<SEC-DOCUMENT>0000048532-24-000005.txt : 20240201
<SEC-HEADER>0000048532-24-000005.hdr.sgml : 20240201
<ACCEPTANCE-DATETIME>20240201101257
ACCESSION NUMBER:		0000048532-24-000005
CONFORMED SUBMISSION TYPE:	144/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20240201
DATE AS OF CHANGE:		20240201

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		24585346

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			O'NEIL PATRICK R.
		CENTRAL INDEX KEY:			0001564926
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144/A

	MAIL ADDRESS:	
		STREET 1:		C/O IONIS PHARMACEUTICALS, INC.
		STREET 2:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
</SEC-HEADER>
<DOCUMENT>
<TYPE>144/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144/A</submissionType>
    <previousAccessionNumber>0000048532-24-000002</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001564926</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000874015</issuerCik>
      <issuerName>IONIS PHARMACEUTICALS INC</issuerName>
      <secFileNumber>000-19125</secFileNumber>
      <issuerAddress>
        <com:street1>2855 GAZELLE COURT</com:street1>
        <com:city>CARLSBAD</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92010</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>7609319200</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>O'NEIL PATRICK R.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>INSIGHT SECURITIES, INC.</name>
        <address>
          <com:street1>600 CENTRAL</com:street1>
          <com:street2>STE 293</com:street2>
          <com:city>HIGHLAND PARK</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60035</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>6450</noOfUnitsSold>
      <aggregateMarketValue>333787.50</aggregateMarketValue>
      <noOfUnitsOutstanding>143100000</noOfUnitsOutstanding>
      <approxSaleDate>01/25/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
      <acquiredDate>01/16/2024</acquiredDate>
      <natureOfAcquisitionTransaction>COMPENSATION</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>IONIS PHARMACEUTICALS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6450</amountOfSecuritiesAcquired>
      <paymentDate>01/16/2024</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>PATRICK O'NEIL</name>
        <address>
          <com:street1>2855 GAZELLE COURT</com:street1>
          <com:city>CARLSBAD</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>92010</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
      <saleDate>12/26/2023</saleDate>
      <amountOfSecuritiesSold>20825</amountOfSecuritiesSold>
      <grossProceeds>1072487.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>PATRICK O'NEIL</name>
        <address>
          <com:street1>2855 GAZELLE COURT</com:street1>
          <com:city>CARLSBAD</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92010</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
      <saleDate>01/17/2024</saleDate>
      <amountOfSecuritiesSold>7645</amountOfSecuritiesSold>
      <grossProceeds>405185.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>INSIGHT SECURITIES SOLD 6,450 SHARES OF IONIS PHARMACEUTICALS, INC. FOR PATRICK O'NEIL ON 1/25/2024.  FILED 144/4 TO CORRECT THE ACQUISITION DATE, THE DATE OF PAYMENT AND ADDED THE SALE ON 1/17/2024.</remarks>
    <noticeSignature>
      <noticeDate>02/01/2024</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>11/16/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>MICHAEL MAKULA</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
