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Collaborative Arrangements and Licensing Agreements, Biogen (Details) $ in Thousands | 3 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Jun. 30, 2024 USD ($) | Jun. 30, 2018 USD ($) | Dec. 31, 2024 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2017 USD ($) | Jan. 31, 2023 USD ($) | Apr. 30, 2018 USD ($) | Dec. 31, 2012 PerformanceObligation
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  | $ 705,138 | $ 787,647 | $ 587,367 |  |  |  |  |
SPINRAZA [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Maximum amount of annual sales on which royalty payments are paid |  |  | $ 1,500,000 |  |  |  |  | $ 1,500,000 |  |
SPINRAZA [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Percentage of royalty payments paid to Royalty Pharma on annual sales of medicine |  |  | 25.00% |  |  |  |  | 25.00% |  |
Maximum royalty payments made before royalty interest reverts back |  |  | $ 475,000 |  |  |  |  | $ 475,000 |  |
SPINRAZA [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Percentage of royalty payments paid to Royalty Pharma on annual sales of medicine |  |  | 45.00% |  |  |  |  | 45.00% |  |
Maximum royalty payments made before royalty interest reverts back |  |  | $ 550,000 |  |  |  |  | $ 550,000 |  |
SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  | 216,090 | 240,379 | 242,314 |  |  |  |  |
Biogen [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Revenue |  |  | 368,058 | 350,146 | $ 366,696 |  |  |  |  |
Deferred contract revenue |  |  | $ 211,000 | $ 307,400 |  |  |  |  |  |
Biogen [Member] | Revenue [Member] | Strategic Partner [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Concentration percentage |  |  | 52.00% | 44.00% | 62.00% |  |  |  |  |
SPINRAZA [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | $ 2,200,000 |  |  |  |  |  |  |
Royalty percentage received on net sales of medicine |  |  | 11.00% |  |  |  |  |  |  |
SPINRAZA [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Royalty percentage received on net sales of medicine |  |  | 15.00% |  |  |  |  |  |  |
SPINRAZA [Member] | SPINRAZA Royalties [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | $ 1,800,000 |  |  |  |  |  |  |
SPINRAZA [Member] | SPINRAZA R&D Revenue [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | 425,000 |  |  |  |  |  |  |
2013 Neurology [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | $ 110,000 |  |  |  |  |  |  |
2013 Neurology [Member] | QALSODY [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Royalty percentage received on net sales of medicine |  |  | 11.00% |  |  |  |  |  |  |
2013 Neurology [Member] | QALSODY [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Royalty percentage received on net sales of medicine |  |  | 15.00% |  |  |  |  |  |  |
2013 Neurology [Member] | QALSODY Royalties [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | $ 3,000 |  |  |  |  |  |  |
2013 Neurology [Member] | QALSODY R&D Revenue [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | 108,000 |  |  |  |  |  |  |
New Antisense Medicines for the Treatment of SMA [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | $ 85,000 |  |  |  |  |  |  |
Royalty percentage received on net sales of medicine |  |  | 20.00% |  |  |  |  |  |  |
Upfront payment received |  |  |  |  |  |  | $ 25,000 |  |  |
Next payment to be achieved |  |  | $ 45,000 |  |  |  |  |  |  |
New Antisense Medicines for the Treatment of SMA [Member] | ION306 [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Maximum amount of payments receivable over term of collaboration |  |  | 555,000 |  |  |  |  |  |  |
Maximum amount of development milestone payments over term of collaboration |  |  | 45,000 |  |  |  |  |  |  |
Maximum amount of regulatory milestone payments over term of collaboration |  |  | 110,000 |  |  |  |  |  |  |
Maximum amount of sales milestone payments over term of collaboration |  |  | 400,000 |  |  |  |  |  |  |
Revenue |  |  |  |  |  | $ 60,000 |  |  |  |
2018 Neurology [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | $ 1,100,000 |  |  |  |  |  |  |
Royalty percentage received on net sales of medicine |  |  | 20.00% |  |  |  |  |  |  |
Upfront payment received |  | $ 375,000 |  |  |  |  |  |  |  |
Next payment to be achieved |  |  | $ 15,000 |  |  |  |  |  |  |
Transaction price |  |  |  |  |  |  |  |  | $ 552,000 |
Premium paid on shares purchased |  | $ 177,000 |  |  |  |  |  |  |  |
Cumulative payments included in transaction price for performance obligation |  |  | 623,000 |  |  |  |  |  |  |
Maximum amount of payments receivable per medicine over term of collaboration |  |  | 270,000 |  |  |  |  |  |  |
Maximum amount of license fees per medicine over term of collaboration |  |  | 15,000 |  |  |  |  |  |  |
Maximum amount of development milestone payments per medicine over term of collaboration |  |  | 105,000 |  |  |  |  |  |  |
Maximum amount of regulatory milestone payments per medicine over term of collaboration |  |  | 150,000 |  |  |  |  |  |  |
2012 Neurology [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Maximum amount of payments receivable over term of collaboration |  |  | 185,000 |  |  |  |  |  |  |
Maximum amount of license fees over term of collaboration |  |  | 45,000 |  |  |  |  |  |  |
Maximum amount of development milestone payments over term of collaboration |  |  | 10,000 |  |  |  |  |  |  |
Maximum amount of regulatory milestone payments over term of collaboration |  |  | 130,000 |  |  |  |  |  |  |
Next payment to be achieved |  |  | 25,000 |  |  |  |  |  |  |
Number of separate performance obligations | PerformanceObligation |  |  |  |  |  |  |  |  |  | 2
Revenue | $ 30 |  |  |  |  |  |  |  |  |
2012 Neurology [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments received |  |  | 230,000 |  |  |  |  |  |  |
2012 Neurology [Member] | IONIS-MAPT [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments included in transaction price for performance obligation |  |  | 57,000 |  |  |  |  |  |  |
2012 Neurology [Member] | ION582 [Member] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |  |  |  |  |  |  |  |  |
Cumulative payments included in transaction price for performance obligation |  |  | $ 68,000 |  |  |  |  |  |  |

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