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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jun. 30, 2024 | Jun. 30, 2023 | Jun. 30, 2024 | Jun. 30, 2023 | Dec. 31, 2023
Operating activities: |  |  |  |  |
Net loss | $ (66,265) | $ (85,290) | $ (209,068) | $ (209,613) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |
Depreciation |  |  | 5,013 | 5,225 |
Amortization of right-of-use operating lease assets |  |  | 4,957 | 4,826 |
Amortization of other assets |  |  | 1,260 | 1,244 |
Amortization of discount on investments, net |  |  | (19,143) | (12,481) |
Amortization of debt issuance costs |  |  | 3,338 | 2,966 |
Non-cash royalty revenue related to sale of royalties |  |  | (16,236) | (12,562) |
Non-cash interest related to sale of future royalties |  |  | 35,949 | 32,915 |
Stock-based compensation expense |  |  | 62,068 | 53,510 |
Loss (gain) on investments |  |  | 1,201 | (301) |
Gain on early retirement of debt |  |  | 0 | (11,292) |
Non-cash losses related to other assets |  |  | 389 | 775 |
Changes in operating assets and liabilities: |  |  |  |  |
Contracts receivable |  |  | 70,519 | (2,254) |
Inventories |  |  | (298) | (3,505) |
Other current and long-term assets |  |  | (9,381) | (19,696) |
Income taxes |  |  | (1,867) | 18,483 |
Accounts payable |  |  | (17,064) | 5,517 |
Accrued compensation |  |  | (32,709) | (19,856) |
Accrued liabilities and other current liabilities |  |  | (39,201) | (37,562) |
Deferred contract revenue |  |  | (109,545) | (27,695) |
Net cash used in operating activities |  |  | (269,818) | (231,356) |
Investing activities: |  |  |  |  |
Purchases of short-term investments |  |  | (803,867) | (932,362) |
Proceeds from sale of short-term investments |  |  | 968,413 | 701,034 |
Purchases of property, plant and equipment |  |  | (10,727) | (22,483) |
Acquisition of licenses and other assets, net |  |  | (15,264) | (2,314) |
Net cash provided by (used in) investing activities |  |  | 138,555 | (256,125) |
Financing activities: |  |  |  |  |
Proceeds from equity, net |  |  | 26,205 | 4,950 |
Proceeds from issuance of 1.75 percent convertible senior notes |  |  | 0 | 575,000 |
1.75 percent convertible senior notes issuance costs |  |  | 0 | (13,658) |
Repurchase of $434.1 million principal amount of 0.125 percent convertible senior notes |  |  | 0 | (420,158) |
Proceeds from sale of future royalties |  |  | 0 | 500,000 |
Payments of transaction costs related to sale of future royalties |  |  | 0 | (10,434) |
Principal payments on mortgage debt |  |  | (78) | (75) |
Net cash provided by financing activities |  |  | 26,127 | 635,625 |
Effects of exchange rates on cash |  |  | (137) | 174 |
Net increase (decrease) in cash and cash equivalents |  |  | (105,273) | 148,318 |
Cash and cash equivalents at beginning of period |  |  | 399,266 | 276,472 | $ 276,472
Cash and cash equivalents at end of period | $ 293,993 | $ 424,790 | 293,993 | 424,790 | $ 399,266
Supplemental disclosures of cash flow information: |  |  |  |  |
Interest paid |  |  | 5,569 | 529 |
Income taxes paid |  |  | 1,992 | 510 |
Supplemental disclosures of non-cash investing and financing activities: |  |  |  |  |
Amounts accrued for capital and patent expenditures |  |  | $ 1,453 | $ 251 |

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