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v3.25.1

Segment Information (Details) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2025 USD ($) Segment | Mar. 31, 2024 USD ($)
Segment Information [Abstract] |  |
Number of operating segments | Segment | 1 |
Revenue | $ 131,612 | $ 119,497
Cost of sales | 1,463 | 2,151
Selling, general and administrative | 76,250 | 52,644
Net loss | (146,938) | (142,803)
Ionis Operations [Member] |  |
Segment Information [Abstract] |  |
Revenue | 131,612 | 119,497
Cost of sales | 1,363 | 1,952
Drug discovery | 26,989 | 28,171
Drug development | 112,946 | 125,751
Medical affairs | 5,642 | 4,676
Manufacturing and development chemistry | 14,281 | 11,441
R&D support | 20,553 | 21,946
Selling, general and administrative | 66,980 | 43,733
Other segment items | 29,796 | 24,630
Net loss | $ (146,938) | $ (142,803)
Segment Reporting, Other Segment Item, Composition, Description | Other segment items include stock-based compensation expense, investment income, interest expense, gain or loss on investments, other income or expense and income tax expense or benefit. |

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