr>

  <tr style="background-color: white; font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; padding-left: 7.7pt; text-align: left; text-indent: -7.7pt; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">All Executive Officers as a Group</span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">4,122,751 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;2,904,447 </span></td>

    <td style="vertical-align: top; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0in; border-bottom: Black 1pt solid; border-right: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;923,275 </span></td>

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  </tr>

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  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0">&#160;</p>
  <!-- Field: Rule-Page -->
  <div style="margin-bottom: 6pt; text-align: left;">
    <div style="font-size: 1pt; border-top: Black 1pt solid; width: 20%">&#160;</div>

  </div>

  <!-- Field: /Rule-Page -->
  <p style="margin-top: 0; margin-bottom: 0"></p>
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  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 0.25in; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 0.25in; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(1)</span></td>

    <td style="text-align: left; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Reflects the target payout of shares under the PRSU awards.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Please see page 47 for information regarding outstanding options and shares
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  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#160;</span></p>
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  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
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  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.65pt; text-align: center; text-indent: 0in; color: #A20067">PROPOSAL 5</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.65pt; text-align: center; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.65pt; text-align: center; text-indent: 0in; color: #A20067">RATIFY INCREASING THE VESTING OF FUTURE INITIAL STOCK OPTION AND RESTRICTED STOCK
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  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.65pt; text-align: center; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20pt">In this Proposal 5, we are requesting our stockholders ratify increasing the vesting of future initial stock
    option and restricted stock unit awards of our new non-employee Directors upon joining the Board such that all initial awards granted under the Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors&#8217; Stock Option Plan will vest equally over three
    years on each annual anniversary of the date of grant. These initial awards currently vest on the one-year anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders, whichever occurs earlier.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">The affirmative vote of the holders of a majority of the shares present or represented by
    proxy at the Annual Meeting and entitled to vote on the matter will be required to ratify increasing the vesting of future initial stock option and restricted stock unit awards to new non-employee Directors from one year to three years. If you indicate
    on your proxy to &#8220;Abstain&#8221; from voting, it will have the same effect as an &#8220;Against&#8221; vote for this Proposal 5. Broker non-votes will have no effect on the outcome of the vote.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: #A20067"><b>THE BOARD UNANIMOUSLY RECOMMENDS A VOTE &#8220;FOR&#8221; APPROVAL OF PROPOSAL 5.</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.65pt; text-align: left; text-indent: -0.65pt">DESCRIPTION OF THE 2002 NON-EMPLOYEE DIRECTORS&#8217; STOCK OPTION PLAN</p>
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  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.65pt; text-align: left; text-indent: 26.35pt"><span style="font-weight: normal">Below is a high-level summary of the terms of the 2002
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      Director&#8217;s Plan. We encourage our stockholders to read the actual text of the Amended Directors Plan in its entirety, a copy of which we filed with this Proxy Statement as Appendix B. References in this Proposal 5 to our Board of Directors include
      the Compensation Committee of the Board, where applicable.</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.65pt; text-align: left; text-indent: 26.35pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067"><b>Purpose</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">The purpose of the Amended Directors&#8217; Plan is to:</p>
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  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in; text-align: left">&#9679;</td>

    <td><span style="font-size: 10pt">retain the services of persons now serving as our non-employee Directors;</span></td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%">


  <tr>

    <td style="width: 0.5in; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; width: 0.25in; text-align: left; text-indent: 0in">&#9679;</td>

    <td style="vertical-align: top; text-align: left; text-indent: 0in"><span style="font-size: 10pt">attract and retain the services of persons capable of serving on our Board; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%">


  <tr>

    <td style="width: 0.5in; text-align: left; text-indent: 0in">&#160;</td>

    <td style="vertical-align: top; width: 0.25in; text-align: left; text-indent: 0in">&#9679;</td>

    <td style="vertical-align: top; text-align: left; text-indent: 0in"><span style="font-size: 10pt">incentivize our non-employee Directors to exert maximum efforts to promote our success.</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067"><b>Administration</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">Our Board administers the Amended Directors&#8217; Plan.&#160; Our Board is empowered to delegate administration of the
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>Stock Subject to the Amended Directors&#8217; Plan</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">An aggregate of 2.8 million shares of common stock are authorized by the Board for issuance under the Amended
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067"><b>Eligibility, Option Grants, RSU Awards</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">The Amended Directors&#8217; Plan provides that we may only grant options and RSU awards to a non-employee
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">Options granted under the Amended Directors&#8217; Plan are nonstatutory stock options, meaning they are not
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">39</span>&#160;</div>

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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">Under the Amended Directors&#8217; Plan, awards are set at fixed amounts as follows:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 37.8pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><i>Initial Grants</i></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 73.8pt"></td>

    <td style="width: 18pt"><span style="font-family: Times New Roman, Times, Serif">&#9675;</span></td>

    <td style="text-align: left">An initial grant of a stock option to purchase shares of common stock to each person when the optionholder first becomes a non-employee Director of Ionis equal to 24,000<i>; </i>and</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 73.8pt"></td>

    <td style="width: 18pt"><span style="font-family: Times New Roman, Times, Serif">&#9675;</span></td>

    <td style="text-align: left">An initial grant of an RSU award on the 15th of the month following the end of the quarter in which the optionholder first becomes a non-employee Director of Ionis in an amount equal to 10,667.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 37.8pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><i>Annual Grants</i></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 73.8pt"></td>

    <td style="width: 18pt"><span style="font-family: Times New Roman, Times, Serif">&#9675;</span></td>

    <td style="text-align: left">An annual grant, on July 1, or the next business day should such date be on a Saturday, Sunday or holiday, of a stock option to purchase 12,000 shares of common stock to each non-employee Director; and</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 73.8pt"></td>

    <td style="width: 18pt"><span style="font-family: Times New Roman, Times, Serif">&#9675;</span></td>

    <td style="text-align: left">An annual grant, on July 1, or the next business day should such date be on a Saturday, Sunday or holiday, of an RSU award to each non-employee Director in an amount equal to 5,333.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>Terms of Options</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 19.8pt">Each option under the Amended Directors&#8217; Plan is subject to the following terms and conditions:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt"><span style="color: #E57200"><i>Vesting Schedule and Option Exercise</i>.&#160; </span>Options granted under the
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

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    <td style="text-align: left"><i>Initial Grants: </i>one-third of the shares subject to the option shall vest on each annual anniversary of the date of grant, provided that the optionholder has, during the entire year prior to such vesting date,
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  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

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    <td style="text-align: left"><i>Annual Grants: </i>100% of the shares subject to the option shall vest on the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders, whichever occurs earlier, provided
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  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt"><span style="color: #E57200"><i>Exercise Price; Payment</i>.&#160; </span>The exercise price of options granted
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt"><span style="color: #E57200"><i>Transferability; Term</i>.&#160; </span>Under the Amended Directors&#8217; Plan, an
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  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left">&#9679;</td>

    <td style="text-align: left">an optionholder&#8217;s spouse, children (by birth or adoption), stepchildren, grandchildren, or parents;</td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 19.8pt">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left">&#9679;</td>

    <td style="text-align: left">a trust or other entity established solely for the optionholder&#8217;s benefit or the benefit of the optionholder&#8217;s spouse, children (by birth or adoption), stepchildren, grandchildren, or parents for estate planning
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  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 19.8pt">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left">&#9679;</td>

    <td style="text-align: left">an organization that is exempt from taxation under Section 501(c)(3) of the Code or to which tax-deductible charitable contributions may be made under Section 170 of the Code.</td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 19.8pt">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 19.8pt">&#160;</p>
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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">40</span>&#160;</div>

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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">No option granted under the Amended Directors&#8217; Plan is exercisable by any person after the expiration of ten
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt"><span style="color: #E57200"><i>Other Provisions</i>.&#160; </span>The option agreement may contain such other
    terms, provisions and conditions not inconsistent with the Amended Directors&#8217; Plan as may be determined by the Board.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>Terms of Restricted Stock Unit Awards</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 19.8pt">Each RSU award under the Amended Directors&#8217; Plan is subject to the following terms and conditions:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt"><span style="color: #E57200"><i>Consideration.</i>&#160; </span>At the time of grant of an RSU award, the Board
    will determine the consideration, if any, to be paid by the Participant upon delivery of each share of common stock subject to the RSU award. The consideration to be paid (if any) by the Participant for each share of common stock subject to an RSU
    award may be paid in any form of legal consideration that may be acceptable to the Board, in its sole discretion, and permissible under applicable law.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt"><span style="color: #E57200"><i>Vesting.</i>&#160; </span>The Amended Directors&#8217; Plan provides that each RSU award
    vests as follows:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in">&#9679;</td>

    <td style="text-align: left"><i>Initial Grants</i>: one-third of the shares subject to the RSU shall vest on each annual anniversary of the date of grant provided that the Participant has, during the entire year prior to such vesting date,
          continuously served as a non-employee Director, employee or consultant of Ionis or one of our affiliates.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in">&#9679;</td>

    <td style="text-align: left"><i>Annual Grants</i>: 100% of the shares subject to the RSU shall vest on the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders, whichever occurs earlier, provided
          that the Participant has, during the entire period from the date of grant through such vesting date, continuously served as a non-employee Director, employee or consultant of Ionis or one of our affiliates.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt"><span style="color: #E57200"><i>Payment.</i>&#160; </span>An RSU award may be settled by the delivery of shares of
    common stock, their cash equivalent, any combination thereof or in any other form of consideration, as determined by the Board and contained in the RSU award agreement. RSU awards settle on July 15<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> of the year in which they vest.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt"><span style="color: #E57200"><i>Additional Restrictions.</i>&#160; </span>At the time of the grant of an RSU
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt"><span style="color: #E57200"><i>Dividend Equivalents.</i>&#160; </span>Dividend equivalents may be credited in
    respect of shares of common stock covered by an RSU award, as determined by the Board and contained in the RSU award agreement.&#160; At the sole discretion of the Board, such dividend equivalents may be converted into additional shares of common stock
    covered by the RSU award in such manner as determined by the Board.&#160; Any additional shares covered by the RSU award credited by reason of such dividend equivalents will be subject to all of the same terms and conditions of the underlying RSU award
    agreement to which they relate.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt"><span style="color: #E57200"><i>Termination of Continuous Service.&#160;</i></span> Except as otherwise provided in
    the applicable award agreement, such portion of the RSU award that has not vested will be forfeited upon the RSU award recipient&#8217;s termination of continuous service as a non-employee Director, or as an employee or consultant of Ionis or one of our
    affiliates.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>Adjustment Provisions</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">If any change is made in, or other event occurs with respect to, the common stock subject to the Amended
    Directors&#8217; Plan, or subject to any stock award, without the receipt of consideration by Ionis (through merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend in property other than cash, stock split,
    liquidating dividend, combination of shares, exchange of shares, change in corporate structure or other transaction not involving the receipt of consideration by Ionis) (each, a &#8220;<b><i>Capitalization Adjustment</i></b>&#8221;), the Amended Directors&#8217; Plan
    will be appropriately adjusted in the class(es) and maximum number of securities subject both to the Amended Directors&#8217; Plan pursuant to the shares reserve and to the nondiscretionary stock awards, and the outstanding stock awards will be appropriately
    adjusted in the class(es) and number of securities and price per share, if applicable, of common stock subject to such outstanding stock awards.&#160; The Board will make such adjustments, and its determination will be final, binding and conclusive.&#160; The
    conversion of any convertible securities of Ionis will not be treated as a transaction &#8220;without receipt of consideration&#8221; by Ionis.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">If there is (i) a sale or other disposition of all or substantially all of our assets, (ii) a sale or other
    disposition of at least 90% of our outstanding securities, or (iii) certain specified types of merger, consolidation or similar transactions (each, a &#8220;<b><i>Corporate Transaction</i></b>&#8221; as defined more specifically in the Amended Directors&#8217; Plan),
    any surviving or acquiring corporation may assume stock awards outstanding under the Amended Directors&#8217; Plan or may substitute similar stock awards.&#160; If any surviving or acquiring corporation does not assume the stock awards or substitute similar stock
    awards, then with respect to stock awards held by optionholders whose service with Ionis or an affiliate of Ionis has not terminated as of the effective date of the Corporate Transaction, the vesting of such stock awards (and, if applicable, the time
    during which such stock awards may be exercised) will be accelerated in full and the stock awards will terminate if not exercised (if applicable) at or prior to such effective date.&#160; With respect to stock awards outstanding under the Amended Directors&#8217;
    Plan that have been neither assumed nor substituted and that are held by award holders whose continuous service has terminated prior to the effective time of the Corporate Transaction, the vesting of the stock awards, and, if applicable, the time at
    which such stock awards may be exercised will not be accelerated unless otherwise provided in a written agreement between Ionis or any affiliate and the holder of the stock award, and such stock awards will terminate if not vested and exercised, as
    applicable, prior to the effective time of the Corporate Transaction.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">41</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">If there is a dissolution or liquidation of Ionis, then all outstanding stock awards under the Amended
    Directors&#8217; Plan will terminate immediately prior to the completion of the dissolution or liquidation.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">In the event of (i) a qualifying merger or consolidation or similar transaction, as described in the Amended
    Directors&#8217; Plan, whereby following such transaction the stockholders of Ionis immediately prior to such transaction do not own outstanding voting securities representing more than 50% of the combined voting power of the entity (or parent of the entity)
    surviving such transaction, (ii) a qualifying sale, lease, license or other disposition of all or substantially all of our assets, (iii) certain entities reporting under Section 13(d) or 14(d) of the Securities Exchange Act of 1934, as amended, (the &#8220;<b><i>Exchange





















        Act</i></b>&#8221;) acquire more than 50% of our voting power under certain qualifying circumstances, or (iv) a majority of our Board is replaced by individuals who are not nominated by members of our current Board or members nominated by our current
    Board or their nominees (each such event, a &#8220;<b><i>Change of Control</i></b>&#8221; for purposes of the Amended Directors&#8217; Plan), the vesting of any outstanding stock awards under the Amended Directors&#8217; Plan held by persons whose continuous service with
    Ionis or an affiliate of Ionis has not terminated prior to the effective date of the Change of Control will accelerate in full, and the stock awards will terminate on the earlier of 12 months following the date of the Change of Control or the
    expiration date set forth in the stock award grant.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">The acceleration of an option in the event of a Corporate Transaction or a Change in Control event may be
    viewed as an anti-takeover provision, which may have the effect of discouraging a proposal to acquire or otherwise obtain control of Ionis.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067"><b>No Repricing, &#8220;Cash-Out,&#8221; or Cancellation and Re-Grant of Options without Stockholder
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">Under the Amended Directors&#8217; Plan, the Board cannot reprice any outstanding options by reducing the exercise
    price of the stock award or cancel any outstanding options in exchange for cash or other stock awards without obtaining the approval of our stockholders within 12 months prior to the repricing or cancellation and re-grant event.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067"><b>Duration, Amendment and Termination</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">The Board at any time, and from time to time, may amend the Amended Directors&#8217; Plan.&#160; However, except as
    relating to Capitalization Adjustments (described above), no amendment will be effective unless approved by our stockholders to the extent stockholder approval is necessary to satisfy the requirements of SEC Rule 16b-3 or any Nasdaq or securities
    exchange listing requirements or such amendment seeks to amend the prohibition on option repricing/ &#8220;cashing-out.&#8221;&#160; The Board, in its sole discretion, may submit any other amendment to the Amended Directors&#8217; Plan for stockholder approval.&#160; Rights under
    any outstanding stock award granted before amendment of the Amended Directors&#8217; Plan will not be impaired by any amendment of the Amended Directors&#8217; Plan unless we request the consent of the award holder and the award holder consents in writing.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 19.8pt">Unless sooner terminated by our Board, the Amended Directors&#8217; Plan will terminate on June 1, 2030.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: #A20067"><b>Federal Income Tax Information</b></p>
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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">Upon disposition of the stock, the optionholder will recognize a capital gain or loss equal to the difference
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    date (or dates), separation from service, death, disability or a change in control. If delivery occurs on another date, unless the stock units otherwise comply with or qualify for an exception to the requirements of Section 409A of the Code, in
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 19.8pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">43</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.65pt; text-align: center; text-indent: 0in; color: #A20067">PROPOSAL 6</p>
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    accounting firm for our 2023 fiscal year and has requested management to ask for stockholder ratification at the Annual Meeting. Ernst &amp; Young LLP has audited our financial statements since we were founded in 1989. Representatives of Ernst &amp;
    Young LLP will be at the virtual Annual Meeting to answer any questions and make a statement should they desire to do so.</p>
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    accounting firm, the Audit Committee would like our stockholders&#8217; opinion as a matter of good corporate practice. If the stockholders do not ratify the selection of Ernst &amp; Young LLP, the Audit Committee will reconsider whether to keep the firm.
    However, even if the stockholders ratify the selection, the Audit Committee may choose to appoint a different independent accounting firm at any time during the year if it believes that a change would be in the best interests of our stockholders and
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>Independent Auditors&#8217; Fees; Pre-Approval Policies and Procedures</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #231F20">The Audit Committee has adopted a policy and procedure for the pre-approval of audit and
    permissible non-audit services rendered by our independent registered public accounting firm, Ernst &amp; Young LLP. The policy generally pre-approves specific services in the defined categories of audit services, audit-related services, and tax
    services up to pre-determined amounts. The Audit Committee may pre-approve services as part of its approval of the scope of the engagement of the independent auditor or on an individual explicit case-by-case basis before the Audit Committee engages the
    independent registered public accounting firm to provide each service. The Audit Committee pre-approved all of the services described below.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #231F20">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">Audit Fees</p>
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      &amp; Young LLP billed us approximately $1.9 million and $1.7 million, respectively, primarily related to the integrated audit of our financial statements and reviews of our interim financial statements. In addition, Ernst &amp; Young LLP billed us
      approximately $180,000 and approximately $400,000 in 2022 and 2021, respectively, related to corporate transactions.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; color: #231F20; text-align: left; text-indent: 22.5pt">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">44</span>&#160;</div>

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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT</b></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #231F20">This table outlines the ownership of our common stock as of March 31, 2023 by:</p>
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    <td style="width: 0.25in"></td>

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    <td style="text-align: left"><span style="color: #231F20">each Director and nominee for Director;</span></td>

  </tr>


</table>
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    <td style="text-align: left"><span style="color: #231F20">each named executive officer;</span></td>

  </tr>


</table>
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    <td style="width: 0.25in"></td>

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    <td style="text-align: left"><span style="color: #231F20">all Directors and executive officers as a group; and</span></td>

  </tr>


</table>
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    <td style="text-align: left"><span style="color: #231F20">every entity that we know beneficially owns more than five percent of our common stock.</span></td>

  </tr>


</table>
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    <td style="text-align: left">&#160;</td>

    <td style="color: #CE0F69; font-weight: bold; padding-bottom: 1pt">&#160;</td>

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  </tr>

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    <td style="color: #CE0F69; font-weight: bold; padding-bottom: 1pt">&#160;</td>

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    <td style="width: 70%; text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">FMR LLC<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></span></td>

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    <td style="width: 12%; text-align: right;">21,307,519</td>

    <td style="width: 1%; text-align: right;">&#160;</td>

    <td style="width: 1%; text-align: right;">&#160;</td>

    <td style="width: 1%; text-align: right;">&#160;</td>

    <td style="width: 12%; text-align: right;">14.90%</td>

    <td style="width: 1%; text-align: left"><br />
        </td>

  </tr>

  <tr style="vertical-align: bottom; background-color: #E7E6E6">

    <td style="text-align: left; text-indent: 0in">245 Summer Street</td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: 0in">&#160;</td>

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    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left; text-indent: 0in">&#160;</td>

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    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">BB Biotech AG<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(6) </sup></span></td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt">Schwertstrasse 6</td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left">CH-8200, Schaffhausen <br />
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    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt">&#160;</td>

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    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">BlackRock, Inc.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(7) </sup></span></td>

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    <td style="text-align: right;">9,182,911</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">55 East 52<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup> Street </span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: left">&#160;<br />
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    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt">&#160;</td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Spencer R. Berthelsen <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(8)</sup></span></td>

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    <td style="text-align: right;">256,217</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: right;"><span style="font-size: 10pt;">*</span></td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Allene M. Diaz<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(9)</sup></span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">26,000</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;"><span style="font-size: 10pt;">*</span></td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Michael Hayden<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(10)</sup></span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">93,109</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;"><span style="font-size: 10pt;">*</span></td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Joan Herman<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">86,665</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;"><span style="font-size: 10pt;">*</span></td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Joseph Klein, III<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(12)</sup></span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">118,891</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;"><span style="font-size: 10pt;">*</span></td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Joseph Loscalzo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(13)</sup></span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">172,472</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;"><span style="font-size: 10pt;">*</span></td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">B. Lynne Parshall<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(14)</sup></span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">358,691</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;"><span style="font-size: 10pt;">*</span></td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Joseph H. Wender<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(15)</sup></span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">220,969</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Joseph Baroldi<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(16)</sup></span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">35,379</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;"><span style="font-size: 10pt;">*</span></td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Frank Bennett<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(17)</sup></span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">294,153</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Brian Birchler<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(18)</sup></span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">178,634</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Onaiza Cadoret-Manier<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(19)</sup></span></td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">106,566</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Richard Geary<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(20)</sup></span></td>

    <td>&#160;</td>

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    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Elizabeth L. Hougen<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(21)</sup></span></td>

    <td>&#160;</td>

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    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Brett Monia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(22)</sup></span></td>

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    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">629,296</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left">&#160;</td>

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    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">248,670</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

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    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">Eugene Schneider<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(24)</sup></span></td>

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    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">166,306</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;"><span style="font-size: 10pt;">*</span></td>

    <td style="text-align: left">&#160;</td>

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    <td style="text-align: left; text-indent: 0in"><span style="font-size: 10pt">Eric Swayze<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(25)</sup></span></td>

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    <td style="text-align: left">&#160;</td>

    <td style="text-align: right;">182,444</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;"><span style="font-size: 10pt;">*</span></td>

    <td style="text-align: left">&#160;</td>

  </tr>

  <tr style="vertical-align: bottom; background-color: #E7E6E6">

    <td style="text-align: left; text-indent: -7.7pt; padding-left: 7.7pt"><span style="font-size: 10pt">All Directors and executive officers as a group (eighteen persons)<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(26)</sup></span></td>

    <td>&#160;</td>

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    <td style="text-align: right;">3,792,257</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">&#160;</td>

    <td style="text-align: right;">2.65%</td>

    <td style="text-align: left"><br />
        </td>

  </tr>

  <tr style="vertical-align: bottom; background-color: white">

    <td style="text-align: left; text-indent: 0in">&#160;</td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right">&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td>&#160;</td>

    <td style="text-align: left">&#160;</td>

    <td style="text-align: right">&#160;</td>

    <td style="text-align: left">&#160;</td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">45</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <!-- Field: Rule-Page -->
  <div style="margin-top: 0pt; margin-bottom: 3pt; text-align: left;">
    <div style="font-size: 1pt; border-top: Black 1pt solid; width: 20%">&#160;</div>

  </div>

  <!-- Field: /Rule-Page -->
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">*Less than one percent</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(1)</td>

    <td style="text-align: left">We base this table upon information supplied by officers, Directors, principal stockholders, and Form 3s, Form 4s, Form 5s, Schedules 13D and 13G filed with the SEC.&#160; Unless otherwise indicated in the footnotes to this
          table and subject to community property laws where applicable, we believe that each of the stockholders named in this table has sole voting and investment power with respect to the shares indicated as beneficially owned.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(2)</td>

    <td style="text-align: left">Applicable percentages are based on 143,022,539 shares of common stock outstanding on March 31, 2023, adjusted as required by rules promulgated by the SEC.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(3)</td>

    <td style="text-align: left">FMR LLC has sole voting power to direct the vote of 21,305,988 shares and sole power to dispose or direct the disposition of 21,307,519 shares. The Fidelity Growth Company Commingled Pool holds the interest of 9,164,615
          shares of our common stock, which amounts to 6.41% of our total outstanding as of March 31, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.5in; text-align: left; text-indent: 0in">Abigail P. Johnson is a Director, the Chairman, and the Chief Executive Officer of FMR LLC. Members of the
    Johnson family, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of FMR LLC, representing 49% of the voting power of FMR LLC. The Johnson family group and all other Series B
    shareholders have entered into a shareholders&#8217; voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common
    shares and the execution of the shareholders&#8217; voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to form a controlling group with respect to FMR LLC.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.5in; text-align: left; text-indent: 0in">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(4)</td>

    <td style="text-align: left">The Vanguard Group has shared voting power to direct the vote of 63,584 shares, sole power to dispose or direct the disposition of 13,349,072 shares, and shared dispositive power for 197,622 shares.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(5)</td>

    <td style="text-align: left">T. Rowe Price Investment Management, Inc. has sole voting power to direct the vote of 4,452,321 shares and sole power to dispose or direct the disposition of 11,678,259 shares.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(6)</td>

    <td style="text-align: left">BB Biotech AG shares voting and dispositive powers for its shares with Biotech Invest N.V.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(7)</td>

    <td style="text-align: left">BlackRock, Inc. is a parent holding company and various persons have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of shares of our common stock. BlackRock has
          sole voting power to direct the vote of 8,795,247 shares and sole power to dispose or direct the disposition of 9,182,911 shares.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(8)</td>

    <td style="text-align: left">Includes 70 shares owned by Dr. Berthelsen&#8217;s daughter for which he disclaims beneficial ownership.&#160; Includes 127,250 shares of common stock issuable upon exercise of options held by Dr. Berthelsen that are exercisable
          on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(9)</td>

    <td style="text-align: left">Includes 18,000 shares of common stock issuable upon exercise of options held by Ms. Diaz that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(10)</td>

    <td style="text-align: left">Includes 68,000 shares of common stock issuable upon exercise of options held by Dr. Hayden that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(11)</td>

    <td style="text-align: left">Includes 60,000 shares of common stock issuable upon exercise of options held by Ms. Herman that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(12)</td>

    <td style="text-align: left">Includes 6,100 shares held in trusts for the benefit of Mr. Klein&#8217;s three children, 20,000 shares of common stock issuable upon exercise of options held by Mr. Klein that are exercisable on or before April 30, 2023, and
          76,000 shares of common stock issuable upon exercise of options held in trusts for the benefit of Mr. Klein&#8217;s three children that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(13)</td>

    <td style="text-align: left">Includes 138,500 shares of common stock issuable upon exercise of options held by Dr. Loscalzo that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(14)</td>

    <td style="text-align: left">Includes 273,213 shares of common stock issuable upon exercise of options held by Ms. Parshall that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">46</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(15)</td>

    <td style="text-align: left">Includes 104,969 shares of common stock held by Mr. Wender in a trust, and 116,000 shares of common stock issuable upon exercise of options held by Mr. Wender that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(16)</td>

    <td style="text-align: left">Includes 851 shares of common stock held by Mr. Baroldi&#8217;s wife, 27,093 shares of common stock issuable upon exercise of options held by Mr. Baroldi that are exercisable on or before April 30, 2023, and 3,822 shares of
          common stock issuable upon exercise of options held by Mr. Baroldi&#8217;s wife that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(17)</td>

    <td style="text-align: left">Includes 224,119 shares of common stock issuable upon exercise of options held by Dr. Bennett that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(18)</td>

    <td style="text-align: left">Includes 143,309 shares of common stock issuable upon exercise of options held by Mr. Birchler that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(19)</td>

    <td style="text-align: left">Includes 85,339 shares of common stock issuable upon exercise of options held by Ms. Cadoret-Manier that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(20)</td>

    <td style="text-align: left">Includes 222,636 shares of common stock issuable upon exercise of options held by Dr. Geary that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(21)</td>

    <td style="text-align: left">Includes 246,540 shares of common stock issuable upon exercise of options held by Ms. Hougen that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(22)</td>

    <td style="text-align: left">Includes 483,991 shares of common stock issuable upon exercise of options held by Dr. Monia that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(23)</td>

    <td style="text-align: left">Includes 206,788 shares of common stock issuable upon exercise of options held by Mr. O&#8217;Neil that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(24)</td>

    <td style="text-align: left">Includes 130,254 shares of common stock issuable upon exercise of options held by Dr. Schneider that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(25)</td>

    <td style="text-align: left">Includes 149,928 shares of common stock issuable upon exercise of options held by Dr. Swayze that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 9pt"></td>

    <td style="width: 27pt">(26)</td>

    <td style="text-align: left">Includes an aggregate of 2,820,782 shares issuable upon exercise of options held by all current Directors and executive officers as a group that are exercisable on or before April 30, 2023.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">Securities Authorized for Issuance Under Equity Compensation Plans</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">The following table sets forth information regarding outstanding options and shares reserved
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">


  <tr style="vertical-align: bottom; background-color: #A20067">

    <td style="border-top: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; text-align: left; padding-left: 0.125in; text-indent: -0.125in"><span style="font-size: 10pt; color: white">&#160;<b>Plan&#160;Category</b></span></td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-top: black 1pt solid; border-bottom: black 1pt solid" colspan="2">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white"><b>Number of <br />
              Shares</b></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white"><b>to be Issued</b></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white"><b>Upon Exercise of</b></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white"><b>Outstanding<br />
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              Warrants and<br />
              Rights</b></p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-top: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-top: black 1pt solid; border-bottom: black 1pt solid" colspan="2">
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              Average</b></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white"><b>Exercise Price<br />
              of</b></p>
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              Options,<br />
              Warrants and<br />
              Rights</b></p>
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    <td style="border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-top: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid" colspan="3">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white"><b>Number of Shares</b></p>
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        </td>

  </tr>

  <tr style="vertical-align: bottom">

    <td style="border-bottom: black 1pt solid; border-left: black 1pt solid; text-align: left; padding-left: 0.125in; text-indent: -0.125in"><span style="font-size: 10pt">Equity compensation plans approved by stockholders<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: right; text-indent: 0in"><span style="font-size: 10pt">17,880,481</span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: left; text-indent: 0in"><span style="font-size: 10pt">$</span></td>

    <td style="border-bottom: black 1pt solid; text-align: right; text-indent: 0in"><span style="font-size: 10pt">50.57</span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in"><span style="font-size: 10pt">&#160;&#160;</span></td>

    <td style="border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: Black 1pt solid; text-align: right; text-indent: 0in"><span style="font-size: 10pt">8,158,690</span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in"><span style="font-size: 10pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></span></td>

  </tr>

  <tr style="vertical-align: bottom; background-color: #D9D9D9">

    <td style="border-bottom: black 1pt solid; border-left: black 1pt solid; text-align: left; width: 53%; padding-left: 0.125in; text-indent: -0.125in"><span style="font-size: 10pt">Equity compensation plans not approved by stockholders</span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in; width: 1%">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: left; text-indent: 0in; width: 1%">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: right; text-indent: 0in; width: 12%"><span style="font-size: 10pt">--</span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: center; text-indent: 0in; width: 1%">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: center; text-indent: 0in; width: 1%">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: center; text-indent: 0in; width: 1%">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: right; text-indent: 0in; width: 12%"><span style="font-size: 10pt">--</span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: center; text-indent: 0in; width: 1%">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: center; text-indent: 0in; width: 1%">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: center; text-indent: 0in; width: 1%">&#160;</td>

    <td style="border-bottom: Black 1pt solid; text-align: right; text-indent: 0in; width: 12%"><span style="font-size: 10pt">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;--</span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in; width: 3%">&#160;</td>

  </tr>

  <tr style="vertical-align: bottom">

    <td style="border-bottom: black 1pt solid; border-left: black 1pt solid; text-align: left; padding-left: 0.125in; text-indent: -0.125in"><span style="font-size: 10pt">Total</span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: right; text-indent: 0in"><span style="font-size: 10pt">17,880,481</span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: left; text-indent: 0in"><span style="font-size: 10pt">$</span></td>

    <td style="border-bottom: black 1pt solid; text-align: right; text-indent: 0in"><span style="font-size: 10pt">50.57</span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in"><span style="font-size: 10pt">&#160;&#160;</span></td>

    <td style="border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: black 1pt solid; text-align: left; text-indent: 0in">&#160;</td>

    <td style="border-bottom: Black 1pt solid; text-align: right; text-indent: 0in"><span style="font-size: 10pt">8,158,690</span></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: left; text-indent: 0in"><span style="font-size: 10pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></span></td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top">

    <td style="width: 0.25in">(1)</td>

    <td style="text-align: left">Consists of five Ionis plans: 1989 Stock Option Plan, Amended and Restated 2002 Non-Employee Directors&#8217; Stock Option Plan, 2011 Equity Incentive Plan, 2020 Equity Incentive Plan and Employee Stock Purchase Plan, or
          ESPP.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top">

    <td style="width: 0.25in">(2)</td>

    <td style="text-align: left">Of these shares 492,176 remained available for purchase under the ESPP as of December 31, 2022.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">47</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20">EXECUTIVE COMPENSATION</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 203.05pt; text-align: left; text-indent: 0in; color: #231F20">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">Compensation Discussion and Analysis</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">2022 NEOs, 2022 &#8220;Say on Pay&#8221; Vote and Summary of Recent Compensation and Governance Changes</p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt"><span style="color: #CE0F69"><i>Named Executive Officers</i>. </span><span style="color: #231F20">At
      December 31, 2022, our Chief Executive Officer, Chief Financial Officer, and our three other most highly compensated executive officers, called our &#8220;named executive officers&#8221; or &#8220;NEOs,&#8221; were as follows:</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 60%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: auto; margin-right: auto;">


  <tr style="vertical-align: top; background-color: #A20067">

    <td style="width: 20%; border: Black 1pt solid; padding-left: 5.4pt; text-align: center; padding-right: 5.4pt"><span style="color: white"><b>Name</b></span></td>

    <td style="width: 40%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: left; padding-right: 5.4pt"><span style="color: white"><b>Title</b></span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: left; padding-right: 5.4pt; padding-left: 5.4pt">Brett P. Monia</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: left; padding-right: 5.4pt; padding-left: 5.4pt">Chief Executive Officer</td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: left; padding-right: 5.4pt; padding-left: 5.4pt">Elizabeth L. Hougen</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: left; padding-right: 5.4pt; padding-left: 5.4pt">Executive Vice President, Finance and Chief Financial Officer</td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: left; padding-right: 5.4pt; padding-left: 5.4pt">Joseph T. Baroldi</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: left; padding-right: 5.4pt; padding-left: 5.4pt">Executive Vice President, Chief Business Officer</td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: left; padding-right: 5.4pt; padding-left: 5.4pt">Onaiza Cadoret-Manier</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: left; padding-right: 5.4pt; padding-left: 5.4pt">Executive Vice President, Chief Global Product Strategy and Operations Officer</td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: left; padding-right: 5.4pt; padding-left: 5.4pt">Richard S. Geary</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: left; padding-right: 5.4pt; padding-left: 5.4pt">Executive Vice President, Chief Development Officer</td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.25in"><span style="color: #CE0F69"><i>&#8220;Say on Pay&#8221; Vote</i>. </span><span style="color: #231F20">In June 2022, we
      held a stockholder advisory vote on the compensation of our named executive officers. Our stockholders overwhelmingly approved, on an advisory basis, the compensation of our named executive officers, with approximately </span>85% of stockholder
    votes cast in favor of our &#8220;say on <span style="color: #231F20">pay&#8221; resolution. In evaluating our general compensation practices during 2022 and in early 2023, we were mindful of the strong support our stockholders expressed for our compensation
      philosophies and practices. We remain committed to considering stockholder feedback on an ongoing basis and ensuring that our compensation practices align with market trends. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.25in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.25in"><span style="color: #CE0F69"><i>Recent Compensation and Governance Changes</i>. </span>We have recently made
    several notable compensation and governance-related changes that we believe appropriately address feedback we have received. We believe these changes continue to align the Company with peer companies and incentivize management to enhance long-term
    stockholder value. Specifically, as discussed in greater detail in the pages that follow, we:&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in">&#9679;</td>

    <td style="text-align: left">implemented performance-based equity awards for our CEO in 2020, and beginning in 2022, increased the allocation of such awards from 20% to 33% of his total equity awards;</td>

  </tr>


</table>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in">&#9679;</td>

    <td style="text-align: left">implemented performance-based equity awards for our other executive officers in 2022, accounting for 20% of their total equity awards;</td>

  </tr>


</table>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in">&#9679;</td>

    <td style="text-align: left">revised the structure of our performance-based equity awards such that they have a single vesting period at the end of three years and require a higher relative TSR percentile rank for maximum payout of the awards
          (increased from the 75th percentile to the 90th percentile);</td>

  </tr>


</table>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in">&#9679;</td>

    <td style="text-align: left">increased the ownership requirements in our stock ownership and holding guidelines applicable to our executive officers and non-employee Directors for 2022, and further increased such holding guidelines for our
          non-employee Directors in 2023;</td>

  </tr>


</table>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in">&#9679;</td>

    <td style="text-align: left">expanded our executive clawback policy to apply to all Section 16 officers;</td>

  </tr>


</table>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in">&#9679;</td>

    <td style="text-align: left">codified compensation for non-employee Directors in a written compensation policy;</td>

  </tr>


</table>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in">&#9679;</td>

    <td style="text-align: left">reduced the size of the annual equity awards for non-employee Directors, and at the 2020 Annual Meeting of Stockholders had our shareholders approve such reduced equity awards as part of the amended and restated Ionis
          Pharmaceuticals, Inc. 2002 Non-Employee Directors&#8217; Stock Option Plan; and</td>

  </tr>


</table>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in">&#9679;</td>

    <td style="text-align: left">adopted a policy for equity awards granted to non-employee Directors in 2021 whereby the Compensation Committee, with input from its independent compensation consultant, may reduce the number of shares to be
          automatically issued on a grant date for each such award so that the awards granted have an aggregate grant date fair value that is aligned with the set of peer companies the Compensation Committee uses to evaluate compensation.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.25in">In addition, at the 2023 Annual Meeting of Stockholders, we are asking our stockholders to ratify increasing
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.25in">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">48</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>Business Overview and 2022 Achievements</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
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    <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.5pt"><span style="color: #CE0F69"><i>Overview</i><span style="font-size: 10pt">. </span></span><span style="font-size: 10pt; background-color: white">We were founded over 30 years ago to deliver new innovative medicines for diseases with great medical need. Today, we are building on our advancements in RNA-targeted therapeutics to move us closer
        to achieving our vision to be the leader in genetic medicine. We believe our medicines have the potential to pioneer new markets, change standards of care and transform the lives of people with devastating diseases.</span></p>
    <p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0">&#160;</p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.5pt"><span style="color: #CE0F69"><i>Our Vision.</i></span> <span style="background-color: white">Our
        scientific innovation began and continues with the knowledge that sick people depend on us, which fuels our vision of becoming the leader in genetic medicine, utilizing a multi-platform approach to discover, develop and deliver life-transforming
        therapies. To achieve our vision, we are focused on the following strategic priorities: delivering an abundance of new medicines to the market, establishing an integrated commercial organization and expanding the reach of our technology platform.</span></p>
  </div>

  <div style="POSITION:RELATIVE;FLOAT:RIGHT;WIDTH:28%">
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: rgb(162,0,102)">


  <tr style="vertical-align: top">

    <td style="text-align: justify; padding: 10pt; width: 100%">
            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt; color: White"><b>We were
                  founded over 30 years ago to deliver new innovative medicines for diseases with great medical need. Today, we are building on our advancements in RNA-targeted therapeutics to move us closer to achieving our vision to be the leader in
                  genetic medicine.</b></span></p>
          </td>

  </tr>


</table>
  </div>

  <div style="CLEAR:BOTH"></div>

  <div><br /></div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; background-color: white"><span style="color: #CE0F69"><i>Our Medicines and Technology</i>.</span> <span style="color: #231F20">Ionis was created with the belief that we could find a better way to design and develop medicines to address diseases that traditional pharmaceutical approaches could not address. This belief, and our unwavering commitment to
      the scientific process, has enabled us to discover and develop medicines that we believe will fundamentally change the standards of care. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; background-color: white">&#160;</p>
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    currently under regulatory review, that if approved, will add to our commercial portfolio. These medicines are eplontersen to treat patients with polyneuropathy caused by hereditary transthyretin amyloidosis (&#8220;<b><i>ATTRv-PN</i></b>&#8221;), and tofersen to
    treat patients with superoxide dismutase 1 amyotrophic lateral sclerosis (&#8220;<b><i>SOD1-ALS</i></b>&#8221;). The FDA accepted the new drug application (&#8220;<b><i>NDA</i></b>&#8221;) for eplontersen in March 2023 and accepted the NDA for tofersen in July 2022.
    Additionally, the European Medicines Agency (&#8220;<b><i>EMA</i></b>&#8221;) accepted the Marketing Authorization Application (&#8220;<b><i>MAA</i></b>&#8221;) for tofersen in December 2022. The FDA has given the application for eplontersen a Prescription Drug User Fee Act
    (&#8220;<b><i>PDUFA</i></b>&#8221;) action date of December 22, 2023 and the application for tofersen a PDUFA action date of April 25, 2023. In addition to our commercial medicines and medicines under regulatory review, we have a rich innovative late- and
    mid-stage pipeline primarily focused on our leading cardiovascular and neurology franchises. We currently have seven medicines in Phase 3 development. In addition to our advancing pipeline, in 2022 we expanded and diversified our technology when we
    advanced new medicines into preclinical development that improve muscle targeting and utilize mesyl phosphoramidate (&#8220;<b><i>MsPA</i></b>&#8221;) backbone chemistry. We also entered into a collaboration with Metagenomi to add next generation gene editing
    capabilities to our technologies.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt"><span style="color: #CE0F69"><i>Our Commercial Vision</i>. </span><span style="color: #231F20">Our commercial
      vision is centered on maximizing the value of our innovative medicines. Today, we are focused on commercializing medicines primarily within our cardiovascular and neurologic disease franchises. We also plan to commercialize medicines from our
      emerging specialty rare pipeline that address underserved medical needs and provide an attractive market opportunity. Today, we have three near-term commercial opportunities, eplontersen, olezarsen and donidalorsen, which we are advancing towards the
      market. In 2021, we entered into an agreement with AstraZeneca to jointly develop and commercialize eplontersen, which we believe</span><span style="background-color: white">&#160;positions eplontersen to maximize value for patients and shareholders while
      also enabling us to bolster our commercial organization and accelerate our preparations for our near-term product launches</span><span style="color: #231F20">. As we approach our first launches, we have accelerated our commercial build out over the
      past year. After our planned launch with AstraZeneca of eplontersen for ATTRv-PN, we are well positioned for our first independent launches with olezarsen and donidalorsen, assuming positive data and approved regulatory submissions. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">&#160;</p>
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    quality of Ionis for many years. <span style="background-color: white">Our multiple sources of revenue and strong balance sheet enable us to continue investing in our strategic priorities to achieve commercial readiness for multiple late-stage
      programs and advance our innovative pipeline. By continuing to focus on these priorities, we believe we are well positioned to drive future growth and to deliver increasing value for patients and shareholders.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt"><span style="background-color: white">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
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    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">49</span>&#160;</div>

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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0"><img alt="" src="ny20007094x2_def14aimg006.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in">(1)</td>

    <td style="text-align: justify">Timing expectations are based on current assumptions and are subject to change.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">Our accomplishments last year led us to meet our 2022 financial guidance, achieve revenues of $587 million
    and end the year with $2 billion in cash<span style="color: #231F20">. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: Red"><img alt="" src="ny20007094x2_def14aimg007.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 0in; color: Red">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in">(2)</td>

    <td style="text-align: justify">Non-GAAP. See footnote below for additional information regarding non-GAAP financial results<span style="font-family: Times New Roman, Times, Serif; color: #231F20"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">8</sup></span>.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <!-- Field: Rule-Page -->
  <div style="margin-top: 3pt; margin-bottom: 3pt; text-align: left;">
    <div style="font-size: 1pt; border-top: Black 1pt solid; width: 20%">&#160;</div>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">8 </sup>We use
      &#8220;non-GAAP&#8221; in place of &#8220;pro-forma&#8221; when discussing our financial results that exclude non-cash compensation expense related to equity awards, costs related to the Akcea Merger, and costs related to our restructured commercial operations and the
      related tax effects because we believe that non-GAAP financial results better represent the economics of our business and how we manage our business. For a detailed reconciliation of non-GAAP and GAAP measures, see Appendix C.</span></p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><span style="font: 9pt Times New Roman, Times, Serif">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
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    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">50</span>&#160;</div>

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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>Summary of Compensation Practices</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">Below we summarize some of our compensation practices, both the practices we implement
    because we believe they are consistent with our vision and building long-term stockholder value, and those we choose not to implement as we believe they are counter to our vision and building long-term stockholder value.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="vertical-align: top">

    <td style="width: 35%; border: Black 1pt solid; padding-left: 0.15in; text-align: left; text-indent: -0.12in"><img alt="" src="ny20007094x2_def14aimg0018.jpg" /> <span style="font-size: 10pt; color: #231F20">General compensation principles</span></td>

    <td style="width: 65%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.45pt; text-align: left; text-indent: -1.6pt">We design our compensation structure to drive the creation of long-term stockholder value and
            mitigate unnecessary or imprudent business risk taking. Specifically, we:</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 38.9pt; text-align: left; text-indent: -0.25in">&#9679;<span style="font-family: Times New Roman, Times, Serif">&#160;&#160;&#160;&#160; </span>Use a combination of
            compensation vehicles that provide a balanced mix of fixed and variable cash incentives, and long-term stock incentives;</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 38.9pt; text-align: left; text-indent: -0.25in">&#9679;<span style="font-family: Times New Roman, Times, Serif">&#160;&#160;&#160;&#160; </span>Require a 12-month
            minimum vesting period for equity awards;</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 38.9pt; text-align: left; text-indent: -0.25in">&#9679;<span style="font-family: Times New Roman, Times, Serif">&#160;&#160;&#160;&#160; </span>Set explicit and
            demanding objectives at the beginning of each year from which we measure performance for the year;</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 38.9pt; text-align: left; text-indent: -0.25in">&#9679;<span style="font-family: Times New Roman, Times, Serif">&#160;&#160;&#160;&#160; </span>Set a strict budget for
            equity awards and salary increases;</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 38.9pt; text-align: left; text-indent: -0.25in">&#9679;<span style="font-family: Times New Roman, Times, Serif">&#160;&#160;&#160;&#160; </span>Do <i><span style="text-decoration: underline;">not</span></i>
            provide perquisites for any employees; and</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 38.9pt; text-align: left; text-indent: -0.25in">&#9679;<span style="font-family: Times New Roman, Times, Serif">&#160;&#160;&#160;&#160; </span>Do <i><span style="text-decoration: underline;">not</span></i>
            provide &#8220;gross-up&#8221; payments, other than for relocation.</p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><img alt="" src="ny20007094x2_def14aimg0018a.jpg" />&#160;&#160;&#160;<span style="font-size: 10pt; color: #231F20">Align executive compensation with Company performance and design performance based awards to drive creation of long-term stockholder value</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.75pt; text-align: left; text-indent: -1.85pt">We tie a significant portion of our executive officers&#8217; compensation to Company performance and
            design performance-based awards to drive the creation of long-term stockholder value. For example, we:</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 38.9pt; text-align: left; text-indent: -0.25in">&#9679;<span style="font-family: Times New Roman, Times, Serif">&#160;&#160;&#160;&#160; </span>Allocated 65% of our
            Chief Executive Officer&#8217;s 2022 compensation in the form of performance-based compensation, which we consider to consist of cash bonuses, stock options and PRSUs;</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 38.9pt; text-align: left; text-indent: -0.25in">&#9679;<span style="font-family: Times New Roman, Times, Serif">&#160;&#160;&#160;&#160; </span>Revised our PRSU
            structure for grants made in 2023 and going forward such that:</p>
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            vesting period at the end of three years; and</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 74.9pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif">&#9675;&#160;&#160;&#160; </span>the relative TSR
            percentile rank for maximum payout of the awards increased from the 75th percentile to the 90th percentile.</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 38.9pt; text-align: left; text-indent: -0.25in">&#9679;<span style="font-family: Times New Roman, Times, Serif">&#160;&#160;&#160;&#160; </span>Place a maximum limit on
            cash bonuses and do not guarantee a cash bonus &#8211; cash bonuses can be, and have been, zero; and</p>
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              occurred in 2021. </span></p>
        </td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><img alt="" src="ny20007094x2_def14aimg0018.jpg" /><span style="font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-size: 10pt; color: #231F20">Stock ownership and holding guidelines</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 4.75pt; text-align: left; text-indent: -1.85pt"><span style="font-size: 10pt">We maintain stock ownership and holding guidelines that require our executive
            officers and non-employee Directors to meet certain ownership thresholds. We increased such ownership requirements for our non-employee Directors in 2023.</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><img alt="" src="ny20007094x2_def14aimg0018a.jpg" /><span style="font-size: 10pt; color: #E57200">&#160;&#160;</span><span style="font-size: 10pt">Clawback policy</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 4.75pt; text-align: left; text-indent: -1.85pt"><span style="font-size: 10pt">We use an executive &#8220;clawback&#8221; policy that applies to all Section 16 officers.</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><img alt="" src="ny20007094x2_def14aimg0018.jpg" /><span style="font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-size: 10pt">Disallow hedging and pledging</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: left; text-indent: -2.5pt"><span style="font-size: 10pt">We do not allow pledging, shorting, or hedging against our stock by Directors or
            employees.</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><img alt="" src="ny20007094x2_def14aimg0018a.jpg" /><span style="font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-size: 10pt">No option re-pricing or cash buyouts</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 4.45pt; text-align: left; text-indent: -1.55pt"><span style="font-size: 10pt">We do not reprice or &#8220;cash-out&#8221; stock options without stockholder approval.</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 17.35pt; text-align: left; text-indent: -13.5pt"><img alt="" src="ny20007094x2_def14aimg0018.jpg" /><span style="font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-size: 10pt">Engage an independent compensation consultant</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.45pt; text-align: left; text-indent: -1.55pt">The Compensation Committee has retained a compensation consultant whose relationship with the
            Company was confirmed to be independent for 2022.</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.45pt; text-align: left; text-indent: -1.55pt">&#160;</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.45pt; text-align: left; text-indent: -1.6pt">The compensation consultant, among other things, assists us in selecting an appropriate peer
            group and annually reviewing our compensation levels, policies, practices, and procedures for our employees and non-employee Directors compared to our peer group.</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.45pt; text-align: left; text-indent: -1.6pt">&#160;</p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 0.25in; text-align: left; text-indent: -13.5pt"><img alt="" src="ny20007094x2_def14aimg0018a.jpg" /><span style="font-size: 10pt; color: #CE0F69">&#160;&#160;</span><span style="font-size: 10pt; color: #231F20">Use a &#8220;double trigger&#8221; for change of control for our executive officers</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 4.75pt; text-align: left; text-indent: 0in"><span style="font-size: 10pt">We use a &#8220;double trigger&#8221; for cash payments and equity acceleration for change of
            control for our executive officers.</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 0.25in; text-align: left; text-indent: -13.7pt"><img alt="" src="ny20007094x2_def14aimg0018.jpg" /> <span style="font-size: 10pt">&#160;Hold























            a &#8220;say on pay&#8221; vote annually </span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 4.75pt; text-align: left; text-indent: 0in"><span style="font-size: 10pt">Provides an effective way for us to obtain information on stockholder sentiment about
            our executive compensation program each year.</span></td>

  </tr>


</table>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
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    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">51</span>&#160;</div>

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  </div>

  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0.25in"><span style="color: #CE0F69"><i>Compensation Overview and the Role of the Compensation Committee</i></span></p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">We have designed our executive compensation program to attract and retain executives who can
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    program. At the end of each year, and as otherwise required, the Compensation Committee recommends that the Board approve the total compensation for our Chief Executive Officer and approves the total compensation for our other executive officers.</p>
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  <tr style="vertical-align: top">

    <td style="width: 27.35pt"></td>

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    <td style="text-align: left"><span style="color: #231F20">reviewing and approving overall compensation strategy;</span></td>

  </tr>


</table>
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  <tr style="vertical-align: top">

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    <td style="text-align: left"><span style="color: #231F20">reviewing and approving corporate performance goals and objectives relevant to the compensation of our executive officers;</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27.35pt"></td>

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    <td style="text-align: left"><span style="color: #231F20">evaluating and recommending to the Board the compensation plans and programs advisable for Ionis, as well as modifying or terminating existing plans and programs;</span></td>

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</table>
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  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

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    <td style="text-align: left"><span style="color: #231F20">establishing policies with respect to stock compensation arrangements;</span></td>

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</table>
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  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


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    <td style="text-align: left"><span style="color: #231F20">reviewing and recommending that the Board approve the total compensation for our Chief Executive Officer and reviewing and approving the total compensation for our other executive officers;</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


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    <td style="text-align: left">reviewing and recommending that the Board approve the compensation arrangements for our Directors<span style="color: #231F20">;</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top">

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    <td style="text-align: left"><span style="color: #231F20">administering our stock-based awards and ESPP;</span></td>

  </tr>


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  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27.35pt"></td>

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    <td style="text-align: left"><span style="color: #231F20">evaluating risks associated with our compensation policies and practices and assessing whether these risks are reasonably likely to have a material adverse effect on us;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27.35pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #231F20">selecting and retaining a qualified, independent compensation consultant;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27.35pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #231F20">performing other functions as may be necessary or convenient in the efficient discharge of the foregoing; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #231F20">reporting to the Board from time to time, or whenever it is called upon to do so.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27.35pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left">assessing Board of Directors compensation;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

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    <td style="text-align: left">providing guidance with respect to the implementation of a program to defer vesting of RSU grants to the Board of Directors;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27.35pt"></td>

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    <td style="text-align: left"><span style="color: #231F20">selecting the 2022 Peer Group used to assess officer and non-employee director compensation;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27.35pt"></td>

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    <td style="text-align: left"><span style="color: #231F20">reviewing the mix of stock options and RSUs for all employees;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27.35pt"></td>

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    <td style="text-align: left">assessing executive officer compensation, including base salary, bonus and equity grants;</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

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    <td style="text-align: left"><span style="color: #231F20">assessing changes to the Severance Benefits Plan that applies to all employees at the Vice President level and above; </span></td>

  </tr>


</table>
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  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27pt"></td>

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    <td style="text-align: left"><span style="color: #231F20">performing the valuation calculations for our CEO&#8217;s PRSU awards that vested and paid out in 2022; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 27.35pt"></td>

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    <td style="text-align: left"><span style="color: #231F20">performing the valuation calculations for equity awards granted in 2020, 2021 and 2022 to calculate compensation actually paid pursuant to Item 402(v) of Regulation S-K.</span></td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><img alt="" src="ny20007094x2_def14aimg003.jpg" /></p>
  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="TEXT-ALIGN: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">52</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
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  <p style="FONT: 10pt Times New Roman, Times, Serif; MARGIN: 0pt 0px">&#160;</p>
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    peer company and industry compensation data and advice regarding executive officers&#8217; compensation. In 2022, we paid Aon approximately $173,000 for Aon&#8217;s consulting services directly related to Compensation Committee support.</p>
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    were not related to Aon&#8217;s Compensation Committee consulting services. Our Human Resources department obtained general benchmarking survey data and performance analytics data from an affiliate of Aon, for which we paid approximately $40,000 in the
    aggregate in 2022. Additionally, our Finance department engaged an affiliate of Aon for insurance brokerage services, for which we paid approximately $780,000 in 2022. Although the Compensation Committee was aware of the nature of these additional
    services, the committee did not review and approve such services, insurance premiums or policies, as those were reviewed and approved by management in the ordinary course of business in consultation with the Audit Committee of the Board.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.3pt; color: #231F20">Aon maintains certain policies and practices to protect the independence of the executive
    compensation consultants engaged by the Compensation Committee. In particular, Aon provides an annual update to the Compensation Committee on the financial relationship between Aon and the Company and provides written assurances that, within Aon, the
    compensation of the affiliate consultants who perform executive compensation services for the Compensation Committee is determined separately from Aon&#8217;s other lines of business and from the other services it provides to the Company. These safeguards
    were designed to help ensure that the Compensation Committee&#8217;s executive compensation consultants continued to fulfill their role in providing independent, objective advice.</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 22.3pt; text-align: left; text-indent: 0in; color: #CE0F69"><i>Compensation Philosophy</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 22.3pt; text-align: left; text-indent: 0in; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">Our compensation philosophy supports and rewards the characteristics and behaviors we believe
    will make us successful and create long-term stockholder value:</p>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><img alt="" src="ny20007094x2_def14aimg008.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt"><span style="color: #E57200"><i><span style="text-decoration: underline;">Pay for Performance</span></i>.</span> <span style="color: #231F20">We
      incorporate a number of features into our compensation structure to mitigate the risk that our compensation policies and practices could encourage unnecessary or imprudent business risk taking. We use a combination of compensation vehicles that
      provide a balanced mix of fixed and variable cash incentives, and long-term stock incentives. Our Performance Management By Objective (&#8220;<b><i>MBO</i></b>&#8221;) awards are not guaranteed (i.e., are 100% at risk) and include a multiplier, or performance
      factor, based on Ionis&#8217; and the employee&#8217;s performance (respectively, the &#8220;<b><i>Company Performance Factor</i></b>&#8221; and the &#8220;<b><i>Individual Performance Factor</i></b>&#8221;). Therefore, if <i><span style="text-decoration: underline;">either</span></i> Ionis or the employee performs poorly,
      the Performance MBO can be, and has been, zero. For example, for 2021 performance, the Compensation Committee exercised downward discretion with respect to the Company Performance Factor for our executive officers based on Company performance and
      awarded our Company&#8217;s executive officers a Company Performance Factor of 95% and all other employees a Company Performance Factor of 110%, due to a few key Company disappointments during the year. For 2022 performance, the Compensation Committee
      awarded a Company Performance Factor of 125% in recognition of the Company&#8217;s achievement of most of its goals for the year across all aspects of our business. </span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
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    <div class="BRPFPageNumberArea" style="text-align: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">53</span></div>

    <div class="BRPFPageBreak" style="page-break-after: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <div style="position: relative; float: left; width: 73%">
    <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 20.15pt">Based on stockholder feedback, beginning in 2020, we added performance-based restricted stock unit (&#8220;<b><i>PRSU</i></b>&#8221;)
awards






















      to our Chief Executive Officer&#8217;s compensation, and increased the proportion of such awards for our CEO&#8217;s total equity awards beginning in 2022. <span style="color: #231F20">Additionally, in 2022, we added PRSU awards to the compensation of our other
        executive officers. These PRSU awards provide our executive officers the opportunity to earn a defined number of shares of our common stock if we achieve pre-determined performance goals. Beginning in 2022, at target level of achievement, the PRSU
        awards represent 33% of our CEO&#8217;s total equity awards and 20% of each other executive officer&#8217;s total equity awards. We structured the PRSU awards to pay out based on relative TSR, which we believe is the best way to directly tie performance that
        positively impacts stockholders with the payout that the executive officers receive at the end of the performance period.</span></p>
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  <div style="position: relative; float: right; width: 23%">
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  <tr>

    <td style="padding-top: 10pt; padding-bottom: 10pt; padding-left: 5pt; border: Black 1pt solid">
            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.5pt; text-align: left; text-indent: 0in; color: white"><b>Beginning in 2022, at target level of achievement, the PRSU awards represent 33%
                of our CEO&#8217;s total equity awards and 20% of each other executive officer&#8217;s total equity awards. </b></p>
          </td>

  </tr>


</table>
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 3pt; margin-left: 0; text-align: left; text-indent: 20.15pt"><span style="color: #231F20">For PRSU grants made before 2023, one third of such PRSUs may vest at the end of
      three separate performance periods spread over the three years following the date of grant (<i>i.e</i>., </span>the one-year period commencing on the date of grant and ending on the first anniversary of the date of grant; the two-year period
    commencing on the date of grant and ending on the second anniversary of the date of grant; and the three-year period commencing on the date of grant and ending on the third anniversary of the date of grant) <span style="color: #231F20">based on the
      Company&#8217;s relative total shareholder return (&#8220;<b><i>TSR</i></b>&#8221;) as compared to a peer group of companies and as measured, in each case, at the end of the applicable performance period. In addition, PRSU grants made before 2023 include an
      alternative three-year payout mechanism (the &#8220;<b><i>Alternative Calculation</i></b>&#8221;) that requires an alternative payout calculation at the end of the final three-year measurement period assuming the only measurement period for all shares under the
      award was the three-year period. If the Alternative Calculation is greater than payouts under the sum of years one, two and three, then such PRSU award will pay out to achieve the number of shares payable under the Alternative Calculation. For PRSU
      grants made before 2023, performance below the threshold level results in a payout of zero shares, performance at the threshold level (25th percentile) results in a payout of 50% of target shares, performance at the target level (50th percentile)
      results in a payout of 100% of target shares, and performance at the maximum level (75th percentile) results in a payout of 150% of target shares.</span></p>
  <div style="position: relative; float: left; width: 73%">
    <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 8pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.5pt; color: #231F20">We evaluated our PRSU structure in 2022 to ensure that it is consistent with market
      practices and will best incentivize our CEO and executive officers to deliver stockholder value. As a result of this evaluation, beginning with PRSU grants made in 2023, such grants will have a single vesting period at the end of three years. In
      addition, we increased the relative TSR percentile rank required for maximum payout of the awards from the 75<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile to the 90<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile and added additional payout thresholds. The payout thresholds for grants made in 2023 and going forward are as follows:</p>
  </div>

  <div style="position: relative; float: right; width: 23%">
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; background-color: rgb(162,0,102)">


  <tr>

    <td style="padding-top: 10pt; padding-bottom: 10pt; padding-left: 5pt; border: Black 1pt solid">
            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white"><b>We evaluated our PRSU structure in 2022 to ensure that it is consistent with market
                practices and will best incentivize our CEO and executive officers to deliver stockholder value.</b></p>
          </td>

  </tr>


</table>
  </div>

  <div style="clear: both"></div>

  <div><br /></div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 22.5pt; color: #231F20"></p>
  <table cellspacing="0" cellpadding="0" style="width: 80%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: auto; margin-right: auto;">


  <tr style="vertical-align: top; background-color: #A20067">

    <td style="width: 40%; border: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: white;"><b>Relative TSR Percentile Rank</b></span></td>

    <td style="width: 40%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: white;"><b>TSR Performance Multiplier</b></span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: #231F20;">&lt;25<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: #231F20;">0%</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 5.4pt; text-align: center; font-size: 10pt"><span style="color: #231F20;"> 25<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile (<b>Threshold</b>) </span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: #231F20;">50%</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: #231F20;">50<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile (<b>Target</b>)</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: #231F20;">100%</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: #231F20;">60<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: #231F20;">125%</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: #231F20;">75<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: #231F20;">150%</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: #231F20;">90<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile (<b>Maximum</b>)</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: #231F20;">200%</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #231F20">Importantly, <b><span style="text-decoration: underline;">all</span></b> of the PRSU grants made since inception of our PRSU program
    include the following <b><span style="text-decoration: underline;">limitations</span></b>:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #231F20">&#160;</p>
  <div style="position: relative; float: left; width: 73%">
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 20.35pt; text-align: left">&#9679;</td>

    <td style="text-align: justify">No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of each performance period may be anywhere from zero to the maximum amount depending on the Company&#8217;s relative TSR<span style="font-size: 10pt; color: #231F20">; and</span></td>

  </tr>


</table>
    <p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0">&#160;</p>
    <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 20.35pt">&#9679;</td>

    <td style="text-align: justify">If the Company&#8217;s TSR is negative over the performance period, the payout will not exceed 100% of the target number even if the percentile rank exceeds the 50<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile.</td>

  </tr>


</table>
  </div>

  <div style="position: relative; float: right; width: 23%">
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; background-color: rgb(162,0,102)">


  <tr>

    <td style="padding-top: 10pt; padding-bottom: 10pt; padding-left: 5pt; border: Black 1pt solid">
            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white"><b>No number of PRSUs is guaranteed to vest.</b></p>
            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white">&#160;</p>
            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white"><b>If the Company&#8217;s TSR is negative over the performance period, the payout will not
                exceed 100% of the target number.</b></p>
          </td>

  </tr>


</table>
  </div>

  <div style="clear: both"></div>

  <div><br /></div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="margin-bottom: 10pt; clear: both; margin-top: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">54</span></div>

    <div class="BRPFPageBreak" style="page-break-after: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #231F20">The PRSUs granted to all of our executive officers in 2022, including our NEOs, paid out to
    our NEOs in January 2023 as follows:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #231F20">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 85%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: auto; margin-right: auto;">


  <tr style="vertical-align: top; background-color: #A20067">

    <td style="width: 17%; border: Black 1pt solid; text-align: center; text-indent: 8.05pt"><span style="color: white"><b>Performance Period</b></span></td>

    <td style="width: 18%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 4.1pt"><span style="color: white"><b>Ionis&#8217; TSR</b></span></td>

    <td style="width: 14%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 0in"><span style="color: white"><b>Relative TSR Percentile Ranking</b></span></td>

    <td style="width: 20%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 3.85pt"><span style="color: white"><b>Percent of Target Number</b></span></td>

    <td style="width: 31%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 3.85pt"><span style="color: white"><b>Total Shares Earned</b></span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center; text-indent: 0in"><span style="color: #231F20">1 of 3</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 4.15pt"><span style="color: #231F20">21.63%</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 3.8pt"><span style="color: #231F20">81<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st</sup></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 3.45pt"><span style="color: #231F20">150%</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: -0.7pt; color: #231F20">Dr. Monia: 25,372</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: -0.7pt; color: #231F20">Ms. Hougen: 4,140</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: -0.7pt; color: #231F20">Ms. Cadoret-Manier: 4,140</p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: -0.7pt; color: #231F20">Dr. Geary: 3,822</p>
        </td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.5in; text-align: left; text-indent: -13.5pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.5in; text-align: left; text-indent: -13.5pt; color: #231F20">The PRSUs granted to our CEO in 2020 and 2021 paid out in January 2023 as follows:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.5in; text-align: left; text-indent: -13.5pt; color: #231F20">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 96%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: 22.5pt">


  <tr style="vertical-align: top; background-color: #A20067">

    <td style="width: 12%; border: Black 1pt solid; text-align: center; text-indent: 0in"><span style="color: white"><b>Grant </b></span></td>

    <td style="width: 16%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 3.65pt; text-align: center; text-indent: 0in"><span style="color: white"><b>Performance Period</b></span></td>

    <td style="width: 18%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 3.9pt; text-align: center; text-indent: 4.5pt"><span style="color: white"><b>Ionis&#8217; TSR</b></span></td>

    <td style="width: 16%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.8pt; text-align: center; text-indent: 0in"><span style="color: white"><b>Relative TSR Percentile Ranking</b></span></td>

    <td style="width: 21%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.35pt; text-align: center; text-indent: -4.5pt"><span style="color: white"><b>Percent of Target Number</b></span></td>

    <td style="width: 17%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 3.45pt; color: white"><b>Total</b></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white"><b>Shares Earned</b></p>
        </td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center; text-indent: 0in"><span style="color: #231F20">2020</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 7.95pt"><span style="color: #231F20">3 of 3</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 9.35pt"><span style="color: #231F20">-36.01%</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 5.5pt"><span style="color: #231F20">54<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 8.3pt"><span style="color: #231F20">100%</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 7.95pt"><span style="color: #231F20">6,511</span><span style="font-size: 10pt"><b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)(2)</sup></b></span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center; text-indent: 0in"><span style="color: #231F20">2021</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 7.95pt"><span style="color: #231F20">2 of 3</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 9.35pt"><span style="color: #231F20">-36.33%</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 5.5pt"><span style="color: #231F20">69<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup></span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 8.3pt"><span style="color: #231F20">100%</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 7.95pt"><span style="color: #231F20">17,210</span><span style="font-size: 10pt"><b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></b></span></td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; color: #231F20; margin-top: 0pt; margin-bottom: 0pt; width: 100%">


  <tr style="vertical-align: top">

    <td style="width: 0pt"></td>

    <td style="width: 20pt; text-align: left">(1)</td>

    <td>This PRSU award paid out less than 100% of target for the first and second performance periods, and after conducting the Alternative Calculation, resulted in an additional payout of 1,146 shares under the first performance period and 1,586
          shares under the second performance period, yielding in the aggregate a payout for the third performance period of 6,511 shares.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; color: #231F20; margin-top: 0pt; margin-bottom: 0pt; width: 100%">


  <tr style="vertical-align: top">

    <td style="width: 0pt"></td>

    <td style="width: 20pt; text-align: left">(2)</td>

    <td>Despite greater than 50<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile performance, payout was capped at 100% due to negative TSR.</td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="margin-bottom: 10pt; clear: both; margin-top: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">55</span></div>

    <div class="BRPFPageBreak" style="page-break-after: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>2022 NEO Compensation: Performance Based vs. Non-Performance Based </b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.5pt; text-align: justify; text-indent: 20.15pt; color: #231F20">We are committed to ensuring that a significant portion of our NEOs&#8217; compensation is
    tied to Company performance. The charts below illustrate the proportion of our CEO&#8217;s and average NEOs&#8217; (excluding the CEO) 2022 total compensation that was allocated among performance based compensation and non-performance based compensation. We
    consider cash bonuses, stock options and PRSUs to be performance based compensation, as the realization of the amount of such bonuses, and value of such options and PRSUs, are directly related to one or more measures of Company performance.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.5pt; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.5pt; text-align: left; text-indent: 20.15pt; color: #CE0F69"><i>2022 CEO Compensation: Performance Based vs. Non-Performance Based</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.5pt; text-align: left; text-indent: 20.15pt; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 40.15pt; color: #231F20"> The performance based compensation reflected below includes the CEO&#8217;s cash bonus for 2022
    performance ($837,688), fair value of stock options granted in 2022 ($1,761,806) and fair value of PRSU awards granted in 2022 ($2,145,668). The non-performance based compensation reflected below includes the CEO&#8217;s 2022 base salary ($824,800) and fair
    value of RSU awards granted in 2022 ($1,678,645).</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><img alt="" src="ny20007094x2_def14aimg009.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.5pt; text-align: justify; text-indent: 20.15pt; color: #CE0F69"><i>2022 Average NEO Compensation: Performance Based vs. Non-Performance Based</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.5pt; text-align: justify; text-indent: 20.15pt; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 40.15pt; color: #231F20"><span style="color: #CE0F69"> </span><span style="color: #231F20">The performance based
      compensation reflected below includes the NEOs&#8217; (excluding the CEO) average cash bonus for 2022 performance ($331,003) and average fair value of stock options granted in 2022 ($787,120). The non-performance based compensation reflected below includes
      the NEOs&#8217; (excluding the CEO) average 2022 base salary ($534,651) and fair value of RSU awards granted in 2022 ($1,100,109). Beginning in 2022, the NEOs (excluding the CEO) receive 20% of their total equity awards in the form of PRSUs.</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #CE0F69"><img alt="" src="ny20007094x2_def14aimg010.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="margin-bottom: 10pt; clear: both; margin-top: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">56</span></div>

    <div class="BRPFPageBreak" style="page-break-after: always">
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #CE0F69"><i>Internal Pay Equity</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">An executive officer&#8217;s salary plus bonus represents the officer&#8217;s total cash compensation.
    Our philosophy has been to have the CEO&#8217;s total cash compensation be between 20-30 times the lowest levels of compensation received by an employee. Historically, the total cash compensation of our CEO over a rolling three-year period has been, on
    average, approximately 30 times that of the average cash compensation for our lowest level employees, and two to three times greater than the average of that of our other executive officers. Our CEO&#8217;s total cash compensation over the last three years
    was on average approximately 19 times greater than the average cash compensation for our lowest level employees, and 1.57 times greater than the average of that of our other executive officers.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">We cover the specific elements of our compensation structure in more detail below.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067"><b>Overview of Our Compensation Program</b></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #A20067">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">Drug discovery and development across a portfolio of many medicines is a long process that
    spans many years, where decisions we make today can have a positive or negative consequence five years, ten years, and even further into the future. As such, it is essential we set goals that incentivize our employees to execute our long-term strategy,
    because we believe our long-term strategy should continue to reward our stockholders into the future.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <div style="position: relative; float: left; width: 73%">
    <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 20.15pt; color: #231F20">For us to retain our technology leadership and effectively manage the technical
      complexity of our development pipeline, our most senior executives and the members of their teams must advance multiple drug strategies and collaborative partnerships in parallel and consistently over many years, versus emphasizing one or two at the
      expense of others that deserve attention. As a result, other than stock price, budget, sales targets and our annual financial guidance to Wall Street, we currently do not use financial-based metrics as objectives, such as earnings per share, because
      financial metrics typically overly emphasize two or three annual business metrics and ignore the complexity of the tasks we are undertaking. By taking this approach, we avoid the temptation to deviate from creating fundamental long-term value to meet
      a short-term metric.</p>
    <p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0">&#160;</p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 20.15pt; color: #231F20">At the beginning of each year, we set aggressive corporate objectives, including
      objective measures, that our Board approves. We strive to structure our corporate objectives such that they are results driven rather than task driven to encourage the prudent spending of stockholder money. In other words, we want to structure our
      objectives to reward success based on judgment, rather than the making of &#8220;bad bets.&#8221; On at least a quarterly basis, the Board evaluates our progress in achieving these objectives. We define excellent performance as a year in which we have met most
      of our objectives.</p>
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    <td style="padding-top: 10pt; padding-bottom: 10pt; padding-left: 5pt; border: Black 1pt solid">
            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 5.35pt; text-align: left; text-indent: 0in; color: white"><b>At the beginning of each year, we set aggressive corporate objectives, including
                objective measures, that our Board approves. On at least a quarterly basis, the Board evaluates our progress towards achieving these objectives.</b></p>
          </td>

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  <div><br /></div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 20.15pt; color: #231F20"></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #CE0F69"><i>Importance of Tenure; Our Investment in Knowledge-Rich Employees</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #CE0F69">&#160;</p>
  <div style="position: relative; float: left; width: 73%">
    <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 20.15pt; color: #231F20">It takes a significant period of time and a substantial investment to recruit and
      develop employees who possess the experience and talent necessary to lead at Ionis given our transformative technology, rich drug development pipeline and emerging commercial business. Senior executives must have experience with all aspects of our
      business to be effective leaders. Our drug technology is a &#8220;platform technology,&#8221; which means the more knowledge and experience an employee has with our technology platform, the better equipped she or he is to create value at Ionis. Given the
      uniqueness and complexity of our technology, it is critical to retain the knowledge and experience of outstanding long service employees. The experience and seniority of our employees is critical to our future success. For these reasons, it is our
      objective to attract and retain the best talent available and to invest in those individuals who deliver long-term productivity. The principles below outline our general approach to achieving this objective:</p>
  </div>

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            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.55pt; text-align: left; text-indent: 0in; color: white"><b>Given the uniqueness and complexity of our technology, it is critical to retain
                the knowledge and experience of outstanding long service employees.</b></p>
          </td>

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  <div><br /></div>

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    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #231F20">Long tenure among a dedicated and highly skilled workforce, combined with the highest performance standards, contributes to our leadership in the industry and serves the interests of
            stockholders.</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #231F20">Our focus on retention is coupled with a strong belief that executive talent most often should be developed and promoted from within Ionis.</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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    <td style="width: 18pt"><span style="font-family: Times New Roman, Times, Serif">&#9675;</span></td>

    <td style="text-align: left"><span style="color: #231F20">The long tenure of high-performing executive officers reflects this strategy at all levels of the organization. Our current executive officers have on average approximately 21 years and
            individually as much as over 33 years of tenure at Ionis.</span></td>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="margin-bottom: 10pt; clear: both; margin-top: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">57</span></div>

    <div class="BRPFPageBreak" style="page-break-after: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
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    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #231F20">The Company has carefully evaluated and selected each of our executive officers through a rigorous performance assessment process over a long career. In their current assignments, they
            remain subject to a challenging annual performance assessment in which they must continue to meet the highest standards or be reassigned or separated from the Company.</span></td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">To recognize our employees, including our named executive officers, who deliver <span style="color: #231F20">long</span>-term





















    productivity to the Company, Ionis has implemented two awards. In 2019, we implemented the &#8220;Career Achievement Award&#8221; to recognize our distinguished, long-tenured, senior-level contributors, including Board members, who made extraordinary contributions
    that helped determine the Company&#8217;s future, with a $50,000 cash award. In 2018, we implemented the &#8220;Commitment to Ionis Award&#8221; to thank employees for their commitment to the Company. The amount of the Commitment to Ionis Award correlates to the
    employee&#8217;s length of service with the Company and is paid on the employee&#8217;s milestone anniversary. The table below shows the Commitment to Ionis award for each corresponding milestone anniversary. We recently added 15-year and 25-year milestone
    anniversaries for which Commitment to Ionis Awards will be awarded and every employee who had a 15-year or 25-year service anniversary between 2018 and 2021 received a one-time &#8220;catch-up&#8221; award in 2022 for one-half of the amount of the applicable
    milestone award. In 2022, Dr. Geary was awarded such &#8220;catch-up&#8221; award to recognize his 25 years of service to Ionis.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
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    <td style="width: 25%; border: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: white"><b>Years of Service</b></span></td>

    <td style="width: 25%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt"><span style="color: white"><b>Award</b></span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">5</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">$5,000</td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">10</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">$10,000</td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">15</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">$15,000</td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">20</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">$20,000</td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">25</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">$25,000</td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">30</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">$30,000</td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">35</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">$35,000</td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">40</td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; text-indent: 0in; font-size: 10pt">$40,000</td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #CE0F69"><i>Elements of Executive Compensation</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left">&#160;</p>
  <div style="position: relative; float: left; width: 79%">
    <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: justify; text-indent: 20.15pt">Employees in our organization do not share either accountability or responsibility equally for strategic
      and/or tactical decisions. It is well ingrained in our culture that not everyone should share the same level of risk/reward for the consequences of these decisions. As a result, we have structured the various components of our compensation system to
      reflect accountability both for the successes and failures (both <span style="color: #231F20">long-term and short-term) of Ionis and our employees. We pay our senior management team for results and their use of judgment in executing the strategies
        they have established. Therefore, the more senior a person becomes within Ionis, the more the person&#8217;s cash compensation will be &#8220;at risk.&#8221; We compensate the more junior employees for accomplishing their work well and, therefore, a lower portion of
        their cash compensation is &#8220;at risk.&#8221;</span></p>
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            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white"><b>The more senior role a person plays, the more that person&#8217;s cash compensation will be
                &#8220;at risk.&#8221;</b></p>
          </td>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">Our executive officers&#8217; total compensation consists of four elements:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
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    <td style="width: 20.15pt">(1)</td>

    <td style="text-align: left">base salary;</td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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    <td style="width: 43.2pt"></td>

    <td style="width: 20.15pt">(2)</td>

    <td style="text-align: left">Performance MBO &#8211; performance-based, at-risk cash compensation, <i>no portion of which is guaranteed</i>;</td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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    <td style="width: 43.2pt"></td>

    <td style="width: 20.15pt">(3)</td>

    <td style="text-align: left">stock-based compensation, including performance-based restricted stock unit awards, <b><i><span style="text-decoration: underline;">which are granted annually each January following the performance year for which such grants are awarded</span></i></b>; and</td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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    <td style="width: 42.85pt"></td>

    <td style="width: 20.15pt">(4)</td>

    <td style="text-align: left">the same benefits, including 401(k) matching, that we provide to all employees.</td>

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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">The PRSU awards are the only element that does not apply to all employees.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
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  </tr>


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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


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    <td style="text-align: justify"><span style="color: #231F20">the Compensation Committee&#8217;s and Board&#8217;s assessment of our CEO&#8217;s and executive officers&#8217; individual performance;</span></td>

  </tr>


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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="margin-bottom: 10pt; clear: both; margin-top: 10pt">
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    <div class="BRPFPageBreak" style="page-break-after: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
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  <tr style="vertical-align: top">

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    <td style="text-align: justify"><span style="color: #231F20">competitive compensation practices;</span></td>

  </tr>


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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

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    <td style="text-align: justify"><span style="color: #231F20">general economic conditions, industry conditions and the Compensation Committee&#8217;s and Board&#8217;s collective business judgment;</span></td>

  </tr>


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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify"><span style="color: #231F20">increased efficiencies and process improvements;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify"><span style="color: #231F20">effective collaboration and teamwork;</span></td>

  </tr>


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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify"><span style="color: #231F20">individual expertise, skills and knowledge;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify"><span style="color: #231F20">the need to retain and motivate;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify"><span style="color: #231F20">the impact an individual&#8217;s judgment has on our success or failure; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

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    <td style="text-align: left"><span style="color: #231F20">the advice of the Compensation Committee&#8217;s independent compensation consultant.</span></td>

  </tr>


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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">We do not have specific weightings assigned to these factors, as the importance of each
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 22.3pt; text-align: left; text-indent: 0in; color: #CE0F69"><i>Peer Group</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 22.3pt; text-align: left; text-indent: 0in; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 22.5pt; color: #231F20">The Compensation Committee considers relevant market pay practices when setting executive
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    Peer Group to benchmark compensation for both our executive officers and non-employee Directors. While the Compensation Committee uses these data to inform and shape decision-making, it does not strictly adhere to quantitative benchmarks. The Peer
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">The Compensation Committee, in consultation with its independent compensation consultant,
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    against the Peer Group&#8217;s executive compensation to ensure that our compensation is competitive and to inform and shape its decision-making when setting compensation.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
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  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #231F20">are similar to Ionis in terms of certain factors, including one or more of the following: size (<i>i.e.</i>, revenue, market capitalization), industry, stage of development and location;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #231F20">have named executive officer positions that are comparable to ours in terms of breadth, complexity, and scope of responsibilities; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #231F20">compete with us for executive talent.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">The Peer Group generally does not include companies headquartered outside the United States
    (because compensation and benefit practices are generally different outside the United States, the comparable compensation data for the named executive officers and non-employee Directors is not available and cost of living is different) or companies
    in industries whose compensation programs are not comparable to our programs, such as non-life science companies.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">In June 2022, the Compensation Committee reviewed the Peer Group using the criteria listed
    above and publicly available data as of May 2022. The Compensation Committee noted Ionis&#8217; 30-day average market capitalization was approximately $5.3 billion and trailing 12-month revenue was approximately $810 million. As part of this process, the
    Compensation Committee looked at companies in Ionis&#8217; industry with an emphasis on companies with 30-day average market capitalizations of between $1.5 billion and $15 billion and trailing 12-month revenue between $375 million and $2 billion. The
    Compensation Committee also looked at companies that identified Ionis as a peer, so called &#8220;reverse peers.&#8221; Based on this evaluation, the Compensation Committee added Ironwood Therapeutics to the Peer Group because it fell within the target market
    capitalization and revenue ranges and is in Ionis&#8217; sector. The Compensation Committee also added Sage Therapeutics to the Peer Group because it fell within the target market capitalization range and is in Ionis&#8217; sector. The Compensation Committee
    removed BeiGene and Bluebird Bio because they both fell outside the target market capitalization and revenue ranges.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="margin-bottom: 10pt; clear: both; margin-top: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">59</span></div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">The following table lists the companies in the 2022 Peer Group, along with Ionis&#8217; rankings
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
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  <tr style="vertical-align: bottom; background-color: #A20067">

    <td style="border: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white"><b>Company (ticker)</b></p>
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    <td style="border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt" colspan="2">
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    <td style="border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt" colspan="2">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white"><b>Market Capitalization</b><br />
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        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white"><b>Stage of Lead Drug</b></p>
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  </tr>

  <tr>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt; width: 39%">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">Acadia Pharmaceuticals (ACAD)</p>
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    <td style="border-bottom: Black 1pt solid; width: 14%; text-align: right">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in;">$484.1</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt; width: 7%">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; width: 15%; text-align: right">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in;">$4,072.8</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt; width: 8%">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt; width: 17%">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
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  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">Agios Pharmaceuticals (AGIO)</p>
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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in;">$0.0</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in;">$1,603.1</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">NDA</p>
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  </tr>

  <tr>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">Alkermes (ALKS)</p>
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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in;">$1,173.8</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in;">$4,472.2</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
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  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">Alnylam Pharmaceuticals (ALNY)</p>
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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in;">$844.3</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in;">$19,632.9</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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  </tr>

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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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  <tr>

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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
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  </tr>

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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
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  </tr>

  <tr>

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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
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  </tr>

  <tr style="background-color: white">

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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
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  </tr>

  <tr style="background-color: #E7E6E6">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
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  </tr>

  <tr>

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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
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  </tr>

  <tr style="background-color: #DDDDDD">

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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
        </td>

  </tr>

  <tr>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in;">$351.4</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
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  <tr style="background-color: #DDDDDD">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">United Therapeutics (UTHR)</p>
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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
        </td>

    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in;">$8,252.0</p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">&#160;</p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">Market</p>
        </td>

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          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white">Ionis Pharmaceuticals, Inc. (IONS)</p>
        </td>

    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white">&#160;</p>
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    <td style="border-bottom: Black 1pt solid; padding-left: 5.4pt; text-align: right">
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        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white">&#160;</p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white">Market</p>
        </td>

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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white">Ionis&#8217; Percentile Rank</p>
        </td>

    <td style="border-bottom: 1pt solid #000000; padding: 0px 0px 0px 5.4pt;">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: right; color: white;">46%</p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">&#160;</td>

    <td style="border-bottom: 1pt solid #000000; padding: 0px 0px 0px 5.4pt;">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: right; color: white;">42%</p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">&#160;</td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in; color: white">N/A</p>
        </td>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0">&#160;</p>
  <!-- Field: Rule-Page -->
  <div style="margin-left: 40pt; margin-top: 3pt; margin-bottom: 3pt; text-align: left;">
    <div style="font-size: 1pt; border-top: Black 1pt solid; width: 20%">&#160;</div>

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    <td style="width: 40pt"></td>

    <td style="width: 20pt; text-align: left">(1)</td>

    <td>Trailing 12-month revenue.</td>

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    <td style="width: 20pt; text-align: left">(2)</td>

    <td>30-day average market cap.</td>

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</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 45.35pt; text-align: left; text-indent: 13.15pt">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 22.5pt; text-align: left; text-indent: 0in; color: #CE0F69"><i>Our Productivity and Strength</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 22.5pt; text-align: left; text-indent: 0in; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">In 2022, we had a number of achievements that demonstrated our productivity and strength:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt">&#160;</p>
  <div style="position: relative; float: left; width: 73%">
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    <td style="width: 38.15pt"></td>

    <td style="width: 18pt; text-align: left">&#9679;</td>

    <td style="text-align: justify">Earned $587 million in revenue, met our 2022 financial guidance and ended the year with $2 billion in cash.</td>

  </tr>


</table>
    <p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0">&#160;</p>
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    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify"><span style="color: #231F20">Announced positive topline results from a 35-week interim analysis of the Phase 3 NEURO-TTRansform study of eplontersen in patients with ATTRv-PN and submitted an NDA with the FDA for
              eplontersen for the treatment of </span>ATTRv-PN<span style="color: #231F20">.</span></td>

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</table>
    <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
    <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify">Delivered nine positive data readouts from our mid- and late-stage pipeline, positioning us to add new products to our commercial portfolio and expand our late-stage pipeline.</td>

  </tr>


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    <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
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    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify">Expanded and diversified our technology when we advanced new medicines with enhanced muscle targeting capabilities and utilizing new MsPA backbone chemistry into preclinical development and completed the Metagenomi
            transaction.</td>

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  <div style="position: relative; float: right; width: 23%">
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    <td style="padding: 10pt 5pt">
            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white"><b>Earned $587 million in revenue, met our 2022 financial guidance and ended the year
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            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white">&#160;</p>
            <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white"><b>Achieved these financial successes while announcing positive topline results in the
                study of eplontersen in patients with ATTRv-PN, submitting an NDA for eplontersen for the treatment of ATTRv-PN, delivering nine positive data readouts from our mid- and late-stage pipeline, expanding and diversifying our technology and
                advancing our commercial strategy and go-to-market plans for eplontersen, olezarsen and donidalorsen.</b></p>
          </td>

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  <div><br /></div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="margin-bottom: 10pt; clear: both; margin-top: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">60</span></div>

    <div class="BRPFPageBreak" style="page-break-after: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <div style="position: relative; float: left; width: 73%">
    <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify">Advanced our commercial strategy and go-to-market plans for our near-term commercial opportunities, eplontersen, olezarsen and donidalorsen.</td>

  </tr>


</table>
    <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
    <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: justify"><span style="color: #231F20">As a consequence of our strong performance, our stock </span>performed at approximately the 81<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st</sup>
            percentile of the Nasdaq Biotechnology Index (&#8220;<b><i>NBI</i></b>&#8221;) in 2022.</td>

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  <div><br /></div>

  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #231F20">Our efficient platform and the dedication of our employees has enabled us to accomplish robust
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  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 22.3pt; text-align: left; text-indent: 0in; color: #CE0F69"><i>Advancing Our Pipeline</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 22.3pt; text-align: left; text-indent: 0in; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">We now have seven Phase 3 medicines for nine indications advancing toward the market. We also
    have a prolific mid-stage pipeline of medicines advancing towards Phase 3 development, many of which are expected to reach pivotal trials in the near term. Based on our anticipated near- and mid-term catalysts, we are well positioned to drive
    increasing and meaningful value for patients and stockholders.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><img width="700" height="393" alt="" src="ny20007094x2_def14aimg011.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.25in; text-align: left; text-indent: 0in; color: #CE0F69"><i>Compensation Allocation/Pay Mix</i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.25in; text-align: left; text-indent: 0in; color: #CE0F69">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">A key element of our compensation philosophy is to monitor and adjust our pay mix for our
    senior management team so the pay mix is less heavily weighted on fixed compensation (salary) and more heavily weighted on at-risk cash compensation and long-term equity incentive compensation. As part of the Compensation Committee&#8217;s review of our
    total pay mix for executive officers, the Compensation Committee focuses on the following:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
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    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #E57200"><i><span style="text-decoration: underline;">A significant portion of cash compensation is at risk</span></i></span><i><span style="color: #231F20">. </span></i><span style="color: #231F20">The Compensation Committee structures
            cash compensation such that a significant proportion of our CEO&#8217;s and other executive officers&#8217; cash compensation is at risk;</span></td>

  </tr>


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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #E57200"><i><span style="text-decoration: underline;">More of total compensation is long-term equity</span></i></span><i><span style="color: #231F20">. </span></i><span style="color: #231F20">The Compensation Committee structures the total
            pay mix for our CEO and other executive officers such that more of their compensation is in the form of long-term equity compensation; and</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="margin-bottom: 10pt; clear: both; margin-top: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">61</span></div>

    <div class="BRPFPageBreak" style="page-break-after: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt">&#9679;</td>

    <td style="text-align: left"><span style="color: #E57200"><i><span style="text-decoration: underline;">Less of total compensation is salary</span></i></span><i><span style="color: #231F20">. </span></i><span style="color: #231F20">The Compensation Committee strives to structure the total
            pay mix for our CEO and other executive officers such that less of their compensation is in the form of salary.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">An annual review of our total pay mix helps Ionis compete for and retain talent in the
    competitive marketplace and maintain compensation equity and balance among positions with similar responsibilities. The target pay mix for our executive officers is a result of the compensation targets that emphasize long-term compensation versus
    short-term compensation. Actual salary levels, annual Performance MBO awards and long-term incentive awards vary based on one or more of the following: an individual&#8217;s responsibilities, tenure in a particular position, experience, individual
    performance, and Company performance.</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #E57200"><i><span style="text-decoration: underline;">Pay Mix Chart</span></i></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #E57200">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">The following chart illustrates the portions of actual total direct compensation for the
    named executive officers that are composed of base salary, annual Performance MBO and long-term equity ($ shown in thousands) for 2022:</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 20.15pt; color: #231F20">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: #231F20"><img alt="" src="ny20007094x2_def14aimg012.jpg" /></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <div class="BRPFPageBreakArea" style="margin-bottom: 10pt; clear: both; margin-top: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">62</span></div>

    <div class="BRPFPageBreak" style="page-break-after: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 95%; border-collapse: collapse; margin-left: auto; margin-right: auto;">


  <tr style="vertical-align: top; background-color: #BFBFBF">

    <td style="border: black 1pt solid; padding-left: 5.4pt" colspan="5"></td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt" colspan="3">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in"><b>% of Total Direct Compensation</b></p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #A20067">

    <td style="width: 27%; border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt; text-align: center; vertical-align: middle">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in; color: white"><b>Name</b></p>
        </td>

    <td style="width: 7%; border-bottom: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt; text-align: center; vertical-align: middle">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in; color: white;"><b>Year</b></p>
        </td>

    <td style="width: 10%; border-bottom: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt; text-align: center; vertical-align: middle">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in; color: white;"><b>Base</b><br />
            <b>Salary</b></p>
        </td>

    <td style="width: 13%; border-bottom: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt; text-align: center; vertical-align: middle">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in; color: white;"><b>Annual</b><br />
            <b>Performance</b><br />
            <b>MBO</b></p>
        </td>

    <td style="width: 12%; border-bottom: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt; text-align: center; vertical-align: middle">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in; color: white;"><b>Long-Term Equity</b></p>
        </td>

    <td style="width: 7%; border-bottom: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt; text-align: center; vertical-align: middle">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in; color: white;"><b>Base Salary</b><br />
            <b>%</b></p>
        </td>

    <td style="width: 12%; border-bottom: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt; text-align: center; vertical-align: middle">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in; color: white;"><b>Annual Performance</b><br />
            <b>MBO</b><br />
            <b>%</b></p>
        </td>

    <td style="width: 7%; border-bottom: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt; text-align: center; vertical-align: middle">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-indent: 0in; color: white;"><b>Long-Term Equity</b><br />
            <b>%</b></p>
        </td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: left; text-indent: 0in">Brett P. Monia</p>
        </td>

    <td style="vertical-align: top; border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt" rowspan="2">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">2022</p>
        </td>

    <td style="vertical-align: top; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">$824,800</p>
        </td>

    <td style="vertical-align: top; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">$837,688</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$5,586,119</p>
        </td>

    <td style="vertical-align: top; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">11%</p>
        </td>

    <td style="vertical-align: top; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">12%</p>
        </td>

    <td style="vertical-align: top; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0; text-align: center; text-indent: 0in">77%</p>
        </td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.5pt; text-align: left; text-indent: 0pt">CEO</p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="vertical-align: top; border-right: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <div style="padding: 0in">
            <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: left; text-indent: 0in;">Elizabeth L. Hougen</p>
            <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: left; text-indent: 3.35pt;">EVP, Finance and CFO</p>
          </div>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">2022</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$584,480</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$379,912</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$1,472,746</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">24%</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">16%</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">60%</p>
        </td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-top: black 1pt solid; border-right: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <div style="padding: 0in">
            <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: left; text-indent: 0in;">Joseph T. Baroldi&#160;</p>
            <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: left; text-indent: 3.35pt;">EVP, Chief Business Officer</p>
          </div>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">2022</p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$476,500</p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$257,310</p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$3,244,069<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">12%</p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">6%<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></b></p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">82%</p>
        </td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="vertical-align: top; border-top: black 1pt solid; border-right: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: left; text-indent: 0in;">Onaiza Cadoret-Manier</p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">2022</p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$530,929</p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$345,104</p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$1,472,746</p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">22%</p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">15%</p>
        </td>

    <td style="border-top: black 1pt solid; border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">63%</p>
        </td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="vertical-align: top; border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.5pt; text-align: left; text-indent: 0pt;">EVP, Chief Global Product Strategy and Operations Officer</p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-left: 5.4pt"></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: left; text-indent: 0in;">Richard S. Geary</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">2022</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$546,694</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$341,684</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">$1,359,351</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">24%</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">15%</p>
        </td>

    <td style="border-right: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center; text-indent: 0in;">61%</p>
        </td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: black 1pt solid; border-bottom: Black 1pt solid; border-left: black 1pt solid; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 4.5pt; text-align: left; text-indent: 0pt;">EVP, Chief Development Officer</p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt"></td>

    <td style="border-right: black 1pt solid; border-bottom: Black 1pt solid; padding-left: 5.4pt"></td>

  </tr>


</table>
  <p style="margin-top: 0px; margin-bottom: 0px; text-align: center;">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 95%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: auto; margin-right: auto;">


  <tr style="vertical-align: top">

    <td style="width: 0"></td>

    <td style="width: 0.25in; text-align: center;">(1)</td>

    <td style="text-align: left;">Includes new hire equity awards granted to Mr. Baroldi when he joined the Company.</td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="margin-top: 0px; margin-bottom: 0px; text-align: center;">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 95%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: auto; margin-right: auto;">


  <tr style="vertical-align: top">

    <td style="width: 0"></td>

    <td style="width: 0.25in; text-align: center;">(2)</td>

    <td style="text-align: left;">Mr. Baroldi&#8217;s Annual Performance MBO bonus was prorated for time served during 2022, as he joined Ionis on January 31, 2022.</td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center;">&#160;</p>
  <div class="BRPFPageBreakArea" style="margin-bottom: 10pt; clear: both; margin-top: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">63</span></div>

    <div class="BRPFPageBreak" style="page-break-after: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: center;">&#160;</p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 37.5pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>2022 Compensation Decisions and
        Results </b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 37.5pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div style="POSITION:RELATIVE;FLOAT:LEFT;WIDTH:65%">
    <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: 0in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Base Salary</i></span></p>
    <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 208.5pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);">&#160;</p>
    <p style="font: 10pt Times New Roman,Times,serif; margin: 0px 0px 0pt; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We determine base compensation levels for
        all our employees primarily by market forces. Accordingly, the Compensation Committee and Board believe that it is important when making compensation decisions to be informed as to the current practices of comparable publicly held companies with
        which we compete for top talent. To this end, the Compensation Committee and Board review market and peer company data, which includes competitive information relating to the mix and levels of compensation for executives in the life sciences
        industry. We obtain this information for the Peer Group based on recent public filings with the SEC. In addition, we also review data from the Radford Global Life Sciences Survey, which is a summary of compensation data submitted by over 1,700 life
        sciences companies. The Compensation Committee and Board use these data to inform and shape their decision-making but do not strictly adhere to quantitative benchmarks. In addition, we assess whether the scope of job responsibilities and internal
        equity warrant a given base salary.</span></p>
  </div>

  <div style="POSITION:RELATIVE;FLOAT:RIGHT;WIDTH:30%">
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 208.5pt 0pt 0; text-align: justify; text-indent: 20.15pt; color: #231F20"></p>
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman,Times,serif; background-color: White; text-align: left;">&#160;</td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; background-color: rgb(162,0,102); padding-top: 10pt; padding-bottom: 10pt; padding-left: 5pt">
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.85pt 0pt 5.35pt; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>We determine base compensation
                  levels for all our employees primarily by market forces. Accordingly, the Compensation Committee and Board believe that it is important when making compensation decisions to be informed as to the current practices of comparable publicly
                  held companies with which we compete for top talent. </b></span></p>
          </td>

  </tr>


</table>
  </div>

  <div style="CLEAR:BOTH"></div>

  <div><br /></div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 208.5pt 0pt 0; text-align: justify; text-indent: 20.15pt; color: #231F20"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Each year all of our employees are
      eligible to receive an appropriate merit salary increase. The Compensation Committee sets a Company-wide merit increase budget percentage based on Ionis&#8217; performance and external factors such as the average merit budget of comparable companies and
      general economic conditions such as inflation. The actual merit increase award for each employee, including our executive officers, will vary depending upon the respective employee&#8217;s contributions to Ionis. For example, the Company-wide merit budget
      for increases effective in January 2022 was 3.5%, with a potential range of individual merit award increases of 0% to 10%. However, regardless of individual employee variances, we do not exceed the Company-wide approved merit budget.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Compensation Committee evaluates
      each executive officer&#8217;s performance to set, or for the CEO, recommend Board approval of, such executive officer&#8217;s annual merit increase. As part of this process, the Compensation Committee reviews the written reports prepared by the CEO evaluating
      the performance of each individual executive officer. The Compensation Committee carefully considers these reports since our CEO is in the best position to evaluate our executive officers&#8217; day-to-day and overall performance. The Compensation
      Committee meets in executive session and evaluates the CEO&#8217;s performance, primarily based upon the CEO&#8217;s achievement of our key corporate objectives for the year. At the end of this process, the Compensation Committee recommends Board approval of the
      CEO&#8217;s merit increase and approves the merit increases for the remaining executive officers. The Board then meets in executive session and approves our CEO&#8217;s merit increase. Our CEO has no role in determining his own compensation.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The executive officers&#8217; new salaries for
      each year are generally calculated as follows:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 38.15pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">Current Base Salary (x) Merit Increase = Increase to Base
            Salary</span></td>

  </tr>


</table>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 38.15pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">Current Base Salary (+) Increase to Base Salary (+) Market
            Adjustment (if applicable) = New Base Salary</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: 0in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">2022 Base Salary Calculations</span></i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: 0in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">The table below reflects the 2022 base
      salary calculations effective December 26, 2021 for our named executive officers. The Compensation Committee, or in the case of our CEO, the Board, approved merit increases to the salaries of the named executive officers of 3.6% on average, which was
      consistent with the budget for merit increases approved by the Compensation Committee. </span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Compensation Committee noted its desired target mix of compensation that is
      less weighted on salary.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">When reviewing salaries in December 2021, the Compensation
      Committee noted that the salaries of our named executive officers were within the competitive range of the Peer Group, with the exceptions of <span style="color: rgb(35, 31, 32);">Dr. Monia, Ms. Hougen and Ms. Cadoret-Manier, whose salaries were
        below the competitive range</span>. Despite Dr. Monia&#8217;s lower salary position to the market, <span style="color: rgb(35, 31, 32);">the Compensation Committee and the Board decided not to give Dr. Monia a market adjustment in 2022 due to the
        Company&#8217;s stock price performance in 2021. To address Ms. Hougen&#8217;s and Ms. Cadoret-Manier&#8217;s lower salary positions to the market and given each individual&#8217;s strong performance for the year, the Compensation Committee approved a market adjustment
        for each as reflected in the table below. </span></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: center; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 95%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: 20pt">


  <tr style="background-color: #A20067; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 25%; border: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Name</b></span></td>

    <td style="width: 17%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>2021 Base Salary</b></span></td>

    <td style="width: 20%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Merit Increase for<br />
              2022</b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Market <br />
              Adjustment</b></span></td>

    <td style="width: 18%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>2022 Base Salary</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: left; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Brett P. Monia</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$800,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">3.1%</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$824,800</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: left; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Elizabeth L. Hougen</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$557,541</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">3.9%</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$5,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$584,480</span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: left; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph T. Baroldi<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$476,500</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: left; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Onaiza Cadoret-Manier</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$482,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">3.9%</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$29,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$530,929</span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: left; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Richard S. Geary</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$527,697</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">3.6%</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; text-indent: 0in; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$546,694</span></td>

  </tr>


</table>
  <p style="margin-top: 0px; margin-bottom: 0px; text-align: center;">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 0.5in; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 0.25in; font: 10pt Times New Roman,Times,serif; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Mr. Baroldi joined Ionis in January 2022; therefore, no salary or merit increase
            data for 2021 is available.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span>&#160;</p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">64</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: 0in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">2023 Base Salary Calculations</span></i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: 0in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">The table below reflects the 2023 base
      salary calculations effective December 25, 2022 for our named executive officers. The Compensation Committee, or in the case of our CEO, the Board, approved merit increases to the salaries of the named executive officers of 4.4% on average, which was
      consistent with the budget for merit increases approved by the Compensation Committee. </span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Compensation Committee noted its desired target mix of compensation that is
      less weighted on salary.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">When reviewing salaries in December 2022, the Compensation
      Committee noted that the salaries of our named executive officers were within the competitive range of the Peer Group, with the exceptions of <span style="color: rgb(35, 31, 32);">Dr. Monia and Mr. Baroldi, whose salaries were below the competitive
        range</span>. <span style="color: rgb(35, 31, 32);">To address Dr. Monia&#8217;s and Mr. Baroldi&#8217;s lower salary positions to the market and given each individual&#8217;s strong performance for the year, the Compensation Committee, or in the case of Dr. Monia,
        the Board, approved a market adjustment for Mr. Baroldi and Dr. Monia as reflected in the table below. </span></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: center; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 95%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: 20pt">


  <tr style="background-color: #A20067; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 25%; border: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Name</b></span></td>

    <td style="width: 17%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>2022 Base Salary</b></span></td>

    <td style="width: 20%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Merit Increase for 2023</b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Market Adjustment</b></span></td>

    <td style="width: 18%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>2023 Base Salary</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: left; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Brett P. Monia</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$824,800</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4.2%</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$97,326</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$960,855</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: left; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Elizabeth L. Hougen</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$584,480</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4.75%</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$612,243</span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: left; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph T. Baroldi</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$476,500</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4.0%</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$20,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$514,374</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: left; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Onaiza Cadoret-Manier</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$530,929</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4.75%</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$556,148</span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: left; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Richard S. Geary</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$546,694</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4.2%</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5pt; text-align: center; padding-left: 5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$569,655</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.3pt; text-align: center; text-indent: 0in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.3pt; text-align: left; text-indent: 0in; color: rgb(206, 15, 105);"><span style="font: 10pt Times New Roman,Times,serif;"><i>Performance MBO Program &#8211; Performance-Based, At-Risk
        Cash Compensation</i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.3pt; text-align: left; text-indent: 0in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The next component of an executive
      officer&#8217;s compensation, and the compensation of the rest of our employees, is an annual performance-based cash payment through our Performance MBO program. While an employee&#8217;s base salary compensates the employee for continued service and
      performance, our Performance MBO program rewards employees for reaching specific objectives and for the judgment they use in making decisions. We do not guarantee a Performance MBO award as compensation. It is totally at risk. As such, a Performance
      MBO award represents an opportunity for reward based upon the individual&#8217;s level of accountability and depends on the relative success of both Ionis and the individual. Our approach for awarding Performance MBO bonuses differs from salary increases
      because, unlike salary increases, market forces do not impact bonus amounts.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We calculate the actual amount of each
      executive officer&#8217;s respective Performance MBO award based on the following formula:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0.5in; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Base Salary (x) Target Performance MBO %
      (x) Company Performance Factor (x) Individual Performance Factor = Performance MBO Amount</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0.5in; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;&#160;</span></p>
  <div style="POSITION:RELATIVE;FLOAT:LEFT;WIDTH:70%">
    <p style="font: 10pt Times New Roman,Times,serif; margin: 10pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(229, 114, 0);"><i><span style="text-decoration: underline;">Performance MBO Awards can be zero</span></i></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">. The multipliers in this formula ensure we award bonuses based on <i>both </i>Ionis&#8217; performance and individual performance. This means an employee may
        not receive a Performance MBO even if the employee performed well in a year in which the Company does not meet its corporate objectives. Similarly, if an employee performed poorly in a year in which the Company met its key corporate objectives, the
        employee may not receive a Performance MBO.</span></p>
  </div>

  <div style="POSITION:RELATIVE;FLOAT:RIGHT;WIDTH:25%">
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 208.5pt 0pt 0; text-align: justify; text-indent: 20.15pt"></p>
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; background-color: rgb(162,0,102); padding-top: 10pt; padding-bottom: 10pt; padding-left: 5pt">
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.85pt 0pt 5.35pt; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Performance MBO awards can be, and
                  have in the past been, <i><span style="text-decoration: underline;">zero</span></i>.</b></span></p>
            <p style="font: 10pt Times New Roman,Times,serif; margin: 5pt 10.85pt 0pt 5.35pt; text-align: left; text-indent: 0in; color: white;"><span style="font: 10pt Times New Roman,Times,serif;"><b>Performance MBO awards have a maximum amount.</b></span></p>
          </td>

  </tr>


</table>
  </div>

  <div style="CLEAR:BOTH"></div>

  <div><br /></div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For 2021 performance, the Compensation
      Committee awarded the Company&#8217;s executive officers a Company Performance Factor of 95%, and all other employees a Company Performance Factor of 110%, due to a few key Company disappointments during the year. In a prior year, we did not pay
      Performance MBOs to executive officers due to the failures we faced at the time. Conversely, in successful years, we reward our executive officers consistent with Ionis&#8217; success.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: center; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: center; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span>&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10pt 0pt 0; text-align: left; text-indent: 20.15pt"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">65</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <div>
    <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(229, 114, 0);"><i><span style="text-decoration: underline;">Performance MBOs have a maximum
            limit</span></i></span><i><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">. </span></i><span style="font: 10pt Times New Roman,Times,serif; color: rgb(35, 31, 32);">Performance MBOs are limited by
        a maximum Company Performance Factor, maximum Individual Performance Factor and Target Performance MBO Percentage:</span></p>
  </div>

  <div> <br />
  </div>

  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 38.15pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">We have a maximum Company Performance Factor of 200% and a
            maximum Individual Performance Factor of 160%. This range represents the boundary conditions for our Performance Factors and ensures we reward our employees consistent with Ionis&#8217; success.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 38.15pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10pt; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">We base Target Performance MBO percentages on position
            levels within Ionis. The Target Performance MBO percentage for 2022 for Executive Vice Presidents was 40% and for the CEO was 65%.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 54.7pt 0pt 0px; text-align: left; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">An individual&#8217;s Target Performance MBO
      percentage does not change unless the individual changes position level or the Compensation Committee sets a new target for that level. The table below summarizes the minimum and maximum Performance MBO for 2022 as a percentage of salary:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 54.7pt 0pt 0px; text-align: center; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 75%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: auto; margin-right: auto;">


  <tr style="background-color: #A20067; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 25%; border: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Name</b></span></p>
        </td>

    <td style="width: 25%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Minimum<br />
                Performance MBO<br />
                Percentage of Salary</b></span></p>
        </td>

    <td style="width: 25%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Maximum<br />
                Performance MBO<br />
                Percentage of Salary</b></span></p>
        </td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Brett P. Monia</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">0%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">208%</span></p>
        </td>

  </tr>

  <tr style="background-color: #DDDDDD; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Elizabeth L. Hougen</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">0%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">128%</span></p>
        </td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph T. Baroldi</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">0%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">128%</span></p>
        </td>

  </tr>

  <tr style="background-color: #DDDDDD; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Onaiza Cadoret-Manier</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">0%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">128%</span></p>
        </td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Richard S. Geary</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">0%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">128%</span></p>
        </td>

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</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Compensation Committee sets the Company
      Performance Factor based on the following process:</span></p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div style="POSITION:RELATIVE;FLOAT:LEFT;WIDTH:65%">
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">At the end of each year, the Compensation Committee meets to evaluate Ionis&#8217; overall performance for the year. As described below in the chart
              called &#8220;Evaluation of Key 2022 Corporate Objectives,&#8221; the Compensation Committee measures Ionis&#8217; performance based upon the achievement of goals set at the beginning of the year with objective measures and agreed upon by our Board and senior
              management.</span></td>

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</table>
    <p style="margin: 0pt 0px; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 0.25in; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">In addition, the Compensation Committee considers our one-, three- and
              five-year TSRs, and based on these returns has <i>negative discretion to reduce the Company Performance Factor and Individual Performance Factors for our executive officers, <span style="text-decoration: underline;">which occurred for 2021 performance</span>. </i></span></td>

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</table>
  </div>

  <div style="POSITION:RELATIVE;FLOAT:RIGHT;WIDTH:30%">
    <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
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    <td style="font: 10pt Times New Roman, Times, Serif; padding: 10pt 5pt; background-color: rgb(162,0,102)">
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 6.5pt 0pt 5.05pt; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Based on our one-, three- and
                  five-year TSRs, the Compensation Committee has negative discretion to reduce the Company Performance Factor and Individual Performance Factors for our executive officers, which occurred for 2021 performance.</b></span></p>
          </td>

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  </div>

  <div style="CLEAR:BOTH"></div>

  <div><br /></div>

  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
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    <td style="width: 0.25in; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">The Compensation Committee then reviews the Company Performance Factor history
            from the prior ten years to form a comparison for our current year&#8217;s successes and/or failures.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 0.5in; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 0.25in; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">Finally, based on the individual&#8217;s performance, the Compensation Committee
            recommends Board approval of the CEO&#8217;s Individual Performance Factor and approves the Individual Performance Factor for our other executive officers.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Once the Compensation Committee has
      determined the elements of the formula above, we use that formula to calculate each executive officer&#8217;s Performance MBO.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(229, 114, 0);"><i><span style="text-decoration: underline;">Evaluation of 2022 Key Corporate
          Objectives</span></i></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">. On December 15, 2022, the Compensation Committee completed its evaluation of the Company&#8217;s performance against the 2022
      Key Corporate Objectives. The Compensation Committee evaluates performance based on the achievement of goals (<i>including objective measures</i>) that the Board and management set at the beginning of each year. The table below provides a detailed
      evaluation of each key objective and the related achievements for 2022, as well as a description of notable unplanned accomplishments that the Compensation Committee considered in evaluating the Company&#8217;s performance. The Compensation Committee set
      the Company Performance Factor for the 2022 Performance MBO at 125%. This was in recognition of a year full of many accomplishments across all aspects of our business, including the following:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 18pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.5pt; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Earned $587 million in revenue, met our 2022 financial guidance and ended the year
            with $2 billion in cash.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


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    <td style="width: 18pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.5pt; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">Announced positive topline results from a 35-week interim
            analysis of the Phase 3 NEURO-TTRansform study of eplontersen in patients with ATTRv-PN and submitted an NDA with the FDA for eplontersen for the treatment of </span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">ATTRv-PN<span style="color: rgb(35, 31, 32);">.</span></span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 18pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.5pt; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Delivered nine positive data readouts from our mid- and late-stage pipeline,
            positioning us to add new products to our commercial portfolio and expand our late-stage pipeline.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 18pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.5pt; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Expanded and diversified our technology when we advanced new medicines with
            enhanced muscle targeting capabilities and utilizing new MsPA backbone chemistry into preclinical development and completed the Metagenomi transaction.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;&#160;</span></p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">66</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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    <td style="width: 18pt; font: 10pt Times New Roman,Times,serif; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 0.15in; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Advanced our commercial strategy and go-to-market plans for our near-term
            commercial opportunities, eplontersen, olezarsen and donidalorsen.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="text-align: left; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">As a consequence of our strong performance, our stock </span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">performed at approximately the 81<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st</sup> percentile of the NBI in 2022.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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  <tr style="vertical-align: top; background-color: #A20067; font: 10pt Times New Roman, Times, Serif">

    <td style="border: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 1pt 5.4pt" colspan="3">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Evaluation of 2022 Key Corporate Objectives</b></span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #CE0F69; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 4%; border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 1pt 5.4pt"></td>

    <td style="width: 45%; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 1pt 5.4pt; border-right: black 1pt solid">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Objective &amp; Pre-Approved Objective Measures</b></span></p>
        </td>

    <td style="width: 51%; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 1pt 5.4pt; border-right: black 1pt solid">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Evaluation</b></span></p>
        </td>

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  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Meet financial goals:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Meet financial guidance</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Meet budget</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">partially met</span></i> this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; We met our financial guidance</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; We exceeded our cash budget; however, we ended
              the year below our revenue budget and above our operating expense budget, driven in part by the upfront payment we made in connection with the Metagenomi transaction</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

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    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Achieve key eplontersen milestones:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Positive Phase 3 data in polyneuropathy with
              competitive profile</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; File NDA</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Establish strong co-commercialization alliance
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Establish plan to transition commercial
              manufacturing to AstraZeneca</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Achieve full enrollment for the eplontersen
              Phase 3 study in patients with transthyretin-mediated amyloid cardiomyopathy</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">exceeded</span></i> this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Obtained positive Phase 3 data in polyneuropathy
              with competitive profile</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; We filed the NDA for eplontersen</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Established a strong co-commercialization
              alliance with AstraZeneca and effective joint commercialization plan</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 22.5pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"> <br />
            </span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Established plan to transition commercial
              manufacturing to AstraZeneca ahead of schedule</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Achieved our original enrollment target, first
              resizing target, and are on track to hit new enrollment target in 2023</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">3</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Achieve key olezarsen milestones:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Complete enrollment for the Phase 3 study of
              olezarsen for familial chylomicronemia syndrome (&#8220;<b><i>FCS</i></b>&#8221;) on time and prepare for 2023 NDA filing</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Keep enrollment for the Phase 3 study of
              olezarsen for severe hypertriglyceridemia (&#8220;<b><i>sHTG</i></b>&#8221;) on track with specified enrollment target</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Initiate second supportive Phase 3 study for
              sHTG</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Complete switch of Waylivra FCS patients in the
              U.S. and Canada to olezarsen</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Establish and implement olezarsen brand plan</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">substantially met</span></i> this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Completed enrollment for the Phase 3 study of
              olezarsen for FCS on time and made progress towards preparation for an NDA filing in 2023</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Kept enrollment on track and hit our specified
              enrollment target in January 2023</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Initiated a second supportive Phase 3 study for
              sHTG</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Completed switch of Waylivra FCS patients in the
              U.S. and Canada to olezarsen</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Established and implemented a brand plan for
              olezarsen</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

  </tr>


</table>
  <p style="margin-top: 0px; text-align: center; margin-bottom: 0px;">&#160;&#160;</p>
  <p style="margin: 0"></p>
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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">67</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
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  <table cellspacing="0" cellpadding="0" border="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="vertical-align: top; background-color: #DDDDDD; font: 10pt Times New Roman, Times, Serif">

    <td style="border-width: 2px 1pt 1pt; border-style: solid; border-color: rgb(0, 0, 0) black black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; border-top: 2px solid rgb(0, 0, 0); width: 45%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Achieve key donidalorsen milestones:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Keep Phase 3 enrollment on track with specified
              enrollment target</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 22.5pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"> <br />
            </span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Initiate open label extension (&#8220;<b><i>OLE</i></b>&#8221;)






















              and SWITCH studies</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 22.5pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"> <br />
            </span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Establish and implement donidalorsen brand plan</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; border-top: 2px solid rgb(0, 0, 0); width: 51%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">substantially met </span></i>this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Kept Phase 3 enrollment on track but did not hit
              our specified enrollment target</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Initiated the OLE and SWITCH studies</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Established and implemented a brand plan for
              donidalorsen</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">5</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 45%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Increase stock price performance by a specified target percentage
              greater than or equal to median of the companies listed in the NBI</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 51%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">exceeded</span></i> this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Ionis&#8217; stock price significantly outperformed
              the median stock price change for companies listed on the NBI, with Ionis stock at 24.12% of the NBI and the NBI median at -34.97% at December 31, 2022</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 45%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Advance key initiatives related to independently commercializing
              medicines from our wholly owned pipeline:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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            </span></p>
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Establish and implement right-sized and
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Establish and implement process for asset
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Optimize process and integration of commercial
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Design and establish enterprise organization
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Approval of longer-term neurology commercial
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Define and initiate IT systems and enterprise
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 51%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">exceeded</span></i> this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Completed the operating models for commercial
              and medical affairs ahead of schedule</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Established and implemented the framework,
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Established and implemented right-sized and
              effective compliance and governance processes</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Advanced process for asset progression and
              partnering decisions</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Optimized process and integration of commercial
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Designed and established enterprise organization
              structure</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; ELT approved longer-term neurology commercial
              strategy</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Defined and initiated IT systems and enterprise
              data roadmap</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 45%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Achieve technology advancements in specified areas:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Advance SPINRAZA follow-on into the clinic</span></p>
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Advance MsPA into development</span></p>
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Identify medicinal chemistry solution for a
              specified delivery</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 51%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">met</span></i> this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Biogen licensed follow-on and initiated clinical
              dosing</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Advanced MsPA into development</span></p>
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Identified MsPA backbone chemistry as solution
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 21.7pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

  </tr>


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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">68</span>&#160;</div>

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    <td style="border-width: 1pt; border-style: solid; border-color: Black Black Black black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%; text-align: center;">&#160;</td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; border-top: 1pt solid Black; width: 45%;">
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in"></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 22.5pt; text-align: left; text-indent: -0.25in"></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 22.5pt; text-align: left; text-indent: -0.25in"></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 22.5pt; text-align: left; text-indent: -0.25in"></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Identify optimal LICA scaffold for delivery to
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Establish resource plan to support new
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        </td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; border-top: 1pt solid Black; width: 51%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Identified optimal scaffold for specific tissue
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Established resource plan to support new
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 21.7pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">8</span></p>
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        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 45%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Achieve additional Phase 3 pipeline goals:</span></p>
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Keep FUS-ALS enrollment on track</span></p>
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Positive decision to initiate Phase 3
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Implement positive path forward for tominersen
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        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 51%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">exceeded</span></i> this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Achieved full enrollment for pelacarsen in
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Positive decision to initiate Phase 3
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            </span></p>
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 1in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">o&#160;&#160;&#160;&#160; Roche approved Phase 2 study start for tominersen</span></p>
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 1in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">o&#160;&#160;&#160;&#160; Received positive OLE data and NDA acceptance with
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        </td>

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    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">9</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 45%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Achieve key mid- and early-stage pipeline goals</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160;&#160;Positive mid-stage pipeline readouts on at least
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160;&#160;Initiate at least three new Phase 2 studies</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160;&#160;Initiate at least three first-in-human trials
              including for two specified programs</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160;&#160;Advance at least three new drugs into
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 13.5pt; text-align: left; text-indent: -13.5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 51%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">substantially met</span></i> this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Achieved positive mid-stage pipeline readouts on
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          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Initiated three new Phase 2 studies</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Initiated three first-in-human trials including
              for one specified program</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Advanced three new drugs into development</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

  </tr>

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    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; font: 10pt Times New Roman,Times,serif; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 4pt; width: 4%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">10</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 4pt; width: 45%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Complete key business development transactions</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Secure ex-US commercial partner for at least one
              wholly-owned asset</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Complete bundled out-license transaction for
              selected assets</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Completed strategic partnership in one new
              non-antisense platform technology</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 4pt; width: 51%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">did not meet</span></i> this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Did not achieve</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Did not achieve</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 22.5pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"> <br />
            </span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Achieved with Metagenomi transaction</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 4pt; width: 4%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">11</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 4pt; width: 45%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Implement long-range growth and space plan</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Advance design and construction of new
              office/lab building in line with long-term growth plans</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Design and begin renovating conference center</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Secure site for new manufacturing facility</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Advance plan to support external CMO API
              manufacturing while building internal capability to manufacture new chemistries to support 2023 development candidates</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.5in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 4pt; width: 51%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">met</span></i> this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Advanced design and construction plans for new
              office/lab building</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 22.5pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"> <br />
            </span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Renovation in progress and will be completed in
              2023</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Secured new site in October 2022</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Advanced plan to support external CMO API
              manufacturing while building internal capability to manufacture new chemistries to support 2023 development candidates</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 21.7pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 45%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Increase involvement in our corporate responsibility initiatives
              internally and increase awareness of these initiatives externally</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Establish corporate responsibility team and
              charter</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Continue diversity, equity and inclusion (&#8220;<b><i>DEI</i></b>&#8221;)






















              efforts across the Company and with the Board</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Include appropriate description of Ionis&#8217;
              corporate responsibility efforts in corporate presentations, on our website and in relevant public filings</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.5in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 51%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">met</span></i> this objective:</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Established corporate responsibility team and
              charter</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Continued our DEI efforts across the Company and
              with the Board</span></p>
          <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 22.5pt; text-align: left; text-indent: -0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"> <br />
            </span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Incorporated our corporate responsibility
              efforts into corporate presentations, on our website and in relevant public filings</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 21.7pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

  </tr>


</table>
  <p style="margin-top: 0px; text-align: center; margin-bottom: 0px;">&#160;&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">69</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="margin: 0"></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%; border-top: Black 1pt solid">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">13</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 45%; border-top: 1pt solid Black;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Support inline products Tegsedi and Waylivra</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Achieve MAA submissions for Waylivra and Tegsedi
              in accordance with Sobi and PTC commercial filings and launch plans</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Effectively manage Sobi and PTC partnerships</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Achieve compliance with global commercial
              product authorizations and license on time</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 51%; border-top: 1pt solid Black;">
          <div>
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ionis <i><span style="text-decoration: underline;">met</span></i> this objective:</span></p>
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Completed submissions in accordance with Sobi
                and PTC commercial filings and launch plans</span></p>
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          </div>
          <div>
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Continued to effectively manage Sobi and PTC
                partnerships</span></p>
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;&#160;&#160;&#160;&#160; Timely achieved compliance with global
                commercial product authorizations and license</span></p>
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 21.7pt; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
          </div>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #E57200; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt;" colspan="3">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; background-color: rgb(229, 114, 0);"><b>Unplanned
                Accomplishments for 2022</b></span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">14</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt;" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Completed sale-leaseback transaction</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">15</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt;" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Completed transaction to build new manufacturing facility</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt; width: 4%;">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16</span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; font: 10pt Times New Roman,Times,serif; padding-right: 5.4pt; padding-left: 5.4pt; padding-top: 8pt;" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Established new 10-year strategic financial plan and updated periodic
              review process</span></p>
        </td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);">&#160;</p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Once the Compensation Committee
      establishes the Company Performance Factor, the committee next reviews each executive officer&#8217;s individual performance and contribution towards the key corporate objectives and other accomplishments set forth above and for our CEO, recommends Board
      approval of, and for all other executive officers, approves MBO awards accordingly. The following table illustrates the Performance MBO awards approved for 2022 performance:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: center; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 95%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: 0.25in">


  <tr style="background-color: #A20067; font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">

    <td style="width: 21%; border: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Name</b></span></p>
        </td>

    <td style="width: 11%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>2022 Base Salary</b></span></p>
        </td>

    <td style="width: 11%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Target Performance MBO %</b></span></p>
        </td>

    <td style="width: 12%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Company Performance Factor</b></span></p>
        </td>

    <td style="width: 12%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Individual Performance Factor</b></span></p>
        </td>

    <td style="width: 12%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Resulting Performance MBO</b></span></p>
        </td>

    <td style="width: 16%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Results Considered When Setting Individual Performance Factor<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></p>
        </td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Brett P. Monia</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$824,800</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">65%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">125%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">125%<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></b></span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$837,688</span></p>
        </td>

    <td style="vertical-align: top; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1-16</span></p>
        </td>

  </tr>

  <tr style="background-color: #DDDDDD; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Elizabeth L. Hougen</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$584,480</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">40%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">125%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">130%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$379,912</span></p>
        </td>

    <td style="vertical-align: top; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1, 5, 6, 11, 12, 14-16</span></p>
        </td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph T. Baroldi</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$476,500</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">40%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">125%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">120%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$257,310</span></p>
        </td>

    <td style="vertical-align: top; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1, 10 &amp; 13</span></p>
        </td>

  </tr>

  <tr style="background-color: #DDDDDD; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Onaiza Cadoret-Manier</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$530,929</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">40%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">125%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">130%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$345,104</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1-4 &amp; 6</span></p>
        </td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Richard S. Geary</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$546,694</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">40%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">125%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">125%</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$341,684</span></p>
        </td>

    <td style="vertical-align: top; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1-4, 6-9 &amp; 11</span></p>
        </td>

  </tr>


</table>
  <p style="margin-top: 0px; margin-bottom: 0px; text-align: center;">&#160;</p>
  <!-- Field: Rule-Page -->
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    <div style="font-size: 1pt; border-top: 1pt solid Black; width: 20%; text-align: left;">&#160;</div>

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  <!-- Field: /Rule-Page -->
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    <td style="width: 0.25in; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The numbers correspond to the enumerated key objectives in the table entitled &#8220;Evaluation of Key 2022
            Corporate Objectives&#8221; on pages 66 through 70. The Compensation Committee reviews the individual&#8217;s contribution towards the key corporate objectives and other accomplishments set forth above when determining or recommending the Individual
            Performance Factors.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 0.25in; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(2)</span></td>

    <td style="text-align: left; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Since our CEO is ultimately responsible for the Company&#8217;s performance, his Individual Performance Factor
            is usually the same as the Company Performance Factor, up to an Individual Performance Factor maximum of 160%.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: 0in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Stock Compensation</i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.5pt; text-align: left; text-indent: 0in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 5.5pt 0pt 0px; text-align: left; text-indent: 22.5pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We use stock options and RSUs to give <i>all</i>
      employees, including Ionis&#8217; executive officers, an economic interest in the long-term appreciation of our common stock. We believe awarding a combination of stock options and RSUs provides a number of benefits. Stock options provide a way to align
      employee interests with those of upper management and the stockholders because as our stock price increases, so too does the employee&#8217;s compensation. In 2012, we started granting RSUs as part of the annual merit equity awards. RSUs are a strong
      retention vehicle for employees as the RSUs vest in annual installments over four years and have value upon vesting, but at the same time, require fewer shares than stock option awards.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 5.5pt 0pt 0px; text-align: center; text-indent: 22.5pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span>&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 5.5pt 0pt 0; text-align: left; text-indent: 22.5pt; color: #231F20"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">70</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <div style="POSITION:RELATIVE;FLOAT:LEFT;WIDTH:70%">
    <p style="margin: 0pt 5.5pt 0pt 0px; font: 10pt Times New Roman,Times,serif; text-align: left; text-indent: 22.5pt;"><span style="font: 10pt Times New Roman,Times,serif;">We grant existing employees new stock options and RSUs annually to provide a
        continuing incentive in Ionis&#8217; long-term success. Each year, the Compensation Committee sets a budget of option equivalents for our executive officers and a budget of option equivalents for all other employees. From these budgets, we set a target
        number of option equivalents for each employee level in the Company. The actual award for each employee can be higher or lower than the target for their level depending on individual performance, but the total awards cannot exceed the budget set by
        the Compensation Committee. Beginning in January 2019, we allocated option equivalents among stock options and RSUs as follows: 60% of option equivalents was allocated to stock options and 40% of option equivalents was allocated to RSUs. In 2022,
        we allocated 50% of option equivalents to stock options and 50% to RSUs. For our executive officers&#8217; 2022 awards, we allocated 33% (for our CEO) or 20% (for all of our other executive officers) of their total equity awards in the form of PRSUs,
        with the remaining option equivalents allocated 50% to stock options and 50% to RSUs.</span></p>
  </div>

  <div style="POSITION:RELATIVE;FLOAT:RIGHT;WIDTH:25%">
    <p style="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></p>
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; background-color: rgb(162,0,102); padding-top: 10pt; padding-bottom: 10pt; padding-left: 5pt">
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 8.65pt 0pt 5.05pt; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>We use stock options and RSUs to
                  give all employees, including Ionis&#8217; executive officers, an economic interest in the long-term appreciation of our common stock. </b></span></p>
            <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 5.05pt; text-align: left; text-indent: 0in; color: white"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b> <br />
                </b></span></p>
          </td>

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  </div>

  <div style="CLEAR:BOTH"></div>

  <div><br /></div>

  <p style="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 5.5pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not use Black-Scholes grant date
      valuation calculations to set the size of our equity awards. Instead, once we identify the number of stock options and RSUs to be awarded from the option equivalent budget for our executive officers, we calculate the Black-Scholes value of the stock
      option awards. As a market check, we then compare the resulting values to the Black-Scholes value of awards granted by the companies in the Peer Group and make adjustments to the size of the awards when appropriate. When our stock price is high, the
      Black-Scholes value of the awards is also high. Unlike other companies, when our stock price is low, we do not automatically increase the equity awards to achieve a pre-defined Black-Scholes value of the stock options and RSUs to be awarded. For
      example, stock options granted in 2021 for 2020 performance had a fair value of $56.78, while stock options granted in 2022 for 2021 performance had a fair value of $32.60, and we did not increase the awards granted in 2022 such that the aggregate
      Black-Scholes value would be consistent with that of the prior year.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 5.5pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">Performance-Based Stock Awards</span></i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div style="POSITION:RELATIVE;FLOAT:LEFT;WIDTH:65%">
    <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In response to stockholder feedback, beginning
        in 2020, we implemented PRSU awards for our CEO&#8217;s compensation, and increased the proportion of such awards for our CEO&#8217;s total equity awards beginning in 2022. Additionally, in 2022, we implemented PRSU awards for our other executive officers.
        These PRSU awards provide our executive officers the opportunity to earn a defined number of shares of our common stock if we achieve pre-determined performance goals. At target level of achievement, the PRSU awards represent 33% of our CEO&#8217;s total
        equity awards and 20% of each of our other executive officer&#8217;s total equity awards. The PRSU awards pay out based on our relative stock price performance compared to a peer group. Measuring our stock performance relative to peers mitigates the
        impact of macroeconomic factors, both positive and negative, that affect the industry and stock price performance and that are beyond the control of management. Measuring our performance in this way also provides rewards that are more directly
        aligned with performance through different economic cycles. We believe these PRSU awards provide a challenging incentive to the executive officers to deliver stockholder value.</span></p>
  </div>

  <div style="POSITION:RELATIVE;FLOAT:RIGHT;WIDTH:30%">
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 199pt 0pt 0; text-align: justify; text-indent: 20.15pt; color: #231F20"></p>
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; background-color: rgb(162,0,102); padding-top: 10pt; padding-bottom: 10pt; padding-left: 5pt">
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 8.95pt 0pt 5.25pt; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Measuring our stock performance
                  relative to peers mitigates the impact of macroeconomic factors, both positive and negative, that affect the industry and stock price performance and that are beyond the control of management. Measuring our performance in this way also
                  provides rewards that are more directly aligned with performance through different economic cycles.</b></span></p>
          </td>

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  </div>

  <div style="CLEAR:BOTH"></div>

  <div><br /></div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 199pt 0pt 0; text-align: justify; text-indent: 20.15pt; color: #231F20"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For PRSU grants made before 2023, one
      third of such PRSUs may vest at the end of three separate performance periods spread over the three years following the date of grant. As discussed above, we evaluated our PRSU structure in 2022 to ensure that it is consistent with market practices
      and will best incentivize long term stock price performance. As a result of such evaluation, beginning with PRSU grants made in 2023, such grants will have a single vesting period at the end of three years. In addition, we increased the relative TSR
      percentile rank for maximum payout of the awards from the 75<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile to the 90<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup>
      percentile and added additional payout thresholds. The payout thresholds for grants made in 2023 and going forward are as follows:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: center; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 70%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: auto; margin-right: auto;">


  <tr style="vertical-align: top; background-color: #A20067; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 35%; border: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Relative TSR Percentile Rank</b></span></td>

    <td style="width: 35%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>TSR Performance Multiplier</b></span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">&lt;25<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th </sup>percentile</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">0%</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);"> 25<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th </sup>percentile (<b>Threshold</b>) </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">50%</span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">50<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th </sup>percentile (<b>Target</b>)</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">100%</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">60<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th </sup>percentile</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">125%</span></td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">75<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th </sup>percentile</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">150%</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">90<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th </sup>percentile (<b>Maximum</b>)</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; font: 10pt Times New Roman,Times,serif; padding: 2pt 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">200%</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: rgb(35, 31, 32);">&#160;&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">71</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; color: #231F20"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.5pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Importantly, <b><span style="text-decoration: underline;">all</span></b> of the PRSU grants
      made since inception of our PRSU program include the following <b><span style="text-decoration: underline;">limitations</span></b>:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.5pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div style="POSITION:RELATIVE;FLOAT:LEFT;WIDTH:50%">
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 38.15pt"></td>

    <td style="width: 20.35pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of each performance period may be anywhere
              from zero to the maximum amount depending on the Company&#8217;s relative TSR; and</span></td>

  </tr>


</table>
    <p style="margin: 0pt 0px; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 38.15pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 20.35pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">If the Company&#8217;s TSR is negative over the performance period, the payout will not exceed 100% of the
              target number even if the percentile rank exceeds the 50<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile.</span></td>

  </tr>


</table>
  </div>

  <div style="POSITION:RELATIVE;FLOAT:RIGHT;WIDTH:45%">
    <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
    <table cellspacing="0" cellpadding="0" style="width: 80%; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; background-color: rgb(162,0,102); padding-top: 10pt; padding-bottom: 10pt; padding-left: 5pt">
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>No number of PRSUs is guaranteed to vest.</b></span></p>
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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                  performance period, the payout will not exceed 100% of the target number.</b></span></p>
          </td>

  </tr>


</table>
  </div>

  <div style="CLEAR:BOTH"></div>

  <div><br /></div>

  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For 2021 performance, in January 2022,
      Dr. Monia received 101,489 time-vested stock options, 50,745 time-vested RSUs and 76,117 PRSUs (target payout of 50,745, multiplied by 150% to account for potential upside). For 2022 performance, in January 2023, Dr. Monia received 118,673
      time-vested stock options, 89,005 time-vested RSUs and 146,127 PRSUs (target payout of 73,064, multiplied by 200% to account for potential upside).</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">Vesting of Stock Awards</span></i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Vesting schedules reward long-term
      performance and incentivize long-term stock appreciation and increased stockholder returns. For each stock option and RSU granted (except PRSUs), the Compensation Committee sets a vesting schedule over four years, with no vesting during the first
      year. Therefore, the stock options and RSUs granted to our executive officers directly align the interests of our executive officers with the interests of our stockholders and Ionis&#8217; long-term success. The actual economic value of stock option awards
      depends directly on the performance of our stock price over the period during which the awards vest and the period during which the stock options may be exercised. In other words, our executive officers will only realize economic value when our stock
      price, and consequently stockholder value, increases, which aligns pay with performance and fosters accountability for Ionis&#8217; long-term success. Conversely, the stock options are not worth anything if our stock price does not increase above the
      exercise price. For example, a total of 173,954 stock options expired underwater for our executive officers in the first quarter of 2022 and a total of 200,193 stock options expired underwater for our executive officers in the first quarter of 2023.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Similarly, in the same way our
      stockholder returns increase and decrease based on our stock&#8217;s performance, the value to our employees of the RSUs increases and decreases based on our stock&#8217;s performance. In addition, RSUs promote retention and reinforce an ownership culture, and
      provide value even during periods of stock price or market underperformance.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">With the exception of PRSUs awarded to our executive officers, <span style="color: rgb(35, 31, 32);">we do not tie vesting to the achievement of specific events, such as annual metrics, because we do not want to encourage our employees to deviate from our company objectives, which we believe optimizes sustained
        stockholder value; nor do we want our employees to take unnecessary risks just to meet a short-term metric.</span></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div style="POSITION:RELATIVE;FLOAT:LEFT;WIDTH:40%">
    <table cellspacing="0" cellpadding="0" style="width: 85%; font: 10pt Times New Roman, Times, Serif; margin-left: 20pt">


  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman,Times,serif; background-color: White; padding-bottom: 10pt; padding-left: 5pt; text-align: left;">&#160;</td>

  </tr>

  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; background-color: rgb(162,0,102); padding-top: 10pt; padding-bottom: 25pt; padding-left: 5pt">
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 6.55pt 0pt 5.35pt; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Each year the Compensation Committee
                  approves a stock option, RSU and PRSU budget for annual employee merit awards. We do not grant options, RSUs or PRSUs in excess of this budget without Compensation Committee approval.</b></span></p>
          </td>

  </tr>


</table>
  </div>

  <div style="POSITION:RELATIVE;FLOAT:RIGHT;WIDTH:55%">
    <p style="margin: 0pt 10pt 0pt 0px; font: 10pt Times New Roman,Times,serif; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The stock option vesting schedule is typically over a
        four-year period at the rate of 25% at the end of the first year and then at the rate of 2.08% per month for 36 months thereafter during the optionee&#8217;s employment. The RSU vesting schedule is typically over a four-year period at the rate of 25% per
        year. In addition, as further described below, our executive officers must hold shares received upon vesting of their RSUs and PRSUs until they meet certain ownership thresholds or no longer serve the Company. These practices align our employee
        compensation with our stockholders&#8217; interests because if stockholder value declines over time, so too will the value of the equity compensation provided to all employees. We have historically had low employee turnover, particularly in our
        management team, and the members of our management have traditionally held their stock options for a long period of time before exercise. Our historically low turnover is indicative of our employees&#8217; commitment to Ionis and its technology and
        reflects our executive officers&#8217; <span style="color: rgb(35, 31, 32);">belief in the long-term value of our stock. </span></span></p>
  </div>

  <div style="CLEAR:BOTH"></div>

  <div><br /></div>

  <p style="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 176.5pt 0pt 0px; text-align: center; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span>&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 176.5pt 0pt 0; text-align: justify; text-indent: 20.15pt"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">72</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 176.5pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <div style="POSITION:RELATIVE;FLOAT:LEFT;WIDTH:69%">
    <p style="margin: 0pt 0px; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><span style="color: rgb(229, 114, 0);"><i><span style="text-decoration: underline;">Our stock compensation budget minimizes dilution</span></i></span><i><span style="color: rgb(35, 31, 32);">. </span></i><span style="font: 10pt Times New Roman,Times,serif; color: rgb(35, 31, 32);">Each year the Compensation </span>Committee approves a budget that sets the number of stock options, RSUs and PRSUs we
        can grant our employees for annual merit awards. We do not grant stock options, RSUs or PRSUs that exceed this budget without the Compensation Committee&#8217;s approval. Over the past three years, the average merit award stock budget set by the
        Compensation Committee has been approximately 2.2% of our outstanding common stock on an issued and outstanding basis. This stock compensation budget, and therefore our equity compensation burn rate, is well below the ISS-adjusted Peer Group
        average of 4.4% from 2019 through 2021. We believe this stock budget is an important tool to balance our compensation objectives with stockholder interests. For 2022 performance, the Compensation Committee set a merit stock award budget that
        resulted in approximately 1.5 million stock options, approximately 1.1 million RSUs and a target number of approximately 140,000 PRSUs awarded to our employees (as applicable), including the executive officers. Together these shares represent
        approximately 1.9% of our outstanding common stock on an issued and outstanding basis for that year. This budget, as well as each employee&#8217;s position level and performance in the previous year, ultimately determines the size of the individual
        annual stock grants.</span></p>
  </div>

  <div style="POSITION:RELATIVE;FLOAT:RIGHT;WIDTH:26%">
    <p style="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></p>
    <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif">


  <tr style="font: 10pt Times New Roman, Times, Serif">

    <td style="font: 10pt Times New Roman, Times, Serif; background-color: rgb(162,0,102); padding-top: 20pt; padding-bottom: 20pt; padding-left: 5pt">
            <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Over the past 3 years, the average merit award
                  stock budget set by the Compensation Committee has been approximately 2.2% of our outstanding common stock on an issued and outstanding basis.</b></span></p>
          </td>

  </tr>


</table>
  </div>

  <div style="CLEAR:BOTH"></div>

  <div><br /></div>

  <p style="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Corporate Governance</b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Stock Ownership Guidelines and
        Holding Periods</i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">Our executive officers and
          members of our Board of Directors must meet a stock ownership guideline and all employees must hold shares purchased under our ESPP for at least six months</span>.</i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Our Compensation Committee and our Board
      set stock ownership and holding guidelines for our executive officers and members of the Board. These guidelines require our executive officers and non-employee Board members to accumulate shares of our stock up to specified amounts. Shares sold or
      surrendered to pay for withholding taxes associated with the RSU and PRSU awards are exempt from these holding requirements.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The number of shares subject to the
      guidelines is determined at the beginning of each calendar quarter, using the product of (i) the number of shares held by the individual on the first business day of such quarter and (ii) the average closing price of the Company&#8217;s common stock over
      the 30 trading days immediately preceding the start of such quarter.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In 2022 we increased the ownership
      guidelines for our executive officers and in 2023 we increased the ownership guidelines for our non-employee Board members such that the current ownership guidelines are as follows:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 80%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: auto; margin-right: auto;">


  <tr style="vertical-align: top; background-color: #A20067; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 40%; border: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: white;"><br />
            <span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Executive Officer/Director</b></span></p>
        </td>

    <td style="width: 40%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Stock Ownership Guideline</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(as a multiple of base salary/annual cash retainer)</b></span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">CEO</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6 times Base Salary</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">All other executive officers</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2 times Base Salary</span></p>
        </td>

  </tr>

  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Non-employee Directors</span></p>
        </td>

    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">5 times Base Annual Cash Retainer</span></p>
        </td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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      Cadoret-Manier do not yet hold enough shares sufficient to meet the guidelines; however, Ms. Diaz currently holds enough shares such that she is only missing the guidelines by approximately 5% as of March 31, 2023.</span></p>
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In addition, our ESPP has a six-month
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Clawback Policy </i></span></p>
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      compensation clawback policy that provides the Compensation Committee with authority to</span> <span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">recover the following performance-based cash and equity incentive compensation of
      any current or former &#8220;officer&#8221; of the Company, as such term is defined under Rule 16a-1(f) of the Securities Exchange Act of 1934, as amended, and as determined by the Company, if such officer engaged in fraud or intentional misconduct that
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20">


  <tr style="vertical-align: top; font: 10pt Times New Roman, Times, Serif">

    <td style="width: 38.15pt; font: 10pt Times New Roman, Times, Serif"></td>

    <td style="width: 18pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt; font: 10pt Times New Roman,Times,serif;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Any incentive-based compensation received by such officer during the one-year
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            basis.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;">&#160;</p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">73</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In October 2022, the SEC adopted final
      rules implementing the incentive-based compensation recovery (clawback) provisions of the Dodd-Frank Act. The final rules direct the stock exchanges to establish listing standards requiring listed companies to develop and implement a policy providing
      for the recovery of erroneously awarded incentive-based compensation received by current or former executive officers and to satisfy related disclosure obligations. Nasdaq has proposed its listing standards, and once they are final, our Nominating,
      Governance and Review Committee will promptly adopt appropriate updates to this policy to comport with such listing standards.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Anti-Hedging Policy and
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(229, 114, 0);"><i><span style="text-decoration: underline;">We explicitly prohibit employees
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      prohibit all employees, including our executive officers, from taking a &#8220;short&#8221; position in our stock and otherwise hedging their position in our stock against a future drop in our stock price including short sales and derivatives such as put or call
      options, swaps, forwards, and futures, or other inherently speculative transactions with respect to Ionis&#8217; securities at any time. </span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In addition, we also prohibit all
      directors and employees, including our named executive officers, from pledging our stock as collateral.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(229, 114, 0);"><i><span style="text-decoration: underline;">10b5-1 plan required for
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      officers, vice presidents and other employees to establish plans that permit prearranged future sales of the employee&#8217;s stock, which plans may be established when the individual is not in possession of material non-public information. We do not allow
      our executive officers or vice presidents to buy or sell our stock outside of the Rule 10b5-1 trading program except for purchases of our stock under our ESPP (but not subsequent sales of the stock) and transactions that are automatically effected by
      Ionis&#8217; stock administrator in connection with the vesting and release of RSUs and PRSUs. </span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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      10b5-1 trading program to comply with the SEC&#8217;s final rules released in December 2022 that impose new conditions on the availability of the Rule 10b5-1 affirmative defense to insider trading and require enhanced disclosures regarding the adoption,
      modification and termination of Rule 10b5-1 plans and other trading arrangements.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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      money responsibly, to building stockholder value and ensuring our processes are transparent. As a result, Ionis&#8217; policies do not provide for perquisites for any employees, including our executive officers.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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      position with regard to the benefits offered to all regular employees, including our executive officers. These benefits include medical, dental and vision insurance, EAP, basic life insurance, short-term disability/sick pay, long-term disability,
      vacation, holidays, a 401(k) plan with employer match, an ESPP and Accidental Death &amp; Dismemberment (&#8220;<b><i>AD&amp;D</i></b>&#8221;) insurance.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">As part of our normal course of
      business, we engage in discussions with other biotechnology and pharmaceutical companies about possible collaborations, licensing and/or other ways in which the companies may work together to further our respective long-term objectives. In addition,
      many larger established pharmaceutical companies consider companies at similar stages of development to ours as potential acquisition targets. Occasionally, a transaction in the biotech/biopharmaceutical industry may start as a licensing transaction,
      but ultimately result in an acquisition. In certain scenarios, the potential for merger or being acquired may be in the best interests of our stockholders. As further described on page 86, we adopted a Change in Control and Severance Benefit Plan to
      provide certain economic benefits to our employees at or above the level of Vice President if their employment is terminated in certain circumstances, including as a result of a transaction that results in a change in control of the Company.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Tax and Accounting Considerations</i></span></p>
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 22.5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Under Section 162(m), compensation paid to each of the
      Company&#8217;s &#8220;covered employees&#8221; that exceeds $1 million per taxable year is generally non-deductible unless the compensation qualifies for certain grandfathered exceptions (including the &#8220;performance-based compensation&#8221; exception) for certain
      compensation paid to such covered employees.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 22.5pt"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">74</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="margin: 0px; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Although the Compensation Committee will continue to consider
      tax implications as one factor in determining executive compensation, the Compensation Committee also looks at other factors in making its decisions and retains the flexibility to provide compensation for the Company&#8217;s named executive officers in a
      manner consistent with the goals of the Company&#8217;s executive compensation program and the best interests of the Company and its stockholders, which may include providing for compensation that is not deductible by the Company due to the deduction limit
      under Section 162(m). The Compensation Committee also retains the flexibility to modify compensation that was initially intended to be exempt from the deduction limit under Section 162(m) if it determines that such modifications are consistent with
      the Company&#8217;s business needs.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Under ASC 718, the Company is required to estimate and record
      an expense for each award of equity compensation over the vesting period of the award. We record share-based compensation expense on an ongoing basis according to ASC 718.&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">75</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Compensation of Executive Officers</span></p>
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      fiscal years ended December 31, 2022, 2021, and 2020, compensation awarded to or paid to, or earned by, our named executive officers.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: center; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Summary Compensation Table</b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr>

    <td style="vertical-align: bottom; border: 1pt solid Black; background-color: rgb(162, 0, 103); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Name and Principal Position</b></span></td>

    <td style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(162, 0, 103); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year</b></span></td>

    <td style="vertical-align: bottom; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; background-color: #A20067; padding-right: 5.4pt; padding-left: 5.4pt" rowspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Salary</b></span></p>
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        </td>

    <td style="vertical-align: bottom; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; background-color: #A20067; padding-right: 5.4pt; padding-left: 5.4pt" rowspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Bonus<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(162, 0, 103); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" colspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Stock Awards<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></b></span></td>

    <td style="vertical-align: bottom; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; background-color: #A20067; padding-right: 5.4pt; padding-left: 5.4pt" rowspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Option Awards<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)&#160;</b></span></p>
        </td>

    <td style="vertical-align: bottom; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; background-color: #A20067; padding-right: 5.4pt; padding-left: 5.4pt" rowspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>All Other Compensation</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="vertical-align: bottom; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; background-color: #A20067; padding-right: 5.4pt; padding-left: 5.4pt" rowspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Total</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="vertical-align: bottom; border-right: Black 1pt solid; border-bottom: Black 1pt solid; background-color: #A20067; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>RSUs<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="vertical-align: bottom; border-right: Black 1pt solid; border-bottom: Black 1pt solid; background-color: #A20067; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>PRSUs</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(S)</b></span></p>
        </td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="width: 20%; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt" rowspan="3">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Brett P. Monia,</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">President, Chief Executive Officer</span></p>
        </td>

    <td style="width: 6%; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="width: 11%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$824,800</span></td>

    <td style="width: 10%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$837,688</span></td>

    <td style="white-space: nowrap; width: 11%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,678,645</span></td>

    <td style="vertical-align: top; width: 10%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$2,145,668</span></td>

    <td style="white-space: nowrap; width: 10%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,761,806</span></td>

    <td style="width: 11%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$50,470<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(5)</sup></b></span></td>

    <td style="width: 11%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$7,299,077</span></td>

    <td style="width: 1%; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$800,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$469,300</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$4,081,860</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$3,984,360<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(6)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$3,919,810</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$50,343</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$13,305,673</span></td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$700,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$601,738</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; white-space: nowrap;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$4,094,657<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(7)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; white-space: nowrap;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,055,547<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(7)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$4,470,351</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40,747</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$10,963,040</span></td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; background-color: #DDDDDD; padding-right: 5.4pt; padding-left: 5.4pt" rowspan="3">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Elizabeth L. Hougen,</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Executive Vice President, Finance and Chief Financial Officer</span></p>
        </td>

    <td style="background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$584,480</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$379,912</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$547,772</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$350,061</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$574,914</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$50,949<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(8)</sup></b></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$2,488,088</span></td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$557,541</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$262,713</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,662,465</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="white-space: nowrap; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,596,488</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$49,121</span></td>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$4,128,329</span></td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-bottom: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$499,555</span></td>

    <td style="background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$298,734</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,663,208</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,815,765</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$63,838</span></td>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$4,341,100</span></td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="3"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph T. Baroldi, Executive Vice President, Chief Business Officer </span></td>

    <td style="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$476,500</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$257,310</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,776,050<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(9)</sup></b></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,468,020<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(9)</sup></b></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$38,693<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(10)</sup></b></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$4,016,572</span></td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">N/A<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(11)</sup></b></span></td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="3"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Onaiza Cadoret-Manier, Executive Vice President, Chief Global Product Strategy and Operations Officer</span></td>

    <td style="background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$530,929</span></td>

    <td style="background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$345,104</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$547,772</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$350,061</span></td>

    <td style="background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$574,914</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$54,787<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(12)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$2,403,567</span></td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$482,000<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(10)</sup></b></span></td>

    <td style="background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$227,118</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,484,692</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,425,753</span></td>

    <td style="border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$46,404</span></td>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$3,665,966</span></td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-bottom: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$430,000</span></td>

    <td style="border-bottom: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$235,461</span></td>

    <td style="border-bottom: 1pt solid Black; border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,151,710</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-bottom: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,595,777</span></td>

    <td style="border-bottom: 1pt solid Black; border-right: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$91,494</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; background-color: rgb(221, 221, 221); padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$3,504,442</span></td>

    <td style="text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="3"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Richard S. Geary, Executive Vice President, Chief Development Officer</span></td>

    <td style="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$546,694</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$341,684</span></td>

    <td style="white-space: nowrap; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$505,595</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$323,127</span></td>

    <td style="white-space: nowrap; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$530,630</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$57,881<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(13)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$2,305,611</span></td>

    <td style="text-align: center;">&#160;</td>

  </tr>

  <tr>

    <td style="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$527,697</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$240,630</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,391,914</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="white-space: nowrap; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,336,671</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$34,807</span></td>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$3,531,719</span></td>

    <td style="text-align: center;">&#160;</td>

  </tr>

  <tr>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$509,630</span></td>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$281,167</span></td>

    <td style="border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,502,162</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in; border-right: 1pt solid Black;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,639,968</span></td>

    <td style="border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$78,379</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$4,011,036</span></td>

    <td style="text-align: center;">&#160;</td>

  </tr>


</table>
  <p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We present bonuses in the years they were earned, not in the year paid. Bonuses represent compensation for achievements and are not necessarily
            paid in the year they are earned; for example, in January 2023 we paid bonuses for 2022 performance.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(2)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We present stock awards in the years they were awarded, not in the year earned. For example, in January 2023 we granted stock awards for 2022
            performance.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(3)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amounts represent the aggregate expense recognized for financial statement reporting purposes in accordance with ASC 718 for RSU and option
            awards granted to our named executive officers. The fair value of RSUs is based on the market price of our common stock on the date of grant. For more information, please see Note 5, <i>Stockholders&#8217; Equity</i>, of the consolidated financial
            statements in our Annual Report on Form 10-K for the year ended December 31, 2022 regarding assumptions underlying valuation of equity awards.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(4)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amounts represent the aggregate expense recognized for financial statement reporting purposes in accordance with ASC 718 for stock and option
            awards granted to our named executive officers. ASC 718 expense for the option awards is based on the fair value of the awards on the date of grant using an option-pricing model. For more information, please see Note 5, <i>Stockholders&#8217; Equity</i>,
            of the consolidated financial statements in our Annual Report on Form 10-K for the year ended December 31, 2022 regarding assumptions underlying valuation of equity awards.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(5)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Includes AD&amp;D ($126), basic life ($6,057), medical ($25,808), dental ($2,225), vision ($12), long term disability ($840), and 401(k) matching
            contributions ($15,250), which are available to all employees. Also includes individual disability insurance ($152), which is only available to employees whose annual base salary exceeds $406,000.</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.5in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(6)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Dr. Monia&#8217;s stock awards increased in 2021 primarily due to an increase in PRSUs awarded to Dr. Monia in 2021 and the higher fair value assigned
            to such PRSUs as a result of using a Monte Carlo simulation. For performance awards based on relative TSR, a Monte Carlo simulation is required under ASC Topic 718 based upon the then-probable outcome of the performance conditions underlying
            such awards. <i><span style="text-decoration: underline;">Since the potential for a maximum payout is captured in the Monte Carlo simulation, the fair value for this award is often higher than the stock price on the date of grant</span></i>. For more information, please see Note 5, <i>Stockholders&#8217;






















              Equity</i>, of the consolidated financial statements in our Annual Report on Form 10-K for the year ended December 31, 2022 regarding assumptions underlying valuation of equity awards.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(7)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Includes equity awards granted to Dr. Monia in connection with his promotion to CEO in 2020.</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.5in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(8)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Includes AD&amp;D ($126), basic life ($6,057), medical ($25,808), dental ($2,270), vision ($503), long term disability ($840), and 401(k)
            matching contributions ($15,250), which are available to all employees. Also includes individual disability insurance ($95), which is only available to employees whose annual base salary exceeds $406,000.</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: left; text-indent: -0.25in"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">76</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: left; text-indent: -0.25in"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(9)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Mr. Baroldi received the following new hire equity awards when he joined the Company in January 2022: 86,700 stock options and 43,350 restricted
            stock units. As an executive officer, Mr. Baroldi will receive 20% of his annual equity awards in the form of performance based restricted stock units beginning in 2023.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(10)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Includes AD&amp;D ($116), basic life ($1,636), medical ($23,657), dental ($2,651), vision ($12), long term disability ($770), and 401(k) matching
            contributions ($8,205), which are available to all employees. Also includes individual disability insurance ($1,646), which is only available to employees whose annual base salary exceeds $406,000.</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.5in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(11)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Mr. Baroldi joined Ionis in January 2022.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(12)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Includes AD&amp;D ($126), basic life ($4,125), medical ($25,808), dental ($5,319), vision ($322), long term disability ($840), and 401(k)
            matching contributions ($15,250), which are available to all employees. Also includes individual disability insurance ($2,997), which is only available to employees whose annual base salary exceeds $406,000. </span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(13)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Includes AD&amp;D ($120), basic life ($10,698), medical ($18,063), dental ($761), vision ($688), long term disability ($840), and 401(k) matching
            contributions ($14,134), which are available to all employees. Also includes individual disability insurance ($77), which is only available to employees whose annual base salary exceeds $406,000, and a Commitment to Ionis Award ($12,500).</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.5in; text-align: left; text-indent: -0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Grants of Plan-Based Awards </b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The following table shows for the
      fiscal year ended December 31, 2022, certain information regarding grants of plan-based awards to our named executive officers:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: center; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Grants of Plan-Based Awards in Fiscal 2022</b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-top: 12pt; padding-bottom: 12pt; text-align: center;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Name</b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-top: 12pt; padding-bottom: 12pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Grant Date</b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-top: 12pt; padding-bottom: 12pt; text-align: center; text-indent: 0in;" colspan="3"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Estimated Future Payouts Under Equity Incentive Plan Awards</b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-top: 12pt; padding-bottom: 12pt; text-align: center; text-indent: 0in;" rowspan="2">
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b> <br />
              </b></span></div>
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>All Other</b></span></div>
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Stock Awards:</b></span></div>
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Number of<br />
              </b></span></div>
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Shares of</b></span></div>
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Stock or Units</b></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><br />
              <span style="color: white;"><b>(#)</b></span></span></div>
        </td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-top: 12pt; padding-bottom: 12pt; text-align: center; text-indent: 0in;" rowspan="2">
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>All Other</b></span></div>
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Option Awards:</b></span></div>
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Number of</b></span></div>
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Securities</b></span></div>
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Underlying</b></span></div>
          <div><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Options</b></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><br />
              <span style="color: white;"><b>(#)</b></span></span></div>
        </td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-top: 12pt; padding-bottom: 12pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Exercise or Base Price of Option Awards</b></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><br />
            <span style="color: white;"><b>($/Sh)</b></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-top: 12pt; padding-bottom: 12pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Grant Date Fair Value of Stock and Option Awards<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></td>

  </tr>

  <tr style="background-color: #A20067">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-top: 12pt; padding-bottom: 12pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Threshold</b></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><br />
            <span style="color: white;"><b>(#)</b></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-top: 12pt; padding-bottom: 12pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Target</b></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><br />
            <span style="color: white;"><b>(#)</b></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-top: 12pt; padding-bottom: 12pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Maximum</b></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><br />
            <span style="color: white;"><b>(#)</b></span></span></td>

  </tr>

  <tr>

    <td style="width: 11%; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-top: 6pt; padding-bottom: 6pt; text-align: left; padding-left: 5.4pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Brett P. Monia</span></td>

    <td style="width: 9%; border-bottom: Black 1pt solid; padding: 4pt 8pt; border-right: Black 1pt solid">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/22</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/22</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/22</span></p>
        </td>

    <td style="width: 10%; border-bottom: Black 1pt solid; padding: 4pt 8pt; border-right: Black 1pt solid">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">25,373</span></p>
        </td>

    <td style="width: 9%; border-bottom: Black 1pt solid; padding: 4pt 8pt; border-right: Black 1pt solid">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">50,745</span></p>
        </td>

    <td style="width: 11%; border-bottom: Black 1pt solid; padding: 4pt 8pt; border-right: Black 1pt solid">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">76,117</span></p>
        </td>

    <td style="width: 11%; border-bottom: Black 1pt solid; padding: 4pt 8pt; border-right: Black 1pt solid">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">50,745</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="width: 11%; border-bottom: Black 1pt solid; padding: 4pt 8pt; border-right: Black 1pt solid">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">101,489</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="width: 10%; border-bottom: Black 1pt solid; padding: 4pt 8pt; border-right: Black 1pt solid">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$32.60</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="width: 18%; border-bottom: Black 1pt solid; padding: 4pt 8pt; border-right: Black 1pt solid">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,761,806</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,678,645</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$2,145,668</span></p>
        </td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-top: 6pt; padding-bottom: 6pt; text-align: left; padding-left: 5.4pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Elizabeth L. Hougen</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/22</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/22</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/22</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4,140</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">8,279</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,419</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,559</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">33,118</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$32.60</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$574,914</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$547,772</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$350,061</span></p>
        </td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-top: 6pt; padding-bottom: 6pt; text-align: left; padding-left: 5.4pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph T. Baroldi</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/31/22</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4/15/22</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">43,350</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">86,700</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$31.80</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,468,020</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,776,050</span></p>
        </td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-top: 6pt; padding-bottom: 6pt; text-align: left; padding-left: 5.4pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Onaiza Cadoret-Manier</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/22</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/22</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/22</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4,140</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">8,279</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,419</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,559</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">33,118</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$32.60</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$574,914</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$547,772</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$350,061</span></p>
        </td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-top: 6pt; padding-bottom: 6pt; text-align: left; padding-left: 5.4pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Richard S. Geary</span></td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/22</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/22</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/22</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">3,715</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,462</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">11,463</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">15,284</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">30,567</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$32.60</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 4pt 8pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$530,630</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$505,595</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$323,127</span></p>
        </td>

  </tr>


</table>
  <p style="margin-top: 0px; margin-bottom: 0px; text-align: center;">&#160;</p>
  <p style="margin-top: 0; margin-bottom: 0"></p>
  <!-- Field: Rule-Page -->
  <div style="margin-top: 3pt; margin-bottom: 3pt; text-align: left;">
    <div style="font-size: 1pt; border-top: 1pt solid Black; width: 20%; text-align: center;">&#160;</div>

  </div>

  <!-- Field: /Rule-Page -->
  <p style="margin-top: 0px; margin-bottom: 0px; text-align: center;">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amounts represent the aggregate expense recognized for financial statement reporting purposes in accordance with ASC 718 for RSU, PRSU and option
            awards granted to our named executive officers.&#160; ASC 718 expense for the option awards is based on the fair value of the awards on the date of grant using an option-pricing model. The fair value of RSUs is based on the market price of our
            common stock on the date of grant. The fair value of PRSUs is based upon the then-probable outcome of the performance conditions underlying such awards and calculated using a Monte Carlo simulation because the performance target is based on our
            relative TSR, which represents a market condition. For more information, please see Note 5, <i>Stockholders&#8217; Equity,</i> of the consolidated financial statements in our Annual Report on Form 10-K for the year ended December 31, 2022 regarding
            assumptions underlying valuation of equity awards.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">77</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Narrative to Summary Compensation Table and
      Grants of Plan-Based Awards Table</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Compensation Committee granted
      merit non-statutory stock options to the executive officers on January 3, 2022 for their 2021 performance. All of these stock options were granted out of our 2011 Plan. The options have a term of ten years and vest at the rate of 25% for the first
      year and then at the rate of 2.08% per month for 36 months thereafter during the optionee&#8217;s employment.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Compensation Committee granted
      RSUs to the executive officers on January 15, 2022 for their 2021 performance. All of these RSUs were granted out of our 2011 Plan. The RSUs vest at the rate of 25% per year over four years with a vesting commencement date of January 15, 2023.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In 2022, Dr. Monia received <span style="color: rgb(35, 31, 32);">thirty-three












        percent of his total equity awards in the form of PRSUs. For these PRSU awards, one third of such PRSUs may vest at the end of three separate performance periods spread over the three years following the date of grant (<i>i.e</i>., the one-year
        period commencing on the date of grant and ending on the first anniversary of the date of grant; the two-year period commencing on the date of grant and ending on the second anniversary of the date of grant; and the three-year period commencing on
        the date of grant and ending on the third anniversary of the date of grant) based on the Company&#8217;s TSR as compared to a peer group of companies, and as measured, in each case, at the end of the applicable performance period. No number of PRSUs is
        guaranteed to vest and the actual number of PRSUs that will vest at the end of each performance period may be anywhere from zero to 150% of the target number depending on the Company&#8217;s relative TSR. Performance below the threshold level results in
        a payout of 0 shares, performance at the threshold level (25<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile) results in a payout of 50% of target shares, performance at the target level (50<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile) results in a payout of 100% of target shares, and performance at the maximum level (75<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> percentile) results in a payout of 150% of target shares.</span>&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">78</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

</div>
<div style="font: 10pt Times New Roman, Times, Serif">

  <ix:nonNumeric name="ecd:PvpTableTextBlock" id="Text_bd344329ec5145809e3a0f8a73a4b506" contextRef="c20220101to20221231" escape="true" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a1"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Pay Versus Performance</b></span></p></ix:nonNumeric>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a1" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a2"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a2" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a3"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Pay Versus Performance Table </i></span></p></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a3" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a4"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a4" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a5"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">As required by Section 953(a) of the Dodd-Frank Wall Street Reform and
      Consumer Protection Act, and Item 402(v) of Regulation S-K (&#8220;<b><i>Item 402(v)</i></b>&#8221;), we are providing the following information about the relationship between executive compensation actually paid and certain financial performance of the Company.
      The amounts set forth below under the headings &#8220;Compensation Actually Paid to PEO&#8221; and &#8220;Average Compensation Actually Paid to non-PEO NEOs&#8221; have been calculated in a manner consistent with Item 402(v). Use of the term &#8220;compensation actually paid&#8221; is
      required by the SEC&#8217;s rules and as a result of the calculation methodology required by the SEC, such amounts differ from compensation actually received by the individuals and the compensation decisions described in the CD&amp;A section of this Proxy
      Statement. For further information concerning the Company&#8217;s pay-for-performance philosophy and how the Company aligns executive compensation with the Company&#8217;s performance, refer to the CD&amp;A section of this Proxy Statement.</span></p></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a5" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a6"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a6" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a7">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; background-color: white; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="vertical-align: bottom; border: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year</b></span></td>

    <td style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Summary Compensation Table Total for PEO<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></td>

    <td style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Compensation Actually Paid to PEO<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></b></span></td>

    <td style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Average Summary Compensation Table Total for Non-PEO NEOs<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></b></span></td>

    <td style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Average Compensation Actually Paid to Non-PEO NEOs<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></b></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;" colspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Value of Initial Fixed $100 Investment Based On:</b></span></td>

    <td style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Net Income (Loss)<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(7)</sup></b></span></td>

    <td style="border-bottom: 1pt solid #000000; border-right: 1pt solid #000000; border-top: 1pt solid #000000; vertical-align: bottom; padding: 0px 5.25pt 0px 1.75pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b><span style="text-indent: 0pt;"><ix:nonNumeric name="ecd:CoSelectedMeasureName" id="Fact_77e423da73b44512ae490c010b399848" contextRef="c20220101to20221231">One-Year Relative Total Shareholder Return</ix:nonNumeric></span><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(8)</sup></b></span></td>

  </tr>

  <tr style="vertical-align: bottom; background-color: #A20067">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Total





















              Shareholder Return<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(5)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Peer





















              Group Total Shareholder Return<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(6)</sup></b></span></td>

  </tr>

  <tr>

    <td style="width: 5%; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoTotalCompAmt" id="Fact_62068631048c4cadbbdace72412c03f7" contextRef="c20220101to20221231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">7,299,077</ix:nonFraction></span></span></td>

    <td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoActuallyPaidCompAmt" id="Fact_a11cd5e8a5b9481abcec7ea9cb5f59d2" contextRef="c20220101to20221231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">5,033,980</ix:nonFraction></span></span></td>

    <td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgTotalCompAmt" id="Fact_7a3f0f0e107f497995f1230a6e87c77c" contextRef="c20220101to20221231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">2,803,964</ix:nonFraction></span></span></td>

    <td style="width: 12%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgCompActuallyPaidAmt" id="Fact_8744a22095034995b821704b628c47ba" contextRef="c20220101to20221231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">2,735,368</ix:nonFraction></span></span></td>

    <td style="width: 10%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:TotalShareholderRtnAmt" id="Fact_081d452c701f4ba396e5a455b39ad6ae" contextRef="c20220101to20221231" unitRef="U001" decimals="2" scale="0" format="ixt:num-dot-decimal">62.52</ix:nonFraction></span></span></td>

    <td style="width: 10%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeerGroupTotalShareholderRtnAmt" id="Fact_9adc613d03f244ccbcbef49b249a03af" contextRef="c20220101to20221231" unitRef="U001" decimals="2" scale="0" format="ixt:num-dot-decimal">113.65</ix:nonFraction></span></span></td>

    <td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="us-gaap:NetIncomeLoss" id="Fact_ce1b8570f22849e084425a39c029f8b6" contextRef="c20220101to20221231" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">269,722,000</ix:nonFraction></span>)</span></td>

    <td style="vertical-align: top; width: 19%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 1.75pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:CoSelectedMeasureAmt" id="Fact_9e5bee145bdc486ea805a913cfb325ee" contextRef="c20220101to20221231" unitRef="U002" decimals="0" scale="0" format="ixt:num-dot-decimal">81</ix:nonFraction></span><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st </sup>percentile</span></td>

  </tr>

  <tr style="background-color: #E7E6E6">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoTotalCompAmt" id="Fact_a689ad706fad42b1adf955ca9ae9cfd7" contextRef="c20210101to20211231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">13,305,673</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoActuallyPaidCompAmt" id="Fact_122ac89bd0b64be7967dabaa63955dcc" contextRef="c20210101to20211231" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">3,095,776</ix:nonFraction></span>)</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgTotalCompAmt" id="Fact_a8fb763656f24e0e922bbf5cc547be8d" contextRef="c20210101to20211231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">3,834,223</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgCompActuallyPaidAmt" id="Fact_68345774ed584541b72664118c555366" contextRef="c20210101to20211231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">713,811</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:TotalShareholderRtnAmt" id="Fact_57ffc8faf70a41cb8b3ee79519e67b3a" contextRef="c20210101to20211231" unitRef="U001" decimals="2" scale="0" format="ixt:num-dot-decimal">50.37</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeerGroupTotalShareholderRtnAmt" id="Fact_4fc08394378342ca915790519b9058e7" contextRef="c20210101to20211231" unitRef="U001" decimals="2" scale="0" format="ixt:num-dot-decimal">126.45</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="us-gaap:NetIncomeLoss" id="Fact_5beb98cdf28a466aa8fbdb3049ac52ee" contextRef="c20210101to20211231" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">28,597,000</ix:nonFraction></span>)</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 1.75pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:CoSelectedMeasureAmt" id="Fact_2b5942ecccf14fb5b11259511fc72f8b" contextRef="c20210101to20211231" unitRef="U002" decimals="0" scale="0" format="ixt:num-dot-decimal">41</ix:nonFraction></span><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st </sup>percentile</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoTotalCompAmt" id="Fact_b19b421e6d5f4eb9a6ca7a1941494860" contextRef="c20200101to20201231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">10,963,040</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoActuallyPaidCompAmt" id="Fact_616d14d261704e4ea4b94908a5460655" contextRef="c20200101to20201231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">3,439,140</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgTotalCompAmt" id="Fact_236686492263494587e425f0aab9e60a" contextRef="c20200101to20201231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">5,450,933</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgCompActuallyPaidAmt" id="Fact_9d0650dee1ea4c87bbff5de53f333e25" contextRef="c20200101to20201231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">1,822,613</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:TotalShareholderRtnAmt" id="Fact_1a3d2d21d8c24d0782069970476d433a" contextRef="c20200101to20201231" unitRef="U001" decimals="2" scale="0" format="ixt:num-dot-decimal">93.59</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeerGroupTotalShareholderRtnAmt" id="Fact_20bcfaac8eea4c629aa122d78a95f948" contextRef="c20200101to20201231" unitRef="U001" decimals="2" scale="0" format="ixt:num-dot-decimal">126.42</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="us-gaap:NetIncomeLoss" id="Fact_b61d1177c7fd41c080e479d43e63393f" contextRef="c20200101to20201231" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">479,743,000</ix:nonFraction></span>)</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 1.75pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:CoSelectedMeasureAmt" id="Fact_646d8fbda24f412b8e1e3b95c650f7db" contextRef="c20200101to20201231" unitRef="U002" decimals="0" scale="0" format="ixt:num-dot-decimal">35</ix:nonFraction></span><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th </sup>percentile</span></td>

  </tr>


</table>
</ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a7" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a8"><p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p></ix:continuation>
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    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts reported are the amounts of total compensation reported for <ix:nonNumeric name="ecd:PeoName" id="Fact_1dc58c508d544ad7930762f83ee32045" contextRef="c20210101to20211231"><ix:nonNumeric name="ecd:PeoName" id="Fact_0f09dc0dab3041a98db159a9f0acabfa" contextRef="c20200101to20201231"><ix:nonNumeric name="ecd:PeoName" id="Fact_085f7627978f459d9b0299982d808c57" contextRef="c20220101to20221231">Dr. Monia</ix:nonNumeric></ix:nonNumeric></ix:nonNumeric> (our Chief Executive Officer) for each corresponding year in the &#8220;Total&#8221; column of the Summary Compensation Table on page 76 of this Proxy Statement.</span></td>

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</table>
</ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a9" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a10"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a10" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a11"><ix:nonNumeric name="ecd:AdjToPeoCompFnTextBlock" id="Text_0c132d52dc3b4b4f85899700cd69f3ed" contextRef="c20220101to20221231" escape="true" continuedAt="Text_9b6831b270ff4210b8b153212fa65b8b1">
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    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(2)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts represent the amount of compensation actually paid to Dr. Monia, as computed in accordance with Item 402(v). The dollar
            amounts do not reflect the actual amount of compensation earned by or paid to Dr. Monia during the applicable year. In accordance with the requirements of Item 402(v), the following adjustments were made to Dr. Monia&#8217;s total compensation for
            each year to determine the compensation actually paid:</span></td>

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</table>
</ix:nonNumeric></ix:continuation>
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    <td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year</b></span></td>

    <td style="width: 21%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Reported Summary Compensation Table Total for PEO</b></span></td>

    <td style="width: 16%; border-top: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Deduct: Reported Value
              of Equity Awards<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(a)</sup></b></span></td>

    <td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Add: Equity Award Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(b)</sup></b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Add: Reported Change in the Actuarial Present Value of Pension Benefits<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(c)</sup></b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Add: Pension Benefit
              Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(c)</sup></b></span></td>

    <td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Compensation Actually Paid to PEO</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoTotalCompAmt" id="Fact_b59003721c414cba89794205d1968a8b" contextRef="c20220101to20221231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">7,299,077</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_033fd84d66cf4cea8aaa4dfe9eef0b35" contextRef="c20220101to20221231_AdjToCompAxis_ReportedValueOfEquityAwardsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">5,586,119</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_14d7bfd710f545b7b863833531043f1e" contextRef="c20220101to20221231_AdjToCompAxis_EquityAwardAdjustmentsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">3,321,022</ix:nonFraction></span> </span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_a9c8bb73b5554ab7802ae0f9bab9e4b0" contextRef="c20220101to20221231_AdjToCompAxis_ReportedChangeInTheActuarialPresentValueOfPensionBenefitsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="border-top: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_5439e05b7ea74fb1ab32d637b06d5f0b" contextRef="c20220101to20221231_AdjToCompAxis_PensionBenefitAdjustmentsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoActuallyPaidCompAmt" id="Fact_d1ad33b7d9574db48595ab8ac1ccb612" contextRef="c20220101to20221231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">5,033,980</ix:nonFraction></span></span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoTotalCompAmt" id="Fact_9d1228993334480aace7a830442e401e" contextRef="c20210101to20211231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">13,305,673</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_936480ef330348e09713700ed17cbe62" contextRef="c20210101to20211231_AdjToCompAxis_ReportedValueOfEquityAwardsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">11,986,030</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_23326319e3d249b0af602839e5991a01" contextRef="c20210101to20211231_AdjToCompAxis_EquityAwardAdjustmentsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">4,415,419</ix:nonFraction></span>)</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_fa264cab0e0641a59b5bef8bd2ef2659" contextRef="c20210101to20211231_AdjToCompAxis_ReportedChangeInTheActuarialPresentValueOfPensionBenefitsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_45e4ea9cb90944cc921f1fd5cc0c9733" contextRef="c20210101to20211231_AdjToCompAxis_PensionBenefitAdjustmentsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoActuallyPaidCompAmt" id="Fact_7866fd502c2d4b7ba9953aa1c93909fd" contextRef="c20210101to20211231" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">3,095,776</ix:nonFraction></span>)</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoTotalCompAmt" id="Fact_911d01729bb04184b588a5d4679af135" contextRef="c20200101to20201231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">10,963,040</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_56ce215871ca41e4b56beb9170211425" contextRef="c20200101to20201231_AdjToCompAxis_ReportedValueOfEquityAwardsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">9,620,555</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_971ff374412245c3aa1034891828cb45" contextRef="c20200101to20201231_AdjToCompAxis_EquityAwardAdjustmentsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">2,096,655</ix:nonFraction></span> </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_4a03c1e299814cc8a5fa6cb029ff61cd" contextRef="c20200101to20201231_AdjToCompAxis_ReportedChangeInTheActuarialPresentValueOfPensionBenefitsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_c9926b84b66349a0afe7f487b9fc112f" contextRef="c20200101to20201231_AdjToCompAxis_PensionBenefitAdjustmentsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:PeoActuallyPaidCompAmt" id="Fact_ba9ea4d4d6124e009ac86e67dad15908" contextRef="c20200101to20201231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">3,439,140</ix:nonFraction></span></span></td>

  </tr>


</table>
</ix:continuation></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a13" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a14"><ix:continuation id="Text_9b6831b270ff4210b8b153212fa65b8b3" continuedAt="Text_9b6831b270ff4210b8b153212fa65b8b4"><p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p></ix:continuation></ix:continuation>
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    <td style="width: 0.5in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(a)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The grant date fair value of equity awards represents the total of the amounts reported in the &#8220;Stock Awards&#8221; and &#8220;Option Awards&#8221; columns in the
            Summary Compensation Table for the applicable year.</span></td>

  </tr>


</table>
</ix:continuation></ix:continuation>
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  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a16" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a17"><ix:continuation id="Text_9b6831b270ff4210b8b153212fa65b8b6" continuedAt="Text_9b6831b270ff4210b8b153212fa65b8b7">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(b)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The equity award adjustments for each applicable year include the addition (or subtraction, as applicable) of the following: (i) the year-end
            fair value of any equity awards granted in the applicable year that are outstanding and unvested as of the end of the year; (ii) the amount of change as of the end of the applicable year (from the end of the prior fiscal year) in fair value of
            any awards granted in prior years that are outstanding and unvested as of the end of the applicable year; (iii) for awards that are granted and vest in the same applicable year, the fair value as of the vesting date; (iv) for awards granted in
            prior years that vest in the applicable year, the amount equal to the change as of the vesting date (from the end of the prior fiscal year) in fair value; (v) for awards granted in prior years that are determined to fail to meet the applicable
            vesting conditions during the applicable year, a deduction for the amount equal to the fair value at the end of the prior fiscal year; and (vi) the dollar value of any dividends or other earnings paid on stock or option awards in the applicable
            year prior to the vesting date that are not otherwise reflected in the fair value of such award or included in any other component of total compensation for the applicable year. The amounts deducted or added in calculating the equity award
            adjustments are as follows:</span></td>

  </tr>


</table>
</ix:continuation></ix:continuation>
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  <tr style="background-color: #A20067">

    <td style="width: 5%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year</b></span></td>

    <td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year End Fair Value of Equity Awards</b></span></td>

    <td style="width: 14%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards </b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(i)</sup></b></span></td>

    <td style="width: 14%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year</b></span></td>

    <td style="width: 19%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year</b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Value of Dividends or other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(ii)</sup></b></span></td>

    <td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Total Equity Award Adjustments</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_7255b9a1f057428f9606dc06cd5e4680" contextRef="c20220101to20221231_AdjToCompAxis_YearEndFairValueOfEquityAwardsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">5,731,326</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_d07d982778ac41a8a36d60b9b385ef0b" contextRef="c20220101to20221231_AdjToCompAxis_YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">2,549,358</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_0cce32ef014643069361f3278e4e1f67" contextRef="c20220101to20221231_AdjToCompAxis_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInTheYearMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_d94e9eff7b674f37b80856ba4097ae15" contextRef="c20220101to20221231_AdjToCompAxis_YearOverYearChangeInFairValueOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">326,316</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_f05d61684e1e46898819512131685cda" contextRef="c20220101to20221231_AdjToCompAxis_FairValueAtTheEndOfThePriorYearOfEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">187,261</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_f26d917a78ca40439cd07345af752629" contextRef="c20220101to20221231_AdjToCompAxis_ValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseReflectedInFairValueOrTotalCompensationMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_137ae7390a99491ebf71a4b63299e111" contextRef="c20220101to20221231_AdjToCompAxis_EquityAwardAdjustmentsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">3,321,022</ix:nonFraction></span> </span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_687e47d746b7412d96d69f0eb034a4cf" contextRef="c20210101to20211231_AdjToCompAxis_YearEndFairValueOfEquityAwardsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">4,655,272</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_bbe655814d40436ab2efefe1fdea3689" contextRef="c20210101to20211231_AdjToCompAxis_YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">8,289,894</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_f290ca648e794bcfb201411e5ac80463" contextRef="c20210101to20211231_AdjToCompAxis_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInTheYearMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_f126fcbbcaf542c3844086ed5a285bd4" contextRef="c20210101to20211231_AdjToCompAxis_YearOverYearChangeInFairValueOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">716,002</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_1823c10f149c48deb0f413cfe5c744a0" contextRef="c20210101to20211231_AdjToCompAxis_FairValueAtTheEndOfThePriorYearOfEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">64,795</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_8719326a51224053bb9493c39a5174c1" contextRef="c20210101to20211231_AdjToCompAxis_ValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseReflectedInFairValueOrTotalCompensationMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_b3d9511bb8ea4bb19d59328bc5794282" contextRef="c20210101to20211231_AdjToCompAxis_EquityAwardAdjustmentsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">4,415,419</ix:nonFraction></span>)</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_21cf9e6feb6c4e16886a33c97b2a90c9" contextRef="c20200101to20201231_AdjToCompAxis_YearEndFairValueOfEquityAwardsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">7,071,074</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_1bc1134f67614b0b99e53c9e9e2352aa" contextRef="c20200101to20201231_AdjToCompAxis_YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">4,319,642</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_c0503d0aefea4ce9a14e978312c14bdb" contextRef="c20200101to20201231_AdjToCompAxis_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInTheYearMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_020bb84ef2fc4ef6be5616fafcc758ca" contextRef="c20200101to20201231_AdjToCompAxis_YearOverYearChangeInFairValueOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">654,778</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_8a2f78b4135e4ca79de15f16a55f6351" contextRef="c20200101to20201231_AdjToCompAxis_FairValueAtTheEndOfThePriorYearOfEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_0e544576fc0e48dfbf5da202f1c5adb6" contextRef="c20200101to20201231_AdjToCompAxis_ValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseReflectedInFairValueOrTotalCompensationMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_581a7688a82446b9b050ed8960bdd62b" contextRef="c20200101to20201231_AdjToCompAxis_EquityAwardAdjustmentsMember_ExecutiveCategoryAxis_PeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">2,096,655</ix:nonFraction></span> </span></td>

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  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a22" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a23"><ix:continuation id="Text_9b6831b270ff4210b8b153212fa65b8b12" continuedAt="Text_9b6831b270ff4210b8b153212fa65b8b13"><p style="margin-top: 0; margin-bottom: 0"></p></ix:continuation></ix:continuation>
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    <td style="width: 0.75in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(i)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not grant any equity awards that vest in the same year as grant.</span></td>

  </tr>


</table>
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  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a25" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a26"><ix:continuation id="Text_9b6831b270ff4210b8b153212fa65b8b15" continuedAt="Text_9b6831b270ff4210b8b153212fa65b8b16">
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    <td style="width: 0.75in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(ii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not pay dividends or other earnings on stock or option awards.</span></td>

  </tr>


</table>
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  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a27" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a28"><ix:continuation id="Text_9b6831b270ff4210b8b153212fa65b8b17">
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    <td style="width: 0.5in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(c)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not provide pension benefits to any employees of the Company.</span></td>

  </tr>


</table>
</ix:continuation></ix:continuation>

  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a28" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a29"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a29" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a30"><ix:nonNumeric name="ecd:NamedExecutiveOfficersFnTextBlock" id="Text_20b1158cc3fb48ce8a880dafb06b0a51" contextRef="c20220101to20221231" escape="true" continuedAt="Text_9684e9cebaaa4a84a06c757b37b43d911">
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    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(3)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts reported represent the average of the amounts reported for the Company&#8217;s NEOs as a group (excluding Dr. Monia) in the &#8220;Total&#8221;
            column of the Summary Compensation Table of the Proxy Statement for each applicable year. The names of each of the NEOs (excluding Dr. Monia) included for purposes of calculating the average amounts in each applicable year are as follows:</span></td>

  </tr>


</table>
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  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a31" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a32"><ix:continuation id="Text_9684e9cebaaa4a84a06c757b37b43d912" continuedAt="Text_9684e9cebaaa4a84a06c757b37b43d913">
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    <td style="width: 54pt"></td>

    <td style="width: 31.5pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(i)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For 2022, Elizabeth L. Hougen (EVP &amp; CFO), Joseph T. Baroldi (EVP, Chief Business Officer), Onaiza Cadoret-Manier (EVP, Chief Global Product
            Strategy and Operations Officer) and Richard S. Geary (EVP, Chief Development Officer);</span></td>

  </tr>


</table>
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  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a33" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a34"><ix:continuation id="Text_9684e9cebaaa4a84a06c757b37b43d914" continuedAt="Text_9684e9cebaaa4a84a06c757b37b43d915">
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    <td style="width: 54pt"></td>

    <td style="width: 31.5pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(ii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For 2021, Elizabeth L. Hougen (EVP &amp; CFO), Patrick R. O&#8217;Neil (EVP, Chief Legal Officer and General Counsel), Onaiza Cadoret-Manier (EVP,
            Chief Global Product Strategy and Operations Officer) and Eric E. Swayze (EVP, Research; and</span></td>

  </tr>


</table>
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  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a35" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a36"><ix:continuation id="Text_9684e9cebaaa4a84a06c757b37b43d916">
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    <td style="width: 54pt"></td>

    <td style="width: 31.5pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(iii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For 2020, Elizabeth L. Hougen (EVP &amp; CFO), Stanley Crooke (Executive Chairman of the Board), Richard S. Geary (EVP, Chief Development
            Officer) and Patrick R. O&#8217;Neil (EVP, Legal and General Counsel).</span></td>

  </tr>


</table>
</ix:continuation></ix:continuation>

  <ix:nonNumeric name="ecd:AdjToNonPeoNeoCompFnTextBlock" id="Text_22f5d6659d1f47d481ee66366c14a04e" contextRef="c20220101to20221231" escape="true" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b811"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a36" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a37"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation></ix:nonNumeric>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b811" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b812"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a37" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a38">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(4)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts reported represent the average amount of compensation actually paid to the NEOs as a group (excluding Dr. Monia), as computed
            in accordance with Item 402(v). The dollar amounts do not reflect the actual average amount of compensation earned by or paid to the NEOs as a group (excluding Dr. Monia) during the applicable year. In accordance with the requirements of Item
            402(v), the following adjustments were made to average total compensation for the NEOs as a group (excluding Dr. Monia) for each year to determine the compensation actually paid, using the same methodology described above in Note 2:</span></td>

  </tr>


</table>
</ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b812" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b813"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a38" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a39"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b813" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b814"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a39" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a40">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="width: 8%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year</b></span></td>

    <td style="width: 23%; border-top: 1pt solid Black; border-right: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Average Reported Summary Compensation
              Table Total for Non-PEO NEOs</b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Deduct: Average Reported Value of Equity Awards</b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Add:
              Average Award Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(a)</sup></b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Add: Average Reported Change in the
              Actuarial Present Value of Pension Benefits<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(b)</sup></b></span></td>

    <td style="width: 16%; border-top: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Add: Average Pension Benefit Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(b)</sup></b></span></td>

    <td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Average
              Compensation Actually Paid to Non-PEO NEOs</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2022</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgTotalCompAmt" id="Fact_15ba00aef154454a9eae44d94512ee35" contextRef="c20220101to20221231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">2,803,964</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_d71ad662f7214f06bf1204a71d2374ea" contextRef="c20220101to20221231_AdjToCompAxis_ReportedValueOfEquityAwardsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">1,887,231</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_862aecf54eb84f0882984704b8bcb773" contextRef="c20220101to20221231_AdjToCompAxis_EquityAwardAdjustmentsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">1,818,634</ix:nonFraction></span> </span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_9763e90d20254ecbae9619c277b2b255" contextRef="c20220101to20221231_AdjToCompAxis_ReportedChangeInTheActuarialPresentValueOfPensionBenefitsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_1b401582e51a4138948823004c0b51c7" contextRef="c20220101to20221231_AdjToCompAxis_PensionBenefitAdjustmentsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgCompActuallyPaidAmt" id="Fact_1b4ea3b1b5444d3bbd7b4343be8b0952" contextRef="c20220101to20221231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">2,735,368</ix:nonFraction></span></span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2021</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgTotalCompAmt" id="Fact_026cd7270fa043549efcc8debe346dbc" contextRef="c20210101to20211231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">3,834,223</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_0b1784f92d874ab9b3f20d75518edcc5" contextRef="c20210101to20211231_AdjToCompAxis_ReportedValueOfEquityAwardsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">3,039,250</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_3e3dbf9761f64d2f98f366ac7af84de1" contextRef="c20210101to20211231_AdjToCompAxis_EquityAwardAdjustmentsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">81,162</ix:nonFraction></span>)</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_f8bd371a16374afdbf348f47e5c0a484" contextRef="c20210101to20211231_AdjToCompAxis_ReportedChangeInTheActuarialPresentValueOfPensionBenefitsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_9cc1f43d0b3b404ea950c3068d5a02a5" contextRef="c20210101to20211231_AdjToCompAxis_PensionBenefitAdjustmentsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgCompActuallyPaidAmt" id="Fact_dbf5f9e2a1974cc1ab4fd8ed17a8fbc9" contextRef="c20210101to20211231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">713,811</ix:nonFraction></span></span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2020</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgTotalCompAmt" id="Fact_5b0501c1fcc14579a6c7c476204780d8" contextRef="c20200101to20201231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">5,450,933</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_d77132a9f1b8442189bdca68f1ca0cbd" contextRef="c20200101to20201231_AdjToCompAxis_ReportedValueOfEquityAwardsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">4,484,784</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_0772a7820f114dbbab153f538572dffd" contextRef="c20200101to20201231_AdjToCompAxis_EquityAwardAdjustmentsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">856,465</ix:nonFraction></span> </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_9ff0ee7b9d1446a69045c0c7c37decb8" contextRef="c20200101to20201231_AdjToCompAxis_ReportedChangeInTheActuarialPresentValueOfPensionBenefitsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_c34793ff9f8144b6aeec7c22b93aa70a" contextRef="c20200101to20201231_AdjToCompAxis_PensionBenefitAdjustmentsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:NonPeoNeoAvgCompActuallyPaidAmt" id="Fact_b0a01f0d7f8e4246a6fe8bdcfa8dc54e" contextRef="c20200101to20201231" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">1,822,613</ix:nonFraction></span></span></td>

  </tr>


</table>
</ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b814" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b815"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a40" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a41"><p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p></ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b815" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b816"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a41" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a42">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(a)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The amounts deducted or added in calculating the total average equity award adjustments are as follows:</span></td>

  </tr>


</table>
</ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b816" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b817"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a42" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a43"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b817" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b818"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a43" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a44">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="width: 6%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year</b></span></td>

    <td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year End Fair Value of Equity Awards</b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards </b></span></td>

    <td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(i)</sup></b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year</b></span></td>

    <td style="width: 16%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year</b></span></td>

    <td style="width: 20%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Value of Dividends or other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(ii)</sup></b></span></td>

    <td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Total Equity Award Adjustments</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2022</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_087631bd305042d3854a9960e9d76c53" contextRef="c20220101to20221231_AdjToCompAxis_YearEndFairValueOfEquityAwardsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">1,962,339</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_480e46372bf04007893f96b46515b8e7" contextRef="c20220101to20221231_AdjToCompAxis_YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">164,642</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_c7eca3c23ad24a278be26b140defd184" contextRef="c20220101to20221231_AdjToCompAxis_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInTheYearMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_44bf4cd9290a4696a3ae91990dd3c7bc" contextRef="c20220101to20221231_AdjToCompAxis_YearOverYearChangeInFairValueOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">20,938</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_897033f0371249c7ac3d307b2f8af13b" contextRef="c20220101to20221231_AdjToCompAxis_FairValueAtTheEndOfThePriorYearOfEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_e8234a18592e4896a70c669b52190665" contextRef="c20220101to20221231_AdjToCompAxis_ValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseReflectedInFairValueOrTotalCompensationMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_9b4f8f6a77af49e0b633941a3c12f844" contextRef="c20220101to20221231_AdjToCompAxis_EquityAwardAdjustmentsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">1,818,634</ix:nonFraction></span> </span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2021</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_52e5ec3147a248d28321172e71523f3a" contextRef="c20210101to20211231_AdjToCompAxis_YearEndFairValueOfEquityAwardsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">1,171,440</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_7e718a00b15e4ef0aa330cbc66bd0995" contextRef="c20210101to20211231_AdjToCompAxis_YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">1,216,952</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_2a5bdff7094f4327ab46ce9ec99a0305" contextRef="c20210101to20211231_AdjToCompAxis_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInTheYearMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_f751013309ba49cb8955093654f6915c" contextRef="c20210101to20211231_AdjToCompAxis_YearOverYearChangeInFairValueOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">35,650</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_e3d5a80ae65c46ca8f12eb2fc22079ef" contextRef="c20210101to20211231_AdjToCompAxis_FairValueAtTheEndOfThePriorYearOfEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(231, 230, 230); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_f16e8c31a37e4472adbf5fed4710a72e" contextRef="c20210101to20211231_AdjToCompAxis_ValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseReflectedInFairValueOrTotalCompensationMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(231, 230, 230); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_0950efcdc233424bb57c033bf70c390f" contextRef="c20210101to20211231_AdjToCompAxis_EquityAwardAdjustmentsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">81,162</ix:nonFraction></span>)</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2020</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_a8b6756506b84728a95a75a281b14773" contextRef="c20200101to20201231_AdjToCompAxis_YearEndFairValueOfEquityAwardsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:num-dot-decimal">3,366,846</ix:nonFraction></span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_ac8fd9ef7dfe4409b17632025f6dc887" contextRef="c20200101to20201231_AdjToCompAxis_YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">2,476,142</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ </span><span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_4e32bdcb353d4730bc52e4f6052107c4" contextRef="c20200101to20201231_AdjToCompAxis_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInTheYearMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_ef1ae184aded423f9876b4ceea0a3afd" contextRef="c20200101to20201231_AdjToCompAxis_YearOverYearChangeInFairValueOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" sign="-" scale="0" format="ixt:num-dot-decimal">34,239</ix:nonFraction></span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$
          </span><span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_a60bd6117f3d462397d910d5d035abe3" contextRef="c20200101to20201231_AdjToCompAxis_FairValueAtTheEndOfThePriorYearOfEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$
            <span style="text-indent: 0pt;"><ix:nonFraction name="ecd:AdjToCompAmt" id="Fact_d86f22e439f14fbfa714d79c8371565f" contextRef="c20200101to20201231_AdjToCompAxis_ValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseReflectedInFairValueOrTotalCompensationMember_ExecutiveCategoryAxis_NonPeoNeoMember" unitRef="U001" decimals="0" scale="0" format="ixt:fixed-zero">-</ix:nonFraction></span></span></td>

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  </tr>


</table>
</ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b818" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b819"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a44" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a45"><p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p></ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b819" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b8110"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a45" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a46">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.75in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(i)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not grant any equity awards that vest in the same year as grant.</span></td>

  </tr>


</table>
</ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b8110" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b8111"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a46" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a47"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b8111" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b8112"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a47" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a48">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.75in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(ii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not pay dividends or other earnings on stock or option awards.</span></td>

  </tr>


</table>
</ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b8112" continuedAt="Text_16a8ac3f06214d71bca2b999ca362b8113"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a48" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a49"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation></ix:continuation>
  <ix:continuation id="Text_16a8ac3f06214d71bca2b999ca362b8113"><ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a49" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a50">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(b)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not provide pension benefits to any employees of the Company.</span></td>

  </tr>


</table>
</ix:continuation></ix:continuation>

  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a50" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a51"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a51" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a52">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(5)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Cumulative TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend
            reinvestment, and the difference between the Company&#8217;s stock price at the end and the beginning of the measurement period by the Company&#8217;s stock price at the beginning of the measurement period.</span></td>

  </tr>


</table>
</ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a52" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a53"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a53" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a54"><ix:nonNumeric name="ecd:PeerGroupIssuersFnTextBlock" id="Text_7544d873547845c38e07865e132ab282" contextRef="c20220101to20221231" escape="true">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(6)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Represents the weighted peer group TSR, weighted according to the respective companies&#8217; stock market capitalization at the beginning of each
            period for which a return is indicated. The peer group used for this purpose is the Nasdaq Biotechnology Index.</span></td>

  </tr>


</table>
</ix:nonNumeric></ix:continuation>

  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a54" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a55"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a55" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a56">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(7)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts reported represent the amount of net income (loss) reflected in the Company&#8217;s audited financial statements for the applicable
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  </tr>


</table>
</ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a56" continuedAt="Text_abba7564575840f0848ff3c560f3fc9a57"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_abba7564575840f0848ff3c560f3fc9a57">
<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(8)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">One-year relative TSR shown is the percentile rank of the Company&#8217;s TSR as compared to the TSRs of all members of the Nasdaq Biotechnology Index,
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  </tr>


</table>
</ix:continuation>

  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">80</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>

  <ix:nonNumeric name="ecd:TotalShareholderRtnVsPeerGroupTextBlock" id="Text_3d713858aab7402b96f91d03881ba75d" contextRef="c20220101to20221231" escape="true" continuedAt="Text_059ede99f8fc4b31922a737a2f8049331"><ix:nonNumeric name="ecd:CompActuallyPaidVsCoSelectedMeasureTextBlock" id="Text_1381d769491d453f86bc4debfae1186c" contextRef="c20220101to20221231" escape="true" continuedAt="Text_cfd4c6eaadfc4c48807bb38b3922d3241"><ix:nonNumeric name="ecd:CompActuallyPaidVsNetIncomeTextBlock" id="Text_a774bf583f854385b7fdabe67fc0f30e" contextRef="c20220101to20221231" escape="true" continuedAt="Text_35aa39eb8cf1497da9dfb9f42d4da3341"><ix:nonNumeric name="ecd:CompActuallyPaidVsTotalShareholderRtnTextBlock" id="Text_171c432a652b4e929e9b79cc7a5545a2" contextRef="c20220101to20221231" escape="true" continuedAt="Text_2f2b0c48fa034894adc5a66548982c4d1"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Analysis of the Information Presented in the
        Pay Versus Performance Table</i></span></p></ix:nonNumeric></ix:nonNumeric></ix:nonNumeric></ix:nonNumeric>
  <ix:continuation id="Text_059ede99f8fc4b31922a737a2f8049331" continuedAt="Text_059ede99f8fc4b31922a737a2f8049332"><ix:continuation id="Text_cfd4c6eaadfc4c48807bb38b3922d3241" continuedAt="Text_cfd4c6eaadfc4c48807bb38b3922d3242"><ix:continuation id="Text_35aa39eb8cf1497da9dfb9f42d4da3341" continuedAt="Text_35aa39eb8cf1497da9dfb9f42d4da3342"><ix:continuation id="Text_2f2b0c48fa034894adc5a66548982c4d1" continuedAt="Text_2f2b0c48fa034894adc5a66548982c4d2"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation></ix:continuation></ix:continuation></ix:continuation>
  <ix:continuation id="Text_059ede99f8fc4b31922a737a2f8049332" continuedAt="Text_059ede99f8fc4b31922a737a2f8049333"><ix:continuation id="Text_cfd4c6eaadfc4c48807bb38b3922d3242" continuedAt="Text_cfd4c6eaadfc4c48807bb38b3922d3243"><ix:continuation id="Text_35aa39eb8cf1497da9dfb9f42d4da3342" continuedAt="Text_35aa39eb8cf1497da9dfb9f42d4da3343"><ix:continuation id="Text_2f2b0c48fa034894adc5a66548982c4d2" continuedAt="Text_2f2b0c48fa034894adc5a66548982c4d3"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">While the Company utilizes several performance
      measures to align executive compensation with Company performance, all of those Company measures are not presented in the Pay Versus Performance Table (&#8220;<b><i>PVP Table</i></b>&#8221;). Moreover, the Company generally seeks to incentivize long-term
      performance, and therefore does not specifically align the Company&#8217;s performance measures with compensation that is actually paid (as computed in accordance with Item 402(v)) for a particular year. In accordance with Item 402(v), the Company is
      providing the descriptions and graphs below regarding the relationships between certain information presented in the PVP Table.</span></p></ix:continuation></ix:continuation></ix:continuation></ix:continuation>

  <ix:continuation id="Text_2f2b0c48fa034894adc5a66548982c4d3" continuedAt="Text_2f2b0c48fa034894adc5a66548982c4d4"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_2f2b0c48fa034894adc5a66548982c4d4" continuedAt="Text_2f2b0c48fa034894adc5a66548982c4d5"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">Compensation Actually Paid and Cumulative
          TSR</span></i></span></p></ix:continuation>
  <ix:continuation id="Text_2f2b0c48fa034894adc5a66548982c4d5" continuedAt="Text_2f2b0c48fa034894adc5a66548982c4d6"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_2f2b0c48fa034894adc5a66548982c4d6" continuedAt="Text_2f2b0c48fa034894adc5a66548982c4d7"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">As demonstrated by the following graph, the amount
      of compensation actually paid to Dr. Monia and the average amount of compensation actually paid to the Company&#8217;s NEOs as a group (excluding Dr. Monia) is aligned with the Company&#8217;s cumulative TSR over the three years presented in the table.</span></p></ix:continuation>
  <ix:continuation id="Text_2f2b0c48fa034894adc5a66548982c4d7" continuedAt="Text_2f2b0c48fa034894adc5a66548982c4d8"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_2f2b0c48fa034894adc5a66548982c4d8" continuedAt="Text_2f2b0c48fa034894adc5a66548982c4d9"><p style="font: 10pt Sans-Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: Red"><img alt="" src="ny20007094x2_def14aimg013.jpg" /></p></ix:continuation>
  <ix:continuation id="Text_2f2b0c48fa034894adc5a66548982c4d9"><p style="font: 10pt sans-serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: Red;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
<div>
   <br />
  &#160;
  </div>
<div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">81</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"> </p>

  <ix:continuation id="Text_059ede99f8fc4b31922a737a2f8049333" continuedAt="Text_059ede99f8fc4b31922a737a2f8049334"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">Cumulative TSR of the Company and Cumulative
          TSR of the NBI</span></i></span></p></ix:continuation>
  <ix:continuation id="Text_059ede99f8fc4b31922a737a2f8049334" continuedAt="Text_059ede99f8fc4b31922a737a2f8049335"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_059ede99f8fc4b31922a737a2f8049335" continuedAt="Text_059ede99f8fc4b31922a737a2f8049336"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The graph below shows the Company&#8217;s cumulative TSR
      over the three-year period against the cumulative TSR of the peer group presented for this purpose, the Nasdaq Biotechnology Index.&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_059ede99f8fc4b31922a737a2f8049336" continuedAt="Text_059ede99f8fc4b31922a737a2f8049337"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"> <br />
  </p></ix:continuation>
  <ix:continuation id="Text_059ede99f8fc4b31922a737a2f8049337" continuedAt="Text_059ede99f8fc4b31922a737a2f8049338"><p style="font: 10pt Sans-Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: Red"><img width="561" height="263" alt="" src="ny20007094x2_def14aimg014.jpg" /></p></ix:continuation>
  <ix:continuation id="Text_059ede99f8fc4b31922a737a2f8049338"><p style="font: 10pt sans-serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: Red;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;"> <br />
        </span></i></span></p>

  <ix:continuation id="Text_35aa39eb8cf1497da9dfb9f42d4da3343" continuedAt="Text_35aa39eb8cf1497da9dfb9f42d4da3344"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">Compensation Actually Paid and Net Income</span></i></span></p></ix:continuation>
  <ix:continuation id="Text_35aa39eb8cf1497da9dfb9f42d4da3344" continuedAt="Text_35aa39eb8cf1497da9dfb9f42d4da3345"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_35aa39eb8cf1497da9dfb9f42d4da3345" continuedAt="Text_35aa39eb8cf1497da9dfb9f42d4da3346"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The graph below shows the amount of compensation
      actually paid to Dr. Monia and the average amount of compensation actually paid to the Company&#8217;s NEOs as a group (excluding Dr. Monia) and the Company&#8217;s net income over the three years presented in the table. As noted above, the Company does not use
      compensation actually paid to set executive compensation.</span></p></ix:continuation>
  <ix:continuation id="Text_35aa39eb8cf1497da9dfb9f42d4da3346" continuedAt="Text_35aa39eb8cf1497da9dfb9f42d4da3347"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
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<div><br /></div>
</ix:continuation>
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  <ix:continuation id="Text_35aa39eb8cf1497da9dfb9f42d4da33410"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p></ix:continuation>

  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
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    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"> </p>
  <p style="font: 10pt sans-serif; margin: 0pt 0px; text-align: left; text-indent: 13.5pt; color: Red;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>

  <ix:continuation id="Text_cfd4c6eaadfc4c48807bb38b3922d3243" continuedAt="Text_cfd4c6eaadfc4c48807bb38b3922d3244"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">Compensation Actually Paid and Relative
          Total Shareholder Return</span></i></span></p></ix:continuation>
  <ix:continuation id="Text_cfd4c6eaadfc4c48807bb38b3922d3244" continuedAt="Text_cfd4c6eaadfc4c48807bb38b3922d3245"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
  <ix:continuation id="Text_cfd4c6eaadfc4c48807bb38b3922d3245" continuedAt="Text_cfd4c6eaadfc4c48807bb38b3922d3246"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The graph below shows the amount of compensation
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      compared to the TSRs of all members of the Nasdaq Biotechnology Index for each of the three years presented in the table. <br />
    </span></p></ix:continuation>
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  <ix:continuation id="Text_cfd4c6eaadfc4c48807bb38b3922d3248"><p style="font: 10pt sans-serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: Red;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>

  <div style="POSITION:RELATIVE;FLOAT:LEFT;WIDTH:68%">
    <ix:nonNumeric name="ecd:TabularListTableTextBlock" id="Text_0e2f8bf16b8847ab88e84ab1cee08212" contextRef="c20220101to20221231" escape="true" continuedAt="Text_56f2be5601b34d92828be9ff978fa5e51"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Financial Performance Measures</i></span></p></ix:nonNumeric>
    <ix:continuation id="Text_56f2be5601b34d92828be9ff978fa5e51" continuedAt="Text_56f2be5601b34d92828be9ff978fa5e52"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p></ix:continuation>
    <ix:continuation id="Text_56f2be5601b34d92828be9ff978fa5e52" continuedAt="Text_56f2be5601b34d92828be9ff978fa5e53"><p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">As
        described in greater detail in the CD&amp;A, we design our executive compensation program to drive the creation of long-term stockholder value and mitigate unnecessary or imprudent business risk taking. To that end, we structure our executive
        compensation program to align executive compensation with Company performance. The most important financial performance measures used by the Company in fiscal year 2022 to link executive compensation actually paid to the Company&#8217;s NEOs to the
        Company&#8217;s performance are listed in the table to the right.</span></p></ix:continuation>
  </div>

  <div style="POSITION:RELATIVE;FLOAT:RIGHT;WIDTH:28%">
    <ix:continuation id="Text_56f2be5601b34d92828be9ff978fa5e53" continuedAt="Text_56f2be5601b34d92828be9ff978fa5e54"><p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 199.5pt 0pt 0; text-align: justify; text-indent: 0.5in; color: #231F20"></p></ix:continuation>
    <ix:continuation id="Text_56f2be5601b34d92828be9ff978fa5e54">
<table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">


  <tr style="vertical-align: top; background-color: #A20067">

    <td style="width: 100%; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Most Important Financial
                Performance Measures</b></span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; padding-bottom: 8pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);"><span style="text-indent: 0pt;"><ix:nonNumeric name="ecd:MeasureName" id="Fact_8875a18c31c54a818966d2979ce65ecb" contextRef="c20220101to20221231_MeasureAxis_1Member">Revenue</ix:nonNumeric></span></span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; padding-bottom: 8pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);"><span style="text-indent: 0pt;"><ix:nonNumeric name="ecd:MeasureName" id="Fact_2edab49b7e384415916f0c9dc5e5fad1" contextRef="c20220101to20221231_MeasureAxis_2Member">Relative TSR Versus the NBI</ix:nonNumeric></span></span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; padding-bottom: 8pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);"><span style="text-indent: 0pt;"><ix:nonNumeric name="ecd:MeasureName" id="Fact_7f1768c683f34354a371a3c2f59b515a" contextRef="c20220101to20221231_MeasureAxis_3Member">Whether We Met Our Non-GAAP Net Operating Loss Guidance</ix:nonNumeric></span></span></td>

  </tr>


</table>
</ix:continuation>
  </div>
<ix:nonNumeric name="ecd:Additional402vDisclosureTextBlock" id="Text_f6fe29f3c9e043efab2e72d88dcb47c2" contextRef="c20220101to20221231" escape="true" continuedAt="Text_afe01503be9f448190ad0eb3decf59ff1">
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<div style="clear: both;"><br /></div>


  <br />
  </div>
</ix:nonNumeric>
  <ix:continuation id="Text_afe01503be9f448190ad0eb3decf59ff1"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>All information provided above under the &#8220;Item
        402(v) Pay Versus Performance&#8221; heading will not be deemed to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after
        the date hereof and irrespective of any general incorporation language in any such filing, except to the extent the Company specifically incorporates such information by reference.</i>&#160;</span></p></ix:continuation>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">83</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

</div>
<div style="font: 10pt Times New Roman, Times, Serif">

  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Outstanding Equity Awards at Fiscal Year-End &#8211;
      Executive Officers</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The following table shows for the
      fiscal year ended December 31, 2022, certain information regarding outstanding equity awards at fiscal year-end for our named executive officers.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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      in the table below, there were no equity incentive plan awards outstanding for our named executive officers at December 31, 2022.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Outstanding Equity Awards as of December 31, 2022 </b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


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    <td style="border-top: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" colspan="4"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Option Awards</b></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" colspan="4"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Stock Awards</b></span></td>

  </tr>

  <tr style="background-color: #A20067">

    <td style="vertical-align: bottom; width: 8%; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Name</b></span></td>

    <td style="vertical-align: bottom; width: 9%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Grant Date</b></span></td>

    <td style="vertical-align: bottom; width: 17%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Number of Securities Underlying Unexercised Options (#) Exercisable<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></td>

    <td style="vertical-align: bottom; width: 12%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Number of Securities Underlying Unexercised Options (#) Unexercisable</b></span></td>

    <td style="vertical-align: bottom; width: 8%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Option Exercise Price ($)</b></span></td>

    <td style="vertical-align: bottom; width: 10%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Option Expiration Date</b></span></td>

    <td style="vertical-align: bottom; width: 9%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Number of Shares or Units of Stock that Have Not Vested<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2) </sup></b></span></td>

    <td style="vertical-align: bottom; width: 10%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Market Value of Shares or Units of Stock that Have Not Vested<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></b></span></td>

    <td style="width: 8%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Equity incentive plan awards: number of unearned shares, units or other rights that have not vested (#)<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></b></span></td>

    <td style="width: 9%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Equity incentive plan awards: market or payout value of unearned shares, units or other rights that have not vested ($)<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(5)</sup></b></span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="16"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Brett P.
            Monia</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/4/2016</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">38,240<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(6)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$61.68 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2023</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2017</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">48,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$47.34 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2024</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2018</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">58,125</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$49.25 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/1/2025</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/14/2018</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">30,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$53.22 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/13/2025</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2019</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">100,756</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2,144</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$53.77 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/1/2026</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2020</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">78,481</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">29,151</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$60.89 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/1/2027</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2020</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">29,766</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">11,056</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$60.89 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/1/2027</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/4/2021</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">71,813</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">78,059</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$56.78 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2028</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">101,489</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$32.60 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2032</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2020</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">11,432</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$431,787 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2021</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">23,918</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$903,383 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">9,071</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$342,612 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2019</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">49,957</span></td>

    <td style="border-right: 1pt solid Black; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,886,876</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2020</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">50,745</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,916,639</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2020</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1,890</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$71,385 </span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2021</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">17,210</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$650,022 </span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">25,373</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$958,338 </span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-width: 1pt; border-style: solid; border-color: Black Black black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="12"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Elizabeth L. Hougen</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/4/2016</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">38,240<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(6)</sup></b></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$61.68 </span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2023</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2017</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">45,225</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$47.34 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2024</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2018</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">54,619</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$49.25 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/1/2025</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2019</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">48,762</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1,038</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$53.77 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/1/2026</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2020</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">43,968</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,331</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$60.89 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/1/2027</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/4/2021</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">29,249</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">31,792</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$56.78 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2028</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">33,118</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;$32.60 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2032</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">5,532</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$208,944 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2019</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">13,400</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$506,118 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2020</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">20,346</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$768,468 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2021</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,559</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$625,433 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2022</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4,140</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$156,368 </span></td>

  </tr>

  <tr>

    <td style="border-right: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left" rowspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph T. Baroldi</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
        </td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/31/2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">86,700</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$31.80 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/30/2032</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4/15/2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-- </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">43,350</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,637,330 </span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-width: 1pt; border-style: solid; border-color: Black Black black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="7"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Onaiza











            Cadoret-Manier</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/9/2020</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">37,187</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">13,813</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$63.27</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/8/2027</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-top: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/4/2021</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">26,121</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">28,392</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$56.78</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2028</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">33,118</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$32.60 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2032</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4/15/2020</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">11,333</span></td>

    <td style="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$428,047 </span></td>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2021</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">18,171</span></td>

    <td style="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$686,319</span></td>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2022</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,559</span></td>

    <td style="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$625,433</span></td>

    <td style="border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2022</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4,140</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$156,368</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="13"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Richard S. Geary</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/4/2016</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">38,240<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(6)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$61.68 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2023</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2017</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">21,225</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$47.34 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2024</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2018</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">58,125</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$49.25 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/1/2025</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2019</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">56,693</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1,207</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$53.77 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/1/2026</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2020</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">39,711</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">14,750</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$60.89 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/1/2027</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/4/2021</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">24,489</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">26,618</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$56.78 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2028</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">30,567</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$32.60 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2032</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2019</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6,432</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$242,937</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2020</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,102</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$457,093</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2021</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">17,035</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$643,412</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">15,284</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$577,277</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/15/2022</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">3,821</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$144,319</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">84</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="margin-top: 0; margin-bottom: 0"></p>
  <p style="margin-top: 0; margin-bottom: 0"></p>
  <p style="margin-top: 0; margin-bottom: 0"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The options granted to our employees vest at the rate of 25% for the first year and then at the rate of 2.08% per month for 36 months thereafter
            during the optionee&#8217;s employment. Options granted to our employees before January 1, 2022 have a term of seven years and options granted to our employees beginning January 1, 2022 have a term of ten years.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(2)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The RSUs granted to our employees were granted out of our 2011 Plan.&#160; The RSUs vest at the rate of 25% per year over four years.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(3)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Market value of stock awards was determined by multiplying the number of unvested shares by $37.77, which was the closing market price of our
            common stock on the Nasdaq Global Select Market on December 30, 2022, the last trading day of fiscal 2022.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(4)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Represents the threshold payout of shares under the PRSU awards granted to our NEOs.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(5)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Market value of PRSUs was determined by multiplying the threshold payout of shares by $37.77, which was the closing market price of our common
            stock on the Nasdaq Global Select Market on December 30, 2022, the last trading day of fiscal 2022.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(6)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">These options expired on January 3, 2023.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Option Exercises and Stock Vested &#8211; Executive
      Officers</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The following table shows for the
      fiscal year ended December 31, 2022, certain information regarding option exercises and stock awards vesting during the last fiscal year with respect to our named executive officers:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">85</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; color: #231F20"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="margin: 0px; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="vertical-align: bottom; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Name</b></span></td>

    <td style="vertical-align: top; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" colspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Option Awards</b></span></td>

    <td style="vertical-align: top; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" colspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Stock Awards</b></span></td>

  </tr>

  <tr style="vertical-align: bottom; background-color: #A20067">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Number of</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Shares</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Acquired</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>on Exercise (#)</b></span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Value Realized</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>on Exercise ($)</b></span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Number of</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Shares</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Acquired</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>on Vesting (#)</b></span></p>
        </td>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Value Realized</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>on Vesting ($)</b></span></p>
        </td>

  </tr>

  <tr>

    <td style="width: 20%; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Brett P. Monia</span></td>

    <td style="width: 20%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="width: 20%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;--</span></td>

    <td style="width: 20%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">65,673</span></td>

    <td style="width: 20%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,999,452</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Elizabeth L. Hougen</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">22,050</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$&#160;&#160;&#160;664,146</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph T. Baroldi</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;--</span></td>

  </tr>

  <tr style="background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Onaiza Cadoret-Manier</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">11,724</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$&#160;&#160;&#160;414,841</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Richard S. Geary</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">21,391</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$&#160;&#160;&#160;644,297</span></td>

  </tr>


</table>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"></p>
  <!-- Field: Rule-Page -->
  <div style="margin-top: 3pt; margin-bottom: 3pt; text-align: left;">
    <div style="font-size: 1pt; border-top: 1pt solid Black; width: 20%; text-align: left;">&#160;</div>

  </div>

  <!-- Field: /Rule-Page -->
  <p style="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0in; color: #A20067"></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Post-Employment Compensation</b></span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.3pt; text-align: left; text-indent: 0in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Pension Benefits and Nonqualified
        Deferred Compensation</i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 22.3pt; text-align: left; text-indent: 0in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Our executive officers are eligible to
      participate in our 401(k) contributory defined contribution plan. In 2022, we contributed to each participant a matching contribution equal to 100% of the first 5% of the participant&#8217;s compensation he or she contributed to the plan. In 2022, the
      maximum matching contribution was $15,250. The Compensation Committee can also grant discretionary contributions under our 401(k) plan. <span style="letter-spacing: -0.4pt;">We </span>do not provide any nonqualified defined contribution or other
      deferred compensation plans.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Employment Agreements</i></span></p>
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Our executive officers do not have
      employment contracts with us; however, they are entitled to participate in our Change of Control and Severance Benefit Plan, as described below.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Potential Payments Upon Termination or
      Change-of-Control</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Severance and Change of Control Arrangements
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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      Employee is terminated without &#8220;cause&#8221; (as defined in the Plan) or resigns for &#8220;good reason&#8221; (as defined in the Plan), except in connection with a &#8220;change in control&#8221; of the Company (as defined in the Plan), the Covered Employee will generally be
      entitled to receive (i) a lump sum payment of the Covered Employee&#8217;s then-current monthly base salary, (ii) accelerated vesting of stock options and restricted stock units previously granted to the Covered Employee by the Compensation Committee and
      outstanding as of the termination date that otherwise would have vested during the periods noted below, and (iii) continued medical group health and dental plan coverage, in each case for the following durations:&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Chief Executive Officer: 18 months;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Executive Vice Presidents: 12 months;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Senior Vice Presidents: 9 months; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Vice Presidents: 6 months.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In addition, for the Chief Executive
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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      Covered Employee&#8217;s termination or resignation occurs during the period that begins three months before and ends twelve months following a change in control, the Covered Employee will generally be entitled to receive (i) a lump sum payment of the
      Covered Employee&#8217;s then-current monthly base salary, (ii) payment of the then-current target bonus, (iii) accelerated vesting of all stock options and restricted stock units previously granted to the Covered Employee by the Compensation Committee and
      outstanding as of the termination date, and (iv) continued medical group health and dental plan coverage, in each of (i), (ii) and (iv) for the following durations:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">86</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
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  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; color: #231F20"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Chief Executive Officer: 24 months;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Executive Vice Presidents: 18 months;</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Senior Vice Presidents: 12 months; and</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Vice Presidents: 9 months.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Payments under the Plan will be
      subject to all required taxes. The Plan includes provisions for adjustment to the timing of payments to minimize accelerated or additional tax pursuant to Section 409A of the Internal Revenue Code. The Plan does not include any tax gross-up or other
      tax indemnity related to payments made to Covered Employees under the Plan; however, payments, benefits or distributions to or for the benefit of the Covered Employee under the Plan may be reduced if doing so would result in a more favorable
      after-tax position for the Covered Employee.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Conditions</i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">As a condition to receiving benefits
      under the Change of Control and Severance Benefit Plan described above, the Covered Employee is required to execute and not revoke a release in favor of the Company, which release will contain a standard release from liability, non-solicitation and
      non-disparagement provisions, and a reaffirmation of the Covered Employee&#8217;s confidentiality obligations to the Company.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Estimate of Benefits under Change
        of Control and Severance Benefit Plan </i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The following table estimates the lump
      sum payments and health benefits that would be required to be paid to our named executive officers under the Change of Control and Severance Benefit Plan as of December 31, 2022. This table estimates the lump sum payments based upon either a
      termination without cause, a resignation with good reason or a termination in connection with a change of control, assuming such event occurred on December 31, 2022. The estimates in this table are forward-looking statements. Please see the special
      note regarding forward-looking statements on page 97 of this Proxy Statement.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 50%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: auto; margin-right: auto;">


  <tr style="vertical-align: bottom; background-color: #A20067">

    <td style="width: 47%; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Name</b></span></td>

    <td style="width: 27%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Total &#8211; Change of Control Event</b></span></td>

    <td style="width: 26%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Total &#8211; Non-Change of Control Event</b></span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Brett P. Monia</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$3,239,439</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$2,117,301</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Elizabeth L. Hougen</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,337,173</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$646,552</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph T. Baroldi</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,131,648</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$548,683</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Onaiza Cadoret-Manier</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,211,697</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$585,339</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Richard S. Geary</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,230,482</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$592,460</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.5pt;">&#160;</p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In addition, in the case of a termination or resignation with good reason
      in connection with a change of control, <span style="color: rgb(35, 31, 32);">stock options and restricted stock units previously granted by the Compensation Committee and outstanding as of the termination date will accelerate as described above.</span></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.5pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Director Compensation</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For the fiscal year ending December 31,
      2022, we paid our non-employee Directors a base cash retainer of $60,000 with additional role-based compensation as noted below:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10pt 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 60%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: auto; margin-right: auto;">


  <tr>

    <td style="vertical-align: bottom; width: 70%; border-bottom: 1pt solid black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(206, 15, 105);"><b>Role</b></span></td>

    <td style="vertical-align: top; width: 30%; border-bottom: 1pt solid black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(206, 15, 105);"><b>2022 Cash Compensation</b></span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Board Member (Base)</span></td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; padding-right: 8.75pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$60,000<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #D9D9D9">

    <td style="border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Non-Executive Chairman of the Board</span></td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40,000</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Independent Lead Director</span></td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40,000</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Committee Chairs (Additional)</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Audit</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$24,000</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Compliance</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$20,000</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Compensation</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$20,000</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Finance</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$20,000</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Nominating, Governance and Review</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$20,000</span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #DDDDDD">

    <td style="border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Science/Medical</span></td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$20,000</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Committee Member (Additional)</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Audit</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$12,000</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Compliance</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$10,000</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Compensation</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$10,000</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Finance</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$10,000</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Nominating, Governance and Review</span></td>

    <td style="border-right: 1pt solid black; padding-right: 16.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$10,000</span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-bottom: 1pt solid Black; border-left: 1pt solid black; padding-left: 7.9pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Science/Medical</span></td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid Black; padding-right: 16.5pt; text-align: center; text-indent: 0in;">
          <div style="text-align: right;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$10,000</span></div>
        </td>

  </tr>


</table>
  <p style="margin-top: 0; margin-bottom: 0"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160; <br />
  </p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 107.8pt"><br />
        </td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left; padding-right: 1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Before March 31, 2024 this annual base cash retainer for each non-employee Director (not including fees for Non-Executive
            Chairman, Independent Lead Director, Committee Chair or Committee Member) is limited to a maximum of $70,000 per year.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160; </span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">87</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <div><br /></div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">If the Board creates new committees,
      we anticipate that the non-employee members of such new committees will receive additional compensation for their role on those committees. <span style="letter-spacing: -0.4pt;">We </span>do not pay Board members additional compensation for
      attending Board meetings, but we do reimburse them for the expenses they incur to attend the meetings.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">In 2022, each non-employee Director also received
      automatic stock award grants under our Non-Employee Director Plan. On July 1, 2022, under the Non-Employee Director Plan, each of our non-employee Directors serving at that time received an option to purchase 12,000 shares of our common stock, at an
      exercise price of $38.06 per share, the fair market value of the common stock on the date of the grant, based on the closing sales price reported on the Nasdaq Global Select Market, and an RSU award for 5,333 shares. The options and RSUs vest</span>
    <span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">on either (1) the annual anniversary of the date of grant, or (2) the next regularly scheduled annual meeting of stockholders, whichever occurs earlier.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In March 2021, the Compensation
      Committee and Board adopted a policy governing compensation the Company pays to its non-employee Directors (the &#8220;<b><i>Director Compensation Policy</i></b>&#8221;). In addition to stating the cash compensation amounts set forth above and the equity grants
      each non-employee Director will receive upon joining the Board and annually thereafter pursuant to the amended and restated 2002 Non-Employee Directors&#8217; Stock Option Plan, the Director Compensation Policy also includes an annual equity cap whereby
      (1) the Compensation Committee, with input from its independent consultant, may reduce the number of shares to be automatically issued to non-employee Directors on a grant date for each such award so that the awards granted have an aggregate grant
      date fair value that is aligned with the set of peer companies the Compensation Committee uses to evaluate compensation, and (2) the initial equity awards granted upon commencement of Board service will be adjusted downward such that they are 1.5
      times the annual equity awards for any given year. The Compensation Committee determined that for 2022, in order to align with the peer companies, if the annual awards to be automatically granted would have an aggregate grant date fair value that
      exceeds $500,000, then the number of shares to be automatically issued will be reduced proportionately for each such award so that the awards granted have an aggregate grant date fair value not in excess of $500,000. The grant date fair value of
      annual awards to be automatically granted in July 2022 did not exceed $500,000; thus, for 2022, each non-employee Director received an annual award of 12,000 stock options and 5,333 RSUs.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Compensation Committee reviews pay
      levels for non-employee Directors every year, with assistance from Aon, which prepares a comprehensive assessment of Ionis&#8217; non-employee Director compensation program. That assessment includes benchmarking of director compensation against the same
      peer group used for executive compensation purposes, an update on recent trends in director compensation, and a review of related corporate governance best practices. The Compensation Committee reviews these assessments prior to making
      recommendations to the Board regarding non-employee Director compensation. In March 2022 the Compensation Committee reviewed Aon&#8217;s assessment in which Aon did not recommend any changes to our non-employee Director compensation program for 2022.
      Following review and discussion of such report the Compensation Committee did not recommend any changes to the Board regarding our non-employee Director compensation program for 2022. We will continue to assess our non-employee Director compensation
      program annually with the assistance of Aon.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In December 2022 the Company adopted a
      deferral program for annual RSUs granted to non-employee Directors beginning in January 2023 and going forward. Such deferral program allows non-employee Directors to defer receipt of shares that may vest under future RSU grants until (1) separation
      from service to Ionis, or (2) the earlier to occur of five years following the vesting date of the RSUs and separation from service to Ionis, subject in all cases to earlier delivery of deferred RSUs upon a change in control of the Company.</span></p>
  <div><br /></div>

  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">88</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The following table shows for the
      fiscal year ended December 31, 2022 certain information with respect to the compensation of our non-employee Directors:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Director Compensation for Fiscal 2022</b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">


  <tr style="vertical-align: bottom; background-color: #A20067">

    <td style="border-top: 1.5pt solid black; border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Name</b></span></td>

    <td style="border-top: 1.5pt solid black; border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: black 1.5pt solid; border-bottom: black 1pt solid; padding: 1.5pt" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Cash Compensation</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Earned or Paid</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="white-space: nowrap; border-top: 1.5pt solid black; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: black 1.5pt solid; border-bottom: black 1pt solid; padding: 1.5pt" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Stock</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Awards</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></p>
        </td>

    <td style="white-space: nowrap; border-top: 1.5pt solid black; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: black 1.5pt solid; border-bottom: black 1pt solid; padding: 1.5pt" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Option</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Awards&#160;</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)&#160;</sup></b></span></p>
        </td>

    <td style="white-space: nowrap; border-top: 1.5pt solid black; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: black 1.5pt solid; border-bottom: black 1pt solid; padding: 1.5pt" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>All Other&#160;</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Compensation&#160;</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)&#160;</sup></b></span></p>
        </td>

    <td style="white-space: nowrap; border-top: 1.5pt solid black; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: black 1.5pt solid; border-bottom: black 1pt solid; padding: 1.5pt" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Total&#160;</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)&#160;</b></span></p>
        </td>

    <td style="white-space: nowrap; border-top: 1.5pt solid black; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="width: 19%; border-left: 1.5pt solid black; padding: 1.5pt 1.5pt 1.5pt 4.2pt; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Spencer R.
            Berthelsen</span></td>

    <td style="width: 1%; border-left: 1.5pt solid black; padding: 1.5pt; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="width: 12%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$100,000</span></td>

    <td style="white-space: nowrap; width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; border-right: 1.5pt solid black; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="width: 13%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$202,974</span></td>

    <td style="white-space: nowrap; width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; border-right: 1.5pt solid black; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="width: 12%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$274,724</span></td>

    <td style="white-space: nowrap; width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; border-right: 1.5pt solid black; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="width: 14%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$--</span></td>

    <td style="white-space: nowrap; width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; border-right: 1.5pt solid black; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="width: 15%; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$577,698</span></td>

    <td style="white-space: nowrap; width: 1%; border-bottom: 1pt solid black; padding: 1.5pt; border-right: 1.5pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt 1.5pt 1.5pt 4.2pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Allene M. Diaz</span></td>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$73,000</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$202,974</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$274,724 </span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$19,044</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$569,743</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt 1.5pt 1.5pt 4.2pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Michael Hayden</span></td>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$80,000</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$202,974</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$274,724</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$18,141</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$575,839</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt 1.5pt 1.5pt 4.2pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joan E. Herman</span></td>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$84,500</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$202,974</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$274,724</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$--</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$562,198</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt 1.5pt 1.5pt 4.2pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph Klein, III</span></td>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$86,500</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$202,974</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$274,724</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$28,646</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$592,845</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt 1.5pt 1.5pt 4.2pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph Loscalzo</span></td>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$120,000</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$202,974</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$274,724</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$--</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$597,698</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt 1.5pt 1.5pt 4.2pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Frederick T. Muto</span></td>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$55,251</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$202,974</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$274,724</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$10,000<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$542,949</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt 1.5pt 1.5pt 4.2pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">B. Lynne Parshall</span></td>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$90,000</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$202,974</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$274,724</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$244,641<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></b></span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$1,037,339</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt 1.5pt 1.5pt 4.2pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph H. Wender</span></td>

    <td style="border-bottom: 1pt solid black; border-left: 1.5pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$150,000</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$202,974</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$274,724</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$--</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><br />
        </td>

    <td style="border-bottom: 1pt solid black; padding: 1.5pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$627,698</span></td>

    <td style="white-space: nowrap; border-right: 1.5pt solid black; border-bottom: 1pt solid black; padding: 1.5pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="margin-top: 0; margin-bottom: 0"></p>
  <p style="margin-top: 0; margin-bottom: 0"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amounts represent the aggregate expense recognized for financial statement reporting purposes in accordance with ASC 718 for stock and option
            awards granted to the Directors.&#160; ASC 718 expense for the option awards is based on the fair value of the awards on the date of grant using an option-pricing model. The fair value of RSUs is based on the market price of our common stock on the
            date of grant.&#160; For more information, please see Note 5, <i>Stockholders&#8217; Equity,</i> of the consolidated financial statements in our Annual Report on Form 10-K for the year ended December 31, 2022 regarding assumptions underlying valuation of
            equity awards.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(2)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For Ms. Diaz, Dr. Hayden, Mr. Klein, and Ms. Parshall, includes medical, dental and vision benefits, which are available to all non-employee
            directors and all employees of the Company.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(3)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Mr. Muto resigned from the Board in July 2022. In December 2022, Mr. Muto received a $10,000 Legacy Award, which he elected to donate to
            non-profit organizations.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(4)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">On January 15, 2018, Ms. Parshall transitioned out of her role as Chief Operating Officer and retired from Ionis after 28 years of service.
            Thereafter, she became a Senior Strategic Advisor to the Company and entered into an Advisory Services Agreement. As a result of this transition, Ms. Parshall&#8217;s &#8220;All Other Compensation&#8221; for 2022 includes $225,000 in consulting fees earned under
            her Advisory Services Agreement. Ms. Parshall&#8217;s Advisory Services Agreement terminated on December 31, 2022.&#160;</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span><br />
  </p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">89</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Outstanding Equity Awards at Fiscal Year-End &#8211;
      Directors</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The following table shows for the
      fiscal year ended December 31, 2022, certain information regarding outstanding awards at fiscal year-end of all our non-employee Directors: <br />
    </span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"> <br />
    </span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Outstanding Equity Awards as of December 31, 2022</b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="vertical-align: bottom; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Name</b></span></td>

    <td style="vertical-align: top; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" colspan="4"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Option Awards</b></span></td>

    <td style="vertical-align: top; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" colspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Stock Awards</b></span></td>

  </tr>

  <tr style="background-color: #A20067">

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Number of
              Securities Underlying Unexercised Options (#) Exercisable<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Number of
              Securities Underlying Unexercised Options (#) Unexercisable</b></span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Option
              Exercise Price ($)</b></span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Option
              Expiration Date</b></span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Number of Shares or Units of Stock that Have Not Vested<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2) (3)</sup></b></span></td>

    <td style="vertical-align: top; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Market Value of Shares or Units of Stock that Have Not Vested<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></b></span></td>

  </tr>

  <tr>

    <td style="width: 15%; border-left: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="9"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Spencer























            R. Berthelsen</span></td>

    <td style="width: 13%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">11,250</span></td>

    <td style="width: 13%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="width: 12%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$28.47 </span></td>

    <td style="width: 20%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2023</span></td>

    <td style="width: 12%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="9"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,110</span></td>

    <td style="width: 15%; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="9"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$268,545 </span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$35.53 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2024</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$57.16 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2025</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$24.42 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2026</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$52.22 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7/2/2027</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$42.88 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7/1/2028</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$64.80 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2029</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$60.20 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2030</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40.05 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2031</span></td>

  </tr>

  <tr>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$38.06 </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2032</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Allene M. Diaz</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">18,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40.05 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2031</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">5,333</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="2"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$201,427</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$38.06 </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2032</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="5"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Michael Hayden</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">32,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$50.80 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">9/19/2028</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="5"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,110</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="5"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$268,545</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$64.80 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2029</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$60.20 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2030</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40.05 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2031</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;-- </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$38.06 </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2032</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="5"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joan E. Herman</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">24,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">8,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$63.90 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/8/2029</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="5"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">10,665</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="5"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$402,817</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$64.80 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2029</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$60.20 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2030</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40.05 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2031</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;-- </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$38.06 </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2032</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="8"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph Klein, III</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$57.16 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2025</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="8"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,110</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="8"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$268,545























          </span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$24.42 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2026</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$52.22 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7/2/2027</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$42.88 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7/1/2028</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$64.80 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2029</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$60.20 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2030</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">-</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40.05 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2031</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;-- </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$38.06 </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2032</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="10"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph Loscalzo</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">22,500</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$49.09 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2/2/2024</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="10"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,110</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="10"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$268,545























          </span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$35.53 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2024</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$57.16 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2025</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$24.42 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2026</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$52.22 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7/2/2027</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$42.88 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7/1/2028</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$64.80 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2029</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$60.20</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2030</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40.05</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2031</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$38.06</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2032</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="10"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Frederick T. Muto<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(5)</sup></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 1pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 1pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 1pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 1pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="10"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="10"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$--</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">11,250</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$28.47 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2023</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$35.53 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2024</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$57.16 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2025</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">8,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$24.42 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2026</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$52.22 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7/2/2027</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$42.88 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7/1/2028</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$64.80 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/20/2029</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$60.20 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2030</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40.05 </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2031</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="9"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">B. Lynne Parshall<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(6)</sup></span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 1pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 1pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 1pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 1pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="9"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,110</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="9"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$268,545</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">107,549</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$61.68 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/3/2023</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">117,638</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$47.34 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/2/2024</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">103,575</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$49.25 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">1/1/2025</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$42.88 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7/1/2028</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$64.80 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2029</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$60.20 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2030</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40.05</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2031</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$38.06</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2032</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; text-indent: 0in;" rowspan="9"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph H. Wender</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$35.53 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2024</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="9"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,110</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;" rowspan="9"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$268,545</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$57.16 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2025</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$24.42 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2026</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$52.22 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7/2/2027</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">16,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$42.88 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7/1/2028</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">4,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$64.80 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2029</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$60.20 </span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2030</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$40.05</span></td>

    <td style="border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2031</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">12,000</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$38.06</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">6/30/2032</span></td>

  </tr>


</table>
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  <p style="margin-top: 0; margin-bottom: 0"></p>
  <!-- Field: Rule-Page -->
  <div style="margin-top: 3pt; margin-bottom: 3pt; text-align: left;">
    <div style="font-size: 1pt; border-top: 1pt solid Black; width: 20%; text-align: left;">&#160;</div>

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  <!-- Field: /Rule-Page -->
  <p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Except for the awards Ms. Parshall received when she was an employee, the options have a term of ten years and were granted out of the 2002
            Non-Employee Directors&#8217; Stock Option Plan. Initial options granted upon commencement of Board service prior to June 4, 2020 vest at the rate of 25% per year over four years and those granted on or after June 4, 2020 vest 100% on the first
            anniversary of the date of grant. Annual options that were granted prior to June 4, 2020 vest equally over four years on each anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders, whichever occurs
            earlier. Annual options that were granted on or after June 4, 2020 vest 100% on either (1) the annual anniversary of the date of grant, or (2) the next regularly scheduled annual meeting of stockholders, whichever occurs earlier. The options
            Ms. Parshall received as an employee vest at the rate of 25% for the first year and then at the rate of 2.08% per month for 36 months thereafter.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">90</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


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    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(2)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Except for the awards Ms. Parshall received as an employee, the RSUs were granted out of our the 2002 Non-Employee Directors&#8217; Stock Option Plan.
            Initial RSUs granted upon commencement of Board service prior to June 4, 2020 vest at the rate of 25% per year over four years and those granted on or after June 4, 2020 vest 100% on the first anniversary of the date of grant. Annual RSUs that
            were granted prior to June 4, 2020 vest equally over four years on each anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders, whichever occurs earlier. Annual RSUs that were granted on or after June 4,
            2020 vest 100% on either (1) the annual anniversary of the date of grant, or (2) the next regularly scheduled annual meeting of stockholders, whichever occurs earlier.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


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    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(3)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">All of our non-employee Directors are subject to our Stock Holding and Ownership Guidelines for RSU Shares, which requires each non-employee
            Director to accumulate and maintain shares of common stock equal to five times such non-employee Director&#8217;s base annual cash retainer for service as a Director (but not for service on a Board committee), or until his or her termination of
            service.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(4)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Market value of stock awards was determined by multiplying the number of unvested shares by $37.77, which was the closing market price of our
            common stock on the Nasdaq Global Select Market on December 31, 2022, the last trading day of fiscal year 2022.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


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    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(5)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Mr. Muto did not receive equity grants in 2022 as he retired from the Board in July 2022.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(6)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Includes awards received by Ms. Parshall during her tenure as an executive officer of the Company.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Option Exercises and Stock Vested - Directors</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The following table shows for the
      fiscal year ended December 31, 2022, certain information regarding option exercises and stock awards vested during the last fiscal year with respect to our non-employee Directors:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Option Exercises and Stock Vested in Fiscal 2022</b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" border="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; text-align: center; text-indent: 0in; width: 50%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-top: 1pt solid black; border-bottom: 1pt solid black; background-color: rgb(162, 0, 103); text-align: center; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: 1pt solid black; border-bottom: 1pt solid black; background-color: rgb(162, 0, 103); text-align: center; text-indent: 0in;" colspan="6"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Option












              Awards</b></span></td>

    <td style="vertical-align: bottom; border-top: 1pt solid black; border-bottom: 1pt solid black; background-color: rgb(162, 0, 103); text-align: center; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-top: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; background-color: rgb(162, 0, 103); text-align: center; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-top: 1pt solid black; border-bottom: 1pt solid black; background-color: rgb(162, 0, 103); text-align: center; text-indent: 0in;" colspan="6"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Stock












              Awards</b></span></td>

    <td style="vertical-align: bottom; border-top: 1pt solid black; border-right: 1pt solid black; border-bottom: 1pt solid black; background-color: rgb(162, 0, 103); text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="vertical-align: bottom; background-color: #A20067">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: center; text-indent: 0in; width: 50%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Name</b></span></td>

    <td style="border-bottom: 1pt solid black; text-align: center; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black;" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Number of</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Shares</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Acquired</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>on Exercise</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(#)</b></span></p>
        </td>

    <td style="border-bottom: 1pt solid black; text-align: center; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: center; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black;" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Value Realized</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>on Exercise</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="border-bottom: 1pt solid black; text-align: center; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: center; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black;" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Number of</b>&#160;</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Shares</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Acquired</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>on Vesting</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(#)</b></span></p>
        </td>

    <td style="border-bottom: 1pt solid black; text-align: center; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: center; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid black;" colspan="2">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Value Realized</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>on Vesting</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="width: 50%; border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.7pt; text-align: left; text-indent: -7.7pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Spencer R. Berthelsen</span></td>

    <td style="vertical-align: bottom; width: 1%; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; width: 3%; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; width: 8%; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">11,250</span></td>

    <td style="vertical-align: bottom; width: 1%; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; width: 1%; border-left: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; width: 3%; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; width: 8%; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">394,088</span></td>

    <td style="vertical-align: bottom; width: 1%; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; width: 1%; border-left: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid rgb(0, 0, 0); vertical-align: bottom; width: 3%; padding: 0px; text-align: right; text-indent: 0in;" rowspan="1"><br />
        </td>

    <td style="border-bottom: 1pt solid #000000; vertical-align: bottom; width: 7%; padding: 0px 0px 0px 4pt; text-align: left; text-indent: 0in;" rowspan="1"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,998</span> <br />
        </td>

    <td style="vertical-align: bottom; width: 1%; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; width: 1%; border-left: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; width: 3%; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; width: 7%; border-bottom: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">314,401</span></td>

    <td style="vertical-align: bottom; width: 1%; border-bottom: 1pt solid black; border-right: 1pt solid black; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.7pt; text-align: left; text-indent: -7.7pt; width: 50%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Allene M. Diaz</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid rgb(0, 0, 0); vertical-align: bottom; width: 3%; padding: 0px; text-align: right; text-indent: 0in;" rowspan="1"><br />
        </td>

    <td style="border-bottom: 1pt solid #000000; vertical-align: bottom; width: 7%; padding: 0px 0px 0px 4pt; text-align: left; text-indent: 0in;" rowspan="1"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">8,000</span> <br />
        </td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 7%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">314,480</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.7pt; text-align: left; text-indent: -7.7pt; width: 50%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Michael Hayden</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid rgb(0, 0, 0); vertical-align: bottom; width: 3%; padding: 0px; text-align: right; text-indent: 0in;" rowspan="1"><br />
        </td>

    <td style="border-bottom: 1pt solid #000000; vertical-align: bottom; width: 7%; padding: 0px 0px 0px 4pt; text-align: left; text-indent: 0in;" rowspan="1"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">8,887</span> <br />
        </td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 7%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">362,160</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.7pt; text-align: left; text-indent: -7.7pt; width: 50%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joan E. Herman</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid rgb(0, 0, 0); vertical-align: bottom; width: 3%; padding: 0px; text-align: right; text-indent: 0in;" rowspan="1"><br />
        </td>

    <td style="border-bottom: 1pt solid rgb(0, 0, 0); vertical-align: bottom; width: 7%; padding: 0px; text-align: left; text-indent: 0in;" rowspan="1"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">10,665</span> <br />
        </td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 7%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">403,066</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 50%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph Klein, III</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid rgb(0, 0, 0); vertical-align: bottom; width: 3%; padding: 0px; text-align: right; text-indent: 0in;" rowspan="1"><br />
        </td>

    <td style="border-bottom: 1pt solid #000000; vertical-align: bottom; width: 7%; padding: 0px 0px 0px 4pt; text-align: left; text-indent: 0in;" rowspan="1"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,998</span> <br />
        </td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 7%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">314,401</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.7pt; text-align: left; text-indent: -7.7pt; width: 50%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph Loscalzo</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid rgb(0, 0, 0); vertical-align: bottom; width: 3%; padding: 0px; text-align: right; text-indent: 0in;" rowspan="1"><br />
        </td>

    <td style="border-bottom: 1pt solid #000000; vertical-align: bottom; width: 7%; padding: 0px 0px 0px 4pt; text-align: left; text-indent: 0in;" rowspan="1"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,998</span> <br />
        </td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 7%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">314,401</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.7pt; text-align: left; text-indent: -7.7pt; width: 50%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Frederick T. Muto</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">11,250</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">428,175</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid rgb(0, 0, 0); vertical-align: bottom; width: 3%; padding: 0px; text-align: right; text-indent: 0in;" rowspan="1"><br />
        </td>

    <td style="border-bottom: 1pt solid #000000; vertical-align: bottom; width: 7%; padding: 0px 0px 0px 4pt; text-align: left; text-indent: 0in;" rowspan="1"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,998</span> <br />
        </td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 7%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">314,401</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.7pt; text-align: left; text-indent: -7.7pt; width: 50%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">B. Lynne Parshall<b><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid rgb(0, 0, 0); vertical-align: bottom; width: 3%; padding: 0px; text-align: right; text-indent: 0in;" rowspan="1"><br />
        </td>

    <td style="border-bottom: 1pt solid rgb(0, 0, 0); vertical-align: bottom; width: 7%; padding: 0px; text-align: left; text-indent: 0in;" rowspan="1"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">13,752</span> <br />
        </td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 7%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">487,712</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid black; border-bottom: 1pt solid black; border-left: 1pt solid black; padding-left: 7.7pt; text-align: left; text-indent: -7.7pt; width: 50%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph H. Wender</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 8%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">--</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="border-bottom: 1pt solid rgb(0, 0, 0); vertical-align: bottom; width: 3%; padding: 0px; text-align: right; text-indent: 0in;" rowspan="1"><br />
        </td>

    <td style="border-bottom: 1pt solid #000000; vertical-align: bottom; width: 7%; padding: 0px 0px 0px 4pt; text-align: left; text-indent: 0in;" rowspan="1"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">7,998</span> <br />
        </td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; border-left: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 3%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$</span></td>

    <td style="vertical-align: bottom; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 7%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">314,401</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid black; border-bottom: 1pt solid black; text-align: left; text-indent: 0in; width: 1%;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>


</table>
  <p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
  <p style="margin-top: 0; margin-bottom: 0"></p>
  <!-- Field: Rule-Page -->
  <div style="margin-top: 3pt; margin-bottom: 3pt; text-align: left;">
    <div style="font-size: 1pt; border-top: 1pt solid Black; width: 20%; text-align: left;">&#160;</div>

  </div>

  <!-- Field: /Rule-Page -->
  <p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Includes shares received by Ms. Parshall pursuant to awards granted during her tenure as an executive officer of the Company.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Certain Relationships and Related Transactions</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We have provided some of the
      information below because you may find it useful when evaluating the proposals contained in this Proxy Statement. When we include a transaction in this section, we do not necessarily mean that the transaction qualifies as a related party transaction
      under the securities laws.&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">91</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32); letter-spacing: -0.2pt;">M</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">ariana Baroldi is a Director in our Corporate Operations department and the wife of Joseph T. Baroldi, EVP and Chief Business Officer. <span style="color: rgb(35, 31, 32); letter-spacing: -0.2pt;">In addition, Grant Swayze</span> joined Ionis as a Research Associate in September 2022 and is the son of Eric E. Swayze, EVP, Research. We <span style="color: rgb(35, 31, 32); letter-spacing: -0.2pt;">reviewed Ms.
        Baroldi&#8217;s and Mr. G. Swayze&#8217;s compensation and determined they are within the range that we target for other employees at the same levels at Ionis. </span></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; letter-spacing: -0.2pt;">For the fiscal
      year 2022, Ms. Baroldi and Mr. G. Swayze received the following compensation:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="vertical-align: bottom; background-color: #A20067">

    <td style="width: 17%; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Name and Principal Position</b></span></td>

    <td style="width: 6%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year</b></span></td>

    <td style="width: 11%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Salary</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="width: 9%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Bonus<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="width: 12%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Stock Awards<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="width: 14%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Option</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Awards<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)(3)</sup></b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="width: 21%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>All Other Compensation<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

    <td style="width: 10%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Total</b></span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center; text-indent: 0in; color: white;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>($)</b></span></p>
        </td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Mariana Baroldi,</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Director, Corporate Operations</span></p>
        </td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$204,986</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$49,883</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$47,139</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$49,457</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$18,773</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$370,238</span></td>

  </tr>

  <tr style="background-color: #E7E6E6">

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Grant Swayze,</span></p>
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Research Associate</span></p>
        </td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$16,962</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$0</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$23,180</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$25,229</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$3,580</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$68,951</span></td>

  </tr>


</table>
  <p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We present bonuses in the years they were earned, not in the year paid.&#160; Bonuses represent compensation for achievements and are not necessarily
            paid in the year they are earned; for example, in January 2023 we paid bonuses for 2022 performance. As Mr. G. Swayze joined Ionis in late 2022, he was not eligible to receive a bonus in 2022.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(2)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amounts represent the aggregate expense recognized for financial statement reporting purposes in accordance with ASC 718 for stock and option
            awards granted to Ms. Baroldi and Mr. G. Swayze.&#160; ASC 718 expense for the option awards is based on the fair value of the awards on the date of grant using an option-pricing model. The fair value of RSUs is based on the market price of our
            common stock on the date of grant.&#160; For more information, please see Note 5, <i>Stockholders&#8217; Equity,</i> of the consolidated financial statements in our Annual Report on Form 10-K for the year ended December 31, 2022 regarding assumptions
            underlying valuation of equity awards.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(3)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">This amount represents the estimated fair value of a stock option grant we recognized as share-based compensation expense. The estimated fair
            value amount was determined using an option-pricing model and is not indicative of whether Ms. Baroldi or Mr. G. Swayze will realize the estimated fair value or any financial benefits from the award.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(4)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For Ms. Baroldi, includes AD&amp;D, basic life, long term disability and 401(k) matching contributions, which are available to all employees. For
            Mr. G. Swayze, includes AD&amp;D, basic life, medical, dental, vision, long term disability and 401(k) matching contributions, which are available to all employees.</span></td>

  </tr>


</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">B. <span style="letter-spacing: -0.15pt;">Lynne </span>Parshall, who was employed by Ionis for 28 years, became a Senior Strategic Advisor to the Company in January 2018. Under Ms. Parshall&#8217;s Advisory Services Agreement, she provided strategic advisory services to the Company,
      including in strategic planning, business development, and with the Company&#8217;s important relationship with Biogen. Pursuant to the Advisory Services Agreement, Ms. Parshall received consulting fees of $225,000 for services provided in 2022. </span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Ms. Parshall&#8217;s Advisory Services Agreement terminated on December 31, 2022.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">One of our Directors, Joseph Wender,
      is a Senior Consultant to Goldman Sachs &amp; Co., a firm we engage from time to time for investment banking services. We paid Goldman an aggregate amount of approximately $260,000 in 2022, which is substantially less than 5% of Goldman&#8217;s gross
      revenues for its 2022 fiscal year.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">One of our Directors, Joseph Loscalzo,
      is Physician-in-Chief Emeritus at Brigham and Women&#8217;s Hospital, a not-for-profit corporation that is part of Mass General Brigham, which we engage from time to time for clinical research support services. We paid Brigham and Women&#8217;s Hospital an
      aggregate amount of approximately $2.6 million in 2022, which is substantially less than 5% of Mass General Brigham&#8217;s gross revenues for its 2022 fiscal year.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In late 2019, the n-Lorem Foundation,
      a non-profit organization, was formed to provide advanced, experimental RNA-targeted medicines free of charge for life to patients living with ultra-rare diseases. The n-Lorem Foundation was established with an initial investment by our former
      Executive Chairman of the Board and Chief Executive Officer, Dr. Stanley Crooke, and his wife, Dr. Rosanne Crooke. The Company did not make a cash donation to the n-Lorem Foundation in 2022 but has made cash donations to n-Lorem in the past. Ms.
      Parshall, Dr. Hayden and Dr. Loscalzo, three of the Company&#8217;s non-employee Directors, also serve as directors for the n-Lorem Foundation. Additionally, Dr. Bennett, our EVP and CSO, serves as a director and the chief technical officer for the n-Lorem
      Foundation, and until February 2022, Mr. O&#8217;Neil, our EVP, General Counsel and Corporate Secretary, served as the corporate secretary for the n-Lorem Foundation. None of our executive officers or Directors is compensated for service to the n-Lorem
      Foundation.&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 10.1pt 0pt 0; text-align: left; text-indent: 20.15pt; color: #231F20"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">92</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We have entered into indemnity
      agreements with each of our executive officers and Directors and certain non-executive officers which provide, among other things, that we will indemnify such officer or Director, under the circumstances and to the extent provided for therein, for
      expenses, damages, judgments, fines and settlements he or she may be required to pay in actions or proceedings which he or she is or may be made a party by reason of his or her position as a Director, officer or other agent of Ionis, and otherwise to
      the fullest extent permitted under Delaware law and our bylaws. Our bylaws provide that we will indemnify our Directors and executive officers to the fullest extent not prohibited by Delaware law or any other applicable <span style="letter-spacing: -0.2pt;">law, </span>except that we will generally not be required to indemnify a Director or executive officer in connection with any proceeding initiated by such Director or executive officer.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Policies and Procedures Regarding
        Related Party Transactions</i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">A committee of the Board composed
      entirely of independent Directors approves transactions with related persons, as defined under SEC regulations. The Compensation Committee approves all compensation we pay to employees who may qualify as related persons, and the Audit Committee
      approves all other related party transactions, as specified in its charter.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For transactions that do not qualify
      as related party transactions, but may otherwise present a conflict of interest, our Code of Ethics and Business Conduct requires the Nominating, Governance and Review Committee of the Board (for our executive officers and Directors) or the Chief
      Executive Officer or Chief Legal Officer (for non-executive officers and non-Directors) to determine that no conflict of interest exists.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Our written policies and procedures
      specifically prohibit personal loans to our executive officers and any officer with a title of Vice President or higher.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">CEO Pay Ratio</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Under SEC rules, we disclose below the
      annual total compensation of our median employee, and the ratio of the annual total compensation of our CEO compared to the annual total compensation of our median employee <span style="letter-spacing: -0.15pt;">(&#8220;<b><i>CEO </i></b></span><b><i>Pay
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32); letter-spacing: -0.4pt;">We </span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">included all employees of Ionis who were employed by us on December 31, 2022. </span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 38.15pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left; padding-right: 10.1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32); letter-spacing: -0.4pt;">We </span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">identified our median employee from this employee population based on the <span style="letter-spacing: -0.2pt;">W-2 </span>income for 2022. <span style="letter-spacing: -0.4pt;">We </span>did not
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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Using this approach, we determined our
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);">For 2022, the median of the annual
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The CEO Pay Ratio above represents our
      reasonable estimate calculated in a manner consistent with SEC rules and applicable guidance. SEC rules and guidance provide significant flexibility in how companies identify the median employee, and each company may use a different methodology and
      make different assumptions particular to that company. As a result, and as explained by the SEC when it adopted these rules, in considering the pay ratio disclosure, stockholders should keep in mind that the rule was not designed to facilitate
      comparisons of pay ratios among different companies, even companies within the same industry, but rather to allow stockholders to better understand and assess each particular company&#8217;s compensation practices and pay ratio disclosures.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Currently, neither the Compensation
      Committee nor our management used the CEO Pay Ratio described above to make compensation decisions. The Compensation Committee does, however, consider the internal pay equity ratios described on page 57 of this Proxy Statement when making
      compensation decisions.&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">93</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">COMPENSATION COMMITTEE REPORT*</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 175.7pt; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Compensation Committee has:</span></p>
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  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


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    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">reviewed and discussed the Compensation Discussion and Analysis included in this Proxy Statement with management; and</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


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    <td style="width: 0.25in"></td>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#9679;</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">based on this review and discussion, the Compensation Committee recommended to the Board of Directors that the Compensation Discussion and
            Analysis be included in our Proxy Statement relating to the 2023 Annual Meeting of Stockholders.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 355.7pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>The Compensation Committee </i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 355.7pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Spencer R. Berthelsen, <i>Chairman </i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 355.7pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joan E. Herman</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 355.7pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph H. Wender</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 355.7pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">*</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">This Section is not &#8220;soliciting material,&#8221; is not deemed filed with the SEC and is not to be incorporated by reference in any filing of Ionis
            under the Securities Act or the Exchange Act.</span></td>

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</table>
  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">94</span></div>

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      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">AUDIT COMMITTEE REPORT*</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 200.9pt; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Audit Committee is made up entirely of
      independent Directors and operates under a written charter that has been adopted by the Board of Directors and is reviewed annually. During fiscal year 2022, the Audit Committee fulfilled its duties and responsibilities as outlined in the charter. At
      its meetings, the Audit Committee meets as a group with members of the Company&#8217;s financial management, the independent auditors, and the internal auditors. In addition, the Audit Committee regularly holds separate, private, executive sessions with
      senior management, the independent auditors, and the internal audit team to discuss applicable audit matters and provide oversight.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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      reporting process on behalf of the Board of Directors. Management has the primary responsibility for the financial statements and the financial reporting process, including the systems of internal controls. In fulfilling its oversight
      responsibilities, the Audit Committee reviewed the audited consolidated financial statements and the related schedules in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022 with management, including a discussion of the
      quality, not just the acceptability, of the accounting principles, the reasonableness of significant judgments, and the clarity of disclosures in the financial statements.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Audit Committee reviewed with our independent
      registered public accounting firm, which is responsible for expressing an opinion on the conformity of our audited consolidated financial statements with U.S. generally accepted accounting principles, their judgments as to the quality, not just the
      acceptability, of our accounting principles and any other matters that are required to be discussed with the Audit Committee under Public Company Accounting Oversight Board (United States) (&#8220;<b><i>PCAOB</i></b>&#8221;) standards. In addition, the Audit
      Committee has discussed with the independent auditors, the auditors&#8217; independence from management and Ionis, including the matters in the written disclosures required by PCAOB Rule 3526. The Audit Committee received from Ernst &amp; <span style="letter-spacing: -0.2pt;">Young </span>LLP written disclosure and the letter regarding its independence as required by applicable requirements of the PCAOB regarding Ernst &amp; <span style="letter-spacing: -0.2pt;">Young </span><span style="letter-spacing: -0.15pt;">LLP&#8217;s </span>communications with the Audit Committee concerning independence. The Audit Committee also discussed with our independent auditors the matters required by Auditing Standard No. 1301, <i>Communications
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Audit Committee also reviewed and discussed,
      together with management and the independent auditors, the audited consolidated financial statements for the fiscal year ended December 31, 2022, and the results of management&#8217;s assessment of the effectiveness of the Company&#8217;s internal control over
      financial reporting and the independent auditor&#8217;s audit of internal control over financial reporting.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Audit Committee discussed with our independent
      auditors the overall scope and plans for their audit. The Audit Committee met with the independent auditors, with and without management present, to discuss the results of their examinations, their evaluations of our internal controls, including
      internal control over financial reporting, and the overall quality of our financial reporting.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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      referred to above, the Audit Committee recommended to the Board of Directors, and the Board has approved, that the audited financial statements be included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022 for filing with
      the SEC. The Audit Committee and the Board have also approved, subject to stockholder ratification, the selection of Ernst &amp; <span style="letter-spacing: -0.2pt;">Young </span>LLP as our independent auditors for 2023.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 22.3pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>The Audit Committee</i></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joseph Klein, III, <i>Chair</i></span></p>
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 396.7pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Joan E. Herman</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 396.7pt 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 0pt"></td>

    <td style="width: 18pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">*</span></td>

    <td style="text-align: left; padding-right: 46.1pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">This Section is not &#8220;soliciting material,&#8221; is not deemed filed with the SEC and is not to be incorporated by reference in
            any filing of Ionis under the Securities Act or the Exchange Act.</span></td>

  </tr>


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  <p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">95</span></div>

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      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">HOUSEHOLDING OF PROXY MATERIALS</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 174.95pt; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The SEC has adopted rules that permit
      companies and intermediaries (e.g. brokers) to satisfy the delivery requirements for Notice Regarding the Availability of Proxy Materials with respect to two or more stockholders sharing the same address by delivering a single Notice Regarding the
      Availability of Proxy Materials addressed to those stockholders. This process, which is commonly referred to as &#8220;householding,&#8221; potentially means extra convenience for stockholders and cost savings for companies.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">This year, a number of brokers with
      account holders who are our stockholders will be &#8220;householding&#8221; our proxy materials. A single Notice Regarding the Availability of Proxy Materials will be delivered to multiple stockholders sharing an address unless contrary instructions have been
      received from the affected stockholders. Once you have been notified by your broker that they will be &#8220;householding&#8221; communications to your address, &#8220;householding&#8221; will continue until you are notified otherwise or until you revoke your consent. If,
      at any time, you no longer wish to participate in &#8220;householding&#8221; and would prefer to receive a separate Notice Regarding the Availability of Proxy Materials, please notify your broker and direct your written request to Ionis Pharmaceuticals, Inc.,
      Attn: Corporate Secretary, 2855 Gazelle Court, Carlsbad, California 92010, or contact our Stock Plan Administrator at (760) 931-9200, and we will promptly provide you a separate Notice Regarding the Availability of Proxy Materials. Stockholders who
      currently receive multiple copies of the Proxy Statement or Notice Regarding the Availability of Proxy Materials at their address and would like to request &#8220;householding&#8221; of their communications should contact their broker.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Board of Directors knows of no
      other matters that will be presented for consideration at the Annual Meeting. If any other issues are properly brought before the meeting, we will ask our proxy holders to vote on the matters using their best judgment.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For further information about
      Ionis Pharmaceuticals, Inc., please request a free copy of our Annual Report on Form 10-K for the year ended December 31, 2022 that we filed with the SEC. Please send written requests to:</span></p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 300.25pt 0pt 0.25in; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Patrick R. O&#8217;Neil, Corporate
        Secretary </b>&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 300.25pt 0pt 0.25in; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Ionis Pharmaceuticals, Inc.</b>&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>2855 Gazelle Court</b>&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Carlsbad, CA 92010</b></span></p>
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; color: #231F20; margin-top: 0; margin-bottom: 0pt; width: 100%">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 50%"></td>

    <td style="width: 50%; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">By Order of the Board of Directors,</span></td>

  </tr>

  <tr style="vertical-align: top; text-align: justify">

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

  </tr>

  <tr style="vertical-align: top; text-align: justify">

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Patrick R. O&#8217;Neil</i></span></td>

  </tr>

  <tr style="vertical-align: top; text-align: justify">

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Corporate Secretary</span></td>

  </tr>


</table>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 281.5pt; text-align: left; text-indent: 0in; color: #231F20"></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 2.6in 0pt 281.5pt; text-align: left; text-indent: 0in; color: #231F20"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 2.6in 0pt 281.5pt; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">April 20, 2023&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left; text-indent: 0in; color: #231F20"></p>
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  <div style="margin-top: 3pt; margin-bottom: 3pt; text-align: left;">
    <div style="font-size: 1pt; border-top: 1pt solid Black; width: 20%; text-align: left;">&#160;</div>

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  <!-- Field: /Rule-Page -->
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">96</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Special Note Regarding Forward-Looking
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  <p style="font: bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">This Proxy Statement and the
      information incorporated herein by reference includes forward-looking statements regarding our business and the therapeutic and commercial potential of SPINRAZA (nusinersen), TEGSEDI (inotersen), WAYLIVRA (volanesorsen), eplontersen, olezarsen,
      donidalorsen, ION363, tofersen, pelacarsen, bepirovirsen and our technologies and products in development. Any statement describing our goals, expectations, financial or other projections, intentions or beliefs, is a forward-looking statement and
      should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties and particularly those inherent in the process of discovering, developing and commercializing medicines that are safe and effective for use as
      human therapeutics, and in the endeavor of building a business around such medicines. Our forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause our results to differ materially from those
      expressed or implied by such forward-looking statements. Although our forward-looking statements reflect the good faith judgment of our management, these statements are based only on facts and factors currently known by us. As a result, you are
      cautioned not to rely on these forward-looking statements. These and other risks concerning our programs are described in additional detail in our Annual Report on Form 10-K for the year ended December 31, 2022, which is on file with the SEC. Copies
      of the 10-K and other documents are available from the Company.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In this Proxy Statement, unless the
      context requires otherwise, &#8220;Ionis,&#8221; &#8220;Company,&#8221; &#8220;we,&#8221; &#8220;our,&#8221; and &#8220;us&#8221; refers to Ionis Pharmaceuticals, Inc. and its subsidiaries.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 10.1pt 0pt 0px; text-align: left; text-indent: 20.15pt; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; letter-spacing: -0.15pt;">&#8220;Ionis,&#8221; </span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">the Ionis logo, and other trademarks or service marks of Ionis Pharmaceuticals, Inc. appearing in this Proxy Statement are the property of Ionis Pharmaceuticals, Inc. <span style="letter-spacing: -0.15pt;">&#8220;Akcea,&#8221; </span>the Akcea logo, and other trademarks or service marks of Akcea Therapeutics, Inc. appearing in this Proxy Statement are the property of Akcea. This Proxy Statement contains additional trade names,
      trademarks, and service marks of others, which are the property of their respective owners. Solely for convenience, trademarks and trade names referred to in this Proxy Statement may appear without the &#174; or TM symbols.&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div class="BRPFPageNumberArea" style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">97</span></div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

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  <!--PROfilePageNumberReset%Num%1%A-%%-->
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in"></p>
  <p style="margin: 0"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b><span style="text-decoration: underline;">Appendix A</span></b></span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended and Restated Ionis Pharmaceuticals,
        Inc.</b></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>2011 Equity Incentive Plan</b></span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Adopted by the Board of Directors: March 23,
        2011</b></span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Approved by the Stockholders: June 16, 2011</b></span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Termination Date: June 15, 2031</b></span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended</b>: June 25, 2013 (</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amendment approved by Board on February 12, 2013&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">and by the Stockholders on June 25, 2013)</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended</b>: June 30, 2015 (</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amendment approved by Board on March 20, 2015</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">and by the Stockholders on June 30, 2015)</span></p>
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  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended</b>: May 24, 2017 (</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amendment approved by Board on March 3, 2017</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">and by the Stockholders on May 24, 2017)</span></p>
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  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended and Restated</b>: June 6, 2019 (</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amendment and Restatement approved by Board on March 22, 2019</span></p>
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  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">and by the Stockholders on June 6, 2019)</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended</b>: June 2, 2021 (</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amendment approved by Board on March 26, 2021</span></p>
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  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">and by the Stockholders on June 2, 2021)</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amendment approved by Board on March 14, 2023</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>SUBJECT TO APPROVAL BY STOCKHOLDERS</b></span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 41.8pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">1.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">General.</span></td>

  </tr>


</table>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Eligible Award Recipients.</b> The persons eligible to
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  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Available Awards.</b> The Plan provides for the grant of
      the following Awards: (i) Options, (ii) Stock Appreciation Rights (iii) Restricted Stock Awards, (iv) Restricted Stock Unit Awards, (v) Performance Stock Awards, and (vi) Performance Cash Awards.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Purpose.</b> The Company, by means of the Plan, seeks to
      secure and retain the services of the group of persons eligible to receive Awards as set forth in Section 1(a), to provide incentives for such persons to exert maximum efforts for the success of the Company and any Affiliate and to provide a means by
      which such eligible recipients may be given an opportunity to benefit from increases in value of the Common Stock through the granting of Awards.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 0in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">2.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">Administration.</span></td>

  </tr>


</table>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Administration by Board.</b> The Board shall administer
      the Plan unless and until the Board delegates administration of the Plan to a Committee or Committees, as provided in Section 2(c).</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Powers of Board.</b> The Board shall have the power,
      subject to, and within the limitations of, the express provisions of the Plan:</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;<b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">To determine from time to time (A) which of the persons eligible under the Plan shall be granted Awards; (B) when and how each Award shall be granted; (C) what type or combination of types of Awards shall be
      granted; (D) the provisions of each Award granted (which need not be identical), including the time or times when a person shall be permitted to receive cash or Common Stock pursuant to a Stock Award; (E) the number of shares of Common Stock with
      respect to which a Stock Award shall be granted to each such person; and (F) the Fair Market Value applicable to a Stock Award.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">To construe and interpret the Plan and Awards granted under it, and to establish, amend and revoke rules and regulations for its administration. The Board, in the exercise of this power, may correct any defect,
      omission or inconsistency in the Plan or in any Stock Award Agreement or in the written terms of a Performance Cash Award, in a manner and to the extent it shall deem necessary or expedient to make the Plan or Award fully effective.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">A-1</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
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  </div>

  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b>To settle all controversies regarding the Plan and
      Awards granted under it.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>Subject to the limitations set forth in Sections 5(f) and 8(j), to accelerate the time at which an Award may first be exercised or the time during which an Award or any part thereof will vest in accordance
      with the Plan, notwithstanding the provisions in the Award stating the time at which it may first be exercised or the time during which it will vest.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(v)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">To suspend or terminate the Plan at any time. Suspension or termination of the Plan shall not impair rights and obligations under any Award granted while the Plan is in effect except with the written consent of
      the affected Participant.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(vi)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">To amend the Plan in any respect the Board deems necessary or advisable. However, except as provided in Section 9(a) relating to Capitalization Adjustments, to the extent required by applicable law or listing
      requirements, stockholder approval shall be required for any amendment of the Plan that either (A) materially increases the number of shares of Common Stock available for issuance under the Plan, (B) materially expands the class of individuals
      eligible to receive Awards under the Plan, (C) materially increases the benefits accruing to Participants under the Plan or materially reduces the price at which shares of Common Stock may be issued or purchased under the Plan, (D) materially extends
      the term of the Plan, or (E)&#160;expands the types of Awards available for issuance under the Plan. Except as provided above, rights under any Award granted before amendment of the Plan shall not be impaired by any amendment of the Plan unless (1) the
      Company requests the consent of the affected Participant, and (2) such Participant consents in writing.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(vii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">To submit any amendment to the Plan for stockholder approval, including, but not limited to, amendments to the Plan intended to satisfy the requirements of Rule 16b-3.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(viii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b>To approve forms of Award Agreements for use under
      the Plan and to amend the terms of any one or more Awards, including, but not limited to, (subject to the limitations on repricing and non-acceleration as provided in Section 2(f), 5(f), and 8(j)) amendments to provide terms more favorable to the
      Participant than previously provided in the Award Agreement, subject to any specified limits in the Plan that are not subject to Board discretion; <i>provided however</i>, that a Participant&#8217;s rights under any Award shall not be impaired by any such
      amendment unless (A) the Company requests the consent of the affected Participant, and (B) such Participant consents in writing. Notwithstanding the foregoing, subject to the limitations of applicable law, if any, the Board may amend the terms of any
      one or more Awards without the affected Participant&#8217;s consent if necessary to bring the Award into compliance with Section 409A of the Code.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ix)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>Generally, to exercise such powers and to perform such acts as the Board deems necessary or expedient to promote the best interests of the Company and that are not in conflict with the provisions of the
      Plan or Awards.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(x)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>To adopt such procedures and sub-plans as are necessary or appropriate to permit participation in the Plan by Employees, Directors or Consultants who are foreign nationals or employed outside the United
      States.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Delegation to Committee.</b></span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; General.</b> The Board may delegate some or all of the
      administration of the Plan to a Committee or Committees. If administration of the Plan is delegated to a Committee, the Committee shall have, in connection with the administration of the Plan, the powers theretofore possessed by the Board that have
      been delegated to the Committee, including the power to delegate to a subcommittee of the Committee any of the administrative powers the Committee is authorized to exercise (and references in this Plan to the Board shall thereafter be to the
      Committee or subcommittee), subject, however, to such resolutions, not inconsistent with the provisions of the Plan, as may be adopted from time to time by the Board. The Committee may, at any time, abolish the subcommittee and/or revest in the
      Committee any powers delegated to the subcommittee. The Board may retain the authority to concurrently administer the Plan with the Committee and may, at any time, revest in the Board some or all of the powers previously delegated.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Rule 16b-3 Compliance.</b> The Committee may consist
      solely of two or more Non-Employee Directors, in accordance with Rule 16b-3 who are independent under applicable Nasdaq rules.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Delegation to an Executive Officer.</b> The Board may
      delegate to one or more Executive Officers of the Company the authority to do one or both of the following: (i) designate Employees who are not Executive Officers of the Company or any of its Subsidiaries to be recipients of Options and Stock
      Appreciation Rights (and, to the extent permitted by applicable law, other Stock Awards) and the terms thereof, and (ii) determine the number of shares of Common Stock to be subject to such Stock Awards granted to such Employees; <i>provided,
        however</i>, that the Board resolutions regarding such delegation shall specify the total number of shares of Common Stock that may be subject to the Stock Awards granted by such Executive Officer and that such Executive Officer may not grant a
      Stock Award to himself or herself or to other Executive Officers. Notwithstanding the foregoing, the Board may not delegate authority to an Executive Officer to determine the Fair Market Value pursuant to Section 13(v) below.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">A-2</span>&#160;</div>

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  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Effect of Board&#8217;s Decision.</b> All determinations,
      interpretations and constructions made by the Board in good faith shall not be subject to review by any person and shall be final, binding and conclusive on all persons.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Prohibition on Reduction of Exercise Prices,
        Cancellation and Re-Grant of Stock Awards</b>. Neither the Board nor any Committee (or subcommittee) shall have the authority to: (i) reduce the exercise price of any outstanding Options or Stock Appreciation Rights under the Plan, or (ii) cancel
      any outstanding Options or Stock Appreciation Rights that have an exercise price or strike price greater than the current Fair Market Value of the Common Stock in exchange for cash or other Stock Awards under the Plan, unless the stockholders of the
      Company have approved such an action within 12 months prior to such an event.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(g)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Dividends and Dividend Equivalents.</b> Dividends or
      dividend equivalents may be paid or credited, as applicable, with respect to any shares of Common Stock subject to a Stock Award (other than an Option or SAR), as determined by the Board and contained in the applicable Stock Award Agreement; <i>provided,





















        however</i>, that (i) no dividends or dividend equivalents may be paid with respect to any such shares before the date such shares have vested under the terms of such Stock Award Agreement, (ii) any dividends or dividend equivalents that are
      credited with respect to any such shares will be subject to all of the terms and conditions applicable to such shares under the terms of such Stock Award Agreement (including, but not limited to, any vesting conditions), and (iii) any dividends or
      dividend equivalents that are credited with respect to any such shares will be forfeited to the Company on the date, if any, such shares are forfeited to or repurchased by the Company due to a failure to meet any vesting conditions under the terms of
      such Stock Award Agreement.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">3.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">Shares Subject to the Plan.</span></td>

  </tr>


</table>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Share Reserve. </b>Subject to Section 9(a) relating to Capitalization Adjustments, the aggregate number of shares of Common Stock that may be issued pursuant to Stock Awards from and after the Effective Date
      shall not exceed 35,200,000 shares (the &#8220;<b><i>Share Reserve</i></b>&#8221;). For clarity, the Share Reserve in this Section 3(a) is a limitation on the number of shares of the Common Stock that may be issued pursuant to the Plan and does not limit the
      granting of Stock Awards except as provided in Section 7(a). Shares may be issued in connection with a merger or acquisition as permitted by, as applicable, NASDAQ Listing Rule 5635(c) or, if applicable, NYSE Listed Company Manual Section 303A.08,
      AMEX Company Guide Section 711 or other applicable rule, and such issuance shall not reduce the number of shares available for issuance under the Plan. Furthermore, if a Stock Award or any portion thereof (i) expires or otherwise terminates without
      all of the shares covered by such Stock Award having been issued or (ii) is settled in cash (<i>i.e.</i>, the Participant receives cash rather than stock), such expiration, termination or settlement shall not reduce (or otherwise offset) the number
      of shares of Common Stock that may be available for issuance under the Plan. Subject to Section&#160;3(b), the number of shares of Common Stock available for issuance under the Plan will be reduced by: (A)&#160;one share for each share of Common Stock issued
      pursuant to an Option or SAR with respect to which the exercise or strike price is at least 100% of the Fair Market Value of the Common Stock subject to the Option or SAR on the date of grant; and (B)&#160;one and seven tenths (1.7) shares for each share
      of Common Stock issued pursuant to a Full Value Award.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Reversion of Shares to the Share Reserve. </b>If (A)&#160;any shares of Common Stock subject to a Stock Award are not issued because such Stock Award or any portion thereof expires or otherwise terminates without
      all of the shares covered by such Stock Award having been issued or is settled in cash (<i>i.e.</i>, the Participant receives cash rather than stock), (B) any shares of Common Stock issued pursuant to a Stock Award are forfeited back to the Company
      because of the failure to meet a contingency or condition required to vest such shares in the Participant, or (C) with respect to a Full Value Award, any shares of Common Stock are reacquired or withheld (or not issued) by the Company to satisfy a
      tax withholding obligation in connection with such Full Value Award, such shares will again become available for issuance under the Plan (collectively, the &#8220;<b><i>2011 Plan Returning Shares</i></b>&#8221;). For clarity, any shares underlying an Option or a
      Stock Appreciation Right that are reacquired by the Company pursuant to Section 8(f) or as consideration for the exercise of an Option or a Stock Appreciation Right shall <i><span style="text-decoration: underline;">not</span></i> again become available for issuance under the Plan. For each
      2011 Plan Returning Share subject to a Full Value Award granted prior to June 2, 2021, the number of shares of Common Stock available for issuance under the Plan will increase by one share, and for each 2011 Plan Returning Share subject to a Full
      Value Award granted on or after June 2, 2021, the number of shares of Common Stock available for issuance under the Plan will increase by one and seven tenths (1.7) shares.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Source of Shares.</b> The stock issuable under the Plan shall be (i) shares of authorized but unissued Common Stock or (ii) shares of reacquired Common Stock, including shares repurchased by the Company on the
      open market or otherwise.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">4.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">Eligibility</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">.</span></td>

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  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Eligibility for Specific Stock Awards</b>. Stock Awards may be granted to Employees, Directors and Consultants; <i>provided, however</i>, Options and SARs may not be granted to Employees, Directors and
      Consultants who are providing Continuous Service only to any &#8220;parent&#8221; of the Company, as such term is defined in Rule&#160;405 promulgated under the Securities Act, unless the stock underlying such Stock Awards is treated as &#8220;service recipient stock&#8221;
      under Section&#160;409A of the Code because the Stock Awards are granted pursuant to a corporate transaction (such as a spin off transaction) or unless such Stock Awards comply with the distribution requirements of Section&#160;409A of the Code.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
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    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">5.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">Provisions Relating to Options and Stock Appreciation Rights.</span></td>

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</table>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Each Option or SAR shall be in such form and shall contain such terms and
      conditions as the Board shall deem appropriate. The provisions of separate Options or SARs need not be identical; <i>provided, however</i>, that each Option Agreement or Stock Appreciation Right Agreement shall conform to (through incorporation of
      provisions hereof by reference in the applicable Award Agreement or otherwise) the substance of each of the following provisions:</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Term.</b> No Option or SAR shall be exercisable after the
      expiration of ten years from the date of its grant or such shorter period specified in the Award Agreement.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Exercise Price.</b> The exercise price (or strike price)
      of each Option or SAR shall be not less than 100% of the Fair Market Value of the Common Stock subject to the Option or SAR on the date the Option or SAR is granted. Notwithstanding the foregoing, an Option or SAR may be granted with an exercise
      price (or strike price) lower than 100% of the Fair Market Value of the Common Stock subject to the Option or SAR if such Option or SAR is granted pursuant to an assumption of or substitution for another option or stock appreciation right pursuant to
      a Corporate Transaction and in a manner consistent with the provisions of Sections 409A and, if applicable, 424(a) of the Code. Each SAR will be denominated in shares of Common Stock equivalents.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Purchase Price for Options.</b> The purchase price of
      Common Stock acquired pursuant to the exercise of an Option shall be paid, to the extent permitted by applicable law and as determined by the Board in its sole discretion, by any combination of the methods of payment set forth below. The Board shall
      have the authority to grant Options that do not permit all of the following methods of payment (or otherwise restrict the ability to use certain methods) and to grant Options that require the consent of the Company to utilize a particular method of
      payment. The permitted methods of payment are as follows:</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">by cash, check, bank draft or money order payable to the Company;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">pursuant to a program developed under Regulation T as promulgated by the Federal Reserve Board that, prior to the issuance of the stock subject to the Option, results in either the receipt of cash (or check) by
      the Company or the receipt of irrevocable instructions to pay the aggregate exercise price to the Company from the sales proceeds;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>by delivery to the Company (either by actual delivery or attestation) of shares of Common Stock; or</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">by a &#8220;net exercise&#8221; arrangement pursuant to which the Company will reduce the number of shares of Common Stock issuable upon exercise by the largest whole number of shares with a Fair Market Value that does not
      exceed the aggregate exercise price; <i>provided, however</i>, that the Company shall accept a cash or other payment from the Participant to the extent of any remaining balance of the aggregate exercise price not satisfied by such reduction in the
      number of whole shares to be issued; <i>provided, further,</i> that shares of Common Stock will no longer be subject to an Option and will not be exercisable thereafter to the extent that (A) shares issuable upon exercise are reduced to pay the
      exercise price pursuant to the &#8220;net exercise,&#8221; (B) shares are delivered to the Participant as a result of such exercise, and (C) shares are withheld to satisfy tax withholding obligations.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#160;(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Exercise and Payment of a SAR.</b> To exercise any
      outstanding Stock Appreciation Right, the Participant must provide written notice of exercise to the Company in compliance with the provisions of the Stock Appreciation Right Agreement evidencing such Stock Appreciation Right. The appreciation
      distribution payable on the exercise of a Stock Appreciation Right will be not greater than an amount equal to the excess of (A) the aggregate Fair Market Value (on the date of the exercise of the Stock Appreciation Right) of a number of shares of
      Common Stock equal to the number of Common Stock equivalents in which the Participant is vested under such Stock Appreciation Right, and with respect to which the Participant is exercising the Stock Appreciation Right on such date, over (B) the
      strike price that will be determined by the Board at the time of grant of the Stock Appreciation Right. The appreciation distribution in respect to a Stock Appreciation Right may be paid in Common Stock, in cash, in any combination of the two or in
      any other form of consideration, as determined by the Board and contained in the Stock Appreciation Right Agreement evidencing such Stock Appreciation Right.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Transferability of Options and SARs.</b> The Board may, in
      its sole discretion, impose such limitations on the transferability of Options and SARs as the Board shall determine. In the absence of such a determination by the Board to the contrary, the following restrictions on the transferability of Options
      and SARs shall apply:</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Restrictions on Transfer.</b> An Option or SAR shall not
      be transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Participant only by the Participant; <i>provided, however</i>, that the Board may, in its sole discretion, permit transfer
      of the Option or SAR in a manner that is not prohibited by applicable tax and securities laws upon the Participant&#8217;s request. Except as explicitly provided herein, neither an Option nor a SAR may be transferred for consideration.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Domestic Relations Orders.</b> Notwithstanding the
      foregoing, an Option or SAR may be transferred pursuant to a domestic relations order.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Beneficiary Designation.</b> Notwithstanding the
      foregoing, the Participant may, by delivering written notice to the Company, in a form provided by or otherwise satisfactory to the Company and any broker designated by the Company to effect Option exercises, designate a third party who, in the event
      of the death of the Participant, shall thereafter be entitled to exercise the Option or SAR and receive the Common Stock or other consideration resulting from such exercise. In the absence of such a designation, the executor or administrator of the
      Participant&#8217;s estate shall be entitled to exercise the Option or SAR and receive the Common Stock or other consideration resulting from such exercise.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Vesting Generally.</b> Subject to Section 8(j), the total
      number of shares of Common Stock subject to an Option or SAR may vest and therefore become exercisable in periodic installments that may or may not be equal. The Option or SAR may be subject to such other terms and conditions on the time or times
      when it may or may not be exercised (which may be based on the satisfaction of Performance Goals or other criteria) as the Board may deem appropriate.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(g)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Termination of Continuous Service.</b> Except as otherwise
      provided in the applicable Award Agreement or other agreement between the Participant and the Company (validly executed by an authorized Executive Officer of the Company), if a Participant&#8217;s Continuous Service terminates (other than upon the
      Participant&#8217;s death or Disability), the Participant may exercise his or her Option or SAR (to the extent that the Participant was entitled to exercise such Award as of the date of termination of Continuous Service) but only within such period of time
      ending on the earlier of (i) the date three months following the termination of the Participant&#8217;s Continuous Service (or such longer or shorter period specified in the applicable Award Agreement), or (ii) the expiration of the term of the Option or
      SAR as set forth in the Award Agreement. If, after termination of Continuous Service, the Participant does not exercise his or her Option or SAR within the time specified herein or in the Award Agreement (as applicable), the Option or SAR shall
      terminate.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(h)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Extension of Termination Date. </b>If the exercise of an
      Option or SAR following the termination of the Participant&#8217;s Continuous Service (other than upon the Participant&#8217;s death or Disability) would be prohibited at any time solely because the issuance of shares of Common Stock would violate the
      registration requirements under the Securities Act, then the Option or SAR shall terminate on the earlier of (i) the expiration of a total period of three months (that need not be consecutive) after the termination of the Participant&#8217;s Continuous
      Service during which the exercise of the Option or SAR would not be in violation of such registration requirements, or (ii) the expiration of the term of the Option or SAR as set forth in the applicable Award Agreement. In addition, unless otherwise
      provided in a Participant&#8217;s Award Agreement, if the immediate sale of any Common Stock received upon exercise of an Option or SAR following the termination of the Participant&#8217;s Continuous Service would violate the Company&#8217;s insider trading policy,
      then the Option or SAR shall terminate on the earlier of (i) the expiration of a period equal to the applicable post-termination exercise period after the termination of the Participant&#8217;s Continuous Service during which the sale of Common Stock
      received upon exercise of the Option or SAR would not be in violation of the Company&#8217;s insider trading policy, or (ii) the expiration of the term of the Option or SAR as set forth in the applicable Award Agreement.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Disability of Participant.</b> Except as otherwise
      provided in the applicable Award Agreement or other agreement between the Participant and the Company (validly executed by an authorized Executive Officer of the Company), if a Participant&#8217;s Continuous Service terminates as a result of the
      Participant&#8217;s Disability, the Participant may exercise his or her Option or SAR (to the extent that the Participant was entitled to exercise such Option or SAR as of the date of termination of Continuous Service), but only within such period of time
      ending on the earlier of (i) the date 12 months following such termination of Continuous Service (or such longer or shorter period specified in the Award Agreement), or (ii) the expiration of the term of the Option or SAR as set forth in the Award
      Agreement. If, after termination of Continuous Service, the Participant does not exercise his or her Option or SAR within the time specified herein or in the Award Agreement (as applicable), the Option or SAR (as applicable) shall terminate.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(j)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Death of Participant.</b> Except as otherwise provided in
      the applicable Award Agreement or other agreement between the Participant and the Company (validly executed by an authorized Executive Officer of the Company), if (i) a Participant&#8217;s Continuous Service terminates as a result of the Participant&#8217;s
      death, or (ii) the Participant dies within the period (if any) specified in the Award Agreement for exercisability after the termination of the Participant&#8217;s Continuous Service (for a reason other than death), then the Option or SAR may be exercised
      (to the extent the Participant was entitled to exercise such Option or SAR as of the date of death) by the Participant&#8217;s estate, by a person who acquired the right to exercise the Option or SAR by bequest or inheritance or by a person designated to
      exercise the Option or SAR upon the Participant&#8217;s death, but only within the period ending on the earlier of (i) the date 18 months following the date of death (or such longer or shorter period specified in the Award Agreement), or (ii) the
      expiration of the term of such Option or SAR as set forth in the Award Agreement. If, after the Participant&#8217;s death, the Option or SAR is not exercised within the time specified herein or in the Award Agreement (as applicable), the Option or SAR
      shall terminate.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(k)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Non-Exempt Employees</b>. Without limiting the provisions
      set forth in Section 5(f), no Option or SAR, whether or not vested, granted to an Employee who is a non-exempt employee for purposes of the Fair Labor Standards Act of 1938, as amended, shall be first exercisable for any shares of Common Stock until
      at least six months following the date of grant of the Option or SAR. Notwithstanding the foregoing, consistent with the provisions of the Worker Economic Opportunity Act, (i) in the event of the Participant&#8217;s death or Disability, (ii) upon a
      Corporate Transaction in which such Option or SAR is not assumed, continued, or substituted, (iii) upon a Change in Control, or (iv) upon the Participant&#8217;s retirement (as such term may be defined in the Participant&#8217;s Award Agreement or in another
      applicable agreement or in accordance with the Company&#8217;s then current employment policies and guidelines), any such vested Options and SARs may be exercised earlier than six months following the date of grant. The foregoing provision is intended to
      operate so that any income derived by a non-exempt employee in connection with the exercise or vesting of an Option or SAR will be exempt from his or her regular rate of pay.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
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  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">6.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Provisions of Stock Awards other than Options and SARs.</span></p>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Restricted Stock Awards.</b> Each Restricted Stock Award
      Agreement shall be in such form and shall contain such terms and conditions as the Board shall deem appropriate. To the extent consistent with the Company&#8217;s Bylaws, at the Board&#8217;s election, shares of Common Stock may be (i) held in book entry form
      subject to the Company&#8217;s instructions until any restrictions relating to the Restricted Stock Award lapse; or (ii)&#160;evidenced by a certificate, which certificate shall be held in such form and manner as determined by the Board. The terms and
      conditions of Restricted Stock Award Agreements may change from time to time, and the terms and conditions of separate Restricted Stock Award Agreements need not be identical; <i>provided, however</i>, that each Restricted Stock Award Agreement
      shall conform to (through incorporation of the provisions hereof by reference in the agreement or otherwise) the substance of each of the following provisions:</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#160;(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Consideration.</b> A Restricted Stock Award may be awarded in consideration for (A) cash, check, bank draft or money order payable to the Company, (B) past services to the Company or an Affiliate, or (C) any
      other form of legal consideration (including future services) that may be acceptable to the Board, in its sole discretion, and permissible under applicable law.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;<b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Vesting. </b>Shares of Common Stock awarded under the Restricted Stock Award Agreement may be subject to forfeiture to the Company in accordance with a vesting schedule to be determined by the Board.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;<b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Termination of Participant&#8217;s Continuous Service.</b> If a Participant&#8217;s Continuous Service terminates, the Company may receive through a forfeiture condition or a repurchase right any or all of the shares of
      Common Stock held by the Participant that have not vested as of the date of termination of Continuous Service under the terms of the Restricted Stock Award Agreement.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#160;(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Transferability.</b> Rights to acquire shares of Common Stock under the Restricted Stock Award Agreement shall be transferable by the Participant only upon such terms and conditions as are set forth in the
      Restricted Stock Award Agreement, as the Board shall determine in its sole discretion, so long as Common Stock awarded under the Restricted Stock Award Agreement remains subject to the terms of the Restricted Stock Award Agreement.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Restricted Stock Unit Awards. </b>Each Restricted Stock
      Unit Award Agreement shall be in such form and shall contain such terms and conditions as the Board shall deem appropriate. The terms and conditions of Restricted Stock Unit Award Agreements may change from time to time, and the terms and conditions
      of separate Restricted Stock Unit Award Agreements need not be identical; <i>provided, however</i>, that each Restricted Stock Unit Award Agreement shall conform to (through incorporation of the provisions hereof by reference in the Agreement or
      otherwise) the substance of each of the following provisions:</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Consideration.</b> At the time of grant of a Restricted Stock Unit Award, the Board will determine the consideration, if any, to be paid by the Participant upon delivery of each share of Common Stock subject to
      the Restricted Stock Unit Award. The consideration to be paid (if any) by the Participant for each share of Common Stock subject to a Restricted Stock Unit Award may be paid in any form of legal consideration that may be acceptable to the Board, in
      its sole discretion, and permissible under applicable law.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Vesting. </b>Subject to the limitations set forth in Section 8(j), at the time of the grant of a Restricted Stock Unit Award, the Board may impose such restrictions on or conditions to the vesting of the
      Restricted Stock Unit Award as it, in its sole discretion, deems appropriate.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Payment</b>. A Restricted Stock Unit Award may be settled by the delivery of shares of Common Stock, their cash equivalent, any combination thereof or in any other form of consideration, as determined by the
      Board and contained in the Restricted Stock Unit Award Agreement.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Additional Restrictions. </b>At the time of the grant of a Restricted Stock Unit Award, the Board, as it deems appropriate, may impose such restrictions or conditions that delay the delivery of the shares of
      Common Stock (or their cash equivalent) subject to a Restricted Stock Unit Award to a time after the vesting of such Restricted Stock Unit Award.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(v)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br />
      </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Termination of Participant&#8217;s Continuous Service. </b>Except as otherwise provided in the applicable Restricted Stock Unit Award Agreement, such portion of the Restricted Stock Unit Award that has not vested
      will be forfeited upon the Participant&#8217;s termination of Continuous Service.</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in"></p>
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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">A-6</span>&#160;</div>

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  </div>

  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;</p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Performance Awards</b>.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Performance Stock Awards</b>. A Performance Stock Award is a Stock Award that may vest or may be exercised contingent upon the attainment during a Performance Period of certain Performance Goals. A Performance
      Stock Award may, but need not, require the completion of a specified period of Continuous Service. The length of any Performance Period, the Performance Goals to be achieved during the Performance Period, and the measure of whether and to what degree
      such Performance Goals have been attained shall be conclusively determined by the Committee, in its sole discretion. The Board may provide for or, subject to such terms and conditions as the Board may specify, may permit a Participant to elect for,
      the payment of any Performance Stock Award to be deferred to a specified date or event. In addition, to the extent permitted by applicable law and the applicable Award Agreement, the Board may determine that cash may be used in payment of Performance
      Stock Awards.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Performance Cash Awards</b>. A Performance Cash Award is a cash award that may be paid contingent upon the attainment during a Performance Period of certain Performance Goals. A Performance Cash Award may also
      require the completion of a specified period of Continuous Service. At the time of grant of a Performance Cash Award, the length of any Performance Period, the Performance Goals to be achieved during the Performance Period, and the measure of whether
      and to what degree such Performance Goals have been attained shall be conclusively determined by the Committee, in its sole discretion. The Board may provide for or, subject to such terms and conditions as the Board may specify, may permit a
      Participant to elect for, the payment of any Performance Cash Award to be deferred to a specified date or event. The Committee may specify the form of payment of Performance Cash Awards, which may be cash or other property, or may provide for a
      Participant to have the option for his or her Performance Cash Award, or such portion thereof as the Board may specify, to be paid in whole or in part in cash or other property.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Board Discretion</b>. The Board retains the discretion to reduce or eliminate the compensation or economic benefit due upon attainment of Performance Goals and to define the manner of calculating the
      Performance Criteria it selects to use for a Performance Period.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: bold 11pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">7.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">Covenants of the Company.</span></td>

  </tr>


</table>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Availability of Shares.</b> During the terms of the Stock Awards, the Company shall keep available at all times the number of shares of Common Stock reasonably required to satisfy such Stock Awards.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Securities Law Compliance.</b> The Company shall seek to obtain from each regulatory commission or agency having jurisdiction over the Plan such authority as may be required to grant Stock Awards and to issue
      and sell shares of Common Stock upon exercise of the Stock Awards; <i>provided, however</i>, that this undertaking shall not require the Company to register under the Securities Act the Plan, any Stock Award or any Common Stock issued or issuable
      pursuant to any such Stock Award. If, after reasonable efforts, the Company is unable to obtain from any such regulatory commission or agency the authority that counsel for the Company deems necessary for the lawful issuance and sale of Common Stock
      under the Plan, the Company shall be relieved from any liability for failure to issue and sell Common Stock upon exercise of such Stock Awards unless and until such authority is obtained. A Participant shall not be eligible for the grant of a Stock
      Award or the subsequent issuance of Common Stock pursuant to the Stock Award if such grant or issuance would violate any applicable securities law.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>No Obligation to Notify or Minimize Taxes. </b>The Company shall have no duty or obligation to any Participant to advise such holder (or the estate of, or transferee of, such holder) as to the time or manner
      of exercising such Stock Award. Furthermore, the Company shall have no duty or obligation to warn or otherwise advise such holder (or the estate of, or transferee of, such holder) of a pending termination or expiration of a Stock Award or a possible
      period in which the Stock Award may not be exercised. The Company has no duty or obligation to minimize the tax consequences of a Stock Award to the holder of such Stock Award.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: bold 11pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">8.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">Miscellaneous.</span></td>

  </tr>


</table>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Use of Proceeds from Sales of Common Stock. </b>Proceeds from the sale of shares of Common Stock pursuant to Stock Awards shall constitute general funds of the Company.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Corporate Action Constituting Grant of Stock Awards.</b> Corporate action constituting a grant by the Company of a Stock Award to any Participant shall be deemed completed as of the date of such corporate
      action, unless otherwise determined by the Board, regardless of when the instrument, certificate, or letter evidencing the Stock Award is communicated to, or actually received or accepted by, the Participant.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Stockholder Rights.</b> No Participant shall be deemed to be the holder of, or to have any of the rights of a holder with respect to, any shares of Common Stock subject to such Stock Award unless and until (i)
      such Participant has satisfied all requirements for exercise of the Stock Award pursuant to its terms, if applicable, and (ii) the issuance of the Common Stock subject to such Stock Award has been entered into the books and records of the Company.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">A-7</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>No Employment or Other Service Rights.</b> Nothing in the Plan, any Stock Award Agreement or any other instrument executed thereunder or in connection with any Award granted pursuant thereto shall confer upon
      any Participant any right to continue to serve the Company or an Affiliate in the capacity in effect at the time the Stock Award was granted or shall affect the right of the Company or an Affiliate to terminate (i) the employment of an Employee with
      or without notice and with or without cause, (ii) the service of a Consultant pursuant to the terms of such Consultant&#8217;s agreement with the Company or an Affiliate, or (iii) the service of a Director pursuant to the Bylaws of the Company or an
      Affiliate, and any applicable provisions of the corporate law of the state in which the Company or the Affiliate is incorporated, as the case may be.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Investment Assurances.</b> The Company may require a Participant, as a condition of exercising or acquiring Common Stock under any Stock Award, (i) to give written assurances satisfactory to the Company as to
      the Participant&#8217;s knowledge and experience in financial and business matters and/or to employ a purchaser representative reasonably satisfactory to the Company who is knowledgeable and experienced in financial and business matters and that he or she
      is capable of evaluating, alone or together with the purchaser representative, the merits and risks of exercising the Stock Award; and (ii) to give written assurances satisfactory to the Company stating that the Participant is acquiring Common Stock
      subject to the Stock Award for the Participant&#8217;s own account and not with any present intention of selling or otherwise distributing the Common Stock. The foregoing requirements, and any assurances given pursuant to such requirements, shall be
      inoperative if (A) the issuance of the shares upon the exercise or acquisition of Common Stock under the Stock Award has been registered under a then currently effective registration statement under the Securities Act, or (B) as to any particular
      requirement, counsel for the Company determines that such requirement need not be met in the circumstances under the then applicable securities laws. The Company may, upon advice of counsel to the Company, place legends on stock certificates issued
      under the Plan as such counsel deems necessary or appropriate in order to comply with applicable securities laws or the Company&#8217;s insider trading policy, including, but not limited to, legends restricting the transfer of the Common Stock.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Withholding Obligations.</b> Unless prohibited by the terms of an Award Agreement, the Company may, in its sole discretion, satisfy any federal, state or local tax withholding obligation relating to an Award by
      any of the following means or by a combination of such means: (i) causing the Participant to tender a cash payment; (ii)&#160;withholding shares of Common Stock from the shares of Common Stock issued or otherwise issuable to the Participant in connection
      with the Award; <i>provided, however, </i>that no shares of Common Stock are withheld with a value exceeding the minimum amount of tax required to be withheld by law (or such lesser amount as may be necessary to avoid classification of the Stock
      Award as a liability for financial accounting purposes); (iii) withholding cash from an Award settled in cash; (iv)&#160;withholding payment from any amounts otherwise payable to the Participant; or (v)&#160;by such other method as may be set forth in the
      Award Agreement.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(g)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Electronic Delivery</b>. Any reference herein to a &#8220;written&#8221; agreement or document shall include any agreement or document delivered electronically or posted on the Company&#8217;s intranet (or other shared
      electronic medium controlled by the Company to which the Participant has access).</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(h)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Deferrals.</b> To the extent permitted by applicable law, the Board, in its sole discretion, may determine that the delivery of Common Stock or the payment of cash, upon the exercise, vesting or settlement of
      all or a portion of any Award may be deferred and may establish programs and procedures for deferral elections to be made by Participants. Deferrals by Participants will be made in accordance with Section 409A of the Code. Consistent with Section
      409A of the Code, the Board may provide for distributions while a Participant is still an employee or otherwise providing services to the Company. The Board is authorized to make deferrals of Awards and determine when, and in what annual percentages,
      Participants may receive payments, including lump sum payments, following the Participant&#8217;s termination of Continuous Service, and implement such other terms and conditions consistent with the provisions of the Plan and in accordance with applicable
      law.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Compliance with Section 409A. </b>To the extent that the Board determines that any Award granted hereunder is subject to Section 409A of the Code, the Award Agreement evidencing such Award shall incorporate
      the terms and conditions necessary to avoid the consequences specified in Section 409A(a)(1) of the Code. To the extent applicable, the Plan and Award Agreements shall be interpreted in accordance with Section 409A of the Code. Notwithstanding
      anything to the contrary in this Plan (and unless the Award Agreement specifically provides otherwise), if the shares of Common Stock are publicly traded and a Participant holding an Award that constitutes &#8220;deferred compensation&#8221; under Section 409A
      of the Code is a &#8220;specified employee&#8221; for purposes of Section 409A of the Code, no distribution or payment of any amount shall be made upon a &#8220;separation from service&#8221; before a date that is six months following the date of such Participant&#8217;s
      &#8220;separation from service&#8221; (as defined in Section 409A of the Code without regard to alternative definitions thereunder) or, if earlier, the date of the Participant&#8217;s death.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(j)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Minimum Vesting. </b>Except as provided in Section 9, no Stock Award will vest until at least twelve (12) months following the date of grant of such Stock Award (excluding, for this purpose, any (A) Stock
      Award granted in assumption, substitution or exchange for previously granted awards of a company acquired by the Company or an Affiliate, and (B) Stock Awards to Non-Employee Directors that vest on the earlier of the one year anniversary of the date
      of grant or the next annual meeting of shareholders (provided that such vesting period may not be less than 50 weeks after grant); <i>provided, however</i>, that up to five percent (5%) of the Share Reserve (as defined in Section 3(a)) may be
      subject to Stock Awards that do not meet such vesting requirements; and <i>provided further</i> that for the avoidance of doubt, that the foregoing restriction does not apply to accelerated exercisability or vesting in accordance with Section 9(c)
      or 9(d) herein.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">A-8</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(k)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br />
      </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Compliance with Insider-Trading Policy</b>. The Company may limit or restrict a Participant&#8217;s ability to exercise options or sell stock pursuant to the Company&#8217;s then-applicable insider-trading policy (or
      similar policy adopted by the Company).</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: bold 11pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">9.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">Adjustments upon Changes in Common Stock; Other Corporate Events.</span></td>

  </tr>


</table>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br />
      </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Capitalization Adjustments</b>. In the event of a Capitalization Adjustment, the Board shall appropriately and proportionately adjust: (i) the class(es) and maximum number of securities subject to the Plan
      pursuant to Section 3(a) and (ii) the class(es) and number of securities and price per share of stock subject to outstanding Stock Awards. The Board shall make such adjustments, and its determination shall be final, binding and conclusive.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Dissolution or Liquidation</b>. Except as otherwise provided in the Stock Award Agreement, in the event of a dissolution or liquidation of the Company, all outstanding Stock Awards (other than Stock Awards
      consisting of vested and outstanding shares of Common Stock not subject to a forfeiture condition or the Company&#8217;s right of repurchase) shall terminate immediately prior to the completion of such dissolution or liquidation, and the shares of Common
      Stock subject to the Company&#8217;s repurchase rights or subject to a forfeiture condition may be repurchased or reacquired by the Company notwithstanding the fact that the holder of such Stock Award is providing Continuous Service, <i>provided, however</i>,
      that the Board may, in its sole discretion, cause some or all Stock Awards to become fully vested, exercisable and/or no longer subject to repurchase or forfeiture (to the extent such Stock Awards have not previously expired or terminated) before the
      dissolution or liquidation is completed but contingent on its completion.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Corporate Transaction.</b> The provisions of this Section 9(c) will apply to Stock Awards in the event of a Corporate Transaction unless otherwise provided in the instrument evidencing the Stock Award or any
      other written agreement between the Company or any Affiliate and the Participant or in any director compensation policy of the Company or unless otherwise expressly provided by the Board at the time of grant of a Stock Award.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#160;(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Stock Awards May Be Assumed</b>. In the event of a Corporate Transaction, any surviving corporation or acquiring corporation (or the surviving or acquiring corporation&#8217;s parent company) may assume or continue
      any or all Stock Awards outstanding under the Plan or may substitute similar stock awards for Stock Awards outstanding under the Plan (including but not limited to, awards to acquire the same consideration paid to the stockholders of the Company
      pursuant to the Corporate Transaction), and any reacquisition or repurchase rights held by the Company in respect of Common Stock issued pursuant to Stock Awards may be assigned by the Company to the successor of the Company (or the successor&#8217;s
      parent company, if any), in connection with such Corporate Transaction. A surviving corporation or acquiring corporation (or its parent) may choose to assume or continue only a portion of a Stock Award or substitute a similar stock award for only a
      portion of a Stock Award, or may choose to assume or continue the Stock Awards held by some, but not all Participants. The terms of any assumption, continuation or substitution will be set by the Board.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Stock Awards Held by Current Participants</b>. In the event of a Corporate Transaction in which the surviving corporation or acquiring corporation (or its parent company) does not assume or continue such
      outstanding Stock Awards or substitute similar stock awards for such outstanding Stock Awards, then with respect to Stock Awards that have not been assumed, continued or substituted and that are held by Participants whose Continuous Service has not
      terminated prior to the effective time of the Corporate Transaction (referred to as the &#8220;Current Participants&#8221;), the vesting of any time-based Stock Awards (and, with respect to Options and Stock Appreciation Rights, the time when such Stock Awards
      may be exercised) will be accelerated in full (and the vesting of any performance-based Stock Awards shall be deemed satisfied at the greater of actual performance or target level) to a date prior to the effective time of such Corporate Transaction
      (contingent upon the effectiveness of the Corporate Transaction) as the Board will determine (or, if the Board does not determine such a date, to the date that is five days prior to the effective time of the Corporate Transaction), and such Stock
      Awards will terminate if not exercised (if applicable) at or prior to the effective time of the Corporate Transaction, and any reacquisition or repurchase rights held by the Company with respect to such Stock Awards will lapse (contingent upon the
      effectiveness of the Corporate Transaction).</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Stock Awards Held by Persons other than Current Participants</b>. In the event of a Corporate Transaction in which the surviving corporation or acquiring corporation (or its parent company) does not assume or
      continue such outstanding Stock Awards or substitute similar stock awards for such outstanding Stock Awards, then with respect to Stock Awards that have not been assumed, continued or substituted and that are held by persons other than Current
      Participants, such Stock Awards will terminate if not exercised (if applicable) prior to the effective time of the Corporate Transaction; provided, however, that any reacquisition or repurchase rights held by the Company with respect to such Stock
      Awards will not terminate and may continue to be exercised notwithstanding the Corporate Transaction.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Payment for Stock Awards in Lieu of Exercise</b>. Notwithstanding the foregoing, in the event a Stock Award will terminate if not exercised prior to the effective time of a Corporate Transaction, the Board may
      provide, in its sole discretion, that the holder of such Stock Award may not exercise such Stock Award but instead will receive a payment, in such form as may be determined by the Board, equal in value to the excess, if any, of (A) the value of the
      property the Participant would have received upon the exercise of the Stock Award immediately prior to the effective time of the Corporate Transaction after application of the vesting acceleration described in (iii) above), over (B) any exercise
      price payable by such holder in connection with such exercise. For clarity, this payment may be zero if the value of the property is equal to or less than the exercise price. Payments under this provision may be delayed to the same extent that
      payment of consideration to the holders of the Company&#8217;s Common Stock in connection with the Corporate Transaction is delayed as a result of escrows, earn outs, holdbacks or any other contingencies.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">A-9</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Change in Control.</b> A Stock Award will not be subject to additional acceleration of vesting and exercisability in connection with a Change in Control, except upon certain termination events that are in
      connection with a Change in Control as provided in the Stock Award Agreement for such Stock Award or as otherwise may be provided in any other written agreement between the Company or any Affiliate and the Participant. In such a case, the Stock Award
      Agreement or other written agreement may provide that vesting (and, if applicable, exercisability) of time-based awards will be accelerated in full and performance-based Stock Awards will be deemed to have been satisfied at the greater of actual
      performance or target level.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: bold 11pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">10.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">Termination or Suspension of the Plan.</span></td>

  </tr>


</table>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Plan Term.</b> The Board may suspend or terminate the Plan at any time. Unless terminated sooner by the Board, the Plan shall automatically terminate on June 15, 2031. No Awards may be granted under the Plan
      while the Plan is suspended or after it is terminated.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>No Impairment of Rights.</b> Suspension or termination of the Plan shall not impair rights and obligations under any Award granted while the Plan is in effect except with the written consent of the affected
      Participant.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: bold 11pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">11.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">Effective Date of Plan.</span></td>

  </tr>


</table>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="margin: 0pt 0px; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">This Plan shall become effective on the date of the annual meeting of stockholders of the Company held in 2011 provided this Plan is approved by the Company&#8217;s stockholders at such meeting (the <i>&#8220;Effective Date&#8221;</i>).</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 41.8pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: bold 11pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%">


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    <td style="width: 0in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">12.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">Choice of Law.</span></td>

  </tr>


</table>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The laws of the State of California shall govern all questions concerning the construction,
      validity and interpretation of this Plan, without regard to that state&#8217;s conflict of laws rules.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: bold 11pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%">


  <tr style="vertical-align: top; text-align: justify">

    <td style="width: 0in"></td>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">13.</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;">Definitions. As used in the Plan, the following definitions shall apply to the capitalized terms indicated below:</span></td>

  </tr>


</table>
  <p style="font: small-caps bold 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Affiliate</i></b>&#8221; means, at the time of determination, any &#8220;parent&#8221; or &#8220;subsidiary&#8221; of the Company as such terms are defined in Rule 405 promulgated under the Securities Act. The Board shall have the
      authority to determine the time or times at which &#8220;parent&#8221; or &#8220;subsidiary&#8221; status is determined within the foregoing definition, and such determination shall be final, binding and conclusive on all persons.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Award</i></b>&#8221; means a Stock Award or a Performance Cash Award.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Award Agreement</i></b>&#8221; means a written agreement between the Company and a Participant evidencing the terms and conditions of an Award.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Board</i></b>&#8221; means the Board of Directors of the Company.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Capitalization Adjustment</i></b>&#8221; means any change that is made in, or other events that occur with respect to, the Common Stock subject to the Plan or subject to any Stock Award after the Effective Date
      without the receipt of consideration by the Company through merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend in property other than cash, large nonrecurring cash dividend, stock split, liquidating
      dividend, combination of shares, exchange of shares, change in corporate structure or any similar equity restructuring transaction, as that term is used in Statement of Financial Accounting Standards No. 123 (revised). Notwithstanding the foregoing,
      the conversion of any convertible securities of the Company shall not be treated as a Capitalization Adjustment.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b> </span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Change in Control</i></b>&#8221; means the consummation, in a single transaction or in a series of related transactions, of any one or more of the following events:</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">A-10</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">any Exchange Act Person becomes the Owner, directly or indirectly, of securities of the Company representing more than 50% of the combined voting power of the Company&#8217;s then outstanding securities other than by
      virtue of a merger, consolidation or similar transaction. Notwithstanding the foregoing, a Change in Control shall not be deemed to occur (A) on account of the acquisition of securities of the Company directly from the Company, (B)&#160;on account of the
      acquisition of securities of the Company by an investor, any affiliate thereof or any other Exchange Act Person that acquires the Company&#8217;s securities in a transaction or series of related transactions the primary purpose of which is to obtain
      financing for the Company through the issuance of equity securities, or (C) solely because the level of Ownership held by any Exchange Act Person (the &#8220;<b><i>Subject Person</i></b>&#8221;) exceeds the designated percentage threshold of the outstanding
      voting securities as a result of a repurchase or other acquisition of voting securities by the Company reducing the number of shares outstanding, provided that if a Change in Control would occur (but for the operation of this sentence) as a result of
      the acquisition of voting securities by the Company, and after such share acquisition, the Subject Person becomes the Owner of any additional voting securities that, assuming the repurchase or other acquisition had not occurred, increases the
      percentage of the then outstanding voting securities Owned by the Subject Person over the designated percentage threshold, then a Change in Control shall be deemed to occur;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>there is consummated a merger, consolidation or similar transaction involving (directly or indirectly) the Company and, immediately after the consummation of such merger, consolidation or similar
      transaction, the stockholders of the Company immediately prior thereto do not Own, directly or indirectly, either (A) outstanding voting securities representing more than 50% of the combined outstanding voting power of the surviving Entity in such
      merger, consolidation or similar transaction or (B) more than 50% of the combined outstanding voting power of the parent of the surviving Entity in such merger, consolidation or similar transaction, in each case in substantially the same proportions
      as their Ownership of the outstanding voting securities of the Company immediately prior to such transaction;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">the stockholders of the Company approve or the Board approves a plan of complete dissolution or liquidation of the Company, or a complete dissolution or liquidation of the Company shall otherwise occur, except for
      a liquidation into a parent corporation;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>there is consummated a sale, lease, exclusive license or other disposition of all or substantially all of the consolidated assets of the Company and its Subsidiaries, other than a sale, lease, license or
      other disposition of all or substantially all of the consolidated assets of the Company and its Subsidiaries to an Entity, more than 50% of the combined voting power of the voting securities of which are Owned by stockholders of the Company in
      substantially the same proportions as their Ownership of the outstanding voting securities of the Company immediately prior to such sale, lease, license or other disposition; or</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(v)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">individuals who, on the date the Plan is adopted by the Board, are members of the Board (the &#8220;<b><i>Incumbent Board</i></b>&#8221;) cease for any reason to constitute at least a majority of the members of the Board; <i>provided,










        however</i>, that if the appointment or election (or nomination for election) of any new Board member was approved or recommended by a majority vote of the members of the Incumbent Board then still in office, such new member shall, for purposes of
      this Plan, be considered as a member of the Incumbent Board.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="margin: 0pt 0px; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 36pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Notwithstanding the foregoing or any other provision of this Plan, (A) the term Change in Control shall not include a sale of assets, merger or other transaction effected exclusively for the purpose of changing
      the domicile of the Company, and (B) the definition of Change in Control (or any analogous term) in an individual written agreement between the Company or any Affiliate and the Participant (validly executed by an authorized Executive Officer of the
      Company or such Affiliate) shall supersede the foregoing definition with respect to Awards subject to such agreement; <i>provided, however</i>, that if no definition of Change in Control or any analogous term is set forth in such an individual
      written agreement, the foregoing definition shall apply.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 41.8pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(g)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Code</i></b>&#8221; means the Internal Revenue Code of 1986, as amended, including any applicable regulations and guidance thereunder.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(h)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Committee</i></b>&#8221; means a committee of one or more Directors to whom authority has been delegated by the Board in accordance with Section 2(c).</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Common Stock</i></b>&#8221; means the common stock of the Company.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(j)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Company</i></b>&#8221; means Ionis Pharmaceuticals, Inc., a Delaware corporation.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(k)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b> </span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Consultant</i></b>&#8221; means any person, including an advisor, who is (i) engaged by the Company or an Affiliate to render consulting or advisory services and is compensated for such services, or (ii) serving
      as a member of the board of directors of an Affiliate and is compensated for such services. However, service solely as a Director, or payment of a fee for such service, shall not cause a Director to be considered a &#8220;Consultant&#8221; for purposes of the
      Plan. Notwithstanding the foregoing, a person is treated as a Consultant under this Plan only if a Form S-8 Registration Statement under the Securities Act is available to register either the offer or the sale of the Company&#8217;s securities to such
      person.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">A-11</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(l)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Continuous Service</i></b>&#8221; means that the Participant&#8217;s service with the Company or an Affiliate, whether as an Employee, Director or Consultant, is not interrupted or terminated. A change in the capacity
      in which the Participant renders service to the Company or an Affiliate as an Employee, Consultant or Director or a change in the entity for which the Participant renders such service, provided that there is no interruption or termination of the
      Participant&#8217;s service with the Company or an Affiliate, shall not terminate a Participant&#8217;s Continuous Service; <i>provided, however, </i>if the Entity for which a Participant is rendering services ceases to qualify as an Affiliate, as determined
      by the Board, in its sole discretion, such Participant&#8217;s Continuous Service shall be considered to have terminated on the date such Entity ceases to qualify as an Affiliate. To the extent permitted by law, the Board or the chief executive officer of
      the Company, in that party&#8217;s sole discretion, may determine whether Continuous Service shall be considered interrupted in the case of (i) any leave of absence approved by the Board or Chief Executive Officer, including sick leave, military leave or
      any other personal leave, or (ii)&#160;transfers between the Company, an Affiliate, or their successors. Notwithstanding the foregoing, a leave of absence shall be treated as Continuous Service for purposes of vesting in a Stock Award only to such extent
      as may be provided in the Company&#8217;s leave of absence policy, in the written terms of any leave of absence agreement or policy applicable to the Participant, or as otherwise required by law.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(m)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Corporate Transaction</i></b>&#8221; means the consummation, in a single transaction or in a series of related transactions, of any one or more of the following events:</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">a sale or other disposition of all or substantially all, as determined by the Board, in its sole discretion, of the consolidated assets of the Company and its Subsidiaries;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">a sale or other disposition of at least 90% of the outstanding securities of the Company;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">a merger, consolidation or similar transaction following which the Company is not the surviving corporation; or</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">a merger, consolidation or similar transaction following which the Company is the surviving corporation but the shares of Common Stock outstanding immediately preceding the merger, consolidation or similar
      transaction are converted or exchanged by virtue of the merger, consolidation or similar transaction into other property, whether in the form of securities, cash or otherwise.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(n)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Director</i></b>&#8221; means a member of the Board.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(o)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Disability</i></b>&#8221; means, with respect to a Participant, the inability of such Participant to engage in any substantial gainful activity by reason of any medically determinable physical or mental
      impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period of not less than 12 months, as provided in Sections 22(e)(3) and 409A(a)(2)(c)(i) of the Code, and shall be determined by the
      Board on the basis of such medical evidence as the Board deems warranted under the circumstances.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(p)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Effective Date</i></b>&#8221; has the meaning set forth in Section 11 of the Plan.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(q)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Employee</i></b>&#8221; means any person employed by the Company or an Affiliate. However, service solely as a Director, or payment of a fee for such services, shall not cause a Director to be considered an
      &#8220;Employee&#8221; for purposes of the Plan.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(r)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Entity</i></b>&#8221; means a corporation, partnership, limited liability company or other entity.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(s)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Exchange Act</i></b>&#8221; means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(t)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Exchange Act Person</i></b>&#8221; means any natural person, Entity or &#8220;group&#8221; (within the meaning of Section 13(d) or 14(d) of the Exchange Act), except that &#8220;Exchange Act Person&#8221; shall not include (i)
      the Company or any Subsidiary of the Company, (ii) any employee benefit plan of the Company or any Subsidiary of the Company or any trustee or other fiduciary holding securities under an employee benefit plan of the Company or any Subsidiary of the
      Company, (iii) an underwriter temporarily holding securities pursuant to a registered public offering of such securities, (iv) an Entity Owned, directly or indirectly, by the stockholders of the Company in substantially the same proportions as their
      Ownership of stock of the Company; or (v) any natural person, Entity or &#8220;group&#8221; (within the meaning of Section 13(d) or 14(d) of the Exchange Act) that, as of the Effective Date, is the Owner, directly or indirectly, of securities of the Company
      representing more than 50% of the combined voting power of the Company&#8217;s then outstanding securities.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(u)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Executive Officer</i></b>&#8221; means a person who is an officer of the Company within the meaning of Section&#160;16 of the Exchange Act.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(v)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b> </span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Fair Market Value</i></b>&#8221; means, as of any date, the value of the Common Stock determined as follows:</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">A-12</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>If the Common Stock is listed on any established stock exchange or traded on any established market, the Fair Market Value of a share of Common Stock shall be the closing sales price for such stock as
      quoted on such exchange or market (or the exchange or market with the greatest volume of trading in the Common Stock) on the date of determination, as reported in a source the Board deems reliable.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Unless otherwise provided by the Board, if there is no closing sales price for the Common Stock on the date of determination, then the Fair Market Value shall be the closing selling price on the last preceding
      date for which such quotation exists.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">In the absence of such markets for the Common Stock, the Fair Market Value shall be determined by the Board in good faith and in a manner that complies with Sections 409A and 422 of the Code.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(w)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Full Value Award</i></b>&#8221; means a Stock Award that is not an Option or SAR with respect to which the exercise or strike price is at least 100% of the Fair Market Value of the Common Stock subject to the
      Option or SAR on the date of grant. </span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(x)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Non-Employee Director</i></b>&#8221; means a Director who either (i) is not a current employee or officer of the Company or an Affiliate, does not receive compensation, either directly or indirectly, from the
      Company or an Affiliate for services rendered as a consultant or in any capacity other than as a Director (except for an amount as to which disclosure would not be required under Item 404(a) of Regulation S-K promulgated pursuant to the Securities
      Act (&#8220;<b><i>Regulation S-K</i></b>&#8221;)), does not possess an interest in any other transaction for which disclosure would be required under Item 404(a) of Regulation S-K, and is not engaged in a business relationship for which disclosure would be
      required pursuant to Item&#160;404(b) of Regulation S-K; or (ii) is otherwise considered a &#8220;non-employee director&#8221; for purposes of Rule 16b-3.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(y)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Option</i></b>&#8221; means a stock option granted pursuant to Section 5 of the Plan to purchase shares of Common Stock granted pursuant to the Plan.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(z)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Option Agreement</i></b>&#8221; means a written agreement between the Company and an Optionholder evidencing the terms and conditions of an Option grant. Each Option Agreement shall be subject to the terms
      and conditions of the Plan.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(aa)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b>&#160;</span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Optionholder</i></b>&#8221; means a person to whom an Option is granted pursuant to the Plan or, if applicable, such other person who holds an outstanding Option.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(bb)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b>&#160;</span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Own,</i></b>&#8221; &#8220;<b><i>Owned,</i></b>&#8221; &#8220;<b><i>Owner,</i></b>&#8221; &#8220;<b><i>Ownership</i></b>&#8221; A person or Entity shall be deemed to &#8220;Own,&#8221; to have &#8220;Owned,&#8221; to be the &#8220;Owner&#8221; of, or to have acquired &#8220;Ownership&#8221; of
      securities if such person or Entity, directly or indirectly, through any contract, arrangement, understanding, relationship or otherwise, has or shares voting power, which includes the power to vote or to direct the voting, with respect to such
      securities.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(cc)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b>&#160;</span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Participant</i></b>&#8221; means a person to whom an Award is granted pursuant to the Plan or, if applicable, such other person who holds an outstanding Stock Award.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(dd)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#8220;<i>Performance Cash Award</i>&#8221; <span style="font-weight: normal;">means an award of cash granted pursuant to the terms and conditions of Section 6(c)(ii).</span></b></span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ee)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Performance Criteria</i></b>&#8221; means the one or more criteria that the Board shall select for purposes of establishing the Performance Goals for a Performance Period. The Performance Criteria that shall be
      used to establish such Performance Goals may be based on any one of, or combination of, the following as determined by the Board: (i) earnings (including earnings per share and net earnings); (ii) earnings before interest, taxes and depreciation;
      (iii) earnings before interest, taxes, depreciation and amortization; (iv) total stockholder return; (v) return on equity or average stockholder&#8217;s equity; (vi) return on assets, investment, or capital employed; (vii) stock price; (viii) margin
      (including gross margin); (ix) income (before or after taxes); (x) operating income; (xi) operating income after taxes; (xii) pre-tax profit; (xiii) operating cash flow; (xiv) sales or revenue targets; (xv) increases in revenue or product revenue;
      (xvi) expenses and cost reduction goals; (xvii) improvement in or attainment of working capital levels; (xiii) economic value added (or an equivalent metric); (xix) market share; (xx) cash flow; (xxi) cash flow per share; (xxii) share price
      performance; (xxiii) debt reduction; (xxiv) implementation or completion of projects or processes (including, but not limited to development and regulatory milestones); (xxv) customer satisfaction; (xxvi) stockholders&#8217; equity; (xxvii) capital
      expenditures; (xxiii) debt levels; (xxix) operating profit or net operating profit; (xxx) workforce diversity; (xxxi) growth of net income or operating income; (xxxii) billings; and (xxxiii) any other measure or measures of performance selected by
      the Board.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ff)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Performance Goals</i></b>&#8221; means, for a Performance Period, the one or more goals established by the Board for the Performance Period based upon the Performance Criteria. Performance Goals may be
      based on a Company-wide basis, with respect to one or more business units, divisions, Affiliates, or business segments, and in either absolute terms or relative to the performance of one or more comparable companies or the performance of one or more
      relevant indices. Unless specified otherwise by the Board (i) in the Award Agreement at the time the Award is granted or (ii) in such other document setting forth the Performance Goals at the time the Performance Goals are established, the Board
      shall appropriately make adjustments in the method of calculating the attainment of Performance Goals for a Performance Period as follows: (1) to exclude restructuring and/or other nonrecurring charges; (2) to exclude exchange rate effects, as
      applicable, for non-U.S. dollar denominated Performance Goals; (3) to exclude the effects of changes to generally accepted accounting principles; (4) to exclude the effects of any statutory adjustments to corporate tax rates; (5) to exclude the
      effects of items that are &#8220;unusual&#8221; in nature or occur &#8220;infrequently&#8221; as determined under generally accepted accounting principles; and (6) to exclude accounting expenses relating to share-based compensation.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">A-13</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(gg)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Performance Period</i></b>&#8221; means the period of time selected by the Board over which the attainment of one or more Performance Goals will be measured for the purpose of determining a Participant&#8217;s
      right to and the payment of a Stock Award or a Performance Cash Award. Performance Periods may be of varying and overlapping duration, at the sole discretion of the Board.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(hh)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Performance Stock Award</i></b>&#8221; means a Stock Award granted under the terms and conditions of Section 6(c)(i).</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Plan</i></b>&#8221; means this Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(jj)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Restricted Stock Award</i></b>&#8221; means an award of shares of Common Stock which is granted pursuant to the terms and conditions of Section 6(a).</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(kk)&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Restricted Stock Award Agreement</i></b>&#8221; means a written agreement between the Company and a holder of a Restricted Stock Award evidencing the terms and conditions of a Restricted Stock Award grant. Each
      Restricted Stock Award Agreement shall be subject to the terms and conditions of the Plan.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ll)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Restricted Stock Unit Award</i></b>&#8221; means a right to receive shares of Common Stock which is granted pursuant to the terms and conditions of Section 6(b).</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(mm)&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Restricted Stock Unit Award Agreement</i></b>&#8221; means a written agreement between the Company and a holder of a Restricted Stock Unit Award evidencing the terms and conditions of a Restricted Stock Unit
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  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(nn)&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Rule 16b-3</i></b>&#8221; means Rule 16b-3 promulgated under the Exchange Act or any successor to Rule 16b-3, as in effect from time to time.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(oo)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Securities Act</i></b>&#8221; means the Securities Act of 1933, as amended.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(pp)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b></b>&#8220;<b><i>Stock Appreciation Right</i></b>&#8221; or &#8220;<b><i>SAR</i></b>&#8221; means a right to receive the appreciation on Common Stock that is granted pursuant to the terms and conditions of Section 5.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(qq)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Stock Appreciation Right Agreement</i></b>&#8221; means a written agreement between the Company and a holder of a Stock Appreciation Right evidencing the terms and conditions of a Stock Appreciation Right grant.
      Each Stock Appreciation Right Agreement shall be subject to the terms and conditions of the Plan.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(rr)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Stock Award</i></b>&#8221; means any right to receive Common Stock granted under the Plan, including an Option, a Restricted Stock Award, a Restricted Stock Unit Award, a Stock Appreciation Right, or a
      Performance Stock Award.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ss)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#8220;<b><i>Stock Award Agreement</i></b>&#8221; means a written agreement between the Company and a Participant evidencing the terms and conditions of a Stock Award grant. Each Stock Award Agreement shall be subject to the
      terms and conditions of the Plan.</span><span style="font-family: Times New Roman,Times,serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </span>&#160;</p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;">&#160;</p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-size: 10pt;"><b>(tt)<span style="font-family: Times New Roman,Times,serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 11pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-size: 10pt;">&#8220;<b><i>Subsidiary</i></b>&#8221;
      means, with respect to the Company, (i) any corporation of which more than 50% of the outstanding capital stock having ordinary voting power to elect a majority of the board of directors of such corporation (irrespective of whether, at the time,
      stock of any other class or classes of such corporation shall have or might have voting power by reason of the happening of any contingency) is at the time, directly or indirectly, Owned by the Company, and (ii) any partnership, limited liability
      company or other entity in which the Company has a direct or indirect interest (whether in the form of voting or participation in profits or capital contribution) of more than 50%.</span></p>
  <p style="font: 11pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;">&#160;</p>
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  <p style="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></p>
  <p style="margin: 0pt 0px; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="margin: 0"></p>
  <p style="margin: 0px; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="margin: 0"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b><span style="text-decoration: underline;">Appendix B</span></b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>IONIS PHARMACEUTICALS, INC.</b></span>&#160;</p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended and Restated</b></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>2002 Non-Employee Directors&#8217; Stock Option
        Plan</b></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Adopted by the Board of Directors September
        11, 2001</b></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Approved by Stockholders May 31, 2002</b></span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Effective Date: May 31, 2002</b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended: April 20, 2006 </b>(A</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">mendment approved by Board on&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">December 12, 2005 and April 20, 2006 and by the Stockholders on May 3,
      2006)</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended: June 5, 2008 </b>(A</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">mendment approved by Board on&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">September 13, 2007 and February 22, 2008 and by the Stockholders on June
      5, 2008)</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended and Restated: June 2, 2010 </b>(A</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">mendment and Restatement approved by Board on&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">February 26, 2010 and by the Stockholders on June 2, 2010)</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended and Restated: June 7, 2012 </b>(</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amendment and Restatement approved by Board on&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">March 27, 2012 and by the Stockholders on June 7, 2012)</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended and Restated: June 10, 2014 </b>(</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amendment and Restatement approved by Board on &#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">February 11, 2014 and by the Stockholders on June 10, 2014)</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended and Restated: June 30, 2015 </b>(</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amendment and Restatement approved by Board on &#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">March 20, 2015 and by the Stockholders on June 30, 2015)</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended and Restated: June 4, 2020 </b>(</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amendment and Restatement approved by Board on &#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">March 24, 2020 and by the Stockholders on June 4, 2020)</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: small-caps;"><b>Amended</b>: March 14, 2023</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">1.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Purposes.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Amendment and Restatement. </b>This Plan was originally an amendment and restatement of the Ionis Pharmaceuticals, Inc. 1992 Non-Employee Directors&#8217; Stock Option Plan, and is an amendment of the Ionis Pharmaceuticals, Inc.
      2002 Non-Employee Directors&#8217; Stock Option Plan, as amended and restated on June 4, 2020.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Eligible Recipients.</b> The persons eligible to receive Stock Awards are the Non-Employee Directors of the Company.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Available Stock Awards.</b> The purpose of the Plan is to provide a means by which Non-Employee Directors may be given an opportunity to benefit from increases in value of the Common Stock through the granting of Stock Awards.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>General Purpose.</b> The Company, by means of the Plan, seeks to retain the services of its Non-Employee Directors, to secure and retain the services of new Non-Employee Directors and to provide incentives for such persons to
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span>&#160;</p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">2.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Definitions.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Affiliate&#8221;</i></b> means any parent corporation or subsidiary corporation of the Company, whether now or hereafter existing, as those terms are defined in Sections 424(e) and (f), respectively, of the Code.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Annual Grant&#8221;</i></b> means an Option and/or RSU Award granted annually to all Non-Employee Directors who meet the criteria specified in subsection 6(b) of the Plan.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Board&#8221;</i></b> means the Board of Directors of the Company.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Capitalization Adjustment&#8221;</i></b> has the meaning ascribed to that term in Section 12(a).</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></p>
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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">B-1</span>&#160;</div>

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  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Change in Control&#8221;</i></b> means the occurrence, in a single transaction or in a series of related transactions, of any one or more of the following events:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;"><b></b>any Exchange Act Person becomes the Owner, directly or indirectly, of securities of the Company representing more than 50% of the combined voting power of the Company&#8217;s then outstanding securities other than by virtue of a
      merger, consolidation or similar transaction and other than by a purchase of securities directly from the Company;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Notwithstanding the foregoing, a Change in Control shall not be deemed to
      occur solely because the level of Ownership held by any Exchange Act Person (the &#8220;Subject Person&#8221;) exceeds the percentage threshold specified above of the outstanding voting securities as a result of a repurchase or other acquisition of voting
      securities by the Company reducing the number of shares outstanding, <i>provided</i> that if a Change in Control would occur (but for the operation of this sentence) as a result of the acquisition of voting securities by the Company, and after such
      share acquisition, the Subject Person becomes the Owner of any additional voting securities (other than through a purchase directly from the Company) that, assuming the repurchase or other acquisition had not occurred, increases the percentage of the
      then outstanding voting securities Owned by the Subject Person over the percentage threshold specified above, then a Change in Control shall be deemed to occur.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#160;&#160;&#160;&#160;&#160;&#160;(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">there is consummated a merger, consolidation or similar transaction involving (directly or indirectly) the Company and, immediately after the consummation of such merger, consolidation or similar transaction, the stockholders of
      the Company immediately prior thereto do not Own, directly or indirectly, outstanding voting securities representing more than 50% of the combined outstanding voting power of the surviving Entity in such merger, consolidation or similar transaction
      or more than 50% of the combined outstanding voting power of the parent of the surviving Entity in such merger, consolidation or similar transaction;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#160;&#160;&#160;&#160;&#160;&#160;(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">the stockholders of the Company approve or the Board approves a plan of complete dissolution or liquidation of the Company, or a complete dissolution or liquidation of the Company shall otherwise occur;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#160;&#160;&#160;&#160;&#160;&#160;(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">there is consummated a sale, lease, license or other disposition of all or substantially all of the consolidated assets of the Company and its Subsidiaries, other than a sale, lease, license or other disposition of all or
      substantially all of the consolidated assets of the Company and its Subsidiaries to an Entity, more than 50% of the combined voting power of the voting securities of which are Owned by stockholders of the Company in substantially the same proportions
      as their Ownership of the Company immediately prior to such sale, lease, license or other disposition; or</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#160;&#160;&#160;&#160;&#160;&#160;(v)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">individuals who, on the date this Plan is adopted by the Board, are members of the Board (the &#8220;Incumbent Board&#8221;) cease for any reason to constitute at least a majority of the members of the Board; (<i>provided, however,</i> that
      if the appointment or election (or nomination for election) of any new Board member was approved or recommended by a majority vote of the members of the Incumbent Board then still in office, such new member shall, for purposes of this Plan, be
      considered as a member of the Incumbent Board).</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Notwithstanding the foregoing or any other provision of this Plan, the
      definition of Change in Control (or any analogous term) in an individual written agreement between the Company or any Affiliate and the Holder shall supersede the foregoing definition with respect to Stock Awards subject to such agreement (it being
      understood, however, that if no definition of Change in Control or any analogous term is set forth in such an individual written agreement, the foregoing definition shall apply).</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Code&#8221;</i></b> means the Internal Revenue Code of 1986, as amended.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(g)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Common Stock&#8221;</i></b> means the common stock of the Company.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(h)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Company&#8221;</i></b> means Ionis Pharmaceuticals, Inc., a Delaware corporation.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Consultant&#8221;</i></b> means any person, including an advisor, (i) engaged by the Company or an Affiliate to render consulting or advisory services and who is compensated for such services or (ii) serving as a member of the
      Board of Directors of an Affiliate and who is compensated for such services. However, the term &#8220;Consultant&#8221; shall not include Directors who are not compensated by the Company for their services as Directors, and the payment of a director&#8217;s fee by the
      Company for services as a Director shall not cause a Director to be considered a &#8220;Consultant&#8221; for purposes of the Plan.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(j)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Continuous Service&#8221;</i></b> means that the Holder&#8217;s service with the Company or an Affiliate, whether as an Employee, Director or Consultant, is not interrupted or terminated. A change in the capacity in which the Holder
      renders service to the Company or an Affiliate as an Employee, Consultant or Director or a change in the entity for which the Holder renders such service, provided that there is no interruption or termination of the Holder&#8217;s service with the Company
      or an Affiliate, shall not terminate a Holder&#8217;s Continuous Service. For example, a change in status from a Non-Employee Director of the Company to a Consultant of an Affiliate or an Employee of the Company shall not constitute an interruption of
      Continuous Service. The Board or the chief executive officer of the Company, in that party&#8217;s sole discretion, may determine whether Continuous Service shall be considered interrupted in the case of any leave of absence approved by that party,
      including sick leave, military leave or any other personal leave.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></p>
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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">B-2</span>&#160;</div>

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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(k)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Corporate Transaction&#8221;</i></b> means the occurrence, in a single transaction or in a series of related transactions, of any one or more of the following events:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">a sale or other disposition of all or substantially all, as determined by the Board in its discretion, of the consolidated assets of the Company and its Subsidiaries;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">a sale or other disposition of at least 90% of the outstanding securities of the Company;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">a merger, consolidation or similar transaction following which the Company is not the surviving corporation; or</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">a merger, consolidation or similar transaction following which the Company is the surviving corporation but the shares of Common Stock outstanding immediately preceding the merger, consolidation or similar transaction are
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(l)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Director&#8221;</i></b> means a member of the Board of Directors of the Company.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(m)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i>&#160;</i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Disability&#8221;</i></b> means the permanent and total disability of a person within the meaning of Section 22(e)(3) of the Code.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(n)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Employee&#8221;</i></b> means any person employed by the Company or an Affiliate. Service as a Director or payment of a director&#8217;s fee by the Company or an Affiliate shall not be sufficient to constitute &#8220;employment&#8221; by the
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(o)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br />
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  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Entity&#8221;</i></b> means a corporation, partnership or other entity.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(p)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Exchange Act&#8221;</i></b> means the Securities Exchange Act of 1934, as amended.</span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b> <br />
      </b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(q)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Exchange Act Person&#8221;</i></b> means any natural person, Entity or &#8220;group&#8221; (within the meaning of Section 13(d) or 14(d) of the Exchange Act), except that &#8220;Exchange Act Person&#8221; shall not include (A) the Company or any
      Subsidiary of the Company, (B) any employee benefit plan of the Company or any Subsidiary of the Company or any trustee or other fiduciary holding securities under an employee benefit plan of the Company or any Subsidiary of the Company, (C) an
      underwriter temporarily holding securities pursuant to an offering of such securities, or (D) an Entity Owned, directly or indirectly, by the stockholders of the Company in substantially the same proportions as their Ownership of stock of the
      Company.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(r)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Fair Market Value&#8221;</i></b> means, as of any date, the value of the Common Stock determined as follows:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#160;&#160;&#160;&#160;&#160;&#160;(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">If the Common Stock is listed on any established stock exchange or traded on the Nasdaq National Market or the Nasdaq SmallCap Market, the Fair Market Value of a share of Common Stock shall be the closing sales price for such
      stock (or the closing bid, if no sales were reported) as quoted on such exchange or market (or the exchange or market with the greatest volume of trading in the Common Stock) on the last market trading day prior to the day of determination, as
      reported in The Wall Street Journal or such other source as the Board deems reliable.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">In the absence of such markets for the Common Stock, the Fair Market Value shall be determined in good faith by the Board.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(s)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Holder&#8221; </i></b>means a person to whom an Option or RSU Award is granted pursuant to the Plan or, if applicable, such other person who holds an outstanding Option or RSU Award.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(t)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Initial Grant&#8221;</i></b> means an Option and/or RSU granted to a Non-Employee Director who meets the criteria specified in subsection 6(a) of the Plan.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(u)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Non-Employee Director&#8221;</i></b> means a Director who is not an Employee.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(v)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Nonstatutory Stock Option&#8221;</i></b> means an Option not intended to qualify as an incentive stock option within the meaning of Section 422 of the Code and the regulations promulgated thereunder.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">B-3</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(w)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Officer&#8221;</i></b> means a person who is an officer of the Company within the meaning of Section 16 of the Exchange Act and the rules and regulations promulgated thereunder.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(x)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Option&#8221;</i></b> means a Nonstatutory Stock Option granted pursuant to the Plan.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(y)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Option Agreement&#8221;</i></b> means a written agreement between the Company and a Holder evidencing the terms and conditions of an individual Option grant. Each Option Agreement shall be subject to the terms and conditions of
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(z)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Own,&#8221; &#8220;Owned,&#8221; &#8220;Owner,&#8221; &#8220;Ownership&#8221;</i></b> A person or Entity shall be deemed to &#8220;Own,&#8221; to have &#8220;Owned,&#8221; to be the &#8220;Owner&#8221; of, or to have acquired &#8220;Ownership&#8221; of securities if such person or Entity, directly or indirectly,
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(aa)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160;<i></i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Plan&#8221;</i></b> means this Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors&#8217; Stock Option Plan, which is an amendment and restatement of the Ionis Pharmaceuticals, Inc. 1992 Non-Employee Directors&#8217; Stock Option Plan.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(bb)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i>&#160;&#160;</i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;RSU Award&#8221;</i></b> means a right to receive shares of Common Stock which is granted pursuant to the terms and conditions of Section 8.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(cc)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i>&#160;</i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;RSU Award Agreement&#8221;</i></b> means a written agreement between the Company and a holder of a RSU Award evidencing the terms and conditions of a RSU Award grant. Each RSU Award Agreement shall be subject to the terms and
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(dd)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i>&#160;&#160;</i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Rule 16b-3&#8221;</i></b> means Rule 16b-3 promulgated under the Exchange Act or any successor to Rule 16b-3, as in effect from time to time.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ee)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i>&#160;</i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Securities Act&#8221;</i></b> means the Securities Act of 1933, as amended.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ff)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i>&#160;</i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Stock Award&#8221;</i></b> means an Option or RSU Award, as applicable.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(gg)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <i>&#160;</i></b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b><i>&#8220;Subsidiary&#8221;</i></b> means, with respect to the Company, (i) any corporation of which more than 50% of the outstanding capital stock having ordinary voting power to elect a majority of the board of directors of such
      corporation (irrespective of whether, at the time, stock of any other class or classes of such corporation shall have or might have voting power by reason of the happening of any contingency) is at the time, directly or indirectly Owned by the
      Company, and (ii) any partnership in which the Company has a direct or indirect interest (whether in the form of voting or participation in profits or capital contribution) of more than 50%.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">3.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Administration.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Administration by Board.</b> The Board shall administer the Plan. The Board may delegate administration of the Plan to a committee. If delegated to a committee, references to the Board will include a reference to the committee,
      as applicable.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Powers of Board.</b> The Board shall have the power, subject to, and within the limitations of, the express provisions of the Plan:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;&#160;&#160;&#160;&#160;&#160;<b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">To determine the provisions of each Stock Award to the extent not specified in the Plan.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">To construe and interpret the Plan and Stock Awards granted under it, and to establish, amend and revoke rules and regulations for its administration. The Board, in the exercise of this power, may correct any defect, omission or
      inconsistency in the Plan or in any Option Agreement or RSU Agreement, in a manner and to the extent it shall deem necessary or expedient to make the Plan fully effective.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;&#160;&#160;&#160;&#160;&#160;<b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">To amend the Plan or a Stock Award as provided in Section 13.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">To terminate or suspend the Plan as provided in Section&#160;14.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(v)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">Generally, to exercise such powers and to perform such acts as the Board deems necessary or expedient to promote the best interests of the Company and that are not in conflict with the provisions of the Plan.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Effect of Board&#8217;s Decision.</b> All determinations, interpretations and constructions made by the Board in good faith shall not be subject to review by any person and shall be final, binding and conclusive on all persons.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></p>
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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">B-4</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Arbitration. </b>Any dispute or claim concerning any Stock Award granted (or not granted) pursuant to the Plan or any disputes or claims relating to or arising out of the Plan shall be fully, finally and exclusively resolved
      by binding arbitration conducted pursuant to the Commercial Arbitration Rules of the American Arbitration Association in San Diego, California. The Company shall pay all arbitration fees. In addition to any other relief, the arbitrator may award to
      the prevailing party recovery of its attorney&#8217;s fees and costs. By accepting a Stock Award, Holders and the Company waive their respective rights to have any such disputes or claims tried by a judge or jury.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">4.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Shares Subject to the Plan.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Share Reserve.</b> Subject to the provisions of Section 12(a) relating to Capitalization Adjustments, the Common Stock that may be issued pursuant to Stock Awards shall not exceed in the aggregate <b>2,800,000</b> shares of
      Common Stock.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Reversion of Shares to the Share Reserve.</b> If any Stock Award shall for any reason expire or otherwise terminate, in whole or in part, without having been exercised or vested in full, the shares of Common Stock not issued
      under such Stock Award shall revert to and again become available for issuance under the Plan.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Source of Shares.</b> The shares of Common Stock subject to the Plan may be unissued shares or reacquired shares, bought on the market or otherwise.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">5.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Eligibility.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Stock Awards as set forth in Section 6 of the Plan automatically shall
      be granted under the Plan to all Non-Employee Directors.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 41.8pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">6.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Non-Discretionary Grants.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Initial Grants. </b>Without any further action of the Board, each person who is elected or appointed for the first time to be a Non-Employee Director shall automatically be granted, on the terms and conditions set forth
      herein, an Initial Grant of Option and RSU Awards as follows:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#160;&#160;&#160;&#160;&#160;&#160;(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">An Option to purchase 24,000 shares of Common Stock; and</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;&#160;&#160;&#160;&#160;&#160;<b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">An RSU Award of 10,667 RSUs.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">The grant date for such initial options will be the date the Non-Employee Director was elected or appointed by the Board or stockholders of the Company, as applicable. The grant date for such initial RSU Awards will be the 15<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> of the month following the end of the quarter in which such Non-Employee Director was elected or appointed by the Board or stockholders of the Company, as applicable.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Annual Grants. </b>Without any further action of the Board, a Non-Employee Director shall be granted an Annual Grant as follows: On July 1 of each year, beginning on July 1, 2020, each person who is then a Non-Employee
      Director automatically shall be granted, on the terms and conditions set forth herein, an Annual Grant of Option and RSU Awards as follows:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>&#160;&#160;&#160;&#160;&#160;&#160;(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">An Option to purchase 12,000 shares of Common Stock; and</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">An RSU Award of 5,333 RSUs.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">7.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Option Provisions.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Each Option shall be in such form and shall contain such terms and
      conditions as the Board shall deem appropriate. Each Option shall include (through incorporation of provisions hereof by reference in the Option or otherwise) the substance of each of the following provisions:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 41.8pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Term.</b> No Option shall be exercisable after the expiration of 10 years from the date it was granted.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Exercise Price.</b> The exercise price of each Option shall be 100% of the Fair Market Value of the Common Stock subject to the Option on the date the Option is granted. Notwithstanding the foregoing, an Option may be granted
      with an exercise price lower than that set forth in the preceding sentence if such Option is granted pursuant to an assumption or substitution for another option in a manner satisfying the provisions of Section 424(a) of the Code.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">B-5</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
      <hr style="BORDER-LEFT-WIDTH: 0px; HEIGHT: 2px; BORDER-RIGHT-WIDTH: 0px; WIDTH: 100%; BORDER-BOTTOM-WIDTH: 0px; COLOR: #000000; CLEAR: both; MARGIN: 4px 0px; BORDER-TOP-WIDTH: 0px; BACKGROUND-COLOR: #000000" /> </div>

  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Consideration.</b> The purchase price of Common Stock acquired pursuant to the exercise of an Option shall be paid, to the extent permitted by applicable law, by any combination of the following methods of payment:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;&#160;&#160;&#160;&#160;&#160;<b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">by cash, check, bank draft or money order payable to the Company; or</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">pursuant to a program developed under Regulation T as promulgated by the Federal Reserve Board that, prior to the issuance of the stock subject to the Option, results in either the receipt of cash (or check) by the Company or the
      receipt of irrevocable instructions to pay the aggregate exercise price to the Company from the sales proceeds.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Transferability.</b> An Option will not be transferable except as determined by the Board.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Exercise Schedule.</b> The Option shall be exercisable as the shares of Common Stock subject to the Option vest.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Vesting Schedule.</b> The Option shall vest and become exercisable as follows:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;&#160;&#160;&#160;&#160;&#160;<b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;"><b></b>Initial Grants: one-third of the shares subject to the Option shall vest on each annual anniversary of the date of grant, provided that the Holder has, during the entire year prior to each vesting date, continuously served
      as a Non-Employee Director or as an Employee of or Consultant to the Company or any Affiliate, whereupon such option shall become fully exercisable in accordance with its terms with respect to that portion of the shares represented by that
      installment.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;">Annual Grants: 100% of the shares subject to the Option shall vest on (1) the annual anniversary of the date of grant, or (2) the next regularly scheduled annual meeting of stockholders, whichever occurs earlier, provided that the
      Holder has, during the entire period from the date of grant through such vesting date, continuously served as a Non-Employee Director or as an Employee of or Consultant to the Company or any Affiliate, whereupon such option shall become fully
      exercisable in accordance with its terms.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(g)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Termination of Continuous Service.</b> In the event that an Holder&#8217;s Continuous Service terminates (other than upon the Holder&#8217;s death or Disability), the Holder may exercise his or her Option (to the extent that the Holder was
      entitled to exercise such Option as of the date of termination) but only within such period of time ending on the earlier of (i) the date 3 months following the termination of the Holder&#8217;s Continuous Service (or such longer or shorter period
      specified in the Option Agreement), or (ii) the expiration of the term of the Option as set forth in the Option Agreement. If, after termination, the Holder does not exercise his or her Option within the time specified in the Option Agreement, the
      Option shall terminate.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(h)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Extension of Termination Date.</b> An Holder&#8217;s Option Agreement may also provide that if the exercise of the Option following the termination of the Holder&#8217;s Continuous Service (other than upon the Holder&#8217;s death or Disability)
      would be prohibited at any time solely because the issuance of shares of Common Stock would violate the registration requirements under the Securities Act, then the Option shall terminate on the earlier of (i) the expiration of the term of the Option
      set forth in subsection 7(a) or (ii) the expiration of a period of 3 months after the termination of the Holder&#8217;s Continuous Service during which the exercise of the Option would not be in violation of such registration requirements. In addition,
      unless otherwise provided in an Holder&#8217;s Option Agreement, if the immediate sale of any Common Stock received upon exercise of an Option following the termination of the Holder&#8217;s Continuous Service would violate the Company&#8217;s insider trading policy,
      then the Option shall terminate on the earlier of (i) the expiration of a period equal to the applicable post-termination exercise period after the termination of the Holder&#8217;s Continuous Service during which the sale of Common Stock received upon
      exercise of the Option would not be in violation of the Company&#8217;s insider trading policy, or (ii) the expiration of the term of the Option as set forth in the applicable Option Agreement.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Disability of Holder.</b> In the event that an Holder&#8217;s Continuous Service terminates as a result of the Holder&#8217;s Disability, the Holder may exercise his or her Option (to the extent that the Holder was entitled to exercise
      such Option as of the date of termination), but only within such period of time ending on the earlier of (i) the date 12 months following such termination (or such longer or shorter period specified in the Option Agreement) or (ii) the expiration of
      the term of the Option as set forth in the Option Agreement. If, after termination, the Holder does not exercise his or her Option within the time specified herein, the Option shall terminate.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(j)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Death of Holder.</b> In the event that (i) an Holder&#8217;s Continuous Service terminates as a result of the Holder&#8217;s death or (ii) the Holder dies within the period (if any) specified in the Option Agreement after the termination
      of the Holder&#8217;s Continuous Service for a reason other than death, then the Option may be exercised (to the extent the Holder was entitled to exercise such Option as of the date of death) by the Holder&#8217;s estate, by a person who acquired the right to
      exercise the Option by bequest or inheritance or by a person designated to exercise the Option upon the Holder&#8217;s death pursuant to subsection 7(d), but only within the period ending on the earlier of (1) the date 18 months following the date of death
      (or such longer or shorter period specified in the Option Agreement) or (2) the expiration of the term of such Option as set forth in the Option Agreement. If, after death, the Option is not exercised within the time specified herein, the Option
      shall terminate.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></p>
  <div class="BRPFPageBreakArea" style="MARGIN-BOTTOM: 10pt; CLEAR: both; MARGIN-TOP: 10pt">
    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">B-6</span>&#160;</div>

    <div class="BRPFPageBreak" style="PAGE-BREAK-AFTER: always">
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  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">8.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Restricted Stock Unit Provisions.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Each Restricted Stock Unit Award Agreement shall be in such form and shall
      contain such terms and conditions as the Board shall deem appropriate. The terms and conditions of Restricted Stock Unit Award Agreements may change from time to time, and the terms and conditions of separate Restricted Stock Unit Award Agreements
      need not be identical; <i>provided, however</i>, that each Restricted Stock Unit Award Agreement shall conform to (through incorporation of the provisions hereof by reference in the Agreement or otherwise) the substance of each of the following
      provisions:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Consideration.</b> At the time of grant of a Restricted Stock Unit Award, the Board will determine the consideration, if any, to be paid by the Holder upon delivery of each share of Common Stock subject to the Restricted Stock
      Unit Award. The consideration to be paid (if any) by the Holder for each share of Common Stock subject to a Restricted Stock Unit Award may be paid in any form of legal consideration that may be acceptable to the Board, in its sole discretion, and
      permissible under applicable law.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Vesting.</b> Each RSU Award under this Plan shall vest as follows:</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;&#160;&#160;&#160;&#160;&#160;<b>(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;"><b></b>Initial Grants: one-third of the shares subject to the RSU shall vest on each annual anniversary of the date of grant, provided that the Holder has, during the entire year prior to each vesting date, continuously served as
      a Non-Employee Director or as an Employee of or Consultant to the Company or any Affiliate.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;">&#160;&#160;&#160;&#160;&#160;&#160;<span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 118pt;"><span style="font-family: Times New Roman,Times,serif;"><b></b>Annual Grants: 100% of the shares subject to the RSU shall vest on (1) the annual anniversary of the date of grant, or (2) the next regularly scheduled annual meeting of stockholders, whichever occurs earlier, provided that
      the Holder has, during the entire period from the date of grant through such vesting date, continuously served as a Non-Employee Director or as an Employee of or Consultant to the Company or any Affiliate; provided such RSU Awards, once vested, will
      be settled on the July 15<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th </sup>following the vesting date.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 1in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Payment.</b> A Restricted Stock Unit Award may be settled by the delivery of shares of Common Stock, their cash equivalent, any combination thereof or in any other form of consideration, as determined by the Board and contained
      in the Restricted Stock Unit Award Agreement.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Additional Restrictions.</b> At the time of the grant of a Restricted Stock Unit Award, the Board, as it deems appropriate, may impose such restrictions or conditions that delay the delivery of the shares of Common Stock (or
      their cash equivalent) subject to a Restricted Stock Unit Award to a time after the vesting of such Restricted Stock Unit Award.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Dividend Equivalents.</b> Dividend equivalents may be credited in respect of shares of Common Stock covered by a Restricted Stock Unit Award, as determined by the Board and contained in the Restricted Stock Unit Award
      Agreement. At the sole discretion of the Board, such dividend equivalents may be converted into additional shares of Common Stock covered by the Restricted Stock Unit Award in such manner as determined by the Board. Any additional shares covered by
      the Restricted Stock Unit Award credited by reason of such dividend equivalents will be subject to all of the same terms and conditions of the underlying Restricted Stock Unit Award Agreement to which they relate.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Termination of Holder&#8217;s Continuous Service.</b> Except as otherwise provided in the applicable Restricted Stock Unit Award Agreement, such portion of the Restricted Stock Unit Award that has not vested will be forfeited upon
      the Holder&#8217;s termination of Continuous Service.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">9.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Covenants of the Company.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Availability of Shares.</b> During the terms of the Stock Awards, the Company shall keep available at all times the number of shares of Common Stock required to satisfy such Stock Awards.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Securities Law Compliance.</b> The Company shall seek to obtain from each regulatory commission or agency having jurisdiction over the Plan such authority as may be required to grant Stock Awards and to issue and sell shares of
      Common Stock upon exercise of the Stock Awards; provided, however, that this undertaking shall not require the Company to register under the Securities Act the Plan, any Stock Award or any Common Stock issued or issuable pursuant to any such Stock
      Award. If, after reasonable efforts, the Company is unable to obtain from any such regulatory commission or agency the authority which counsel for the Company deems necessary for the lawful issuance and sale of Common Stock under the Plan, the
      Company shall be relieved from any liability for failure to issue and sell Common Stock upon exercise of such Stock Awards unless and until such authority is obtained. A Non-Employee Director shall not be eligible for the grant of a Stock Award or
      the subsequent issuance of Common Stock pursuant to the Stock Award if such grant or issuance would violate any applicable securities law.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>No Obligation to Notify or Minimize Taxes. </b>The Company shall have no duty or obligation to any Holder to advise such Holder (or the estate of, or transferee of, such Holder) as to the time or manner of exercising such
      Stock Award. Furthermore, the Company shall have no duty or obligation to warn or otherwise advise such Holder (or the estate of, or transferee of, such Holder) of a pending termination or expiration of a Stock Award or a possible period in which the
      Stock Award may not be exercised. The Company has no duty or obligation to minimize the tax consequences of a Stock Award to the Holder of such Stock Award.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></p>
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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">B-7</span>&#160;</div>

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  </div>

  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">10.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Use of Proceeds from Stock.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Proceeds from the sale of Common Stock pursuant to Options or RSU Awards
      (if any) shall constitute general funds of the Company.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">11.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Miscellaneous.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Acceleration of Exercisability and Vesting.</b> The Board shall have the power to accelerate the time at which a Stock Award may first be exercised or the time during which a Stock Award or any part thereof will vest in
      accordance with the Plan, notwithstanding the provisions in the Stock Award stating the time at which it may first be exercised or the time during which it will vest.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Stockholder Rights.</b> No Holder shall be deemed to be the holder of, or to have any of the rights of a holder with respect to, any shares of Common Stock subject to such Stock Award unless and until such Holder has satisfied
      all requirements for exercise of the Option or settlement of the RSU Award, as applicable, pursuant to its terms.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>No Service Rights.</b> Nothing in the Plan or any instrument executed or Stock Award granted pursuant thereto shall confer upon any Holder any right to continue to serve the Company as a Non-Employee Director or shall affect
      the right of the Company or an Affiliate to terminate (i) the employment of an Employee with or without notice and with or without cause, (ii) the service of a Consultant pursuant to the terms of such Consultant&#8217;s agreement with the Company or an
      Affiliate or (iii) the service of a Director pursuant to the Bylaws of the Company or an Affiliate, and any applicable provisions of the corporate law of the state in which the Company or the Affiliate is incorporated, as the case may be.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Investment Assurances.</b> The Company may require a Holder, as a condition of exercising or acquiring Common Stock under any Award, (i) to give written assurances satisfactory to the Company as to the Holder&#8217;s knowledge and
      experience in financial and business matters and/or to employ a purchaser representative reasonably satisfactory to the Company who is knowledgeable and experienced in financial and business matters and that he or she is capable of evaluating, alone
      or together with the purchaser representative, the merits and risks of exercising the Stock Award; and (ii) to give written assurances satisfactory to the Company stating that the Holder is acquiring the Common Stock subject to the Stock Award for
      the Holder&#8217;s own account and not with any present intention of selling or otherwise distributing the Common Stock. The foregoing requirements, and any assurances given pursuant to such requirements, shall be inoperative if (1) the issuance of the
      shares of Common Stock upon the exercise or acquisition of Common Stock under the Stock Award has been registered under a then currently effective registration statement under the Securities Act or (2) as to any particular requirement, a
      determination is made by counsel for the Company that such requirement need not be met in the circumstances under the then applicable securities laws. The Company may, upon advice of counsel to the Company, place legends on stock certificates issued
      under the Plan as such counsel deems necessary or appropriate in order to comply with applicable securities laws, including, but not limited to, legends restricting the transfer of the Common Stock.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Withholding Obligations.</b> To the extent provided by the terms of the applicable Option Agreement or RSU Award Agreement, the Holder may satisfy any federal, state or local tax withholding obligation relating to the exercise
      or acquisition of Common Stock under a Stock Award by any of the following means (in addition to the Company&#8217;s right to withhold from any compensation paid to the Holder by the Company) or by a combination of such means: (i) tendering a cash payment;
      (ii) authorizing the Company to withhold shares of Common Stock from the shares of Common Stock otherwise issuable to the Holder as a result of the exercise or acquisition of Common Stock under the Stock Award, <i>provided, however</i>, that no
      shares of Common Stock are withheld with a value exceeding the minimum amount of tax required to be withheld by law (or such lower amount as may be necessary to avoid variable award accounting); or (iii) delivering to the Company owned and
      unencumbered shares of Common Stock.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Electronic Delivery</b>. Any reference herein to a &#8220;written&#8221; agreement or document shall include any agreement or document delivered electronically or posted on the Company&#8217;s intranet (or other shared electronic medium
      controlled by the Company to which the Holder has access).</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">12.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Adjustments upon Changes in Stock.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Capitalization Adjustments.</b> If any change is made in, or other event occurs with respect to, the Common Stock subject to the Plan, or subject to any Stock Award, without the receipt of consideration by the Company (through
      merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend in property other than cash, stock split, liquidating dividend, combination of shares, exchange of shares, change in corporate structure or other
      transaction not involving the receipt of consideration by the Company) (each, a &#8220;Capitalization Adjustment&#8221;), the Plan will be appropriately adjusted in the class(es) and maximum number of securities subject both to the Plan pursuant to subsection
      4(a) and to the nondiscretionary Stock Awards specified in Section 6, and the outstanding Stock Awards will be appropriately adjusted in the class(es) and number of securities and price per share of Common Stock subject to such outstanding Stock
      Awards. The Board shall make such adjustments, and its determination shall be final, binding and conclusive. (The conversion of any convertible securities of the Company shall not be treated as a transaction &#8220;without receipt of consideration&#8221; by the
      Company.)</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></p>
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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">B-8</span>&#160;</div>

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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Dissolution or Liquidation.</b> In the event of a dissolution or liquidation of the Company, then all outstanding Stock Awards shall terminate immediately prior to the completion of such dissolution or liquidation.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Corporate Transaction.</b> In the event of a Corporate Transaction, any surviving corporation or acquiring corporation may assume any or all Stock Awards outstanding under the Plan or may substitute similar stock awards for
      Stock Awards outstanding under the Plan (it being understood that similar stock awards include, but are not limited to, options to acquire, or restricted stock unit rights to receive, the same consideration paid to the stockholders or the Company, as
      the case may be, pursuant to the Corporate Transaction). In the event that any surviving corporation or acquiring corporation does not assume any or all such outstanding Stock Awards or substitute similar stock awards for such outstanding Stock
      Awards, then with respect to Stock Awards that have been neither assumed nor substituted and that are held by Holders whose Continuous Service has not terminated prior to the effective time of the Corporate Transaction, the vesting of such Stock
      Awards (and, if applicable, the time at which such Stock Awards may be exercised) shall (contingent upon the effectiveness of the Corporate Transaction) be accelerated in full to a date prior to the effective time of such Corporate Transaction as the
      Board shall determine (or, if the Board shall not determine such a date, to the date that is 5 days prior to the effective time of the Corporate Transaction), and the Stock Awards shall terminate if not exercised at or prior to such effective time.
      With respect to Stock Awards outstanding under the Plan that have been neither assumed nor substituted and that are held by Holders whose Continuous Service has terminated prior to the effective time of the Corporate Transaction, the vesting of such
      Stock Awards (and, if applicable, the time at which such Stock Award may be exercised) shall not be accelerated unless otherwise provided in a written agreement between the Company or any Affiliate and the holder of such Stock Award, and such Stock
      Awards shall terminate if not exercised prior to the effective time of the Corporate Transaction.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Change in Control.</b> Notwithstanding any other provisions of the Plan to the contrary, if a Change in Control occurs and the Holder&#8217;s Continuous Service has not terminated prior to the effective date of such Change in
      Control, then the vesting and exercisability of the shares of Common Stock subject to the Holder&#8217;s Stock Awards shall be accelerated in full as of the effective date of the Change in Control. Following such Change in Control (other than a Change in
      Control resulting from a plan of complete dissolution or liquidation of the Company) and notwithstanding any other provision of the Plan to the contrary and provided that the Holder&#8217;s Continuous Service has not terminated prior to the effective date
      of the Change in Control, then the Holder&#8217;s Options shall expire on the earliest of (i) 12 months following the effective date of such Change in Control or (ii) the Expiration Date indicated in the Holder&#8217;s Grant Notice.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Parachute Payments.</b> If any payment or benefit the Holder would receive pursuant to a Change in Control from the Company or otherwise (&#8220;Payment&#8221;) would (i) constitute a &#8220;parachute payment&#8221; within the meaning of Section 280G
      of the Code, and (ii) but for this sentence, be subject to the excise tax imposed by Section 4999 of the Code (the &#8220;Excise Tax&#8221;), then such Payment shall be reduced to the Reduced Amount. The &#8220;Reduced Amount&#8221; shall be either (x) the largest portion
      of the Payment that would result in no portion of the Payment being subject to the Excise Tax or (y) the largest portion, up to and including the total, of the Payment, whichever amount, after taking into account all applicable federal, state and
      local employment taxes, income taxes, and the Excise Tax (all computed at the highest applicable marginal rate), results in the Holder&#8217;s receipt, on an after-tax basis, of the greater amount of the Payment notwithstanding that all or some portion of
      the Payment may be subject to the Excise Tax. If a reduction in a Payment is required pursuant to the preceding sentence and the Reduced Amount is determined pursuant to clause (x) of the preceding sentence, the reduction shall occur in the manner
      (the &#8220;<b><i>Reduction Method</i></b>&#8221;) that results in the greatest economic benefit for Holder. If more than one method of reduction will result in the same economic benefit, the items so reduced will be reduced pro rata (the &#8220;<b><i>Pro Rata
          Reduction Method</i></b>&#8221;). Notwithstanding the foregoing, if the Reduction Method or the Pro Rata Reduction Method would result in any portion of the Payment being subject to taxes pursuant to Section 409A of the Code that would not otherwise be
      subject to taxes pursuant to Section 409A of the Code, then the Reduction Method and/or the Pro Rata Reduction Method, as the case may be, shall be modified so as to avoid the imposition of taxes pursuant to Section 409A of the Code as follows: (A)
      as a first priority, the modification shall preserve to the greatest extent possible, the greatest economic benefit for Holder as determined on an after-tax basis; (B) as a second priority, Payments that are contingent on future events (e.g., being
      terminated without cause), shall be reduced (or eliminated) before Payments that are not contingent on future events; and (C) as a third priority, Payments that are &#8220;deferred compensation&#8221; within the meaning of Section 409A of the Code shall be
      reduced (or eliminated) before Payments that are not deferred compensation within the meaning of Section 409A of the Code.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The accounting firm engaged by the Company for general audit purposes as of
      the day prior to the effective date of the Change in Control shall perform the foregoing calculations. If the accounting firm so engaged by the Company is serving as accountant or auditor for the individual, entity or group effecting the Change in
      Control, the Company shall appoint a nationally recognized accounting firm to make the determinations required hereunder. The Company shall bear all expenses with respect to the determinations by such accounting firm required to be made hereunder.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></p>
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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The accounting firm engaged to make the determinations hereunder shall
      provide its calculations, together with detailed supporting documentation, to the Holder and the Company within 15 calendar days after the date on which the Holder&#8217;s right to a Payment is triggered (if requested at that time by the Holder or the
      Company) or such other time as requested by the Holder or the Company. If the accounting firm determines that no Excise Tax is payable with respect to a Payment, either before or after the application of the Reduced Amount, it shall furnish the
      Company and the Holder with an opinion reasonably acceptable to the Holder that no Excise Tax will be imposed with respect to such Payment. Any good faith determinations of the accounting firm made hereunder shall be final, binding and conclusive
      upon the Holder and the Company.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">13.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Amendment of the Plan and Stock Awards.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Amendment of Plan.</b> The Board at any time, and from time to time, may amend the Plan. However, except as provided in Section 12(a) relating to Capitalization Adjustments, no amendment shall be effective unless approved by
      the stockholders of the Company to the extent stockholder approval is necessary to satisfy the requirements of Rule 16b-3 or any Nasdaq or securities exchange listing requirements.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Stockholder Approval.</b> The Board, in its sole discretion, may submit any other amendment to the Plan for stockholder approval.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>No Impairment of Rights.</b> Rights under any Stock Award granted before amendment of the Plan shall not be impaired by any amendment of the Plan unless (i) the Company requests the consent of the Holder and (ii) the Holder
      consents in writing.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Amendment of Stock Awards.</b> The Board at any time, and from time to time, may amend the terms of any one or more Stock Awards; <i>provided, however</i>, that the rights under any Stock Award shall not be impaired by any
      such amendment unless (i) the Company requests the consent of the Holder and (ii) the Holder consents in writing.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Prohibition on Reduction of Exercise Prices, Cancellation and Re-Grant of Stock Awards.</b> Neither the Board nor any Committee (or subcommittee) shall have the authority to: (i) reduce the exercise price of any outstanding
      Options under the Plan, or (ii) cancel any outstanding Options that have an exercise price or strike price greater than the current Fair Market Value of the Common Stock in exchange for cash or other Stock Awards under the Plan, unless the
      stockholders of the Company have approved such an action within 12 months prior to such an event. Notwithstanding the foregoing, this paragraph will not be construed to apply to &#8220;issuing or assuming a stock option in a transaction to which section
      424(a) applies,&#8221; within the meaning of Section 424 of the Code.&#8221;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">14.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Termination or Suspension of the Plan.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>Plan Term</b>. The Board may suspend or terminate the Plan at any time. Unless sooner terminated, the Plan shall terminate on June 1, 2030. No Stock Awards may be granted under the Plan while the Plan is suspended or after it
      is terminated.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </b></span></p>
  <p style="margin: -12pt 0px 0pt; line-height: normal; font-family: 'Times New Roman',Times,serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; text-align: left; text-indent: 86pt;"><span style="font-family: Times New Roman,Times,serif;"><b>No Impairment of Rights.</b> Suspension or termination of the Plan shall not impair rights and obligations under any Stock Award granted while the Plan is in effect except with the written consent of the Holder.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">15.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Effective Date of Plan.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The Plan shall become effective as determined by the Board, but no Stock
      Award shall be exercised unless and until the Plan has been approved by the stockholders of the Company, which approval shall be within 12 months before or after the date the Plan is adopted by the Board.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 41.8pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; font-variant: normal;">16.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Choice of Law.</span></p>
  <p style="font: small-caps bold 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The law of the State of California shall govern all questions concerning
      the construction, validity and interpretation of this Plan without regard to such state&#8217;s conflict of laws rules.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></p>
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    <div style="text-align: center;"><span style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; font-weight: normal; color: rgb(229, 114, 0); font-style: normal;">B-10</span>&#160;</div>

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  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"><span style="font: 10pt Times New Roman,Times,serif;"><b><span style="text-decoration: underline;">Appendix C</span></b></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Reconciliation of GAAP to Non-GAAP Basis</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">As illustrated in the table below, non-GAAP operating expenses, non-GAAP
      income (loss) from operations, and non-GAAP net income (loss) were adjusted from GAAP to exclude compensation expense related to equity awards and the related tax effects. Compensation expense related to equity awards are non-cash. In 2022 our
      non-GAAP net loss excluded the gain on property related to the sale and leaseback transaction and the related tax effect. In 2021 all non-GAAP amounts also excluded expenses related to the Akcea Merger and restructured commercial operations. Expenses
      related to the Akcea Merger and restructured commercial operations included: severance costs, retention costs and other costs related to commercial operations. We have regularly reported non-GAAP measures for operating results as non-GAAP results.
      These measures are provided as supplementary information and are not a substitute for financial measures calculated in accordance with GAAP. We report these non-GAAP results to better enable financial statement users to assess and compare its
      historical performance and project its future operating results and cash flows. Further, the presentation of our non-GAAP results is consistent with how our management internally evaluates the performance of its operations.</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.5in; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>IONIS PHARMACEUTICALS, INC.</b></span>&#160;</p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Reconciliation of GAAP to Non-GAAP Basis:</b>&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"><span style="font: 10pt Times New Roman,Times,serif;"><span style="font: 10pt Times New Roman,Times,serif;"><b>Condensed Consolidated Operating Expenses, Income
          (Loss) From Operations, and Net Income (Loss)</b></span></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"><span style="font: 10pt Times New Roman,Times,serif;"><span style="font: 10pt Times New Roman,Times,serif;"><b><span style="font: 10pt Times New Roman,Times,serif;"><b>(In























              Millions)</b></span></b></span></span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
  <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-indent: 0px; text-align: left;"><span style="font: 10pt Times New Roman,Times,serif;">&#160;</span></p>
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="vertical-align: bottom">

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center;" colspan="3"><span style="font-size: 10pt;">Three months ended</span><br />
          <span style="font-size: 10pt;">December 31,</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: center;">&#160;</td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: center;" colspan="3"><span style="font-size: 10pt;">Year ended</span><br />
          <span style="font-size: 10pt;">December 31,</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; width: 60%; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: top; width: 2%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; width: 8%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center;"><span style="font-size: 10pt;">2022</span></td>

    <td style="vertical-align: bottom; width: 2%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center;">&#160;</td>

    <td style="vertical-align: bottom; width: 8%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center;"><span style="font-size: 10pt;">2021</span></td>

    <td style="vertical-align: bottom; width: 2%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-left: 5.4pt; text-align: center;">&#160;</td>

    <td style="vertical-align: bottom; width: 8%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-left: 5.4pt; text-align: center;"><span style="font-size: 10pt;">2022</span></td>

    <td style="vertical-align: bottom; width: 2%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-left: 5.4pt; text-align: center;">&#160;</td>

    <td style="vertical-align: bottom; width: 8%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-left: 5.4pt; text-align: center;"><span style="font-size: 10pt;">2021</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: center;" colspan="7"><span style="font-size: 10pt;">(unaudited)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;"><span style="font-size: 10pt;"><b>As reported research,
              development and patent expenses according to GAAP</b></span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$308</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$179</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$833</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$643</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;"><span style="font-size: 10pt;">Excluding compensation
            expense related to equity awards&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(19)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(16)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(74)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(88)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;">Excluding Akcea Merger and restructured commercial operation
          costs*&#160;&#160;&#160;&#160;&#160;&#160;&#160;</td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(1)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(9)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;"><span style="font-size: 10pt;"><b>Non-GAAP research,
              development and patent expenses</b></span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$289</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$162</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$759</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$546</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
          <p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px 0pt 0.25in; text-indent: -0.25in; text-align: left;"><b>As reported selling, general and administrative expenses according to GAAP&#160;</b></p>
        </td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$48</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$38</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$151</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$186</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;">Excluding compensation expense related to equity
          awards&#160;&#160;&#160;&#160;&#160;&#160;&#160;</td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(7)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(7)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(26)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(33)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;"><span style="font-size: 10pt;">Excluding Akcea Merger and
            restructured commercial operation costs*&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">1</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(15)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;"><span style="font-size: 10pt;"><b>Non-GAAP selling, general
              and administrative expenses</b></span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$41</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$32</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$125</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$138</span></td>

  </tr>

  <tr>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt"></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;"><span style="font-size: 10pt;"><b>As reported operating
              expenses according to GAAP</b></span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$360</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$219</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$998</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$840</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;"><span style="font-size: 10pt;">Excluding compensation
            expense related to equity awards&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(25)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(23)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(100)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(121)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;"><span style="font-size: 10pt;">Excluding Akcea merger and
            restructured commercial operation costs*&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;"><b>-</b></span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(24)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;"><span style="font-size: 10pt;"><b>Non-GAAP operating expenses</b></span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$335</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$196</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$898</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$695</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt"></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;"><span style="font-size: 10pt;"><b>As reported income (loss)
              from operations according to GAAP</b></span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">($208)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$221</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">($411)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">($30)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;">Excluding compensation expense related to equity
          awards&#160;&#160;&#160;&#160;&#160;&#160;&#160;</td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(25)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(23)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(100)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(121)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;">Excluding Akcea Merger and restructured commercial operation
          costs*&#160;&#160;&#160;&#160;&#160;&#160;&#160;</td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(24)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;"><span style="font-size: 10pt;"><b>Non-GAAP income (loss) from
              operations</b></span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">($183)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$244</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">($311)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$115</span></td>

  </tr>

  <tr>

    <td style="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt"></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;">&#160;</td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left;"><span style="font-size: 10pt;"><b>As reported net income
              (loss) according to GAAP</b></span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">($52)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">$225</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">($270)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">($29)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;">Excluding compensation expense related to equity
          awards&#160;&#160;&#160;&#160;&#160;&#160;&#160;</td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(25)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(23)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(100)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(121)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;">Excluding Akcea Merger and restructured commercial operation
          costs*&#160;&#160;&#160;&#160;&#160;&#160;&#160;</td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(24)</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;">Excluding gain on sale of real estate assets**</td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">150</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">150</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

  </tr>

  <tr>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 0.25in; text-align: left;">Excluding income tax effect related to gain on sale of real
          estate assets</td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: left;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(9)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">(9)</span></td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-left: 5.4pt; text-align: right;">&#160;</td>

    <td style="vertical-align: bottom; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: right;"><span style="font-size: 10pt;">-</span></td>

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<DOCUMENT>
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<span style="display: none;">v3.23.1</span><table class="report" border="0" cellspacing="2" id="idm140707604898832">
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<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Document and Entity Information<br></strong></div></th>
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<td class="text">&#160;<span></span>
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<td class="text">Ionis Pharmaceuticals, Inc.<span></span>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
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<span style="display: none;">v3.23.1</span><table class="report" border="0" cellspacing="2" id="idm140707596947360">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Pay vs Performance Disclosure<br></strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th">
<div>Dec. 31, 2022 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Dec. 31, 2021 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Dec. 31, 2020 </div>
<div>USD ($)</div>
</th>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTableTextBlock', window );">Pay vs Performance [Table Text Block]</a></td>
<td class="text"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><b>Pay Versus Performance</b></span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Pay Versus Performance Table </i></span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">As required by Section 953(a) of the Dodd-Frank Wall Street Reform and
      Consumer Protection Act, and Item 402(v) of Regulation S-K (&#8220;<b><i>Item 402(v)</i></b>&#8221;), we are providing the following information about the relationship between executive compensation actually paid and certain financial performance of the Company.
      The amounts set forth below under the headings &#8220;Compensation Actually Paid to PEO&#8221; and &#8220;Average Compensation Actually Paid to non-PEO NEOs&#8221; have been calculated in a manner consistent with Item 402(v). Use of the term &#8220;compensation actually paid&#8221; is
      required by the SEC&#8217;s rules and as a result of the calculation methodology required by the SEC, such amounts differ from compensation actually received by the individuals and the compensation decisions described in the CD&amp;A section of this Proxy
      Statement. For further information concerning the Company&#8217;s pay-for-performance philosophy and how the Company aligns executive compensation with the Company&#8217;s performance, refer to the CD&amp;A section of this Proxy Statement.</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; background-color: white; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td rowspan="2" style="vertical-align: bottom; border: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year</b></span></td>

    <td rowspan="2" style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Summary Compensation Table Total for PEO<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></b></span></td>

    <td rowspan="2" style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Compensation Actually Paid to PEO<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></b></span></td>

    <td rowspan="2" style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Average Summary Compensation Table Total for Non-PEO NEOs<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></b></span></td>

    <td rowspan="2" style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Average Compensation Actually Paid to Non-PEO NEOs<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></b></span></td>

    <td colspan="2" style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Value of Initial Fixed $100 Investment Based On:</b></span></td>

    <td rowspan="2" style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Net Income (Loss)<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(7)</sup></b></span></td>

    <td rowspan="2" style="border-bottom: 1pt solid #000000; border-right: 1pt solid #000000; border-top: 1pt solid #000000; vertical-align: bottom; padding: 0px 5.25pt 0px 1.75pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b><span style="text-indent: 0pt;">One-Year Relative Total Shareholder Return</span><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(8)</sup></b></span></td>

  </tr>

  <tr style="vertical-align: bottom; background-color: #A20067">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Total





















              Shareholder Return<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(5)</sup></b></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Peer





















              Group Total Shareholder Return<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(6)</sup></b></span></td>

  </tr>

  <tr>

    <td style="width: 5%; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">7,299,077</span></span></td>

    <td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">5,033,980</span></span></td>

    <td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">2,803,964</span></span></td>

    <td style="width: 12%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">2,735,368</span></span></td>

    <td style="width: 10%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">62.52</span></span></td>

    <td style="width: 10%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">113.65</span></span></td>

    <td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">269,722,000</span>)</span></td>

    <td style="vertical-align: top; width: 19%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 1.75pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;<span style="text-indent: 0pt;">81</span><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st </sup>percentile</span></td>

  </tr>

  <tr style="background-color: #E7E6E6">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">13,305,673</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">3,095,776</span>)</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">3,834,223</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">713,811</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">50.37</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">126.45</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">28,597,000</span>)</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 1.75pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;<span style="text-indent: 0pt;">41</span><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st </sup>percentile</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">10,963,040</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">3,439,140</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">5,450,933</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">1,822,613</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">93.59</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">126.42</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">479,743,000</span>)</span></td>

    <td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 1.75pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;<span style="text-indent: 0pt;">35</span><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th </sup>percentile</span></td>

  </tr>


</table>
<p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(1)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts reported are the amounts of total compensation reported for Dr. Monia (our Chief Executive Officer) for each corresponding year in the &#8220;Total&#8221; column of the Summary Compensation Table on page 76 of this Proxy Statement.</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(2)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts represent the amount of compensation actually paid to Dr. Monia, as computed in accordance with Item 402(v). The dollar
            amounts do not reflect the actual amount of compensation earned by or paid to Dr. Monia during the applicable year. In accordance with the requirements of Item 402(v), the following adjustments were made to Dr. Monia&#8217;s total compensation for
            each year to determine the compensation actually paid:</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 94%; border-collapse: collapse; margin-left: auto; margin-right: auto;">


  <tr style="background-color: #A20067">

    <td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year</b></span></td>

    <td style="width: 21%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Reported Summary Compensation Table Total for PEO</b></span></td>

    <td style="width: 16%; border-top: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Deduct: Reported Value
              of Equity Awards<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(a)</sup></b></span></td>

    <td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Add: Equity Award Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(b)</sup></b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Add: Reported Change in the Actuarial Present Value of Pension Benefits<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(c)</sup></b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Add: Pension Benefit
              Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(c)</sup></b></span></td>

    <td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Compensation Actually Paid to PEO</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">7,299,077</span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">5,586,119</span>)</span></td>

    <td style="white-space: nowrap; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">3,321,022</span> </span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-top: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">5,033,980</span></span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">13,305,673</span></span></td>

    <td style="white-space: nowrap; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">11,986,030</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">4,415,419</span>)</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">3,095,776</span>)</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">10,963,040</span></span></td>

    <td style="white-space: nowrap; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">9,620,555</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">2,096,655</span> </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">3,439,140</span></span></td>

  </tr>


</table>
<p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(a)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The grant date fair value of equity awards represents the total of the amounts reported in the &#8220;Stock Awards&#8221; and &#8220;Option Awards&#8221; columns in the
            Summary Compensation Table for the applicable year.</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(b)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The equity award adjustments for each applicable year include the addition (or subtraction, as applicable) of the following: (i) the year-end
            fair value of any equity awards granted in the applicable year that are outstanding and unvested as of the end of the year; (ii) the amount of change as of the end of the applicable year (from the end of the prior fiscal year) in fair value of
            any awards granted in prior years that are outstanding and unvested as of the end of the applicable year; (iii) for awards that are granted and vest in the same applicable year, the fair value as of the vesting date; (iv) for awards granted in
            prior years that vest in the applicable year, the amount equal to the change as of the vesting date (from the end of the prior fiscal year) in fair value; (v) for awards granted in prior years that are determined to fail to meet the applicable
            vesting conditions during the applicable year, a deduction for the amount equal to the fair value at the end of the prior fiscal year; and (vi) the dollar value of any dividends or other earnings paid on stock or option awards in the applicable
            year prior to the vesting date that are not otherwise reflected in the fair value of such award or included in any other component of total compensation for the applicable year. The amounts deducted or added in calculating the equity award
            adjustments are as follows:</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="width: 5%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year</b></span></td>

    <td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year End Fair Value of Equity Awards</b></span></td>

    <td style="width: 14%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards </b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(i)</sup></b></span></td>

    <td style="width: 14%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year</b></span></td>

    <td style="width: 19%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year</b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Value of Dividends or other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(ii)</sup></b></span></td>

    <td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Total Equity Award Adjustments</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">5,731,326</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">2,549,358</span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">326,316</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">187,261</span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">3,321,022</span> </span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">4,655,272</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">8,289,894</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">716,002</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">64,795</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">4,415,419</span>)</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">7,071,074</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">4,319,642</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">654,778</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">2,096,655</span> </span></td>

  </tr>


</table>
<p style="margin-top: 0; margin-bottom: 0"/><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p><p style="margin-top: 0; margin-bottom: 0"/>
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    <td style="width: 0.75in"/>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(i)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not grant any equity awards that vest in the same year as grant.</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.75in"/>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(ii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not pay dividends or other earnings on stock or option awards.</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


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    <td style="width: 0.5in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(c)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not provide pension benefits to any employees of the Company.</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


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    <td style="width: 0.25in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(3)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts reported represent the average of the amounts reported for the Company&#8217;s NEOs as a group (excluding Dr. Monia) in the &#8220;Total&#8221;
            column of the Summary Compensation Table of the Proxy Statement for each applicable year. The names of each of the NEOs (excluding Dr. Monia) included for purposes of calculating the average amounts in each applicable year are as follows:</span></td>

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</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 54pt"/>

    <td style="width: 31.5pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(i)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For 2022, Elizabeth L. Hougen (EVP &amp; CFO), Joseph T. Baroldi (EVP, Chief Business Officer), Onaiza Cadoret-Manier (EVP, Chief Global Product
            Strategy and Operations Officer) and Richard S. Geary (EVP, Chief Development Officer);</span></td>

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</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


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    <td style="width: 54pt"/>

    <td style="width: 31.5pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(ii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For 2021, Elizabeth L. Hougen (EVP &amp; CFO), Patrick R. O&#8217;Neil (EVP, Chief Legal Officer and General Counsel), Onaiza Cadoret-Manier (EVP,
            Chief Global Product Strategy and Operations Officer) and Eric E. Swayze (EVP, Research; and</span></td>

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</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


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    <td style="width: 54pt"/>

    <td style="width: 31.5pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(iii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For 2020, Elizabeth L. Hougen (EVP &amp; CFO), Stanley Crooke (Executive Chairman of the Board), Richard S. Geary (EVP, Chief Development
            Officer) and Patrick R. O&#8217;Neil (EVP, Legal and General Counsel).</span></td>

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</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


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    <td style="width: 0.25in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(4)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts reported represent the average amount of compensation actually paid to the NEOs as a group (excluding Dr. Monia), as computed
            in accordance with Item 402(v). The dollar amounts do not reflect the actual average amount of compensation earned by or paid to the NEOs as a group (excluding Dr. Monia) during the applicable year. In accordance with the requirements of Item
            402(v), the following adjustments were made to average total compensation for the NEOs as a group (excluding Dr. Monia) for each year to determine the compensation actually paid, using the same methodology described above in Note 2:</span></td>

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</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="width: 8%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year</b></span></td>

    <td style="width: 23%; border-top: 1pt solid Black; border-right: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Average Reported Summary Compensation
              Table Total for Non-PEO NEOs</b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Deduct: Average Reported Value of Equity Awards</b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Add:
              Average Award Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(a)</sup></b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Add: Average Reported Change in the
              Actuarial Present Value of Pension Benefits<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(b)</sup></b></span></td>

    <td style="width: 16%; border-top: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Add: Average Pension Benefit Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(b)</sup></b></span></td>

    <td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Average
              Compensation Actually Paid to Non-PEO NEOs</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2022</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">2,803,964</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">1,887,231</span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">1,818,634</span> </span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">2,735,368</span></span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2021</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">3,834,223</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">3,039,250</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">81,162</span>)</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">713,811</span></span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2020</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">5,450,933</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">4,484,784</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">856,465</span> </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">1,822,613</span></span></td>

  </tr>


</table>
<p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(a)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The amounts deducted or added in calculating the total average equity award adjustments are as follows:</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="width: 6%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year</b></span></td>

    <td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year End Fair Value of Equity Awards</b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards </b></span></td>

    <td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(i)</sup></b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year</b></span></td>

    <td style="width: 16%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year</b></span></td>

    <td style="width: 20%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Value of Dividends or other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(ii)</sup></b></span></td>

    <td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Total Equity Award Adjustments</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2022</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">1,962,339</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">164,642</span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">20,938</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">1,818,634</span> </span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2021</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">1,171,440</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">1,216,952</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">35,650</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(231, 230, 230); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(231, 230, 230); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">81,162</span>)</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2020</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">3,366,846</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">2,476,142</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ </span><span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">34,239</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$
          </span><span style="text-indent: 0pt;">-</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$
            <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">856,465</span> </span></td>

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<p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
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    <td style="width: 0.75in"/>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(i)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not grant any equity awards that vest in the same year as grant.</span></td>

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</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(ii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not pay dividends or other earnings on stock or option awards.</span></td>

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</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(b)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not provide pension benefits to any employees of the Company.</span></td>

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    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(5)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Cumulative TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend
            reinvestment, and the difference between the Company&#8217;s stock price at the end and the beginning of the measurement period by the Company&#8217;s stock price at the beginning of the measurement period.</span></td>

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    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(6)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Represents the weighted peer group TSR, weighted according to the respective companies&#8217; stock market capitalization at the beginning of each
            period for which a return is indicated. The peer group used for this purpose is the Nasdaq Biotechnology Index.</span></td>

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<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(7)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts reported represent the amount of net income (loss) reflected in the Company&#8217;s audited financial statements for the applicable
            year.</span></td>

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<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(8)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">One-year relative TSR shown is the percentile rank of the Company&#8217;s TSR as compared to the TSRs of all members of the Nasdaq Biotechnology Index,
            ranked in descending order, for the one-year period commencing on January 15<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> of the applicable year and ending January 15<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> of the following year, which time period is consistent with the one-year measurement period used in the PRSUs awarded in 2020-2022.</span></td>

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<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
</td>
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<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_CoSelectedMeasureName', window );">Company Selected Measure Name</a></td>
<td class="text">One-Year Relative Total Shareholder Return<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_NamedExecutiveOfficersFnTextBlock', window );">Named Executive Officers, Footnote [Text Block]</a></td>
<td class="text">
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    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(3)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts reported represent the average of the amounts reported for the Company&#8217;s NEOs as a group (excluding Dr. Monia) in the &#8220;Total&#8221;
            column of the Summary Compensation Table of the Proxy Statement for each applicable year. The names of each of the NEOs (excluding Dr. Monia) included for purposes of calculating the average amounts in each applicable year are as follows:</span></td>

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<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
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    <td style="width: 31.5pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(i)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For 2022, Elizabeth L. Hougen (EVP &amp; CFO), Joseph T. Baroldi (EVP, Chief Business Officer), Onaiza Cadoret-Manier (EVP, Chief Global Product
            Strategy and Operations Officer) and Richard S. Geary (EVP, Chief Development Officer);</span></td>

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    <td style="width: 54pt"/>

    <td style="width: 31.5pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(ii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For 2021, Elizabeth L. Hougen (EVP &amp; CFO), Patrick R. O&#8217;Neil (EVP, Chief Legal Officer and General Counsel), Onaiza Cadoret-Manier (EVP,
            Chief Global Product Strategy and Operations Officer) and Eric E. Swayze (EVP, Research; and</span></td>

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    <td style="width: 54pt"/>

    <td style="width: 31.5pt; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(iii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">For 2020, Elizabeth L. Hougen (EVP &amp; CFO), Stanley Crooke (Executive Chairman of the Board), Richard S. Geary (EVP, Chief Development
            Officer) and Patrick R. O&#8217;Neil (EVP, Legal and General Counsel).</span></td>

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</table>
<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PeerGroupIssuersFnTextBlock', window );">Peer Group Issuers, Footnote [Text Block]</a></td>
<td class="text">
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    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(6)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">Represents the weighted peer group TSR, weighted according to the respective companies&#8217; stock market capitalization at the beginning of each
            period for which a return is indicated. The peer group used for this purpose is the Nasdaq Biotechnology Index.</span></td>

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</table>
<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
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<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PeoTotalCompAmt', window );">PEO Total Compensation Amount</a></td>
<td class="nump">$ 7,299,077<span></span>
</td>
<td class="nump">$ 13,305,673<span></span>
</td>
<td class="nump">$ 10,963,040<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PeoActuallyPaidCompAmt', window );">PEO Actually Paid Compensation Amount</a></td>
<td class="nump">$ 5,033,980<span></span>
</td>
<td class="num">(3,095,776)<span></span>
</td>
<td class="nump">3,439,140<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToPeoCompFnTextBlock', window );">Adjustment To PEO Compensation, Footnote [Text Block]</a></td>
<td class="text">
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    <td style="width: 0.25in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(2)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts represent the amount of compensation actually paid to Dr. Monia, as computed in accordance with Item 402(v). The dollar
            amounts do not reflect the actual amount of compensation earned by or paid to Dr. Monia during the applicable year. In accordance with the requirements of Item 402(v), the following adjustments were made to Dr. Monia&#8217;s total compensation for
            each year to determine the compensation actually paid:</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 94%; border-collapse: collapse; margin-left: auto; margin-right: auto;">


  <tr style="background-color: #A20067">

    <td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year</b></span></td>

    <td style="width: 21%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Reported Summary Compensation Table Total for PEO</b></span></td>

    <td style="width: 16%; border-top: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Deduct: Reported Value
              of Equity Awards<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(a)</sup></b></span></td>

    <td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Add: Equity Award Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(b)</sup></b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Add: Reported Change in the Actuarial Present Value of Pension Benefits<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(c)</sup></b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Add: Pension Benefit
              Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(c)</sup></b></span></td>

    <td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Compensation Actually Paid to PEO</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">7,299,077</span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">5,586,119</span>)</span></td>

    <td style="white-space: nowrap; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">3,321,022</span> </span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-top: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">5,033,980</span></span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">13,305,673</span></span></td>

    <td style="white-space: nowrap; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">11,986,030</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">4,415,419</span>)</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">3,095,776</span>)</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">10,963,040</span></span></td>

    <td style="white-space: nowrap; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">9,620,555</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">2,096,655</span> </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">3,439,140</span></span></td>

  </tr>


</table>
<p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(a)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The grant date fair value of equity awards represents the total of the amounts reported in the &#8220;Stock Awards&#8221; and &#8220;Option Awards&#8221; columns in the
            Summary Compensation Table for the applicable year.</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(b)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The equity award adjustments for each applicable year include the addition (or subtraction, as applicable) of the following: (i) the year-end
            fair value of any equity awards granted in the applicable year that are outstanding and unvested as of the end of the year; (ii) the amount of change as of the end of the applicable year (from the end of the prior fiscal year) in fair value of
            any awards granted in prior years that are outstanding and unvested as of the end of the applicable year; (iii) for awards that are granted and vest in the same applicable year, the fair value as of the vesting date; (iv) for awards granted in
            prior years that vest in the applicable year, the amount equal to the change as of the vesting date (from the end of the prior fiscal year) in fair value; (v) for awards granted in prior years that are determined to fail to meet the applicable
            vesting conditions during the applicable year, a deduction for the amount equal to the fair value at the end of the prior fiscal year; and (vi) the dollar value of any dividends or other earnings paid on stock or option awards in the applicable
            year prior to the vesting date that are not otherwise reflected in the fair value of such award or included in any other component of total compensation for the applicable year. The amounts deducted or added in calculating the equity award
            adjustments are as follows:</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="width: 5%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year</b></span></td>

    <td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year End Fair Value of Equity Awards</b></span></td>

    <td style="width: 14%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards </b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(i)</sup></b></span></td>

    <td style="width: 14%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year</b></span></td>

    <td style="width: 19%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year</b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Value of Dividends or other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(ii)</sup></b></span></td>

    <td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Total Equity Award Adjustments</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2022</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">5,731,326</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">2,549,358</span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">326,316</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">187,261</span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">3,321,022</span> </span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2021</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">4,655,272</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">8,289,894</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">716,002</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">64,795</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">4,415,419</span>)</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">2020</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">7,071,074</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">4,319,642</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">($<span style="text-indent: 0pt;">654,778</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$ <span style="text-indent: 0pt;">-</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">$<span style="text-indent: 0pt;">2,096,655</span> </span></td>

  </tr>


</table>
<p style="margin-top: 0; margin-bottom: 0"/><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p><p style="margin-top: 0; margin-bottom: 0"/>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.75in"/>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(i)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not grant any equity awards that vest in the same year as grant.</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.75in"/>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(ii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not pay dividends or other earnings on stock or option awards.</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(c)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not provide pension benefits to any employees of the Company.</span></td>

  </tr>


</table>
<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_NonPeoNeoAvgTotalCompAmt', window );">Non-PEO NEO Average Total Compensation Amount</a></td>
<td class="nump">$ 2,803,964<span></span>
</td>
<td class="nump">3,834,223<span></span>
</td>
<td class="nump">5,450,933<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_NonPeoNeoAvgCompActuallyPaidAmt', window );">Non-PEO NEO Average Compensation Actually Paid Amount</a></td>
<td class="nump">$ 2,735,368<span></span>
</td>
<td class="nump">713,811<span></span>
</td>
<td class="nump">1,822,613<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToNonPeoNeoCompFnTextBlock', window );">Adjustment to Non-PEO NEO Compensation Footnote [Text Block]</a></td>
<td class="text"><p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.25in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(4)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The dollar amounts reported represent the average amount of compensation actually paid to the NEOs as a group (excluding Dr. Monia), as computed
            in accordance with Item 402(v). The dollar amounts do not reflect the actual average amount of compensation earned by or paid to the NEOs as a group (excluding Dr. Monia) during the applicable year. In accordance with the requirements of Item
            402(v), the following adjustments were made to average total compensation for the NEOs as a group (excluding Dr. Monia) for each year to determine the compensation actually paid, using the same methodology described above in Note 2:</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="width: 8%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year</b></span></td>

    <td style="width: 23%; border-top: 1pt solid Black; border-right: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Average Reported Summary Compensation
              Table Total for Non-PEO NEOs</b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Deduct: Average Reported Value of Equity Awards</b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Add:
              Average Award Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(a)</sup></b></span></td>

    <td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Add: Average Reported Change in the
              Actuarial Present Value of Pension Benefits<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(b)</sup></b></span></td>

    <td style="width: 16%; border-top: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Add: Average Pension Benefit Adjustments<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(b)</sup></b></span></td>

    <td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Average
              Compensation Actually Paid to Non-PEO NEOs</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2022</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">2,803,964</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">1,887,231</span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">1,818,634</span> </span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">2,735,368</span></span></td>

  </tr>

  <tr style="background-color: #D9D9D9">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2021</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">3,834,223</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">3,039,250</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">81,162</span>)</span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">713,811</span></span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2020</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">5,450,933</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">4,484,784</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">856,465</span> </span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">1,822,613</span></span></td>

  </tr>


</table>
<p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(a)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The amounts deducted or added in calculating the total average equity award adjustments are as follows:</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">


  <tr style="background-color: #A20067">

    <td style="width: 6%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year</b></span></td>

    <td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year End Fair Value of Equity Awards</b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards </b></span></td>

    <td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(i)</sup></b></span></td>

    <td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year</b></span></td>

    <td style="width: 16%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year</b></span></td>

    <td style="width: 20%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Value of Dividends or other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(ii)</sup></b></span></td>

    <td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"><b>Total Equity Award Adjustments</b></span></td>

  </tr>

  <tr>

    <td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2022</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">1,962,339</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">164,642</span>)</span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">20,938</span> </span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">1,818,634</span> </span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2021</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">1,171,440</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">1,216,952</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">35,650</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(231, 230, 230); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(231, 230, 230); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">81,162</span>)</span></td>

  </tr>

  <tr>

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">2020</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">3,366,846</span> </span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">2,476,142</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$ </span><span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">($<span style="text-indent: 0pt;">34,239</span>)</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$
          </span><span style="text-indent: 0pt;">-</span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$
            <span style="text-indent: 0pt;">-</span></span></td>

    <td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 9pt;">$<span style="text-indent: 0pt;">856,465</span> </span></td>

  </tr>


</table>
<p style="margin-top: 0px; margin-bottom: 0px; text-align: left;">&#160;</p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.75in"/>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(i)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not grant any equity awards that vest in the same year as grant.</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.75in"/>

    <td style="width: 0.5in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(ii)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not pay dividends or other earnings on stock or option awards.</span></td>

  </tr>


</table>
<p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p>
<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;">


  <tr style="vertical-align: top">

    <td style="width: 0.5in"/>

    <td style="width: 0.25in; text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">(b)</span></td>

    <td style="text-align: left;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">We do not provide pension benefits to any employees of the Company.</span></td>

  </tr>


</table>
<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_CompActuallyPaidVsTotalShareholderRtnTextBlock', window );">Compensation Actually Paid vs. Total Shareholder Return [Text Block]</a></td>
<td class="text"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Analysis of the Information Presented in the
        Pay Versus Performance Table</i></span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">While the Company utilizes several performance
      measures to align executive compensation with Company performance, all of those Company measures are not presented in the Pay Versus Performance Table (&#8220;<b><i>PVP Table</i></b>&#8221;). Moreover, the Company generally seeks to incentivize long-term
      performance, and therefore does not specifically align the Company&#8217;s performance measures with compensation that is actually paid (as computed in accordance with Item 402(v)) for a particular year. In accordance with Item 402(v), the Company is
      providing the descriptions and graphs below regarding the relationships between certain information presented in the PVP Table.</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">Compensation Actually Paid and Cumulative
          TSR</span></i></span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">As demonstrated by the following graph, the amount
      of compensation actually paid to Dr. Monia and the average amount of compensation actually paid to the Company&#8217;s NEOs as a group (excluding Dr. Monia) is aligned with the Company&#8217;s cumulative TSR over the three years presented in the table.</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Sans-Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: Red"><img alt="" src="ny20007094x2_def14aimg013.jpg"/></p><p style="font: 10pt sans-serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: Red;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_CompActuallyPaidVsNetIncomeTextBlock', window );">Compensation Actually Paid vs. Net Income [Text Block]</a></td>
<td class="text"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Analysis of the Information Presented in the
        Pay Versus Performance Table</i></span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">While the Company utilizes several performance
      measures to align executive compensation with Company performance, all of those Company measures are not presented in the Pay Versus Performance Table (&#8220;<b><i>PVP Table</i></b>&#8221;). Moreover, the Company generally seeks to incentivize long-term
      performance, and therefore does not specifically align the Company&#8217;s performance measures with compensation that is actually paid (as computed in accordance with Item 402(v)) for a particular year. In accordance with Item 402(v), the Company is
      providing the descriptions and graphs below regarding the relationships between certain information presented in the PVP Table.</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">Compensation Actually Paid and Net Income</span></i></span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The graph below shows the amount of compensation
      actually paid to Dr. Monia and the average amount of compensation actually paid to the Company&#8217;s NEOs as a group (excluding Dr. Monia) and the Company&#8217;s net income over the three years presented in the table. As noted above, the Company does not use
      compensation actually paid to set executive compensation.</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Sans-Serif; margin: 0pt 0; text-align: center; text-indent: 13.5pt; color: Red"><img alt="" src="ny20007094x2_def14aimg015.jpg" style="height: 316px; width: 561px"/></p>
<div><br/></div>
<p style="font: 10pt Sans-Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: Red"/><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;">&#160;</p><span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_CompActuallyPaidVsCoSelectedMeasureTextBlock', window );">Compensation Actually Paid vs. Company Selected Measure [Text Block]</a></td>
<td class="text"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Analysis of the Information Presented in the
        Pay Versus Performance Table</i></span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">While the Company utilizes several performance
      measures to align executive compensation with Company performance, all of those Company measures are not presented in the Pay Versus Performance Table (&#8220;<b><i>PVP Table</i></b>&#8221;). Moreover, the Company generally seeks to incentivize long-term
      performance, and therefore does not specifically align the Company&#8217;s performance measures with compensation that is actually paid (as computed in accordance with Item 402(v)) for a particular year. In accordance with Item 402(v), the Company is
      providing the descriptions and graphs below regarding the relationships between certain information presented in the PVP Table.</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">Compensation Actually Paid and Relative
          Total Shareholder Return</span></i></span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The graph below shows the amount of compensation
      actually paid to Dr. Monia and the average amount of compensation actually paid to the Company&#8217;s NEOs as a group (excluding Dr. Monia) and the Company&#8217;s one-year relative total shareholder return shown as a percentile rank of the Company&#8217;s TSR as
      compared to the TSRs of all members of the Nasdaq Biotechnology Index for each of the three years presented in the table. <br/>
    </span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"> <br/>
  </p><p style="font: 10pt Sans-Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: Red"><img alt="" height="322" src="ny20007094x2_def14aimg016.jpg" width="561"/></p><p style="font: 10pt sans-serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: Red;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_TotalShareholderRtnVsPeerGroupTextBlock', window );">Total Shareholder Return Vs Peer Group [Text Block]</a></td>
<td class="text"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Analysis of the Information Presented in the
        Pay Versus Performance Table</i></span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">While the Company utilizes several performance
      measures to align executive compensation with Company performance, all of those Company measures are not presented in the Pay Versus Performance Table (&#8220;<b><i>PVP Table</i></b>&#8221;). Moreover, the Company generally seeks to incentivize long-term
      performance, and therefore does not specifically align the Company&#8217;s performance measures with compensation that is actually paid (as computed in accordance with Item 402(v)) for a particular year. In accordance with Item 402(v), the Company is
      providing the descriptions and graphs below regarding the relationships between certain information presented in the PVP Table.</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i><span style="text-decoration: underline;">Cumulative TSR of the Company and Cumulative
          TSR of the NBI</span></i></span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">The graph below shows the Company&#8217;s cumulative TSR
      over the three-year period against the cumulative TSR of the peer group presented for this purpose, the Nasdaq Biotechnology Index.&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: center;"> <br/>
  </p><p style="font: 10pt Sans-Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: Red"><img alt="" height="263" src="ny20007094x2_def14aimg014.jpg" width="561"/></p><p style="font: 10pt sans-serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: Red;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_TabularListTableTextBlock', window );">Tabular List [Table Text Block]</a></td>
<td class="text"><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>Financial Performance Measures</i></span></p><p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(206, 15, 105);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">&#160;</span></p><p style="font: 10pt Times New Roman,Times,serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;">As
        described in greater detail in the CD&amp;A, we design our executive compensation program to drive the creation of long-term stockholder value and mitigate unnecessary or imprudent business risk taking. To that end, we structure our executive
        compensation program to align executive compensation with Company performance. The most important financial performance measures used by the Company in fiscal year 2022 to link executive compensation actually paid to the Company&#8217;s NEOs to the
        Company&#8217;s performance are listed in the table to the right.</span></p><p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 199.5pt 0pt 0; text-align: justify; text-indent: 0.5in; color: #231F20"/>
<table cellpadding="0" cellspacing="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">


  <tr style="vertical-align: top; background-color: #A20067">

    <td style="width: 100%; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"><b>Most Important Financial
                Performance Measures</b></span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; padding-bottom: 8pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);"><span style="text-indent: 0pt;">Revenue</span></span></td>

  </tr>

  <tr style="vertical-align: top; background-color: #E7E6E6">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; padding-bottom: 8pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);"><span style="text-indent: 0pt;">Relative TSR Versus the NBI</span></span></td>

  </tr>

  <tr style="vertical-align: top">

    <td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; padding-bottom: 8pt;"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);"><span style="text-indent: 0pt;">Whether We Met Our Non-GAAP Net Operating Loss Guidance</span></span></td>

  </tr>


</table>
<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_TotalShareholderRtnAmt', window );">Total Shareholder Return Amount</a></td>
<td class="nump">$ 62.52<span></span>
</td>
<td class="nump">50.37<span></span>
</td>
<td class="nump">93.59<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PeerGroupTotalShareholderRtnAmt', window );">Peer Group Total Shareholder Return Amount</a></td>
<td class="nump">113.65<span></span>
</td>
<td class="nump">126.45<span></span>
</td>
<td class="nump">126.42<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_us-gaap_NetIncomeLoss', window );">Net Income (Loss)</a></td>
<td class="num">$ (269,722,000)<span></span>
</td>
<td class="num">$ (28,597,000)<span></span>
</td>
<td class="num">$ (479,743,000)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_CoSelectedMeasureAmt', window );">Company Selected Measure Amount</a></td>
<td class="nump">81<span></span>
</td>
<td class="nump">41<span></span>
</td>
<td class="nump">35<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PeoName', window );">PEO Name</a></td>
<td class="text">Dr. Monia<span></span>
</td>
<td class="text">Dr. Monia<span></span>
</td>
<td class="text">Dr. Monia<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_Additional402vDisclosureTextBlock', window );">Additional 402(v) Disclosure [Text Block]</a></td>
<td class="text">
<div>
<div style="clear: both;"><br/></div>


  <br/>
  </div>
<p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"><span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"><i>All information provided above under the &#8220;Item
        402(v) Pay Versus Performance&#8221; heading will not be deemed to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after
        the date hereof and irrespective of any general incorporation language in any such filing, except to the extent the Company specifically incorporates such information by reference.</i>&#160;</span></p><span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_MeasureAxis=1', window );">Measure [Axis]: 1</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_MeasureName', window );">Measure Name</a></td>
<td class="text">Revenue<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_MeasureAxis=2', window );">Measure [Axis]: 2</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_MeasureName', window );">Measure Name</a></td>
<td class="text">Relative TSR Versus the NBI<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_MeasureAxis=3', window );">Measure [Axis]: 3</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_MeasureName', window );">Measure Name</a></td>
<td class="text">Whether We Met Our Non-GAAP Net Operating Loss Guidance<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_PeoMember', window );">PEO [Member] | Reported Value of Equity Awards [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="num">$ (5,586,119)<span></span>
</td>
<td class="num">$ (11,986,030)<span></span>
</td>
<td class="num">$ (9,620,555)<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_PeoMember', window );">PEO [Member] | Equity Award Adjustments [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">3,321,022<span></span>
</td>
<td class="num">(4,415,419)<span></span>
</td>
<td class="nump">2,096,655<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_PeoMember', window );">PEO [Member] | Year End Fair Value of Equity Awards [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">5,731,326<span></span>
</td>
<td class="nump">4,655,272<span></span>
</td>
<td class="nump">7,071,074<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_PeoMember', window );">PEO [Member] | Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="num">(2,549,358)<span></span>
</td>
<td class="num">(8,289,894)<span></span>
</td>
<td class="num">(4,319,642)<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_PeoMember', window );">PEO [Member] | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_PeoMember', window );">PEO [Member] | Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">326,316<span></span>
</td>
<td class="num">(716,002)<span></span>
</td>
<td class="num">(654,778)<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_PeoMember', window );">PEO [Member] | Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="num">(187,261)<span></span>
</td>
<td class="num">(64,795)<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_PeoMember', window );">PEO [Member] | Value of Dividends or Other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_PeoMember', window );">PEO [Member] | Reported Change in the Actuarial Present Value of Pension Benefits [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_PeoMember', window );">PEO [Member] | Pension Benefit Adjustments [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_NonPeoNeoMember', window );">Non-PEO NEO [Member] | Reported Value of Equity Awards [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="num">(1,887,231)<span></span>
</td>
<td class="num">(3,039,250)<span></span>
</td>
<td class="num">(4,484,784)<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_NonPeoNeoMember', window );">Non-PEO NEO [Member] | Equity Award Adjustments [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">1,818,634<span></span>
</td>
<td class="num">(81,162)<span></span>
</td>
<td class="nump">856,465<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_NonPeoNeoMember', window );">Non-PEO NEO [Member] | Year End Fair Value of Equity Awards [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">1,962,339<span></span>
</td>
<td class="nump">1,171,440<span></span>
</td>
<td class="nump">3,366,846<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_NonPeoNeoMember', window );">Non-PEO NEO [Member] | Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="num">(164,642)<span></span>
</td>
<td class="num">(1,216,952)<span></span>
</td>
<td class="num">(2,476,142)<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_NonPeoNeoMember', window );">Non-PEO NEO [Member] | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_NonPeoNeoMember', window );">Non-PEO NEO [Member] | Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">20,938<span></span>
</td>
<td class="num">(35,650)<span></span>
</td>
<td class="num">(34,239)<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_NonPeoNeoMember', window );">Non-PEO NEO [Member] | Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_NonPeoNeoMember', window );">Non-PEO NEO [Member] | Value of Dividends or Other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_NonPeoNeoMember', window );">Non-PEO NEO [Member] | Reported Change in the Actuarial Present Value of Pension Benefits [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_AdjToCompAmt', window );">Adjustment to Compensation Amount</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_ExecutiveCategoryAxis=ecd_NonPeoNeoMember', window );">Non-PEO NEO [Member] | Pension Benefit Adjustments [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_ecd_PvpTable', window );"><strong>Pay vs Performance Disclosure [Table]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 3<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 3<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 3<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 2<br> -Subparagraph vi<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 2<br> -Subparagraph vi<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 5<br> -Subparagraph iii<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 5<br> -Subparagraph ii<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 5<br> -Subparagraph i<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 2<br> -Subparagraph vi<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 3<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 2<br> -Subparagraph iii<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
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<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 2<br> -Subparagraph ii<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">ecd_NonPeoNeoAvgTotalCompAmt</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>ecd_</td>
</tr>
<tr>
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<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
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</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_ecd_PeerGroupIssuersFnTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 2<br> -Subparagraph iv<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">ecd_PeerGroupIssuersFnTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>ecd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dtr-types:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_ecd_PeerGroupTotalShareholderRtnAmt">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 2<br> -Subparagraph iv<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">ecd_PeerGroupTotalShareholderRtnAmt</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>ecd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_ecd_PeoActuallyPaidCompAmt">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 2<br> -Subparagraph iii<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">ecd_PeoActuallyPaidCompAmt</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>ecd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_ecd_PeoName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 3<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">ecd_PeoName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>ecd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_ecd_PeoTotalCompAmt">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 2<br> -Subparagraph ii<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">ecd_PeoTotalCompAmt</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>ecd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
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</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_ecd_PvpTable">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 1<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">ecd_PvpTable</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<tr>
<td><strong> Data Type:</strong></td>
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<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
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<tr>
<td><strong> Period Type:</strong></td>
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</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_ecd_PvpTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 1<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">ecd_PvpTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>ecd_</td>
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<tr>
<td><strong> Data Type:</strong></td>
<td>dtr-types:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_ecd_TabularListTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 6<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">ecd_TabularListTableTextBlock</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<td><strong> Data Type:</strong></td>
<td>dtr-types:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
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</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_ecd_TotalShareholderRtnAmt">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 2<br> -Subparagraph iv<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">ecd_TotalShareholderRtnAmt</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>ecd_</td>
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<td><strong> Data Type:</strong></td>
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<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
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</table></div>
</div></td></tr>
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<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-K<br> -Number 229<br> -Section 402<br> -Subsection v<br> -Paragraph 5<br> -Subparagraph iv<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">ecd_TotalShareholderRtnVsPeerGroupTextBlock</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<td><strong> Balance Type:</strong></td>
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<td><strong> Period Type:</strong></td>
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</table></div>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetIncomeLoss">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.</p></div>
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      contextRef="c20220101to20221231"
      id="Text_bd344329ec5145809e3a0f8a73a4b506">&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&lt;b&gt;Pay Versus Performance&lt;/b&gt;&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(162, 0, 103);"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&lt;i&gt;Pay Versus Performance Table &lt;/i&gt;&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in; color: rgb(206, 15, 105);"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;As required by Section 953(a) of the Dodd-Frank Wall Street Reform and
      Consumer Protection Act, and Item 402(v) of Regulation S-K (&#x201c;&lt;b&gt;&lt;i&gt;Item 402(v)&lt;/i&gt;&lt;/b&gt;&#x201d;), we are providing the following information about the relationship between executive compensation actually paid and certain financial performance of the Company.
      The amounts set forth below under the headings &#x201c;Compensation Actually Paid to PEO&#x201d; and &#x201c;Average Compensation Actually Paid to non-PEO NEOs&#x201d; have been calculated in a manner consistent with Item 402(v). Use of the term &#x201c;compensation actually paid&#x201d; is
      required by the SEC&#x2019;s rules and as a result of the calculation methodology required by the SEC, such amounts differ from compensation actually received by the individuals and the compensation decisions described in the CD&amp;amp;A section of this Proxy
      Statement. For further information concerning the Company&#x2019;s pay-for-performance philosophy and how the Company aligns executive compensation with the Company&#x2019;s performance, refer to the CD&amp;amp;A section of this Proxy Statement.&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.25in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; background-color: white; border-collapse: collapse"&gt;


  &lt;tr style="background-color: #A20067"&gt;

    &lt;td rowspan="2" style="vertical-align: bottom; border: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td rowspan="2" style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Summary Compensation Table Total for PEO&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(1)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td rowspan="2" style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Compensation Actually Paid to PEO&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(2)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td rowspan="2" style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Average Summary Compensation Table Total for Non-PEO NEOs&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(3)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td rowspan="2" style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Average Compensation Actually Paid to Non-PEO NEOs&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(4)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td colspan="2" style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Value of Initial Fixed $100 Investment Based On:&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td rowspan="2" style="vertical-align: bottom; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Net Income (Loss)&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(7)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td rowspan="2" style="border-bottom: 1pt solid #000000; border-right: 1pt solid #000000; border-top: 1pt solid #000000; vertical-align: bottom; padding: 0px 5.25pt 0px 1.75pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;&lt;span style="text-indent: 0pt;"&gt;One-Year Relative Total Shareholder Return&lt;/span&gt;&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(8)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr style="vertical-align: bottom; background-color: #A20067"&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Total





















              Shareholder Return&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(5)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Peer





















              Group Total Shareholder Return&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(6)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="width: 5%; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2022&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;7,299,077&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;5,033,980&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;2,803,964&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 12%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;2,735,368&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 10%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;62.52&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 10%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;113.65&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 11%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;269,722,000&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="vertical-align: top; width: 19%; border-bottom: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.25pt; padding-left: 1.75pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;span style="text-indent: 0pt;"&gt;81&lt;/span&gt;&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;st &lt;/sup&gt;percentile&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr style="background-color: #E7E6E6"&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2021&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;13,305,673&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;3,095,776&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,834,223&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;713,811&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;50.37&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;126.45&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;28,597,000&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 1.75pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;span style="text-indent: 0pt;"&gt;41&lt;/span&gt;&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;st &lt;/sup&gt;percentile&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2020&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;10,963,040&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,439,140&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;5,450,933&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;1,822,613&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;93.59&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;126.42&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 5.25pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;479,743,000&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="vertical-align: top; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.25pt; padding-left: 1.75pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;span style="text-indent: 0pt;"&gt;35&lt;/span&gt;&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;th &lt;/sup&gt;percentile&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0px; margin-bottom: 0px; text-align: left;"&gt;&#160;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.25in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(1)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The dollar amounts reported are the amounts of total compensation reported for Dr. Monia (our Chief Executive Officer) for each corresponding year in the &#x201c;Total&#x201d; column of the Summary Compensation Table on page 76 of this Proxy Statement.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.25in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(2)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The dollar amounts represent the amount of compensation actually paid to Dr. Monia, as computed in accordance with Item 402(v). The dollar
            amounts do not reflect the actual amount of compensation earned by or paid to Dr. Monia during the applicable year. In accordance with the requirements of Item 402(v), the following adjustments were made to Dr. Monia&#x2019;s total compensation for
            each year to determine the compensation actually paid:&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 94%; border-collapse: collapse; margin-left: auto; margin-right: auto;"&gt;


  &lt;tr style="background-color: #A20067"&gt;

    &lt;td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 21%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Reported Summary Compensation Table Total for PEO&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 16%; border-top: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Deduct: Reported Value
              of Equity Awards&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(a)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Add: Equity Award Adjustments&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(b)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Add: Reported Change in the Actuarial Present Value of Pension Benefits&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(c)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 12%; border-top: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Add: Pension Benefit
              Adjustments&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(c)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Compensation Actually Paid to PEO&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2022&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;7,299,077&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;5,586,119&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,321,022&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;5,033,980&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr style="background-color: #D9D9D9"&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2021&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;13,305,673&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;11,986,030&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;4,415,419&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;3,095,776&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2020&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;10,963,040&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;9,620,555&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;2,096,655&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,439,140&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0px; margin-bottom: 0px; text-align: left;"&gt;&#160;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.5in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(a)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The grant date fair value of equity awards represents the total of the amounts reported in the &#x201c;Stock Awards&#x201d; and &#x201c;Option Awards&#x201d; columns in the
            Summary Compensation Table for the applicable year.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.5in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(b)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The equity award adjustments for each applicable year include the addition (or subtraction, as applicable) of the following: (i) the year-end
            fair value of any equity awards granted in the applicable year that are outstanding and unvested as of the end of the year; (ii) the amount of change as of the end of the applicable year (from the end of the prior fiscal year) in fair value of
            any awards granted in prior years that are outstanding and unvested as of the end of the applicable year; (iii) for awards that are granted and vest in the same applicable year, the fair value as of the vesting date; (iv) for awards granted in
            prior years that vest in the applicable year, the amount equal to the change as of the vesting date (from the end of the prior fiscal year) in fair value; (v) for awards granted in prior years that are determined to fail to meet the applicable
            vesting conditions during the applicable year, a deduction for the amount equal to the fair value at the end of the prior fiscal year; and (vi) the dollar value of any dividends or other earnings paid on stock or option awards in the applicable
            year prior to the vesting date that are not otherwise reflected in the fair value of such award or included in any other component of total compensation for the applicable year. The amounts deducted or added in calculating the equity award
            adjustments are as follows:&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"&gt;


  &lt;tr style="background-color: #A20067"&gt;

    &lt;td style="width: 5%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Year End Fair Value of Equity Awards&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 14%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards &lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(i)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 14%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 19%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Value of Dividends or other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(ii)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Total Equity Award Adjustments&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2022&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;5,731,326&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;2,549,358&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;326,316&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;187,261&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,321,022&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr style="background-color: #D9D9D9"&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2021&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;4,655,272&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;8,289,894&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;716,002&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;64,795&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;4,415,419&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2020&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;7,071,074&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;4,319,642&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;654,778&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;2,096,655&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0; margin-bottom: 0"/&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"&gt;&#160;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"&gt;&#160;&lt;/p&gt;&lt;p style="margin-top: 0; margin-bottom: 0"/&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.75in"/&gt;

    &lt;td style="width: 0.5in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(i)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not grant any equity awards that vest in the same year as grant.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.75in"/&gt;

    &lt;td style="width: 0.5in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(ii)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not pay dividends or other earnings on stock or option awards.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.5in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(c)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not provide pension benefits to any employees of the Company.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.25in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(3)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The dollar amounts reported represent the average of the amounts reported for the Company&#x2019;s NEOs as a group (excluding Dr. Monia) in the &#x201c;Total&#x201d;
            column of the Summary Compensation Table of the Proxy Statement for each applicable year. The names of each of the NEOs (excluding Dr. Monia) included for purposes of calculating the average amounts in each applicable year are as follows:&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 54pt"/&gt;

    &lt;td style="width: 31.5pt; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(i)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;For 2022, Elizabeth L. Hougen (EVP &amp;amp; CFO), Joseph T. Baroldi (EVP, Chief Business Officer), Onaiza Cadoret-Manier (EVP, Chief Global Product
            Strategy and Operations Officer) and Richard S. Geary (EVP, Chief Development Officer);&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 54pt"/&gt;

    &lt;td style="width: 31.5pt; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(ii)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;For 2021, Elizabeth L. Hougen (EVP &amp;amp; CFO), Patrick R. O&#x2019;Neil (EVP, Chief Legal Officer and General Counsel), Onaiza Cadoret-Manier (EVP,
            Chief Global Product Strategy and Operations Officer) and Eric E. Swayze (EVP, Research; and&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 54pt"/&gt;

    &lt;td style="width: 31.5pt; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(iii)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;For 2020, Elizabeth L. Hougen (EVP &amp;amp; CFO), Stanley Crooke (Executive Chairman of the Board), Richard S. Geary (EVP, Chief Development
            Officer) and Patrick R. O&#x2019;Neil (EVP, Legal and General Counsel).&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.25in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(4)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The dollar amounts reported represent the average amount of compensation actually paid to the NEOs as a group (excluding Dr. Monia), as computed
            in accordance with Item 402(v). The dollar amounts do not reflect the actual average amount of compensation earned by or paid to the NEOs as a group (excluding Dr. Monia) during the applicable year. In accordance with the requirements of Item
            402(v), the following adjustments were made to average total compensation for the NEOs as a group (excluding Dr. Monia) for each year to determine the compensation actually paid, using the same methodology described above in Note 2:&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"&gt;


  &lt;tr style="background-color: #A20067"&gt;

    &lt;td style="width: 8%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 23%; border-top: 1pt solid Black; border-right: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Average Reported Summary Compensation
              Table Total for Non-PEO NEOs&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 15%; border-top: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Deduct: Average Reported Value of Equity Awards&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Add:
              Average Award Adjustments&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(a)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Add: Average Reported Change in the
              Actuarial Present Value of Pension Benefits&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(b)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 16%; border-top: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Add: Average Pension Benefit Adjustments&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(b)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Average
              Compensation Actually Paid to Non-PEO NEOs&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2022&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;2,803,964&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;1,887,231&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;1,818,634&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;2,735,368&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr style="background-color: #D9D9D9"&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2021&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,834,223&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;3,039,250&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;81,162&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;713,811&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2020&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;5,450,933&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;4,484,784&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;856,465&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;1,822,613&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0px; margin-bottom: 0px; text-align: left;"&gt;&#160;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.5in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(a)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The amounts deducted or added in calculating the total average equity award adjustments are as follows:&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"&gt;


  &lt;tr style="background-color: #A20067"&gt;

    &lt;td style="width: 6%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Year End Fair Value of Equity Awards&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards &lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(i)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 16%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 20%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Value of Dividends or other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(ii)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Total Equity Award Adjustments&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2022&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;1,962,339&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;164,642&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;20,938&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;1,818,634&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2021&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;1,171,440&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;1,216,952&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;35,650&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(231, 230, 230); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(231, 230, 230); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;81,162&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2020&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,366,846&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;2,476,142&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;/span&gt;&lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;34,239&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$
          &lt;/span&gt;&lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$
            &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;856,465&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0px; margin-bottom: 0px; text-align: left;"&gt;&#160;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.75in"/&gt;

    &lt;td style="width: 0.5in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(i)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not grant any equity awards that vest in the same year as grant.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.75in"/&gt;

    &lt;td style="width: 0.5in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(ii)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not pay dividends or other earnings on stock or option awards.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.5in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(b)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not provide pension benefits to any employees of the Company.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.25in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(5)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;Cumulative TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend
            reinvestment, and the difference between the Company&#x2019;s stock price at the end and the beginning of the measurement period by the Company&#x2019;s stock price at the beginning of the measurement period.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.25in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(6)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;Represents the weighted peer group TSR, weighted according to the respective companies&#x2019; stock market capitalization at the beginning of each
            period for which a return is indicated. The peer group used for this purpose is the Nasdaq Biotechnology Index.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.25in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(7)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The dollar amounts reported represent the amount of net income (loss) reflected in the Company&#x2019;s audited financial statements for the applicable
            year.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.25in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(8)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;One-year relative TSR shown is the percentile rank of the Company&#x2019;s TSR as compared to the TSRs of all members of the Nasdaq Biotechnology Index,
            ranked in descending order, for the one-year period commencing on January 15&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;th&lt;/sup&gt; of the applicable year and ending January 15&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;th&lt;/sup&gt; of the following year, which time period is consistent with the one-year measurement period used in the PRSUs awarded in 2020-2022.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
</ecd:PvpTableTextBlock>
    <ecd:CoSelectedMeasureName
      contextRef="c20220101to20221231"
      id="Fact_77e423da73b44512ae490c010b399848">One-Year Relative Total Shareholder Return</ecd:CoSelectedMeasureName>
    <ecd:PeoTotalCompAmt
      contextRef="c20220101to20221231"
      decimals="0"
      id="Fact_62068631048c4cadbbdace72412c03f7"
      unitRef="U001">7299077</ecd:PeoTotalCompAmt>
    <ecd:PeoActuallyPaidCompAmt
      contextRef="c20220101to20221231"
      decimals="0"
      id="Fact_a11cd5e8a5b9481abcec7ea9cb5f59d2"
      unitRef="U001">5033980</ecd:PeoActuallyPaidCompAmt>
    <ecd:NonPeoNeoAvgTotalCompAmt
      contextRef="c20220101to20221231"
      decimals="0"
      id="Fact_7a3f0f0e107f497995f1230a6e87c77c"
      unitRef="U001">2803964</ecd:NonPeoNeoAvgTotalCompAmt>
    <ecd:NonPeoNeoAvgCompActuallyPaidAmt
      contextRef="c20220101to20221231"
      decimals="0"
      id="Fact_8744a22095034995b821704b628c47ba"
      unitRef="U001">2735368</ecd:NonPeoNeoAvgCompActuallyPaidAmt>
    <ecd:TotalShareholderRtnAmt
      contextRef="c20220101to20221231"
      decimals="2"
      id="Fact_081d452c701f4ba396e5a455b39ad6ae"
      unitRef="U001">62.52</ecd:TotalShareholderRtnAmt>
    <ecd:PeerGroupTotalShareholderRtnAmt
      contextRef="c20220101to20221231"
      decimals="2"
      id="Fact_9adc613d03f244ccbcbef49b249a03af"
      unitRef="U001">113.65</ecd:PeerGroupTotalShareholderRtnAmt>
    <us-gaap:NetIncomeLoss
      contextRef="c20220101to20221231"
      decimals="0"
      id="Fact_ce1b8570f22849e084425a39c029f8b6"
      unitRef="U001">-269722000</us-gaap:NetIncomeLoss>
    <ecd:CoSelectedMeasureAmt
      contextRef="c20220101to20221231"
      decimals="0"
      id="Fact_9e5bee145bdc486ea805a913cfb325ee"
      unitRef="U002">81</ecd:CoSelectedMeasureAmt>
    <ecd:PeoTotalCompAmt
      contextRef="c20210101to20211231"
      decimals="0"
      id="Fact_a689ad706fad42b1adf955ca9ae9cfd7"
      unitRef="U001">13305673</ecd:PeoTotalCompAmt>
    <ecd:PeoActuallyPaidCompAmt
      contextRef="c20210101to20211231"
      decimals="0"
      id="Fact_122ac89bd0b64be7967dabaa63955dcc"
      unitRef="U001">-3095776</ecd:PeoActuallyPaidCompAmt>
    <ecd:NonPeoNeoAvgTotalCompAmt
      contextRef="c20210101to20211231"
      decimals="0"
      id="Fact_a8fb763656f24e0e922bbf5cc547be8d"
      unitRef="U001">3834223</ecd:NonPeoNeoAvgTotalCompAmt>
    <ecd:NonPeoNeoAvgCompActuallyPaidAmt
      contextRef="c20210101to20211231"
      decimals="0"
      id="Fact_68345774ed584541b72664118c555366"
      unitRef="U001">713811</ecd:NonPeoNeoAvgCompActuallyPaidAmt>
    <ecd:TotalShareholderRtnAmt
      contextRef="c20210101to20211231"
      decimals="2"
      id="Fact_57ffc8faf70a41cb8b3ee79519e67b3a"
      unitRef="U001">50.37</ecd:TotalShareholderRtnAmt>
    <ecd:PeerGroupTotalShareholderRtnAmt
      contextRef="c20210101to20211231"
      decimals="2"
      id="Fact_4fc08394378342ca915790519b9058e7"
      unitRef="U001">126.45</ecd:PeerGroupTotalShareholderRtnAmt>
    <us-gaap:NetIncomeLoss
      contextRef="c20210101to20211231"
      decimals="0"
      id="Fact_5beb98cdf28a466aa8fbdb3049ac52ee"
      unitRef="U001">-28597000</us-gaap:NetIncomeLoss>
    <ecd:CoSelectedMeasureAmt
      contextRef="c20210101to20211231"
      decimals="0"
      id="Fact_2b5942ecccf14fb5b11259511fc72f8b"
      unitRef="U002">41</ecd:CoSelectedMeasureAmt>
    <ecd:PeoTotalCompAmt
      contextRef="c20200101to20201231"
      decimals="0"
      id="Fact_b19b421e6d5f4eb9a6ca7a1941494860"
      unitRef="U001">10963040</ecd:PeoTotalCompAmt>
    <ecd:PeoActuallyPaidCompAmt
      contextRef="c20200101to20201231"
      decimals="0"
      id="Fact_616d14d261704e4ea4b94908a5460655"
      unitRef="U001">3439140</ecd:PeoActuallyPaidCompAmt>
    <ecd:NonPeoNeoAvgTotalCompAmt
      contextRef="c20200101to20201231"
      decimals="0"
      id="Fact_236686492263494587e425f0aab9e60a"
      unitRef="U001">5450933</ecd:NonPeoNeoAvgTotalCompAmt>
    <ecd:NonPeoNeoAvgCompActuallyPaidAmt
      contextRef="c20200101to20201231"
      decimals="0"
      id="Fact_9d0650dee1ea4c87bbff5de53f333e25"
      unitRef="U001">1822613</ecd:NonPeoNeoAvgCompActuallyPaidAmt>
    <ecd:TotalShareholderRtnAmt
      contextRef="c20200101to20201231"
      decimals="2"
      id="Fact_1a3d2d21d8c24d0782069970476d433a"
      unitRef="U001">93.59</ecd:TotalShareholderRtnAmt>
    <ecd:PeerGroupTotalShareholderRtnAmt
      contextRef="c20200101to20201231"
      decimals="2"
      id="Fact_20bcfaac8eea4c629aa122d78a95f948"
      unitRef="U001">126.42</ecd:PeerGroupTotalShareholderRtnAmt>
    <us-gaap:NetIncomeLoss
      contextRef="c20200101to20201231"
      decimals="0"
      id="Fact_b61d1177c7fd41c080e479d43e63393f"
      unitRef="U001">-479743000</us-gaap:NetIncomeLoss>
    <ecd:CoSelectedMeasureAmt
      contextRef="c20200101to20201231"
      decimals="0"
      id="Fact_646d8fbda24f412b8e1e3b95c650f7db"
      unitRef="U002">35</ecd:CoSelectedMeasureAmt>
    <ecd:PeoName
      contextRef="c20210101to20211231"
      id="Fact_1dc58c508d544ad7930762f83ee32045">Dr. Monia</ecd:PeoName>
    <ecd:PeoName
      contextRef="c20200101to20201231"
      id="Fact_0f09dc0dab3041a98db159a9f0acabfa">Dr. Monia</ecd:PeoName>
    <ecd:PeoName
      contextRef="c20220101to20221231"
      id="Fact_085f7627978f459d9b0299982d808c57">Dr. Monia</ecd:PeoName>
    <ecd:AdjToPeoCompFnTextBlock
      contextRef="c20220101to20221231"
      id="Text_0c132d52dc3b4b4f85899700cd69f3ed">
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.25in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(2)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The dollar amounts represent the amount of compensation actually paid to Dr. Monia, as computed in accordance with Item 402(v). The dollar
            amounts do not reflect the actual amount of compensation earned by or paid to Dr. Monia during the applicable year. In accordance with the requirements of Item 402(v), the following adjustments were made to Dr. Monia&#x2019;s total compensation for
            each year to determine the compensation actually paid:&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 94%; border-collapse: collapse; margin-left: auto; margin-right: auto;"&gt;


  &lt;tr style="background-color: #A20067"&gt;

    &lt;td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 21%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Reported Summary Compensation Table Total for PEO&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 16%; border-top: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Deduct: Reported Value
              of Equity Awards&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(a)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Add: Equity Award Adjustments&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(b)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Add: Reported Change in the Actuarial Present Value of Pension Benefits&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(c)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 12%; border-top: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Add: Pension Benefit
              Adjustments&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(c)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Compensation Actually Paid to PEO&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2022&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;7,299,077&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;5,586,119&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,321,022&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;5,033,980&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr style="background-color: #D9D9D9"&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2021&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;13,305,673&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;11,986,030&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;4,415,419&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;3,095,776&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2020&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;10,963,040&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;9,620,555&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;2,096,655&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,439,140&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0px; margin-bottom: 0px; text-align: left;"&gt;&#160;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.5in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(a)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The grant date fair value of equity awards represents the total of the amounts reported in the &#x201c;Stock Awards&#x201d; and &#x201c;Option Awards&#x201d; columns in the
            Summary Compensation Table for the applicable year.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.5in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(b)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The equity award adjustments for each applicable year include the addition (or subtraction, as applicable) of the following: (i) the year-end
            fair value of any equity awards granted in the applicable year that are outstanding and unvested as of the end of the year; (ii) the amount of change as of the end of the applicable year (from the end of the prior fiscal year) in fair value of
            any awards granted in prior years that are outstanding and unvested as of the end of the applicable year; (iii) for awards that are granted and vest in the same applicable year, the fair value as of the vesting date; (iv) for awards granted in
            prior years that vest in the applicable year, the amount equal to the change as of the vesting date (from the end of the prior fiscal year) in fair value; (v) for awards granted in prior years that are determined to fail to meet the applicable
            vesting conditions during the applicable year, a deduction for the amount equal to the fair value at the end of the prior fiscal year; and (vi) the dollar value of any dividends or other earnings paid on stock or option awards in the applicable
            year prior to the vesting date that are not otherwise reflected in the fair value of such award or included in any other component of total compensation for the applicable year. The amounts deducted or added in calculating the equity award
            adjustments are as follows:&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"&gt;


  &lt;tr style="background-color: #A20067"&gt;

    &lt;td style="width: 5%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Year End Fair Value of Equity Awards&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 14%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards &lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(i)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 14%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 19%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Value of Dividends or other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(ii)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Total Equity Award Adjustments&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2022&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;5,731,326&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;2,549,358&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;326,316&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;187,261&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,321,022&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr style="background-color: #D9D9D9"&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2021&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;4,655,272&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;8,289,894&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;716,002&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;64,795&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;4,415,419&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;2020&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;7,071,074&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;4,319,642&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;654,778&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;2,096,655&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0; margin-bottom: 0"/&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"&gt;&#160;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left;"&gt;&#160;&lt;/p&gt;&lt;p style="margin-top: 0; margin-bottom: 0"/&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.75in"/&gt;

    &lt;td style="width: 0.5in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(i)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not grant any equity awards that vest in the same year as grant.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.75in"/&gt;

    &lt;td style="width: 0.5in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(ii)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not pay dividends or other earnings on stock or option awards.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.5in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(c)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not provide pension benefits to any employees of the Company.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
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    <ecd:NamedExecutiveOfficersFnTextBlock
      contextRef="c20220101to20221231"
      id="Text_20b1158cc3fb48ce8a880dafb06b0a51">
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.25in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(3)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The dollar amounts reported represent the average of the amounts reported for the Company&#x2019;s NEOs as a group (excluding Dr. Monia) in the &#x201c;Total&#x201d;
            column of the Summary Compensation Table of the Proxy Statement for each applicable year. The names of each of the NEOs (excluding Dr. Monia) included for purposes of calculating the average amounts in each applicable year are as follows:&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 54pt"/&gt;

    &lt;td style="width: 31.5pt; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(i)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;For 2022, Elizabeth L. Hougen (EVP &amp;amp; CFO), Joseph T. Baroldi (EVP, Chief Business Officer), Onaiza Cadoret-Manier (EVP, Chief Global Product
            Strategy and Operations Officer) and Richard S. Geary (EVP, Chief Development Officer);&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 54pt"/&gt;

    &lt;td style="width: 31.5pt; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(ii)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;For 2021, Elizabeth L. Hougen (EVP &amp;amp; CFO), Patrick R. O&#x2019;Neil (EVP, Chief Legal Officer and General Counsel), Onaiza Cadoret-Manier (EVP,
            Chief Global Product Strategy and Operations Officer) and Eric E. Swayze (EVP, Research; and&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 54pt"/&gt;

    &lt;td style="width: 31.5pt; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(iii)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;For 2020, Elizabeth L. Hougen (EVP &amp;amp; CFO), Stanley Crooke (Executive Chairman of the Board), Richard S. Geary (EVP, Chief Development
            Officer) and Patrick R. O&#x2019;Neil (EVP, Legal and General Counsel).&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
</ecd:NamedExecutiveOfficersFnTextBlock>
    <ecd:AdjToNonPeoNeoCompFnTextBlock
      contextRef="c20220101to20221231"
      id="Text_22f5d6659d1f47d481ee66366c14a04e">&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.25in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(4)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The dollar amounts reported represent the average amount of compensation actually paid to the NEOs as a group (excluding Dr. Monia), as computed
            in accordance with Item 402(v). The dollar amounts do not reflect the actual average amount of compensation earned by or paid to the NEOs as a group (excluding Dr. Monia) during the applicable year. In accordance with the requirements of Item
            402(v), the following adjustments were made to average total compensation for the NEOs as a group (excluding Dr. Monia) for each year to determine the compensation actually paid, using the same methodology described above in Note 2:&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"&gt;


  &lt;tr style="background-color: #A20067"&gt;

    &lt;td style="width: 8%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 23%; border-top: 1pt solid Black; border-right: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Average Reported Summary Compensation
              Table Total for Non-PEO NEOs&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 15%; border-top: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Deduct: Average Reported Value of Equity Awards&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Add:
              Average Award Adjustments&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(a)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 15%; border-top: 1pt solid Black; border-right: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Add: Average Reported Change in the
              Actuarial Present Value of Pension Benefits&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(b)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 16%; border-top: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Add: Average Pension Benefit Adjustments&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(b)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Average
              Compensation Actually Paid to Non-PEO NEOs&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2022&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;2,803,964&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;1,887,231&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;1,818,634&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;2,735,368&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr style="background-color: #D9D9D9"&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2021&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,834,223&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;3,039,250&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;81,162&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;713,811&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2020&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;5,450,933&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;4,484,784&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;856,465&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;1,822,613&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0px; margin-bottom: 0px; text-align: left;"&gt;&#160;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.5in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(a)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;The amounts deducted or added in calculating the total average equity award adjustments are as follows:&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"&gt;


  &lt;tr style="background-color: #A20067"&gt;

    &lt;td style="width: 6%; border-top: 1pt solid Black; border-right: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 10%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Year End Fair Value of Equity Awards&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards &lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 13%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(i)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 12%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 16%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 20%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Value of Dividends or other Earnings Paid on Stock or Option Awards Not Otherwise Reflected in Fair Value or Total Compensation&lt;sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"&gt;(ii)&lt;/sup&gt;&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="width: 11%; border-top: 1pt solid Black; border-right: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt; color: white;"&gt;&lt;b&gt;Total Equity Award Adjustments&lt;/b&gt;&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2022&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;1,962,339&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;164,642&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;20,938&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-top: 1pt solid Black; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;1,818,634&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2021&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;1,171,440&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;1,216,952&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;35,650&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(217, 217, 217); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(231, 230, 230); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; background-color: rgb(231, 230, 230); padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;81,162&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;

  &lt;tr&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;2020&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;3,366,846&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;2,476,142&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$ &lt;/span&gt;&lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;($&lt;span style="text-indent: 0pt;"&gt;34,239&lt;/span&gt;)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$
          &lt;/span&gt;&lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$
            &lt;span style="text-indent: 0pt;"&gt;-&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

    &lt;td style="white-space: nowrap; border-right: 1pt solid Black; border-bottom: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 9pt;"&gt;$&lt;span style="text-indent: 0pt;"&gt;856,465&lt;/span&gt; &lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0px; margin-bottom: 0px; text-align: left;"&gt;&#160;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.75in"/&gt;

    &lt;td style="width: 0.5in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(i)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not grant any equity awards that vest in the same year as grant.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.75in"/&gt;

    &lt;td style="width: 0.5in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(ii)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not pay dividends or other earnings on stock or option awards.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
&lt;p style="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman,Times,serif; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;
&lt;table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%;"&gt;


  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="width: 0.5in"/&gt;

    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(b)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;We do not provide pension benefits to any employees of the Company.&lt;/span&gt;&lt;/td&gt;

  &lt;/tr&gt;


&lt;/table&gt;
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    &lt;td style="width: 0.25in; text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;(6)&lt;/span&gt;&lt;/td&gt;

    &lt;td style="text-align: left;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;Represents the weighted peer group TSR, weighted according to the respective companies&#x2019; stock market capitalization at the beginning of each
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      performance, and therefore does not specifically align the Company&#x2019;s performance measures with compensation that is actually paid (as computed in accordance with Item 402(v)) for a particular year. In accordance with Item 402(v), the Company is
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      performance, and therefore does not specifically align the Company&#x2019;s performance measures with compensation that is actually paid (as computed in accordance with Item 402(v)) for a particular year. In accordance with Item 402(v), the Company is
      providing the descriptions and graphs below regarding the relationships between certain information presented in the PVP Table.&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&lt;i&gt;&lt;span style="text-decoration: underline;"&gt;Compensation Actually Paid and Cumulative
          TSR&lt;/span&gt;&lt;/i&gt;&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(229, 114, 0);"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;As demonstrated by the following graph, the amount
      of compensation actually paid to Dr. Monia and the average amount of compensation actually paid to the Company&#x2019;s NEOs as a group (excluding Dr. Monia) is aligned with the Company&#x2019;s cumulative TSR over the three years presented in the table.&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0.5in; color: rgb(35, 31, 32);"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Sans-Serif; margin: 0pt 0; text-align: center; text-indent: 0in; color: Red"&gt;&lt;img alt="" src="ny20007094x2_def14aimg013.jpg"/&gt;&lt;/p&gt;&lt;p style="font: 10pt sans-serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: Red;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&#160;&lt;/span&gt;&lt;/p&gt;</ecd:CompActuallyPaidVsTotalShareholderRtnTextBlock>
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        described in greater detail in the CD&amp;amp;A, we design our executive compensation program to drive the creation of long-term stockholder value and mitigate unnecessary or imprudent business risk taking. To that end, we structure our executive
        compensation program to align executive compensation with Company performance. The most important financial performance measures used by the Company in fiscal year 2022 to link executive compensation actually paid to the Company&#x2019;s NEOs to the
        Company&#x2019;s performance are listed in the table to the right.&lt;/span&gt;&lt;/p&gt;&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 199.5pt 0pt 0; text-align: justify; text-indent: 0.5in; color: #231F20"/&gt;
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    &lt;td style="width: 100%; border: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: white;"&gt;&lt;b&gt;Most Important Financial
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  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; padding-bottom: 8pt;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);"&gt;&lt;span style="text-indent: 0pt;"&gt;Revenue&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

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  &lt;tr style="vertical-align: top; background-color: #E7E6E6"&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; padding-bottom: 8pt;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);"&gt;&lt;span style="text-indent: 0pt;"&gt;Relative TSR Versus the NBI&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

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  &lt;tr style="vertical-align: top"&gt;

    &lt;td style="border-right: 1pt solid Black; border-bottom: 1pt solid Black; border-left: 1pt solid Black; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; padding-bottom: 8pt;"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt; color: rgb(35, 31, 32);"&gt;&lt;span style="text-indent: 0pt;"&gt;Whether We Met Our Non-GAAP Net Operating Loss Guidance&lt;/span&gt;&lt;/span&gt;&lt;/td&gt;

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  &lt;br/&gt;
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&lt;p style="font: 10pt Times New Roman,Times,serif; margin: 0pt 0px; text-align: left; text-indent: 0in; color: rgb(35, 31, 32);"&gt;&lt;span style="font-family: Times New Roman,Times,serif; font-size: 10pt;"&gt;&lt;i&gt;All information provided above under the &#x201c;Item
        402(v) Pay Versus Performance&#x201d; heading will not be deemed to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after
        the date hereof and irrespective of any general incorporation language in any such filing, except to the extent the Company specifically incorporates such information by reference.&lt;/i&gt;&#160;&lt;/span&gt;&lt;/p&gt;</ecd:Additional402vDisclosureTextBlock>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
