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Income Taxes | 12 Months Ended
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Dec. 31, 2024
Income Taxes [Abstract] |
Income Taxes | 9. Income Taxes Loss before income taxes is comprised of (in thousands):
|  | Year Ended December 31, |
|  | 2024 |  |  | 2023 |  |  | 2022 |
United States |  | $ | (460,712 | ) |  | $ | (334,707 | ) |  | $ | (258,493 | )
Foreign |  |  | 644 |  |  |  | 742 |  |  |  | 508 |
Loss before income taxes |  | $ | (460,068 | ) |  | $ | (333,965 | ) |  | $ | (257,985 | )
Our income tax expense (benefit) was as follows (in thousands):
|  | Year Ended December 31, |
|  | 2024 |  |  | 2023 |  |  | 2022 |
Current: |  |  |  |  |  |  |  |  |
Federal |  | $ | (5,492 | ) |  | $ | 35,861 |  |  | $ | 10,522 |
State |  |  | (848 | ) |  |  | (3,687 | ) |  |  | 1,129 |
Foreign |  |  | 169 |  |  |  | 147 |  |  |  | 86 |
Total current income tax expense (benefit) |  |  | (6,171 | ) |  |  | 32,321 |  |  |  | 11,737 |
Deferred: |  |  |  |  |  |  |  |  |  |  |  |
Federal |  |  | — |  |  |  | — |  |  |  | — |
State |  |  | — |  |  |  | — |  |  |  | — |
Total deferred income tax benefit |  |  | — |  |  |  | — |  |  |  | — |
Total income tax expense (benefit) |  | $ | (6,171 | ) |  | $ | 32,321 |  |  | $ | 11,737 |
Our expense (benefit) for income taxes differs from the amount computed by applying the U.S. federal statutory rate to loss before income taxes. The sources and tax effects of the differences are as follows (in thousands):
|  | Year Ended December 31, |
|  | 2024 |  |  | 2023 |  |  | 2022 |
Pre-tax loss |  | $ | (460,068 | ) |  |  |  |  | $ | (333,965 | ) |  |  |  |  | $ | (257,985 | ) |  |  |
Statutory rate |  |  | (96,614 | ) |  |  | 21.0 | % |  |  | (70,133 | ) |  |  | 21.0 | % |  |  | (54,177 | ) |  |  | 21.0 | %
State income tax net of federal benefit |  |  | (11,889 | ) |  |  | 2.6 | % |  |  | (22,597 | ) |  |  | 6.8 | % |  |  | (13,622 | ) |  |  | 5.3 | %
Foreign |  |  | 15 |  |  |  | 0.0 | % |  |  | (22 | ) |  |  | 0.0 | % |  |  | (49 | ) |  |  | 0.0 | %
Net change in valuation allowance |  |  | 152,590 |  |  |  | (33.2 | )% |  |  | 175,388 |  |  |  | (52.5 | )% |  |  | 104,951 |  |  |  | (40.7 | )%
Tax credits |  |  | (53,497 | ) |  |  | 11.6 | % |  |  | (67,131 | ) |  |  | 20.1 | % |  |  | (39,729 | ) |  |  | 15.4 | %
Tax rate change |  |  | 10,815 |  |  |  | (2.4 | )% |  |  | 1,023 |  |  |  | (0.3 | )% |  |  | (3,091 | ) |  |  | 1.2 | %
Non-deductible compensation |  |  | 1,895 |  |  |  | (0.4 | )% |  |  | 3,814 |  |  |  | (1.1 | )% |  |  | 3,023 |  |  |  | (1.2 | )%
Other non-deductible items |  |  | 188 |  |  |  | 0.0 | % |  |  | 327 |  |  |  | (0.1 | )% |  |  | 57 |  |  |  | 0.0 | %
Foreign-derived intangible income benefit |  |  | (21,071 | ) |  |  | 4.6 | % |  |  | (7,493 | ) |  |  | 2.2 | % |  |  | — |  |  |  | — |
Stock-based compensation |  |  | 10,732 |  |  |  | (2.3 | )% |  |  | 19,546 |  |  |  | (5.9 | )% |  |  | 14,030 |  |  |  | (5.4 | )%
Other |  |  | 665 |  |  |  | (0.2 | )% |  |  | (401 | ) |  |  | 0.1 | % |  |  | 344 |  |  |  | (0.1 | )%
Effective rate |  | $ | (6,171 | ) |  |  | 1.3 | % |  | $ | 32,321 |  |  |  | (9.7 | )% |  | $ | 11,737 |  |  |  | (4.5 | )%
Deferred income taxes reflect the net tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of our deferred tax assets and liabilities as of December 31, 2024 and 2023 are as follows (in thousands):
|  | Year Ended December 31, |
|  | 2024 |  |  | 2023 |
Deferred Tax Assets: |  |  |  |  |  |
Net operating loss carryovers |  | $ | 95,851 |  |  | $ | 77,964 |
Tax credits |  |  | 310,703 |  |  |  | 239,962 |
Deferred revenue |  |  | 54,063 |  |  |  | 71,683 |
Stock-based compensation |  |  | 82,660 |  |  |  | 77,468 |
Intangible and capital assets |  |  | 93,541 |  |  |  | 104,380 |
Convertible debt |  |  | 9,310 |  |  |  | 16,849 |
Capitalized research and development expenses |  |  | 323,560 |  |  |  | 238,738 |
Long-term lease liabilities |  |  | 41,481 |  |  |  | 43,718 |
Sale of future royalties |  |  | 148,918 |  |  |  | 144,608 |
Other |  |  | 14,024 |  |  |  | 10,343 |
Total deferred tax assets |  | $ | 1,174,111 |  |  | $ | 1,025,713 |
Deferred Tax Liabilities: |  |  |  |  |  |  |  |
Fixed assets |  |  | (5,719 | ) |  |  | (4,166 | )
Right-of-use assets |  |  | (36,788 | ) |  |  | (42,007 | )
Other |  |  | (1,896 | ) |  |  | (1,910 | )
Net deferred tax asset |  | $ | 1,129,708 |  |  | $ | 977,630 |
Valuation allowance |  |  | (1,129,708 | ) |  |  | (977,630 | )
Total net deferred tax assets and liabilities |  | $ | — |  |  | $ | — |
As of December 31, 2024, we maintained a full valuation allowance on our net deferred tax assets. We determined the valuation allowance in accordance with the provisions of ASC 740, Accounting for Income Taxes, which requires an assessment of both positive and negative evidence when determining whether it is more likely than not that deferred tax assets are realizable. Our recent history of cumulative losses and expected near-term future losses require us to record a full valuation allowance against all net deferred tax assets. We will maintain a full valuation allowance on net deferred tax assets until sufficient positive evidence exists to support reversal of the valuation allowance. Our valuation allowance increased by $152 million from December 31, 2023 to December 31, 2024. The increase was primarily related to increases in our deferred tax assets for capitalized research and development expenses and tax credits. At December 31, 2024, we had federal and state, primarily California, tax net operating loss carryforwards of $290.2 million and $526.9 million, respectively. Our federal tax loss carryforwards are available indefinitely. Our California tax loss carryforwards will begin to expire in 2032. At December 31, 2024, we also had federal and California research and development tax credit carryforwards of $234.2 million and $137.6 million, respectively. Our federal research and development tax credit carryforwards will begin to expire in 2037. Our California research and development tax credit carryforwards are available indefinitely. Utilization of the net operating loss and tax credit carryforwards may be subject to an annual limitation due to the ownership change limitations provided by the Internal Revenue Code of 1986, as amended, and similar state provisions. The annual limitation may result in the expiration of net operating losses and credits before utilization. We analyze filing positions in all U.S. federal, state and foreign jurisdictions where we file income tax returns, and all open tax years in these jurisdictions to determine if we have any uncertain tax positions on any of our income tax returns. We recognize the impact of an uncertain tax position on an income tax return at the largest amount that the relevant taxing authority is more-likely-than not to sustain upon audit. We do not recognize uncertain income tax positions if they have less than 50 percent likelihood of the applicable tax authority sustaining our position. The following table summarizes our gross unrecognized tax benefits (in thousands):
|  | Year Ended December 31, |
|  | 2024 |  |  | 2023 |  |  | 2022 |
Beginning balance of unrecognized tax benefits |  | $ | 43,298 |  |  | $ | 56,567 |  |  | $ | 55,085 |
Decrease for lapse of statute of limitations |  |  | (7,579 | ) |  |  | (14,993 | ) |  |  | — |
Decrease for prior period tax positions |  |  | (110 | ) |  |  | (737 | ) |  |  | (267 | )
Increase for prior period tax positions |  |  | 1,902 |  |  |  | 429 |  |  |  | 259 |
Increase for current period tax positions |  |  | 3,650 |  |  |  | 2,032 |  |  |  | 1,490 |
Ending balance of unrecognized tax benefits |  | $ | 41,161 |  |  | $ | 43,298 |  |  | $ | 56,567 |
Included in the balance of unrecognized tax benefits at December 31, 2024, 2023 and 2022 was $0.3 million, $0.3 million and $6.2 million respectively, that if we recognized, could impact our effective tax rate, subject to our remaining valuation allowance. We do not expect any material changes to our gross unrecognized tax benefits within the next 12 months. We recognize interest and/or penalties related to income tax matters in income tax expense. During the years ended December 31, 2024, 2023 and 2022, we recognized $0.1 million, $0.1 million and $0.8 million, respectively, of accrued interest and penalties related to gross unrecognized tax benefits. We are subject to taxation in the U.S. and various state and foreign jurisdictions. U.S. tax years 2021 through 2023 remain open to examination and tax years 2020 through 2023 remain open to examination by major state taxing jurisdictions, primarily California, although net operating loss and credit carryforwards generated prior to these periods may still be adjusted upon examination by the Internal Revenue Service or state tax authorities if they have been used in an open period or are used in a future period.

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