<SEC-DOCUMENT>0001140361-23-038715.txt : 20230809
<SEC-HEADER>0001140361-23-038715.hdr.sgml : 20230809
<ACCEPTANCE-DATETIME>20230809111526
ACCESSION NUMBER:		0001140361-23-038715
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		15
CONFORMED PERIOD OF REPORT:	20230809
ITEM INFORMATION:		Results of Operations and Financial Condition
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20230809
DATE AS OF CHANGE:		20230809

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		231154016

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>

    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold;">Washington, D.C.&#160; 20549</div>

    <div>&#160;</div>

    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 18pt; font-weight: bold;">FORM <ix:nonNumeric name="dei:DocumentType" id="Fact_274b5f424cce4e7888774011716d2ce1" contextRef="c20230809to20230809">8-K</ix:nonNumeric></div>

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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">CURRENT REPORT</div>

    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">PURSUANT TO SECTION 13 OR 15(d) OF THE</div>

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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">(Exact Name of Registrant as Specified in Charter)</div>

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    <div>&#160;</div>

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    <td style="width: 49%; vertical-align: top;">
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    <td style="width: 2%; vertical-align: top;"><br />
          </td>

    <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">(IRS Employer Identification No.)</div>
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<div>&#160;
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    <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:</div>

    <div style="text-align: left;"><span style="font-family: 'Times New Roman'; font-size: 10pt;"> </span><br />
    </div>

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          </td>

    <td style="width: auto; vertical-align: top; text-align: left;">
            <div style="font-family: 'Times New Roman'; font-size: 10pt;">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</div>
          </td>

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</table>
    <div style="text-align: left; text-indent: -18pt; margin-left: 18pt;"><span style="font-family: 'Times New Roman'; font-size: 10pt;"> </span><br />
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    <td style="width: auto; vertical-align: top; text-align: left;">
            <div style="font-family: 'Times New Roman'; font-size: 10pt;">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</div>
          </td>

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</table>
    <div style="text-align: left; text-indent: -18pt; margin-left: 18pt;"><span style="font-family: 'Times New Roman'; font-size: 10pt;"> </span><br />
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          </td>

    <td style="width: auto; vertical-align: top; text-align: left;">
            <div style="font-family: 'Times New Roman'; font-size: 10pt;">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</div>
          </td>

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</table>
    <div style="text-align: left; text-indent: -18pt; margin-left: 18pt;"><span style="font-family: 'Times New Roman'; font-size: 10pt;"> </span><br />
    </div>

    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable">


  <tr>

    <td style="width: 18pt; vertical-align: top; color: #000000; font-family: 'Times New Roman'; font-size: 10pt;"><ix:nonNumeric name="dei:PreCommencementIssuerTenderOffer" id="Fact_d16e2f700d4644959aca387e095cd870" contextRef="c20230809to20230809" format="ixt-sec:boolballotbox">&#x2610;</ix:nonNumeric><br />
          </td>

    <td style="width: auto; vertical-align: top; text-align: left;">
            <div style="font-family: 'Times New Roman'; font-size: 10pt;">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</div>
          </td>

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</table>
    <div>&#160;</div>

    <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">Securities registered pursuant to Section 12(b) of the Act:</div>

    <div><br />
    </div>

    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">


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    <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">Title of each class</div>
          </td>

    <td style="width: 2%; vertical-align: top;"><br />
          </td>

    <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">Trading symbol</div>
          </td>

    <td style="width: 2%; vertical-align: top;"><br />
          </td>

    <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">Name of each exchange on which registered</div>
          </td>

  </tr>

  <tr>

    <td style="width: 32%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;"><ix:nonNumeric name="dei:Security12bTitle" id="Fact_a3973225ac5f4d7799c2f0487868f9f7" contextRef="c20230809to20230809">Common Stock, $.001 Par Value</ix:nonNumeric><br />
            </div>
          </td>

    <td style="width: 2%; vertical-align: top;"><br />
          </td>

    <td style="width: 32%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">&#8220;<ix:nonNumeric name="dei:TradingSymbol" id="Fact_a6d45091350a4d14bc53d2f7cf5742fe" contextRef="c20230809to20230809">IONS</ix:nonNumeric>&#8221; </div>
          </td>

    <td style="width: 2%; vertical-align: top;"><br />
          </td>

    <td style="width: 32%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;"><ix:nonNumeric name="dei:SecurityExchangeName" id="Fact_181b441beb13481cb8d8f9801b770cfb" contextRef="c20230809to20230809" format="ixt-sec:exchnameen">The Nasdaq Stock Market, LLC</ix:nonNumeric><br />
            </div>
          </td>

  </tr>


</table>
    <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"> <br />
    </div>

    <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (Section 230.405 of this chapter) or Rule
      12b-2 of the Securities Exchange Act of 1934 (Section 240.12b-2 of this chapter).</div>

    <div style="text-align: right;"><span style="font-family: 'Times New Roman'; font-size: 10pt;">Emerging growth company</span> <ix:nonNumeric name="dei:EntityEmergingGrowthCompany" id="Fact_400b189812234dd7850b48a2e9316ec7" contextRef="c20230809to20230809" format="ixt-sec:boolballotbox">&#x2610;</ix:nonNumeric><span style="font-family: 'Times New Roman'; font-size: 10pt;">&#160;&#160;</span></div>

    <div>&#160;</div>

    <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised
      financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.&#160; &#9744;</div>

    <div style="font-family: 'Times New Roman'; font-size: 10pt;">
<div>&#160;
      </div>
<hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" /></div>

    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" /></div>

    </div>

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  <tr>

    <td style="width: 63pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Item 2.02.</td>

    <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Results of Operations and Financial Condition.</div>
          </td>

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</table>
    <div>&#160;</div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On August 9, 2023, Ionis Pharmaceuticals, Inc. (the &#8220;<span style="font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; font-style: italic;">Company</span>&#8221;)


      issued a press release announcing the Company&#8217;s financial results for the quarter ended June 30, 2023.&#160; In addition to disclosing results that are determined in accordance with Generally Accepted Accounting Principles (&#8220;<span style="font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; font-style: italic;">GAAP</span>&#8221;), the Company also discloses pro forma or non-GAAP results of operations, which are adjusted from GAAP to exclude non-cash compensation expense related to
      equity awards and the related tax effects. The Company is presenting pro forma information excluding non-cash compensation expense and the related tax effects because the Company believes it better enables financial statement users to assess and
      compare its historical performance and project its future operating results and cash flows.&#160; A copy of the release is furnished with this report as an exhibit pursuant to &#8220;Item 2.02. Results of Operations and Financial Condition&#8221; of Form 8-K in
      accordance with SEC Release Nos. 33-8216 and 34-47583.</div>

    <div>&#160;</div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The information in this Current Report on Form 8-K and the Exhibit attached hereto shall not be deemed &#8220;filed&#8221; for purposes of Section 18 of the Securities Exchange Act
      of 1934 (the &#8220;<span style="font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold; font-style: italic;">Exchange Act</span>&#8221;) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any
      filing under the Securities Act of 1933 or the Exchange Act, regardless of any general incorporation language in such filing.</div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br />
    </div>

    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable">


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    <td style="width: 63pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Item 9.01.</td>

    <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Financial Statements and Exhibits.</div>
          </td>

  </tr>


</table>
    <div>&#160;</div>

    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">(d) Exhibits.</div>

    <div>&#160;</div>

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    <td style="width: 15%; vertical-align: bottom;">
            <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;"><span style="text-decoration: underline;">Exhibit No.</span></div>
          </td>

    <td style="width: 85%; vertical-align: bottom;">
            <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;"><span style="text-decoration: underline;">Description</span></div>
          </td>

  </tr>

  <tr>

    <td style="width: 15%; vertical-align: top;">
            <div style="text-align: center;"><a href="brhc20057227_ex99-1.htm">99.1 <br />
              </a></div>
          </td>

    <td style="width: 85%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Press Release dated August 9, 2023.</div>
          </td>

  </tr>

  <tr>

    <td style="width: 15%; vertical-align: top;" rowspan="1"><br />
          </td>

    <td style="width: 85%; vertical-align: top;" rowspan="1"><br />
          </td>

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    <td style="width: 15%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">104</div>
          </td>

    <td style="width: 85%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Cover Page Interactive Data File (embedded within the Inline XBRL document).</div>
          </td>

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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-variant: small-caps; font-weight: bold;">SIGNATURE</div>

    <div>&#160;</div>

    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;">Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf
      by the undersigned, thereunto duly authorized.</div>

    <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"> <br />
    </div>

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            <div>
              <div>
                <div>
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                    <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">
                      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-variant: small-caps; font-weight: bold;">Ionis Pharmaceuticals, Inc.</div>
                    </div>
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              </div>
            </div>
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    <td rowspan="1" style="width: 50%; vertical-align: top;">&#160;</td>

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    <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">
            <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Dated:&#160; August 9, 2023</div>
          </td>

    <td style="width: 3%; vertical-align: top; padding-bottom: 2px;">
            <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">By:</div>
          </td>

    <td style="width: 47%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">/s/ Patrick R. O&#8217;Neil</div>
          </td>

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            <div style="font-size: 10pt;">
              <div style="text-align: justify; font-family: 'Times New Roman'; font-variant: small-caps; font-weight: bold;">Patrick R. O&#8217;Neil</div>
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          </td>

    <td style="width: 3%; vertical-align: top;"><br />
          </td>

    <td style="width: 47%; vertical-align: top;">
            <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Executive Vice President, Chief Legal Officer and General Counsel</div>
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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>brhc20057227_ex99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
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    <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 99.1</font><br>
    </div>
    <div><br>
    </div>
    <div>
      <div>
        <div style="text-align: left; font-size: 10pt;"><img src="image2.jpg"></div>
        <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;"> <br>
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        <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Ionis reports second quarter 2023 financial results</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: center; margin-left: 18pt; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Reported Phase 3 data showing eplontersen continued to show improvement in ATTRv-PN </div>
        <div style="text-align: center; margin-left: 18pt; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">through 85 weeks; December 22, 2023 PDUFA date</div>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: center; margin-left: 18pt; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Completed enrollment in donidalorsen OASIS-HAE study and eplontersen CARDIO-TTRansform</div>
        <div style="text-align: center; margin-left: 18pt; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;"> ATTR-CM study keeping Phase 3 data readouts on track</div>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: center; margin-left: 18pt; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">On track to achieve 2023 financial guidance</div>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">CARLSBAD, Calif., August 9, 2023</font><font style="font-size: 10pt;"> &#8211; Ionis
            Pharmaceuticals, Inc. (Nasdaq: IONS) (the &#8220;Company&#8221;)<font style="font-family: 'Times New Roman';">,</font> today reported financial results for the second quarter of 2023<font style="font-family: 'Times New Roman';">.</font> Financial results
            are summarized below:</font></div>
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              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 42%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" colspan="6" style="vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">Three months ended</div>
                <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">June 30,</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="text-align: center; vertical-align: bottom; width: 1%; font-family: 'Times New Roman'; font-size: 10pt;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="vertical-align: bottom; width: 1%; font-family: 'Times New Roman'; font-size: 10pt; text-align: center;">&#160;</td>
              <td valign="bottom" colspan="6" style="vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">
                <div style="text-align: center;">Six months ended</div>
                <div style="text-align: center;">June 30,</div>
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              <td valign="bottom" style="vertical-align: top; font-size: 10pt; padding-bottom: 2px; width: 42%;">&#160;</td>
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              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';"> 2023</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
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                <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">2022</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="text-align: left; vertical-align: bottom; padding-bottom: 2px; width: 1%;">&#160;</td>
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              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';">2023</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
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                <div style="text-align: center; font-family: 'Times New Roman';">2022</div>
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              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 42%;">&#160;</td>
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                <div style="font-family: 'Times New Roman';">188</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
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                <div style="font-family: 'Times New Roman';">134</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">319</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
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              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">276</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
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                <div style="text-align: left; font-family: 'Times New Roman';">Operating expenses</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">279</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">220</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">523</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">419</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
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              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 42%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman';">Operating expenses on a non-GAAP basis</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">252</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">195</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">469</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">368</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
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              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 42%;">
                <div style="text-align: left; font-family: 'Times New Roman';">Loss from operations</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">(91</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">(86</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
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              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
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              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
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            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 42%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman';">Loss from operations on a non-GAAP basis</div>
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              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
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                <div style="font-family: 'Times New Roman';">(61</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
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              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(150</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(92</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
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        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Financial Highlights</div>
        <div style="font-size: 10pt;"><br>
        </div>
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            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Revenue increased for the second quarter and first half of 2023 by 40% and 16% compared to the same periods last year, respectively, driven by significant partner payments</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zddacfed6a011416e85fc3b94cd8f4bbf">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Operating expenses increased in the second quarter and first half of 2023 compared to the prior year as planned, reflecting investments in advancing Ionis&#8217; pipeline and go-to-market activities
                  for eplontersen, olezarsen and donidalorsen</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zea898692b710459aade5cecd1c0c04b8">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Cash and short-term investments of $2.4 billion as of June 30, 2023 enables continued investments to drive increasing value</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z0169ebe9445f47de9cc4b693f8f82634">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Well-capitalized balance sheet reflects 2024 convertible note refinancing that extended maturity to 2028 while maintaining a low coupon and retaining the flexibility to mitigate potential equity
                  dilution</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z59a01d730a1d43eaabe1559966b2d311">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Reaffirmed 2023 financial guidance</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">1</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
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        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">&#8220;Ionis is creating significant value in 2023 as we successfully execute on our strategy to bring a steady cadence of transformational medicines to the market. Our
          growing late-stage pipeline now includes eight medicines for 10 indications, highlighted by eplontersen. Based on the strong and consistent data generated to date and an attractive self-administration profile, we expect eplontersen to be an
          important new medicine for people with ATTRv-polyneuropathy. We also added QALSODY to our commercial portfolio, a breakthrough treatment for people with SOD1-ALS further strengthening Ionis&#8217; leadership in RNA-based therapies for neurological
          diseases,&#8221; said Brett P. Monia, Ph.D., chief executive officer of Ionis. &#8220;In the second half, we expect continued positive momentum including the Phase 3 readout for olezarsen in familial chylomicronemia syndrome and the potential approval of
          eplontersen for ATTRv-PN in December.&#8221;</div>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Recent Highlights From Commercial Medicines</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z0d033f444a2d416585ede87fecb82e56">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Biogen presented interim data from the Phase 4 RESPOND study of SMA patients demonstrating improved motor function in most participants treated with SPINRAZA who had unmet medical needs after
                  treatment with gene therapy</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb8ac9ac1ef6a48bca3bffb12b4adadf1">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">FDA granted Biogen accelerated approval of QALSODY (tofersen), a first-in-class medicine for patients with SOD1-ALS</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Recent Highlights From Near-Term Commercial Opportunities</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z9520a290a6024ea8a33db818daaef93f">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Reported positive results from the Phase 3 NEURO-TTRansform study in patients with ATTRv-PN showing eplontersen continued to halt neuropathy disease progression and improve quality of life
                  through 85 weeks</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zdd824e51f0544e789a97becb3eb322a5">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Completed enrollment of the Phase 3 CARDIO-TTRansform study of eplontersen in patients with ATTR cardiomyopathy, the largest study ever conducted in ATTR-CM; on track for data readout as early as
                  H1:2025</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zef48f3b8978346408f91ce3d5ce0c577">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Licensed eplontersen Latin America rights to AstraZeneca</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zdfb122aeb02c4e58b4dab0314ebdcbec">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Completed enrollment of the Phase 3 OASIS-HAE study of donidalorsen in patients with hereditary angioedema; on track for data readout in H1:2024</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb6b5b810b8534034bfe0737942e1c920">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Reported positive topline Phase 2 open label extension data of donidalorsen in patients with hereditary angioedema treated for two years</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Recent Highlights From Partnered Programs</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z55ad8a3f1b3940198b3fb5b3c7791a01">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: left; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Roche advanced IONIS-FB-L<sub style="vertical-align: bottom; line-height: 1; font-size: smaller;">Rx</sub> into Phase 3 development in patients with immunoglobulin A nephropathy</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zcfb05d5613104a7db5a4536a2603aade">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">GSK presented durable response data from the Phase 2 B-Sure long-term follow-up study of bepirovirsen in complete responder patients from the Phase 2b B-Clear study of patients with HBV</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zed5208804b04457d911a1ae0343e74c3">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Completed enrollment in the Phase 2 GOLDEN study of IONIS-FB-L<sub style="vertical-align: bottom; line-height: 1; font-size: smaller;">Rx</sub> in patients with geographic atrophy</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2d2887ed68a3489281d160881a5e847b">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">AstraZeneca initiated a Phase 2b study of ION839 (AZD2693) targeting PNPLA3 to treat patients with NASH</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z17671f2a4d6d4ddab1bc6b8ef3bc40a1">

            <tr>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt;">
                <div style="font-family: 'Times New Roman';">Entered collaboration with Novartis to advance a next generation program targeting Lp(a) for cardiovascular disease</div>
              </td>
            </tr>

        </table>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">2</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Second Quarter 2023 Financial Results</div>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">&#8220;Our results for the first half of the year keep us on track to achieve our 2023 guidance. We continued to generate substantial and sustained revenue, that together
          with our well-capitalized balance sheet, allows us to continue investing in key opportunities across our business,&#8221; said Elizabeth L. Hougen, chief financial officer of Ionis. &#8220;With three near-term commercial opportunities that have a combined
          multi<font style="font-family: 'Times New Roman';">-</font>billion-dollar peak sales potential and a steady cadence of medicines poised to follow closely behind, we are positioned to drive substantial revenue growth and long-term value for
          shareholders.&#8221;</div>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Revenue</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Ionis&#8217; revenue was comprised of the following:</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <table cellspacing="0" cellpadding="0" class="cfttable" id="z89d8ce9d63874a09a2d4357c7ca2e5ef" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;">

            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="6" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';">Three months ended</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="6" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';">Six months ended</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="6" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';"> June 30,</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="6" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';">June 30,</div>
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              <td valign="bottom" style="vertical-align: top; font-size: 10pt; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';"> 2023</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">2022</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="text-align: left; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';">2023</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';">2022</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
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              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Revenue:</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="14" style="vertical-align: top; font-size: 10pt;">
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
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              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Commercial revenue:</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
            </tr>
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              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">SPINRAZA royalties</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">61</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">60</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">111</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">113</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">Other commercial revenue:</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt; font-family: 'Times New Roman';">TEGSEDI and WAYLIVRA revenue, net</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">11</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">10</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">17</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">17</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt; font-family: 'Times New Roman';">Licensing and royalty revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">6</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">8</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">18</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">20</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 43.2pt; font-family: 'Times New Roman';">Total commercial revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">78</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">78</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">146</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">150</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Research and development revenue:</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
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              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">Amortization from upfront payments</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">15</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">18</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">29</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">36</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">Milestone payments</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">51</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">18</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">74</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">45</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">License fees</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">20</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">-</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">20</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">2</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">Other services</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">4</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">3</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">6</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">6</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
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            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt; font-family: 'Times New Roman';">Collaborative agreement revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">90</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">39</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">129</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">89</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">Eplontersen joint development revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">20</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">17</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">44</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">37</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 43.2pt; font-family: 'Times New Roman';">Total research and development revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">110</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">56</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">173</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">126</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 52.2pt; font-family: 'Times New Roman';">Total revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">188</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">134</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">319</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">276</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
            </tr>

        </table>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Ionis&#8217; revenue increased in the second quarter and first half of 2023 compared to the same periods in 2022 because of increased payments from partnered programs.
          Ionis believes its substantial and sustainable revenue is an important source of funding that supports the Company&#8217;s investments to bring potentially transformational medicines to the market.</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Commercial revenue for the second quarter and first half of 2023 included $61 million and $111 million from SPINRAZA royalties, respectively. Global SPINRAZA product
          sales of $437 million and $880 million were essentially flat for the second quarter and first half of 2023, respectively, compared to the same periods last year reflecting SPINRAZA&#8217;s resilience against emerging competition<font style="font-family: 'Times New Roman';">.</font> Ionis&#8217; commercial revenue in the second quarter and first half of 2023 also included royalties from the U.S. launch of QALSODY.</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">R&amp;D revenue essentially doubled for the second quarter of 2023 and increased more than 35% for the first half of 2023 compared to the same periods in 2022
          reflecting the value Ionis&#8217; technology is creating as numerous partnered programs advanced<font style="font-family: 'Times New Roman';">.</font></div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><font style="font-family: 'Times New Roman';"> <br>
          </font></div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">3</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Operating Expenses</div>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Ionis&#8217; operating expenses increased in the second quarter and first half of 2023 compared to the same periods in 2022, consistent with expectations. As Ionis
          advanced its robust pipeline, study costs increased as most of the Company&#8217;s Phase 3 studies were either fully enrolled or approaching full enrollment resulting in higher R&amp;D expenses year over year. Additionally, as Ionis prepares to launch
          eplontersen, olezarsen and donidalorsen, the Company&#8217;s SG&amp;A expenses also increased year over year<font style="font-family: 'Times New Roman';">.</font></div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Balance Sheet</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As of June 30, 2023, Ionis&#8217; cash, cash equivalents and short-term investments increased to $2.4 billion compared to $2.0 billion at December 31, 2022 primarily due
          to the $500 million Ionis received from Royalty Pharma in January 2023<font style="font-family: 'Times New Roman';">.</font> Ionis&#8217; working capital also increased over the same period primarily due to the Company&#8217;s higher cash and short-term
          investments balance. In the first quarter of 2023 the Company recorded a long-term liability for future royalties due to Royalty Pharma<font style="font-family: 'Times New Roman';">.</font> In June 2023 Ionis issued $575 million of senior
          convertible notes due in June 2028 with an interest rate of 1.75%. Ionis used the majority of the proceeds to repurchase $434 million of its 2024 convertible notes. The Company plans to utilize the residual proceeds to settle the 2024 notes that
          remain outstanding.</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Webcast</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Management will host a conference call and webcast to discuss Ionis&#8217; second quarter 2023 results at 11:30 a.m. Eastern time on Wednesday, August 9, 2023. Interested
          parties may access the webcast <u><font style="font-family: 'Times New Roman';">here</font></u>. A webcast replay will be available for a limited time at the same address. To access the Company&#8217;s second quarter 2023 earnings slides
          click <u><font style="font-family: 'Times New Roman';">here</font></u><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 255);">.</font></div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">About Ionis Pharmaceuticals, Inc.</div>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">For more than 30 years, Ionis has been a leader in RNA-targeted therapy, pioneering new markets and changing standards of care. Ionis currently has four marketed
          medicines and a promising late-stage pipeline highlighted by cardiovascular and neurological franchises. Our scientific innovation began and continues with the knowledge that sick people depend on us, which fuels our vision to become the leader
          in genetic medicine, utilizing a multi-platform approach to discover, develop and deliver life-transforming therapies.</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; color: #000000;">To learn more about Ionis visit </font><u><font style="font-size: 10pt; font-family: 'Times New Roman';">www.ionispharma.com</font></u><font style="font-size: 10pt; font-family: 'Times New Roman'; color: #000000;"> or follow us on Twitter @ionispharma.</font></div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Ionis&#8217; Forward-looking Statement</div>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">This press release includes forward-looking statements regarding Ionis&#8217; business, financial guidance and the therapeutic and commercial potential of QALSODY
          (tofersen), SPINRAZA (nusinersen), TEGSEDI (inotersen), WAYLIVRA (volanesorsen), eplontersen, olezarsen, donidalorsen, ulefnersen, pelacarsen, bepirovirsen, IONIS-FB-L<sub style="vertical-align: bottom; line-height: 1; font-size: smaller;">Rx</sub><font style="font-family: 'Times New Roman';">,</font> Ionis'
          technologies and Ionis&#8217; other products in development. Any statement describing Ionis&#8217; goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such
          statements are subject to certain risks and uncertainties including those inherent in the process of discovering, developing and commercializing medicines that are safe and effective for use as human therapeutics, and in the endeavor of building
          a business around such medicines. Ionis&#8217; forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking
          statements. Although Ionis&#8217; forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Ionis. As a result, you are cautioned not to rely on these
          forward-looking statements. These and other risks concerning Ionis' programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended December 31, 2022, and most recent Form 10-Q, which are on file with the
          Securities and Exchange Commission. Copies of these and other documents are available from the Company<font style="font-family: 'Times New Roman';">.</font></div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">4</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">In this press release, unless the context requires otherwise, &#8220;Ionis,&#8221; &#8220;Company,&#8221; &#8220;we,&#8221; &#8220;our&#8221; and &#8220;us&#8221; all refer to Ionis Pharmaceuticals and its subsidiaries.</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Ionis Pharmaceuticals<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> is a registered trademark of Ionis Pharmaceuticals, Inc. Akcea Therapeutics<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> is a registered trademark of Akcea
          Therapeutics, Inc. TEGSEDI<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> is a registered trademark of Akcea Therapeutics, Inc. WAYLIVRA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> is a registered trademark of Akcea Therapeutics, Inc. QALSODY<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">TM</sup> is a trademark of Biogen. SPINRAZA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> is a
          registered trademark of Biogen.</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Ionis Investor Contact:</div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">D. Wade Walke, Ph.D.</div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">info@ionisph.com 760-603-2331</div>
        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Ionis Media Contact:</div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">David Polk, J.D.</div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">ionis_ca@ionisph.com 760-603-4679</div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"> <br>
        </div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">5</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
        </div>
        <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">IONIS PHARMACEUTICALS, INC.</div>
        <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">SELECTED FINANCIAL INFORMATION</div>
        <div style="font-size: 10pt;">
          <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Condensed Consolidated Statements of Operations</div>
          <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">(In Millions, Except Per Share Data)</div>
        </div>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" class="cfttable" id="zde690ed0cd4e4cdd92b080b8e151b0f1" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;">

            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="6" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';">Three months ended,</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="6" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';">Six months ended</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="6" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';"> June 30<font style="font-family: 'Times New Roman';">,</font></div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="6" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';">June 30,</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';"> 2023</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';">2022</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';">2023</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';">2022</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="14" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';">(unaudited)</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Revenue:</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Commercial revenue:</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: bottom; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: bottom; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: bottom; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: bottom; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">SPINRAZA royalties</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">61</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">60</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">111</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">113</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">Other commercial revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">17</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">18</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">35</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">37</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt; font-family: 'Times New Roman';">Total commercial revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">78</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">78</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">146</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">150</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Research and development revenue:</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">Collaborative agreement revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">90</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">39</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">129</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">89</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">Eplontersen joint development revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">20</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">17</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">44</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">37</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt; font-family: 'Times New Roman';">Total research and development revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">110</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">56</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">173</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">126</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">Total revenue</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">188</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">134</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">319</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">276</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Expenses:</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Cost of sales</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">3</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">5</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">4</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">9</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Research, development and patent</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">230</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">181</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">428</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">342</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman'; font-size: 10pt;">Selling, general and administrative</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">46</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">34</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">91</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">68</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">Total operating expenses</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">279</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">220</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">523</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">419</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Loss from operations</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">(91</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">(86</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">(204</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">(143</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
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            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Other income (expense):</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Interest expense related to the sale of future royalties:</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(18</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">-</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(33</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">-</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Other income (expense), net</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">32</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(17</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">47</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(24</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Loss before income tax expense</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(77</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(103</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(190</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(167</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Income tax expense</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(8</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(2</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(20</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(3</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
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            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Net loss</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
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              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(85</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
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              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(105</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
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              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(210</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(170</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Basic and diluted net loss per share</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(0.60</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(0.74</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(1.47</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(1.20</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 4px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Shares used in computing basic and diluted net loss per share</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;">
                <div style="font-family: 'Times New Roman';">143</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;">
                <div style="font-family: 'Times New Roman';">142</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;">
                <div style="font-family: 'Times New Roman';">143</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;">
                <div style="font-family: 'Times New Roman';">142</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px;">&#160;</td>
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        <div style="font-size: 10pt;"><br>
        </div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">6</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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        <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">IONIS PHARMACEUTICALS, INC.</div>
        <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Reconciliation of GAAP to Non-GAAP Basis:</div>
        <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">
          <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Condensed Consolidated Operating Expenses, Loss From Operations, and Net Loss</div>
          <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">(In Millions)</div>
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        <div><br>
        </div>
        <table cellspacing="0" cellpadding="0" class="cfttable" id="zf4decec2ed57456db7f4450715064828" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;">

            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; padding-left: 9pt;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="6" style="vertical-align: top;">
                <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">Three months ended</div>
                <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">June 30<font style="font-family: 'Times New Roman';">,</font></div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="6" style="vertical-align: top;">
                <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">Six months ended</div>
                <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">June 30,</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="text-align: left; vertical-align: bottom;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; padding-left: 9pt; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';"> 2023</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';">2022</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';">2023</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman';">2022</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; padding-left: 9pt;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="14" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';">(unaudited)</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">As reported research, development and patent expenses according to GAAP</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">230</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">181</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">428</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">342</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; font-family: 'Times New Roman'; margin-left: 9pt;">Excluding compensation expense related to equity awards</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">(19</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">(19</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">(39</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">(38</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Non-GAAP research, development and patent expenses</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">211</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">162</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">389</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">304</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: middle; font-size: 10pt; width: 52%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; width: 52%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">As reported selling, general and administrative expenses according to GAAP</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">46</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">34</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">91</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">68</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; font-family: 'Times New Roman'; margin-left: 9pt;">Excluding compensation expense related to equity awards</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(7</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(6</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(14</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(13</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Non-GAAP selling, general and administrative expenses</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">39</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">28</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">77</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">55</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: middle; font-size: 10pt; width: 52%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">As reported operating expenses according to GAAP</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">279</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">220</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">523</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">419</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; font-family: 'Times New Roman'; margin-left: 9pt;">Excluding compensation expense related to equity awards</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(27</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(25</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(54</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(51</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Non-GAAP operating expenses</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">252</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">195</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">469</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">368</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">As reported loss from operations according to GAAP</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(91</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(86</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(204</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(143</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; font-family: 'Times New Roman'; margin-left: 9pt;">Excluding compensation expense related to equity awards</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(27</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(25</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(54</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(51</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Non-GAAP loss from operations</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
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              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
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              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
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              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
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              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(92</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
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            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: middle; font-size: 10pt; width: 52%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
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              <td valign="bottom" colspan="1" style="vertical-align: middle; font-size: 10pt; width: 52%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">As reported net loss according to GAAP</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(85</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(105</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(210</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(170</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
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            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 2px;">
                <div style="text-align: left; font-family: 'Times New Roman'; margin-left: 9pt;">Excluding compensation expense related to equity awards and related tax effects</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(27</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(25</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(54</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">(51</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
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            <tr>
              <td valign="bottom" colspan="1" style="vertical-align: top; font-size: 10pt; width: 52%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Non-GAAP net loss</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(58</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(80</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(156</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$&#160;</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">(119</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">)</div>
              </td>
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        <div style="font-size: 10pt;"><br>
        </div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;"><u>Reconciliation of GAAP to Non-GAAP Basis</u></div>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As illustrated in the Selected Financial Information in this press release, non-GAAP operating expenses, non-GAAP loss from operations, and non-GAAP net loss were
          adjusted from GAAP to exclude compensation expense related to equity awards and the related tax effects. Compensation expense related to equity awards are non-cash. These measures are provided as supplementary information and are not a substitute
          for financial measures calculated in accordance with GAAP. Ionis reports these non-GAAP results to better enable financial statement users to assess and compare its historical performance and project its future operating results and cash flows.
          Further, the presentation of Ionis' non-GAAP results is consistent with how Ionis' management internally evaluates the performance of its operations.</div>
        <div style="font-size: 10pt;">&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">7</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
        </div>
        <div style="font-size: 10pt;">
          <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">IONIS PHARMACEUTICALS, INC.</div>
          <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Condensed Consolidated Balance Sheets</div>
        </div>
        <div style="font-size: 10pt; text-align: center;">&#160;(In Millions)</div>
        <div style="font-size: 10pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" class="cfttable" id="ze898da635f4a4567bdde54f0e0120309" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;">

            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';"> June 30,</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';">December 31,</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: #000000 solid 2px;">
                <div style="text-align: center; font-family: 'Times New Roman';"> 2023</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt; border-bottom: #000000 solid 2px;">
                <div style="text-align: center; font-family: 'Times New Roman';">2022</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman';">(unaudited)</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Assets:</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom;">&#160;</td>
              <td valign="bottom" colspan="2" style="vertical-align: top; font-size: 10pt;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom;">&#160;</td>
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            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Cash, cash equivalents and short-term investments</div>
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              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
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              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">2,385</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">1,987</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
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            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Contracts receivable</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">28</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">26</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
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            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Other current assets</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">203</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">190</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
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            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Property, plant and equipment, net</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">92</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">74</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Right-of-use assets</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">177</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">182</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; padding-bottom: 2px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Other assets</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">86</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
                <div style="font-family: 'Times New Roman';">75</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
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            <tr>
              <td valign="bottom" style="vertical-align: top; width: 76%; padding-bottom: 4px; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman'; font-size: 10pt;">Total assets</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">2,971</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;">
                <div style="font-family: 'Times New Roman';">2,534</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;">&#160;</td>
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            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; background-color: #CCEEFF;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman';">Liabilities and stockholders&#8217; equity:</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" rowspan="1" style="vertical-align: top; font-size: 10pt; width: 76%;">&#160;</td>
              <td valign="bottom" rowspan="1" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" rowspan="1" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" rowspan="1" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" rowspan="1" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" rowspan="1" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" rowspan="1" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" rowspan="1" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
              <td valign="bottom" nowrap="nowrap" rowspan="1" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Other current liabilities</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">192</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">221</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Current portion of deferred contract revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">96</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">91</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">1.75% convertible senior notes, net</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">561</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">-</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">0% convertible senior notes, net</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">624</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">622</div>
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              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">0.125% convertible senior notes, net</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">114</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">545</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Liability related to sale of future royalties, net</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">510</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">-</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Long-term lease liabilities</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">175</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">178</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Long-term obligations, less current portion</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">17</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%;">
                <div style="font-family: 'Times New Roman';">16</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Long-term deferred contract revenue</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">254</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">288</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; padding-bottom: 2px;">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman';">Total stockholders&#8217; equity</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">428</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman';">573</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: top; font-size: 10pt; width: 76%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">
                <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt; font-family: 'Times New Roman';">Total liabilities and stockholders&#8217; equity</div>
              </td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">2,971</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftguttercell" colspan="1" style="font-size: 10pt; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">&#160;</td>
              <td valign="bottom" class="cftcurrcell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">$</div>
              </td>
              <td valign="bottom" class="cftnumcell" colspan="1" style="font-size: 10pt; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
                <div style="font-family: 'Times New Roman';">2,534</div>
              </td>
              <td valign="bottom" nowrap="nowrap" class="cftfncell" colspan="1" style="font-size: 10pt; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">&#160;</td>
            </tr>

        </table>
        <div> <br>
        </div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">8</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
        </div>
        <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">2023 Key Value Driving Events</font><font style="font-size: 10pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></font></div>
        <div style="font-size: 10pt;"><br>
        </div>
        <table cellspacing="0" cellpadding="1" border="0" align="center" style="border-collapse: collapse; width: 90%; color: #000000; font-family: 'Times New Roman'; font-size: 10pt; text-align: left;" id="zc0cc17235444455cbc3b3963a409d40e">

            <tr>
              <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Regulatory Actions</div>
              </td>
            </tr>
            <tr>
              <td style="width: 21%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Program</div>
              </td>
              <td style="width: 25.51%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Indication</div>
              </td>
              <td style="width: 25%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Regulatory Action</div>
              </td>
              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Achieved</div>
              </td>
            </tr>
            <tr>
              <td rowspan="2" style="width: 21%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">QALSODY</div>
              </td>
              <td rowspan="2" style="width: 25.51%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">SOD1-ALS</div>
              </td>
              <td style="width: 25%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">NDA approval</div>
              </td>
              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: center;"><img width="13" height="13" src="image1.jpg"></div>
              </td>
            </tr>
            <tr>
              <td style="width: 25%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">EU approval<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">2</sup></div>
              </td>
              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">&#160;</td>
            </tr>
            <tr>
              <td rowspan="2" style="width: 21%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">Eplontersen (TTR)</div>
              </td>
              <td rowspan="2" style="width: 25.51%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">ATTRv polyneuropathy</div>
              </td>
              <td style="width: 25%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">NDA approval</div>
              </td>
              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 25%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">OUS filings</div>
              </td>
              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">&#160;</td>
            </tr>

        </table>
        <div style="font-size: 10pt;"><br>
        </div>
        <table cellspacing="0" cellpadding="1" border="0" align="center" style="font-family: 'Times New Roman'; font-size: 10pt; width: 90%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="z46f9af21149041c1a1d1ef7189a97dbd">

            <tr>
              <td colspan="4" style="vertical-align: middle; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Key Clinical Data Events</div>
              </td>
            </tr>
            <tr>
              <td style="width: 21%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Program</div>
              </td>
              <td style="width: 25.51%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Indication</div>
              </td>
              <td style="width: 25%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Event</div>
              </td>
              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Achieved</div>
              </td>
            </tr>
            <tr>
              <td style="width: 21%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">Eplontersen (TTR)</div>
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              <td style="width: 25.51%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
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                <div style="text-align: left; font-family: 'Times New Roman';">Phase 3 data (week 35<font style="font-family: 'Times New Roman';">,</font> 66 &amp; 85)</div>
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              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: center;"><img width="13" height="13" src="image1.jpg"></div>
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            <tr>
              <td style="width: 21%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">Olezarsen (APOCIII)</div>
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              <td style="width: 25.51%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
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                <div style="text-align: left; font-family: 'Times New Roman';">Phase 3 data</div>
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              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">&#160;</td>
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              <td style="width: 21%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">Donidalorsen (PKK)</div>
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              <td style="width: 25.51%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
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                <div style="text-align: left; font-family: 'Times New Roman';">Phase 2, OLE 1-year data</div>
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                <div style="text-align: center;"><img width="13" height="13" src="image1.jpg"></div>
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              <td style="width: 21%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">Donidalorsen (PKK)</div>
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              <td style="width: 25.51%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
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                <div style="text-align: left; font-family: 'Times New Roman';">Phase 2, OLE 2-year data</div>
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                <div style="text-align: center;"><img width="13" height="13" src="image1.jpg"></div>
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                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Enrollment Achievements</div>
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                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Event</div>
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              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Achieved</div>
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            <tr>
              <td style="width: 21%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">Eplontersen (TTR)</div>
              </td>
              <td style="width: 25.51%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">ATTR cardiomyopathy</div>
              </td>
              <td style="width: 25%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">Phase 3 full enrollment</div>
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              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: center;"><img width="13" height="13" src="image1.jpg"></div>
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              <td style="width: 21%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">Donidalorsen (PKK)</div>
              </td>
              <td style="width: 25.51%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">HAE</div>
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              <td style="width: 25%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">Phase 3 full enrollment</div>
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              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: center;"><img width="13" height="13" src="image1.jpg"></div>
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              <td style="width: 21%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">IONIS-FB-L<sub style="vertical-align: bottom; line-height: 1; font-size: smaller;">Rx</sub></div>
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              <td style="width: 25.51%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">Geographic Atrophy</div>
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              <td style="width: 25%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman';">Phase 2 full enrollment</div>
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              <td style="width: 18%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: center;"><img width="13" height="13" src="image1.jpg"></div>
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              <td style="width: 22%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Program</div>
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              <td style="width: 46%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
                <div style="text-align: left; font-family: 'Times New Roman'; font-weight: bold;">Indication</div>
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                <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Achieved</div>
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                <div style="text-align: left; font-family: 'Times New Roman';">Bepirovirsen (HBV)</div>
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              <td style="width: 46%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); font-size: 10pt;">
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                <div style="text-align: center;"><img width="13" height="13" src="image1.jpg"></div>
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                <div style="text-align: left; font-family: 'Times New Roman';">IONIS-FB-L<sub style="vertical-align: bottom; line-height: 1; font-size: smaller;">Rx</sub></div>
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                <div style="text-align: center;"><img width="13" height="13" src="image1.jpg"></div>
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                <div style="font-family: 'Times New Roman';">Timing expectations based on current assumptions and subject to change.</div>
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                <div style="font-family: 'Times New Roman';">CHMP opinion anticipated in Q4:2023.</div>
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        <div style="text-align: center; margin-right: 4.5pt; font-family: 'Times New Roman'; font-size: 10pt;">#&#160;&#160; #&#160;&#160; #</div>
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  <link:labelLink xlink:type="extended" xlink:role="http://www.xbrl.org/2003/role/link">
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    <link:label xlink:type="resource" xlink:label="dei_DocumentType_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentType_lbl" xml:lang="en-US" id="dei_DocumentType_lbl">Document Type</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_WrittenCommunications" xlink:label="WrittenCommunications" xlink:title="WrittenCommunications" />
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    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="WrittenCommunications" xlink:to="dei_WrittenCommunications_lbl" xlink:title="label: WrittenCommunications to dei_WrittenCommunications_lbl" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SolicitingMaterial" xlink:label="SolicitingMaterial" xlink:title="SolicitingMaterial" />
    <link:label xlink:type="resource" xlink:label="dei_SolicitingMaterial_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_SolicitingMaterial_lbl" xml:lang="en-US" id="dei_SolicitingMaterial_lbl">Soliciting Material</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="SolicitingMaterial" xlink:to="dei_SolicitingMaterial_lbl" xlink:title="label: SolicitingMaterial to dei_SolicitingMaterial_lbl" />
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    <link:label xlink:type="resource" xlink:label="dei_PreCommencementTenderOffer_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_PreCommencementTenderOffer_lbl" xml:lang="en-US" id="dei_PreCommencementTenderOffer_lbl">Pre-commencement Tender Offer</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementIssuerTenderOffer" xlink:label="PreCommencementIssuerTenderOffer" xlink:title="PreCommencementIssuerTenderOffer" />
    <link:label xlink:type="resource" xlink:label="dei_PreCommencementIssuerTenderOffer_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_PreCommencementIssuerTenderOffer_lbl" xml:lang="en-US" id="dei_PreCommencementIssuerTenderOffer_lbl">Pre-commencement Issuer Tender Offer</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag" xlink:label="AmendmentFlag" xlink:title="AmendmentFlag" />
    <link:label xlink:type="resource" xlink:label="dei_AmendmentFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_AmendmentFlag_lbl" xml:lang="en-US" id="dei_AmendmentFlag_lbl">Amendment Flag</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentFiscalYearFocus" xlink:label="DocumentFiscalYearFocus" xlink:title="DocumentFiscalYearFocus" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentFiscalYearFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentFiscalYearFocus_lbl" xml:lang="en-US" id="dei_DocumentFiscalYearFocus_lbl">Document Fiscal Year Focus</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="DocumentFiscalPeriodFocus" xlink:title="DocumentFiscalPeriodFocus" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentFiscalPeriodFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentFiscalPeriodFocus_lbl" xml:lang="en-US" id="dei_DocumentFiscalPeriodFocus_lbl">Document Fiscal Period Focus</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="DocumentFiscalPeriodFocus" xlink:to="dei_DocumentFiscalPeriodFocus_lbl" xlink:title="label: DocumentFiscalPeriodFocus to dei_DocumentFiscalPeriodFocus_lbl" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentPeriodEndDate" xlink:label="DocumentPeriodEndDate" xlink:title="DocumentPeriodEndDate" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentPeriodEndDate_lbl" xml:lang="en-US" id="dei_DocumentPeriodEndDate_lbl">Document Period End Date</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="DocumentPeriodEndDate" xlink:to="dei_DocumentPeriodEndDate_lbl" xlink:title="label: DocumentPeriodEndDate to dei_DocumentPeriodEndDate_lbl" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName" xlink:label="EntityRegistrantName" xlink:title="EntityRegistrantName" />
    <link:label xlink:type="resource" xlink:label="dei_EntityRegistrantName_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityRegistrantName_lbl" xml:lang="en-US" id="dei_EntityRegistrantName_lbl">Entity Registrant Name</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey" xlink:label="EntityCentralIndexKey" xlink:title="EntityCentralIndexKey" />
    <link:label xlink:type="resource" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityCentralIndexKey_lbl" xml:lang="en-US" id="dei_EntityCentralIndexKey_lbl">Entity Central Index Key</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityFileNumber" xlink:label="EntityFileNumber" xlink:title="EntityFileNumber" />
    <link:label xlink:type="resource" xlink:label="dei_EntityFileNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityFileNumber_lbl" xml:lang="en-US" id="dei_EntityFileNumber_lbl">Entity File Number</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityTaxIdentificationNumber" xlink:label="EntityTaxIdentificationNumber" xlink:title="EntityTaxIdentificationNumber" />
    <link:label xlink:type="resource" xlink:label="dei_EntityTaxIdentificationNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityTaxIdentificationNumber_lbl" xml:lang="en-US" id="dei_EntityTaxIdentificationNumber_lbl">Entity Tax Identification Number</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="EntityIncorporationStateCountryCode" xlink:title="EntityIncorporationStateCountryCode" />
    <link:label xlink:type="resource" xlink:label="dei_EntityIncorporationStateCountryCode_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityIncorporationStateCountryCode_lbl" xml:lang="en-US" id="dei_EntityIncorporationStateCountryCode_lbl">Entity Incorporation, State or Country Code</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityEmergingGrowthCompany" xlink:label="EntityEmergingGrowthCompany" xlink:title="EntityEmergingGrowthCompany" />
    <link:label xlink:type="resource" xlink:label="dei_EntityEmergingGrowthCompany_lbl" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityEmergingGrowthCompany_lbl" xml:lang="en-US" id="dei_EntityEmergingGrowthCompany_lbl">Entity Emerging Growth Company</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine1" xlink:label="EntityAddressAddressLine1" xlink:title="EntityAddressAddressLine1" />
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine2" xlink:label="EntityAddressAddressLine2" xlink:title="EntityAddressAddressLine2" />
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressPostalZipCode" xlink:label="EntityAddressPostalZipCode" xlink:title="EntityAddressPostalZipCode" />
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_Security12bTitle" xlink:label="Security12bTitle" xlink:title="Security12bTitle" />
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SecurityExchangeName" xlink:label="SecurityExchangeName" xlink:title="SecurityExchangeName" />
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</link:linkbase>
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</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.PRE
<SEQUENCE>5
<FILENAME>ions-20230809_pre.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE
<TEXT>
<XBRL>
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<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="include/report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
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<body>
<span style="display: none;">v3.23.2</span><table class="report" border="0" cellspacing="2" id="idm140004525951872">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Document and Entity Information<br></strong></div></th>
<th class="th"><div>Aug. 09, 2023</div></th>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CoverAbstract', window );"><strong>Cover [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentType', window );">Document Type</a></td>
<td class="text">8-K<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_AmendmentFlag', window );">Amendment Flag</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentPeriodEndDate', window );">Document Period End Date</a></td>
<td class="text">Aug.  09,  2023<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityFileNumber', window );">Entity File Number</a></td>
<td class="text">000-19125<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityRegistrantName', window );">Entity Registrant Name</a></td>
<td class="text">IONIS PHARMACEUTICALS, INC.<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityCentralIndexKey', window );">Entity Central Index Key</a></td>
<td class="text">0000874015<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityIncorporationStateCountryCode', window );">Entity Incorporation, State or Country Code</a></td>
<td class="text">DE<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityTaxIdentificationNumber', window );">Entity Tax Identification Number</a></td>
<td class="text">33-0336973<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine1', window );">Entity Address, Address Line One</a></td>
<td class="text">2855 Gazelle Court<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressCityOrTown', window );">Entity Address, City or Town</a></td>
<td class="text">Carlsbad<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressStateOrProvince', window );">Entity Address, State or Province</a></td>
<td class="text">CA<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressPostalZipCode', window );">Entity Address, Postal Zip Code</a></td>
<td class="text">92010<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CityAreaCode', window );">City Area Code</a></td>
<td class="text">760<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_LocalPhoneNumber', window );">Local Phone Number</a></td>
<td class="text">931-9200<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Title of 12(b) Security</a></td>
<td class="text">Common Stock, $.001 Par Value<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">IONS<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NASDAQ<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityEmergingGrowthCompany', window );">Entity Emerging Growth Company</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_WrittenCommunications', window );">Written Communications</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SolicitingMaterial', window );">Soliciting Material</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementTenderOffer', window );">Pre-commencement Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementIssuerTenderOffer', window );">Pre-commencement Issuer Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_AmendmentFlag">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AmendmentFlag</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
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<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CityAreaCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Area code of city</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CityAreaCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CoverAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Cover page.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CoverAbstract</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentPeriodEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period.  The format of the date is YYYY-MM-DD.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentPeriodEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:dateItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentType">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentType</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:submissionTypeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 1 such as Attn, Building Name, Street Name</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine1</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressCityOrTown">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the City or Town</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressCityOrTown</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressPostalZipCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Code for the postal or zip code</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressPostalZipCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressStateOrProvince">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the state or province.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressStateOrProvince</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:stateOrProvinceItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCentralIndexKey">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCentralIndexKey</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:centralIndexKeyItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityEmergingGrowthCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate if registrant meets the emerging growth company criteria.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityEmergingGrowthCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityFileNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityFileNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:fileNumberItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityIncorporationStateCountryCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Two-character EDGAR code representing the state or country of incorporation.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityIncorporationStateCountryCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarStateCountryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityRegistrantName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityRegistrantName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityTaxIdentificationNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityTaxIdentificationNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:employerIdItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_LocalPhoneNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Local phone number for entity.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_LocalPhoneNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementIssuerTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 13e<br> -Subsection 4c<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementIssuerTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14d<br> -Subsection 2b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_Security12bTitle">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Title of a 12(b) registered security.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_Security12bTitle</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:securityTitleItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SecurityExchangeName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the Exchange on which a security is registered.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection d1-1<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SecurityExchangeName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarExchangeCodeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SolicitingMaterial">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Section 14a<br> -Number 240<br> -Subsection 12<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SolicitingMaterial</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_TradingSymbol">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Trading symbol of an instrument as listed on an exchange.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_TradingSymbol</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:tradingSymbolItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_WrittenCommunications">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Securities Act<br> -Number 230<br> -Section 425<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_WrittenCommunications</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
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<td><strong> Balance Type:</strong></td>
<td>na</td>
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<td>duration</td>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
