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v3.24.0.1

Organization and Significant Accounting Policies, Property, Plant and Equipment (Details) | Dec. 31, 2023
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Computer Software, Laboratory, Manufacturing and Other Equipment [Member] | Minimum [Member] |
Property, Plant and Equipment [Abstract] |
Estimated useful life | 3 years
Computer Software, Laboratory, Manufacturing and Other Equipment [Member] | Maximum [Member] |
Property, Plant and Equipment [Abstract] |
Estimated useful life | 10 years
Building, Building Improvements and Building Systems [Member] | Minimum [Member] |
Property, Plant and Equipment [Abstract] |
Estimated useful life | 15 years
Building, Building Improvements and Building Systems [Member] | Maximum [Member] |
Property, Plant and Equipment [Abstract] |
Estimated useful life | 40 years
Land Improvements [Member] |
Property, Plant and Equipment [Abstract] |
Estimated useful life | 20 years
Leasehold Improvements [Member] | Minimum [Member] |
Property, Plant and Equipment [Abstract] |
Estimated useful life | 5 years
Leasehold Improvements [Member] | Maximum [Member] |
Property, Plant and Equipment [Abstract] |
Estimated useful life | 15 years
Furniture and Fixtures [Member] | Minimum [Member] |
Property, Plant and Equipment [Abstract] |
Estimated useful life | 5 years
Furniture and Fixtures [Member] | Maximum [Member] |
Property, Plant and Equipment [Abstract] |
Estimated useful life | 10 years

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- References No definition available. + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

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- Definition Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment. + References No definition available. + Details
Name: | us-gaap_PropertyPlantAndEquipmentUsefulLife
Namespace Prefix: | us-gaap_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | instant

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- Details
Name: | us-gaap_PropertyPlantAndEquipmentByTypeAxis=ions_EquipmentAndComputerSoftwareMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
Name: | srt_RangeAxis=srt_MinimumMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
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Namespace Prefix: |
Data Type: | na
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- Details
Name: | us-gaap_PropertyPlantAndEquipmentByTypeAxis=us-gaap_BuildingAndBuildingImprovementsMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
Name: | us-gaap_PropertyPlantAndEquipmentByTypeAxis=us-gaap_LandImprovementsMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
Name: | us-gaap_PropertyPlantAndEquipmentByTypeAxis=us-gaap_LeaseholdImprovementsMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
Name: | us-gaap_PropertyPlantAndEquipmentByTypeAxis=us-gaap_FurnitureAndFixturesMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |