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Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2024 | Dec. 31, 2023
Deferred Tax Assets [Abstract] |  |
Net operating loss carryovers | $ 95,851 | $ 77,964
Tax credits | 310,703 | 239,962
Deferred revenue | 54,063 | 71,683
Stock-based compensation | 82,660 | 77,468
Intangible and capital assets | 93,541 | 104,380
Convertible debt | 9,310 | 16,849
Capitalized research and development expenses | 323,560 | 238,738
Long-term lease liabilities | 41,481 | 43,718
Sale of future royalties | 148,918 | 144,608
Other | 14,024 | 10,343
Total deferred tax assets | 1,174,111 | 1,025,713
Deferred Tax Liabilities [Abstract] |  |
Fixed assets | (5,719) | (4,166)
Right-of-use assets | (36,788) | (42,007)
Other | (1,896) | (1,910)
Net deferred tax asset | 1,129,708 | 977,630
Valuation allowance | (1,129,708) | (977,630)
Total net deferred tax assets and liabilities | 0 | $ 0
Increase in valuation allowance | $ 152,000 |

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- Definition Represents the net amount of deferred tax assets (before reduction for valuation allowance) and liabilities as of the balance sheet date, which result from applying the applicable enacted tax rate to net temporary differences and carryforwards pertaining to assets or liabilities. + References No definition available. + Details
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from deferred income. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 6 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-6 + Details
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- Definition Amount, before allocation of a valuation allowances, of deferred tax assets attributable to deductible tax credit carryforwards including, but not limited to, research, foreign, general business, alternative minimum tax, and other deductible tax credit carryforwards. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 6 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-6 + Details
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