<SEC-DOCUMENT>0000874015-24-000224.txt : 20241001
<SEC-HEADER>0000874015-24-000224.hdr.sgml : 20241001
<ACCEPTANCE-DATETIME>20241001180146
ACCESSION NUMBER:		0000874015-24-000224
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20240929
FILED AS OF DATE:		20241001
DATE AS OF CHANGE:		20241001

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Devers Shannon L.
		CENTRAL INDEX KEY:			0002037721
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		241344667

	MAIL ADDRESS:	
		STREET 1:		C/O IONIS PHARMACEUTICALS, INC.
		STREET 2:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
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        <issuerName>IONIS PHARMACEUTICALS INC</issuerName>
        <issuerTradingSymbol>IONS</issuerTradingSymbol>
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            <rptOwnerCik>0002037721</rptOwnerCik>
            <rptOwnerName>Devers Shannon L.</rptOwnerName>
        </reportingOwnerId>
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            <rptOwnerStreet1>2855 GAZELLE COURT</rptOwnerStreet1>
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            <rptOwnerZipCode>92010</rptOwnerZipCode>
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            <isTenPercentOwner>0</isTenPercentOwner>
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            <officerTitle>EVP, Chief Human Resourses Ofc</officerTitle>
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                    <value>D</value>
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            <securityTitle>
                <value>Restricted Stock Unit</value>
                <footnoteId id="F1"/>
            </securityTitle>
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                <value>0.0</value>
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        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Each restricted stock unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.</footnote>
        <footnote id="F2">Grants to reporting person of restricted stock units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan on January 15, 2021, January 15, 2022, January 15, 2023 and January 15, 2024. The restricted stock units vest in four equal annual installments.  Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>By: Patrick R. O'Neil, attorney-in-fact For: Shannon L. Devers</signatureName>
        <signatureDate>2024-10-01</signatureDate>
    </ownerSignature>
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