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v3.25.2

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2025 | Jun. 30, 2024
Operating activities: |  |
Net loss | $ (23,387) | $ (209,068)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |
Depreciation | 4,494 | 5,013
Amortization of right-of-use operating lease assets | 5,177 | 4,957
Amortization of other assets | 1,180 | 1,260
Amortization of discount on investments, net | (12,978) | (19,143)
Amortization of debt issuance costs | 3,288 | 3,338
Non-cash royalty revenue related to sale of royalties | (24,894) | (16,236)
Non-cash interest related to sale of future royalties | 37,165 | 35,949
Stock-based compensation expense | 59,408 | 62,068
Loss on investments, net | 20,471 | 1,201
Non-cash losses related to other assets | 297 | 389
Changes in operating assets and liabilities: |  |
Contracts receivable | 39,608 | 70,519
Inventories | (12,465) | (298)
Other current and long-term assets | (22,536) | (9,381)
Accounts payable | (20,309) | (17,064)
Income taxes | 47 | (1,867)
Accrued compensation | (23,050) | (32,709)
Accrued liabilities and other current liabilities | 3,535 | (39,201)
Deferred contract revenue | (34,488) | (109,545)
Net cash provided by (used in) operating activities | 563 | (269,818)
Investing activities: |  |
Purchases of short-term investments | (802,657) | (803,867)
Proceeds from sale of short-term investments | 880,545 | 968,413
Purchases of property, plant and equipment | (24,882) | (10,727)
Acquisition of licenses and other assets, net | (2,615) | (15,264)
Net cash provided by investing activities | 50,391 | 138,555
Financing activities: |  |
Proceeds from issuance of common stock through equity plans, net | 3,528 | 26,205
Principal payments on mortgage debt | (82) | (78)
Net cash provided by financing activities | 3,446 | 26,127
Effects of exchange rates on cash | 827 | (137)
Net increase (decrease) in cash and cash equivalents | 55,227 | (105,273)
Cash and cash equivalents at beginning of period | 242,077 | 399,266
Cash and cash equivalents at end of period | 297,304 | 293,993
Supplemental disclosures of cash flow information: |  |
Interest paid | 5,214 | 5,569
Income taxes paid (refunds received), net | (383) | 1,992
Supplemental disclosures of non-cash investing and financing activities: |  |
Right-of-use assets obtained in exchange for lease obligations | 7,253 | 0
Amounts accrued for capital and patent expenditures | $ 145 | $ 1,453

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