<SEC-DOCUMENT>0000048532-23-000012.txt : 20230929
<SEC-HEADER>0000048532-23-000012.hdr.sgml : 20230929
<ACCEPTANCE-DATETIME>20230929160646
ACCESSION NUMBER:		0000048532-23-000012
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20230929
DATE AS OF CHANGE:		20230929

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		231295533

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BENNETT C FRANK
		CENTRAL INDEX KEY:			0001073387
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		STREET 2:		C/O IONIS PHARMACEUTICALS, INC.
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001073387</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000874015</issuerCik>
      <issuerName>IONIS PHARMACEUTICALS INC</issuerName>
      <secFileNumber>000-19125</secFileNumber>
      <issuerAddress>
        <com:street1>2855 GAZELLE COURT</com:street1>
        <com:city>CARLSBAD</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92010</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>7609319200</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BENNETT C FRANK</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>INSIGHT SECURITIES, INC.</name>
        <address>
          <com:street1>600 CENTRAL</com:street1>
          <com:street2>STE 293</com:street2>
          <com:city>HIGHLAND PARK</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60035</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>4460</noOfUnitsSold>
      <aggregateMarketValue>207390.00</aggregateMarketValue>
      <noOfUnitsOutstanding>143100000</noOfUnitsOutstanding>
      <approxSaleDate>09/28/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
      <acquiredDate>01/15/2015</acquiredDate>
      <natureOfAcquisitionTransaction>COMPENSATION</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>IONIS PHARMACEUTICALS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1161</amountOfSecuritiesAcquired>
      <paymentDate>01/15/2015</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
      <acquiredDate>01/15/2016</acquiredDate>
      <natureOfAcquisitionTransaction>COMPENSATION</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>IONIS PHARMACEUTICALS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1128</amountOfSecuritiesAcquired>
      <paymentDate>01/15/2016</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
      <acquiredDate>01/15/2017</acquiredDate>
      <natureOfAcquisitionTransaction>COMPENSATION</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>IONIS PHARMACEUTICALS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1142</amountOfSecuritiesAcquired>
      <paymentDate>01/15/2017</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
      <acquiredDate>01/15/2018</acquiredDate>
      <natureOfAcquisitionTransaction>COMPENSATION</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>IONIS PHARMACEUTICALS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1029</amountOfSecuritiesAcquired>
      <paymentDate>01/15/2018</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>INSIGHT SECURITIES SOLD 4,460 SHARES OF IONIS PHARMACEUTICALS, INC. FOR FRANK C. BENNETT.</remarks>
    <noticeSignature>
      <noticeDate>09/29/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>06/29/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>MICHAEL MAKULA</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
