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Collaborative Arrangements and Licensing Agreements (Details) - Ono Collaboration [Member] - USD ($) $ in Millions | 1 Months Ended |
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Apr. 30, 2025 | Mar. 31, 2025
Collaborative Arrangement and Licensing Agreement [Abstract] |  |
Maximum amount of payments receivable over term of collaboration |  | $ 940
Maximum amount of upfront payments over term of collaboration |  | 280
Maximum amount of development, regulatory and sales milestone payments over term of collaboration |  | $ 660
Subsequent Event [Member] |  |
Collaborative Arrangement and Licensing Agreement [Abstract] |  |
Upfront payment achieved | $ 280 |

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- References No definition available. + Details
Name: | ions_CollaborativeArrangementAndLicensingAgreementAbstract
Namespace Prefix: | ions_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

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- Definition The maximum amount of development, regulatory and sales milestone payments to be received over the term of the collaboration. + References No definition available. + Details
Name: | ions_MaximumAmountOfDevelopmentRegulatoryAndSalesMilestonePaymentsOverTermOfCollaboration
Namespace Prefix: | ions_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | instant

X
- Definition The maximum amount of payments the Company is eligible to receive over the term of the collaboration. + References No definition available. + Details
Name: | ions_MaximumAmountOfPaymentsReceivableOverTermOfCollaboration
Namespace Prefix: | ions_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | instant

X
- Definition The maximum amount of upfront payments to be received over the term of the collaboration. + References No definition available. + Details
Name: | ions_MaximumAmountOfUpfrontPaymentsOverTermOfCollaboration
Namespace Prefix: | ions_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | instant

X
- Definition The amount of upfront payments achieved during the period under the collaboration agreement. + References No definition available. + Details
Name: | ions_UpfrontPaymentAchieved
Namespace Prefix: | ions_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- Details
Name: | us-gaap_TypeOfArrangementAxis=ions_OnoCollaborationMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_SubsequentEventTypeAxis=us-gaap_SubsequentEventMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |