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Collaborative Arrangements and Licensing Agreements, AstraZeneca (Details) $ in Thousands | 3 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Dec. 31, 2024 USD ($) | Dec. 31, 2024 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) PerformanceObligation Component | Dec. 31, 2015 USD ($) | Jul. 31, 2015 USD ($) PerformanceObligation
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  | $ 705,138 | $ 787,647 | $ 587,367 |  |  |
AstraZeneca [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue |  | 129,759 | 202,236 | $ 79,160 |  |  |
Deferred contract revenue | $ 0 | $ 0 | $ 0 |  |  |  |
AstraZeneca [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Concentration percentage |  | 18.00% | 26.00% | 13.00% |  |  |
WAINUA [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Maximum amount of payments receivable over term of collaboration | 3,600,000 | $ 3,600,000 |  |  |  |  |
Upfront payment received |  |  |  |  | $ 200,000 |  |
Maximum amount of development milestone payments over term of collaboration | 485,000 | 485,000 |  |  |  |  |
Maximum amount of sales milestone payments over term of collaboration | 2,900,000 | $ 2,900,000 |  |  |  |  |
Royalty percentage received on sales of medicine in U.S. |  | 20.00% |  |  |  |  |
Number of material components | Component |  |  |  |  | 4 |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  | 1 |  |
Transaction price |  |  |  |  | $ 200,000 |  |
Percentage of costs associated with ongoing global Phase 3 development program paid by AstraZeneca |  | 55.00% |  |  |  |  |
Revenue |  |  | $ 20,000 |  |  |  |
WAINUA [Member] | Maximum [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Next payment to be achieved | 200,000 | $ 200,000 |  |  |  |  |
WAINUA [Member] | Minimum [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Cumulative payments received | 465,000 | 465,000 |  |  |  |  |
Next payment to be achieved | 115,000 | 115,000 |  |  |  |  |
WAINUA [Member] | ATTRv-PN [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Revenue | 30,000 |  |  |  |  |  |
Cardiovascular, Renal and Metabolic Diseases [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Maximum amount of payments receivable over term of collaboration | 4,300,000 | 4,300,000 |  |  |  |  |
Upfront payment received |  |  |  |  |  | $ 65,000 |
Maximum amount of license fees over term of collaboration | 175,000 | 175,000 |  |  |  |  |
Maximum amount of development milestone payments over term of collaboration | 514,000 | 514,000 |  |  |  |  |
Maximum amount of regulatory milestone payments over term of collaboration | 863,000 | 863,000 |  |  |  |  |
Maximum amount of sales milestone payments over term of collaboration | 2,800,000 | 2,800,000 |  |  |  |  |
Next payment to be achieved | 30,000 | 30,000 |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  |  |  | 1
Transaction price |  |  |  |  |  |  | $ 65,000
Cumulative payments included in transaction price for performance obligation | 90,000 | $ 90,000 |  |  |  |  |
Revenue | 25,000 |  |  |  |  |  |
Cardiovascular, Renal and Metabolic Diseases [Member] | Maximum [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Royalty percentage received on net sales of medicine |  | 10.00% |  |  |  |  |
Cardiovascular, Renal and Metabolic Diseases [Member] | Minimum [Member] |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |
Cumulative payments received | $ 340,000 | $ 340,000 |  |  |  |  |

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