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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Operating activities: |  |  |
Net loss | $ (366,286) | $ (269,722) | $ (28,597)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation | 10,292 | 14,328 | 15,487
Amortization of right-of-use operating lease assets | 9,647 | 5,362 | 1,721
Amortization of other assets | 2,559 | 2,415 | 2,352
Amortization of premium (discount) on investments, net | (28,885) | 7,389 | 17,776
Amortization of debt issuance costs | 6,330 | 5,373 | 4,958
Non-cash royalty revenue related to sale of royalties | (44,628) | 0 | 0
Non-cash interest related to sale of future royalties | 68,238 | 0 | 0
Stock-based compensation expense | 105,809 | 100,264 | 120,678
Loss (gain) on early retirement of debt | (13,389) | 0 | 8,627
Non-cash losses related to disposal of property, plant and equipment | 16,649 | 531 | 0
Loss (gain) on sale of real estate assets | 161 | (150,135) | 0
Loss (gain) on investments | 1,589 | 224 | (1,092)
Non-cash losses related to other assets | 1,661 | 2,030 | 2,707
Changes in operating assets and liabilities: |  |  |
Contracts receivable | (72,059) | 36,358 | 14,308
Inventories | (6,392) | 2,773 | (2,841)
Other current and long-term assets | (29,840) | (24,682) | (877)
Accounts payable | 8,119 | 1,094 | (6,000)
Income taxes | (4,098) | 6,213 | (280)
Accrued compensation | 18,549 | 10,368 | (26,918)
Accrued liabilities and other current liabilities | (5,506) | 46,695 | (8,381)
Deferred contract revenue | 13,967 | (71,248) | (82,829)
Net cash provided by (used in) operating activities | (307,513) | (274,370) | 30,799
Investing activities: |  |  |
Purchases of short-term investments | (1,770,814) | (1,485,772) | (1,124,193)
Proceeds from sale of short-term investments | 1,584,676 | 989,152 | 1,344,185
Purchases of property, plant and equipment | (23,805) | (15,721) | (11,955)
Proceeds from sale of real estate assets | 22 | 254,083 | 0
Acquisition of licenses and other assets, net | (4,206) | (4,378) | (5,946)
Purchases of strategic investments | 0 | 0 | (7,185)
Net cash provided by (used in) investing activities | (214,127) | (262,636) | 194,906
Financing activities: |  |  |
Proceeds from equity, net | 49,442 | 6,373 | 11,565
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options | 0 | (10,953) | (16,725)
Proceeds from sale of future royalties | 500,000 | 0 | 0
Payments of transaction costs related to sale of future royalties | (10,434) | (29) | 0
Proceeds from real estate transaction | 32,352 | 0 | 0
Repayment of remaining principal amount of 1 percent convertible senior notes at maturity | 0 | 0 | (61,967)
Proceeds from issuance of warrants | 0 | 0 | 89,752
Purchase of note hedges | 0 | 0 | (136,620)
Principal payments on debt | (160) | (50,686) | 0
Net cash provided by (used in) financing activities | 644,082 | (55,295) | 245,933
Effects of exchange rates on cash | 352 | (418) | (111)
Net increase (decrease) in cash and cash equivalents | 122,794 | (592,719) | 471,527
Cash and cash equivalents at beginning of year | 276,472 | 869,191 | 397,664
Cash and cash equivalents at end of year | 399,266 | 276,472 | 869,191
Supplemental disclosures of cash flow information: |  |  |
Interest paid | 6,512 | 2,898 | 4,778
Income taxes paid | 48,334 | 5,010 | 38
Supplemental disclosures of non-cash investing and financing activities: |  |  |
Right-of-use assets obtained in exchange for lease liabilities | 0 | 168,931 | 6,641
Amounts accrued for capital and patent expenditures | 172 | 4,767 | 705
1.75 Percent Convertible Senior Notes [Member] |  |  |
Financing activities: |  |  |
Proceeds from issuance of convertible senior notes | 575,000 | 0 | 0
Convertible senior notes issuance costs | (14,175) | 0 | 0
0.125 Percent Convertible Senior Notes [Member] |  |  |
Financing activities: |  |  |
Repurchase of convertible senior notes | (487,943) | 0 | 0
Repayment of remaining principal amount of 1 percent convertible senior notes at maturity | (504,400) |  |
0 Percent Convertible Senior Notes [Member] |  |  |
Financing activities: |  |  |
Proceeds from issuance of convertible senior notes | 0 | 0 | 632,500
Convertible senior notes issuance costs | 0 | 0 | (15,609)
Proceeds from issuance of warrants |  |  | 89,800
Purchase of note hedges |  |  | (136,700)
1 Percent Convertible Senior Notes [Member] |  |  |
Financing activities: |  |  |
Repurchase of convertible senior notes | $ 0 | $ 0 | (256,963)
Repayment of remaining principal amount of 1 percent convertible senior notes at maturity |  |  | $ (309,900)

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