XML 48 R31.htm IDEA: XBRL DOCUMENT v3.25.0.1

Long-Term Obligations and Commitments (Tables)

12 Months Ended

Dec. 31, 2024

Convertible Debt [Abstract]

Long-Term Obligations

The carrying value of our long-term obligations was as follows (in thousands):

		December 31,
		2024				2023
1.75% convertible senior notes		$	565,026			$	562,285
0% convertible senior notes			628,535				625,380
Liability related to sale of future royalties			542,212				513,736
Lease liabilities			170,869				178,969
Mortgage debt			8,714				8,859
Other obligations			43,425				33,714
Total		$	1,958,781			$	1,922,943
Less: current portion			(9,279	)			(8,831	)
Total Long-Term Obligations		$	1,949,502			$	1,914,112

Convertible Debt [Abstract]

Debt Maturity Schedules

Annual convertible and mortgage debt maturities, including fixed and determinable interest, at December 31, 2024 are as follows (in thousands):

2025		$	10,657
2026			643,157
2027			18,737
2028			580,091
2029			60
Thereafter			360
Total debt and mortgage maturities		$	1,253,062
Less: Current portion included in other current liabilities			(165	)
Less: Fixed and determinable interest			(36,511	)
Less: Debt issuance costs			(13,981	)
Total debt		$	1,202,405

Amounts Related to Operating Leases

Amounts related to our operating leases were as follows (dollar amounts in millions):

		At December 31, 2024
Right-of-use operating lease assets		$	161.9
Operating lease liabilities		$	170.9
Weighted average remaining lease term		12.1 years
Weighted average discount rate			6.9	%

Future Payments for Operating Lease Liabilities

As of December 31, 2024, the future payments for our operating lease liabilities are as follows (in thousands):

		Operating Leases
Year ending December 31,
2025		$	20,870
2026			21,032
2027			21,054
2028			20,973
2029			18,687
Thereafter			157,622
Total minimum lease payments			260,238
Less: Imputed interest			(89,369	)
Less: Current portion (included in other current liabilities)			(9,064	)
Total long-term lease liabilities		$	161,805

Liability Related to Sale of Future Royalties

The following is a summary of our liability related to sale of future royalties for the year ended December 31, 2024 (in thousands):

Proceeds from sale of future royalties in January 2023		$	500,000
Issuance costs related to sale of future royalties			(10,434	)
Royalty payments to Royalty Pharma			(44,628	)
Interest expense related to sale of future royalties			68,238
Amortization of issuance costs related to sale of future royalties			560
Net liability related to sale of future royalties as of December 31, 2023			513,736
Royalty payments to Royalty Pharma			(44,981	)
Interest expense related to sale of future royalties			72,846
Amortization of issuance costs related to sale of future royalties			611
Net liability related to sale of future royalties as of December 31, 2024		$	542,212

1.75% Notes [Member]

Convertible Debt [Abstract]

Convertible Senior Notes

At December 31, 2024, we had the following 1.75% Notes outstanding (in millions, except interest rate and price per share data):

		1.75% Notes
Outstanding principal balance		$	575.0
Unamortized debt issuance costs		$	10.0
Maturity date		June 2028
Interest rate			1.75	%
Effective interest rate			2.3	%
Conversion price per share		$	53.73
Total shares of common stock subject to conversion			10.7

0% Notes [Member]

Convertible Debt [Abstract]

Convertible Senior Notes

At December 31, 2024, we had the following 0% Notes outstanding (in millions, except interest rate and price per share data):

		0% Notes
Outstanding principal balance		$	632.5
Unamortized debt issuance costs		$	4.0
Maturity date		April 2026
Interest rate			0	%
Effective interest rate			0.5	%
Conversion price per share		$	57.84
Effective conversion price per share with call spread		$	76.39
Total shares of common stock subject to conversion			10.9

X

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

+ Details

Name:	ions_ConvertibleNotesDisclosureLineItems
Namespace Prefix:	ions_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of information on lessee's operating leases, including carrying value of right-of-use assets and lease liabilities, weighted-average remaining term and weighted-average discount rate.

+ References

No definition available.

+ Details

Name:	ions_LesseeOperatingLeaseInformationTableTextBlock
Namespace Prefix:	ions_
Data Type:	dtr-types:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of contractual obligation by timing of payment due. Includes, but is not limited to, long-term debt obligation, lease obligation, and purchase obligation.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Name Regulation S-X (SX)
-Number 210
-Section 12
-Subsection 04
-Subparagraph (a)
-Publisher SEC

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 3
-Subparagraph (SX 210.12-04(a))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480678/235-10-S99-3

+ Details

Name:	srt_ContractualObligationFiscalYearMaturityScheduleTableTextBlock
Namespace Prefix:	srt_
Data Type:	dtr-types:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of convertible debt instrument. Includes, but is not limited to, principal amount and amortized premium or discount.

+ References

No definition available.

+ Details

Name:	us-gaap_ConvertibleDebtTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	dtr-types:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- References

No definition available.

+ Details

Name:	us-gaap_DebtDisclosureAbstract
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of undiscounted cash flows of lessee's operating lease liability. Includes, but is not limited to, reconciliation of undiscounted cash flows to operating lease liability recognized in statement of financial position.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 842
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478964/842-20-50-6

+ Details

Name:	us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	dtr-types:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of other noncurrent liabilities.

+ References

No definition available.

+ Details

Name:	us-gaap_OtherNoncurrentLiabilitiesTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	dtr-types:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of long-debt instruments or arrangements, including identification, terms, features, collateral requirements and other information necessary to a fair presentation. These are debt arrangements that originally required repayment more than twelve months after issuance or greater than the normal operating cycle of the entity, if longer.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02(22))
-SubTopic 10
-Topic 210
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1

Reference 2: http://www.xbrl.org/2003/role/exampleRef
-Topic 470
-SubTopic 20
-Name Accounting Standards Codification
-Section 55
-Paragraph 69B
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481568/470-20-55-69B

Reference 3: http://www.xbrl.org/2003/role/exampleRef
-Topic 470
-SubTopic 20
-Name Accounting Standards Codification
-Section 55
-Paragraph 69E
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481568/470-20-55-69E

Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 3
-Subparagraph (SX 210.12-04(a))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480678/235-10-S99-3

Reference 5: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 835
-SubTopic 30
-Name Accounting Standards Codification
-Section 45
-Paragraph 2
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482925/835-30-45-2

Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-3

Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 942
-SubTopic 470
-Section 50
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147477734/942-470-50-3

Reference 8: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 8
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-8

Reference 9: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-6

Reference 10: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 7
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-7

+ Details

Name:	us-gaap_ScheduleOfDebtInstrumentsTextBlock
Namespace Prefix:	us-gaap_
Data Type:	dtr-types:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Details

Name:	us-gaap_DebtInstrumentAxis=ions_ConvertibleSeniorNotes175PercentMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

X

- Details

Name:	us-gaap_DebtInstrumentAxis=ions_ConvertibleSeniorNotes0PercentMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type: