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Revenues (Details) $ in Thousands | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jun. 30, 2024 USD ($) | Jun. 30, 2023 USD ($) | Jun. 30, 2024 USD ($) | Jun. 30, 2023 USD ($) | Dec. 31, 2021 USD ($) Component PerformanceObligation
Revenues [Abstract] |  |  |  |  |
Revenue | $ 225,250 | $ 188,411 | $ 344,748 | $ 318,935 |
WAINUA (Eplontersen) Collaboration with AstraZeneca [Member] |  |  |  |  |
Revenues [Abstract] |  |  |  |  |
Upfront payment received |  |  |  |  | $ 200,000
Number of material components | Component |  |  |  |  | 4
Number of performance obligations | PerformanceObligation |  |  |  |  | 1
Transaction price |  |  |  |  | $ 200,000
Percentage of costs associated with ongoing global Phase 3 development program paid by AstraZeneca |  |  | 55.00% |  |
Commercial Revenue [Member] |  |  |  |  |
Revenues [Abstract] |  |  |  |  |
Revenue | 72,036 | 77,897 | $ 131,629 | 145,664 |
SPINRAZA Royalties [Member] |  |  |  |  |
Revenues [Abstract] |  |  |  |  |
Revenue | 56,743 | 61,012 | 95,198 | 111,258 |
WAINUA Royalties [Member] |  |  |  |  |
Revenues [Abstract] |  |  |  |  |
Revenue | 3,781 | 0 | 4,907 | 0 |
Other Commercial Revenue [Member] |  |  |  |  |
Revenues [Abstract] |  |  |  |  |
Revenue | 11,512 | 16,885 | 31,524 | 34,406 |
TEGSEDI and WAYLIVRA Revenue, Net [Member] |  |  |  |  |
Revenues [Abstract] |  |  |  |  |
Revenue | 8,192 | 10,655 | 16,820 | 17,133 |
Licensing and Other Royalty Revenue [Member] |  |  |  |  |
Revenues [Abstract] |  |  |  |  |
Revenue | 3,320 | 6,230 | 14,704 | 17,273 |
Research and Development Revenue [Member] |  |  |  |  |
Revenues [Abstract] |  |  |  |  |
Revenue | 153,214 | 110,514 | 213,119 | 173,271 |
Collaborative Agreement Revenue [Member] |  |  |  |  |
Revenues [Abstract] |  |  |  |  |
Revenue | 141,524 | 91,013 | 190,870 | 129,347 |
WAINUA Joint Development Revenue [Member] |  |  |  |  |
Revenues [Abstract] |  |  |  |  |
Revenue | $ 11,690 | $ 19,501 | $ 22,249 | $ 43,924 |

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