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Collaborative Arrangements and Licensing Agreements, Alnylam Pharmaceuticals, Inc. (Details) $ in Thousands | 12 Months Ended
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Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2015 Program Target
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |
Revenue | $ 787,647 | $ 587,367 | $ 810,456 |
R&D Revenue [Member] |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |
Revenue | 479,056 | 284,009 | $ 468,061 |
Alnylam [Member] |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |
Number of therapeutic programs | Program |  |  |  | 4
Number of therapeutic targets granted to Ionis | Target |  |  |  | 4
Number of unnamed therapeutic targets granted to Ionis | Target |  |  |  | 2
Number of therapeutic targets granted by Ionis | Target |  |  |  | 4
Deferred revenue | $ 0 | $ 0 |  |
Alnylam [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |
Concentration percentage | 4.00% | 4.00% | 0.00% |
Alnylam [Member] | R&D Revenue [Member] |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |
Revenue | $ 28,426 | $ 21,389 | $ 0 |

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