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Collaborative Arrangements and Licensing Agreements, Roche (Details) $ in Thousands | 3 Months Ended | 6 Months Ended |  |
--- | --- | --- | --- | ---
Jun. 30, 2024 USD ($) Agreement | Jun. 30, 2023 USD ($) | Jun. 30, 2024 USD ($) Agreement | Jun. 30, 2023 USD ($) | Jul. 31, 2024 USD ($) | Dec. 31, 2023 USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Revenue | $ 225,250 | $ 188,411 | $ 344,748 | $ 318,935 |  |
Roche [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Number of collaboration agreements | Agreement | 3 |  | 3 |  |  |
Revenue | $ 11,089 | $ 5,754 | $ 22,595 | $ 8,121 |  |
Deferred contract revenue | $ 15,000 |  | $ 15,000 |  |  | $ 36,700
Roche [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Concentration percentage | 5.00% | 3.00% | 7.00% | 3.00% |  |
Roche [Member] | Minimum [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Cumulative payments received | $ 345,000 |  | $ 345,000 |  |  |
HD [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Number of collaboration agreements | Agreement | 1 |  | 1 |  |  |
IONIS-FB-L for Complement-Mediated Diseases [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Number of collaboration agreements | Agreement | 1 |  | 1 |  |  |
IONIS-FB-L for Complement-Mediated Diseases [Member] | Subsequent Event [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Maximum amount of payments receivable over term of collaboration |  |  |  |  | $ 430,000 |
Maximum amount of license fees over term of collaboration |  |  |  |  | 35,000 |
Maximum amount of development milestone payments over term of collaboration |  |  |  |  | 25,000 |
Maximum amount of regulatory milestone payments over term of collaboration |  |  |  |  | 90,000 |
Maximum amount of sales milestone payments over term of collaboration |  |  |  |  | 280,000 |
Next payment to be achieved |  |  |  |  | $ 23,500 |
RNA-targeted Programs for AD and HD [Member] |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |
Number of collaboration agreements | Agreement | 1 |  | 1 |  |  |

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