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Long-Term Obligations and Commitments, Royalty Revenue Monetization (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Jan. 31, 2023 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Royalty Revenue Monetization [Abstract] |  |  |  |
Upfront payment received | $ 500,000 |  |  |
Maximum amount of payments receivable for additional milestones | 625,000 |  |  |
Transaction costs |  | $ 0 | $ 10,434 | $ 29
Proceeds from sale of future royalties |  | 0 | 500,000 | 0
Issuance costs related to sale of future royalties |  | 0 | (10,434) | (29)
Royalty payments to Royalty Pharma |  | (44,981) | (44,628) | 0
Interest expense related to sale of future royalties |  | 72,846 | 68,238 | $ 0
Net liability related to sale of future royalties |  | 542,212 | 513,736 |
SPINRAZA [Member] |  |  |  |
Royalty Revenue Monetization [Abstract] |  |  |  |
Maximum amount of annual sales on which royalty payments are paid | $ 1,500,000 | $ 1,500,000 |  |
SPINRAZA [Member] | Minimum [Member] |  |  |  |
Royalty Revenue Monetization [Abstract] |  |  |  |
Percentage of royalty payments paid on annual sales of medicine | 25.00% | 25.00% |  |
Maximum royalty payments made before royalty interest reverts back | $ 475,000 | $ 475,000 |  |
SPINRAZA [Member] | Maximum [Member] |  |  |  |
Royalty Revenue Monetization [Abstract] |  |  |  |
Percentage of royalty payments paid on annual sales of medicine | 45.00% | 45.00% |  |
Maximum royalty payments made before royalty interest reverts back | $ 550,000 | $ 550,000 |  |
Pelacarsen [Member] |  |  |  |
Royalty Revenue Monetization [Abstract] |  |  |  |
Percentage of royalty payments paid on annual sales of medicine | 25.00% |  |  |
Royalty Purchase Agreement [Member] |  |  |  |
Royalty Revenue Monetization [Abstract] |  |  |  |
Transaction costs |  | $ 10,400 | $ 10,434 |
Effective interest rate |  | 13.50% | 13.50% |
Proceeds from sale of future royalties | $ 500,000 |  |  |
Issuance costs related to sale of future royalties |  | $ (10,400) | $ (10,434) |
Royalty payments to Royalty Pharma |  | (44,981) | (44,628) |
Interest expense related to sale of future royalties |  | 72,846 | 68,238 |
Amortization of issuance costs related to sale of future royalties |  | 611 | 560 |
Net liability related to sale of future royalties |  | $ 542,212 | $ 513,736 |

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- Definition Amount, after accumulated amortization, of the unamortized liability related to the sale of future royalties, pursuant to a royalty purchase agreement, that the Company is entitled to receive under collaboration agreements with Biogen and Novartis. The balance will be amortized over the estimated life of the arrangement using the effective interest rate method. + References No definition available. + Details
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