XML 74 R56.htm IDEA: XBRL DOCUMENT
v3.25.2

Liability Related to Sale of Future Royalties (Details) - Royalty Purchase Agreement [Member] - USD ($) $ in Millions | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2023 | Jun. 30, 2025 | Jun. 30, 2024
Royalty Revenue Monetization [Abstract] |  |  |
Upfront payment received | $ 500.0 |  |
Maximum amount of payments receivable for additional milestones |  | $ 625.0 |
Transaction costs | $ 10.4 |  |
Effective interest rate |  | 12.70% | 13.50%
SPINRAZA [Member] |  |  |
Royalty Revenue Monetization [Abstract] |  |  |
Maximum amount of annual sales on which royalty payments are paid |  | $ 1,500.0 |
SPINRAZA [Member] | Minimum [Member] |  |  |
Royalty Revenue Monetization [Abstract] |  |  |
Percentage of royalty payments paid on annual sales of medicine |  | 25.00% |
Maximum royalty payments made before royalty interest reverts back |  | $ 475.0 |
SPINRAZA [Member] | Maximum [Member] |  |  |
Royalty Revenue Monetization [Abstract] |  |  |
Percentage of royalty payments paid on annual sales of medicine |  | 45.00% |
Maximum royalty payments made before royalty interest reverts back |  | $ 550.0 |
Pelacarsen [Member] |  |  |
Royalty Revenue Monetization [Abstract] |  |  |
Percentage of royalty payments paid on annual sales of medicine |  | 25.00% |

X
- Definition The maximum amount of annual sales on which royalty payments are paid under the royalty purchase agreement. + References No definition available. + Details
Name: | ions_MaximumAmountOfAnnualSalesOnWhichRoyaltyPaymentsArePaid
Namespace Prefix: | ions_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

X
- Definition The maximum amount of payments receivable for additional milestones under the royalty purchase agreement. + References No definition available. + Details
Name: | ions_MaximumAmountOfPaymentsReceivableForAdditionalMilestones
Namespace Prefix: | ions_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | instant

X
- Definition Maximum royalty payments under the royalty purchase agreement made before royalty interest reverts back to the Company. + References No definition available. + Details
Name: | ions_MaximumRoyaltyPaymentsMadeBeforeRoyaltyInterestRevertsBack
Namespace Prefix: | ions_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

X
- Definition The cash outflow paid to third parties for transaction costs in connection with a monetization transaction of future SPINRAZA and pelacarsen royalties the Company is entitled to under collaboration and licensing agreements. + References No definition available. + Details
Name: | ions_PaymentsForTransactionCostsRelatedToSaleOfFutureRoyalties
Namespace Prefix: | ions_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

X
- Definition The percentage of royalty payments paid on annual sales of medicine. + References No definition available. + Details
Name: | ions_PercentageOfRoyaltyPaymentsPaidOnAnnualSalesOfMedicine
Namespace Prefix: | ions_
Data Type: | dtr:percentItemType
Balance Type: | na
Period Type: | instant

X
- Definition The amount of upfront payments received during the period under the royalty purchase agreement. + References No definition available. + Details
Name: | ions_UpfrontRoyaltyPaymentReceived
Namespace Prefix: | ions_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 808 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Subparagraph (d) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479402/808-10-50-1 + Details
Name: | us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Effective interest rate for the funds borrowed under the debt agreement considering interest compounding and original issue discount or premium. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 835 -SubTopic 30 -Name Accounting Standards Codification -Section 55 -Paragraph 8 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482949/835-30-55-8 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 210 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(22)(a)(1)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Topic 835 -SubTopic 30 -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482900/835-30-50-1 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Topic 835 -SubTopic 30 -Name Accounting Standards Codification -Section 45 -Paragraph 2 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482925/835-30-45-2 Reference 5: http://www.xbrl.org/2003/role/disclosureRef -Topic 470 -SubTopic 20 -Name Accounting Standards Codification -Section 50 -Paragraph 6 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147481139/470-20-50-6 + Details
Name: | us-gaap_DebtInstrumentInterestRateEffectivePercentage
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | instant

X
- Details
Name: | us-gaap_TypeOfArrangementAxis=ions_RoyaltyPurchaseAgreementMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_ProductOrServiceAxis=ions_SpinrazaMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_RangeAxis=srt_MinimumMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_RangeAxis=srt_MaximumMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_ProductOrServiceAxis=ions_PelacarsenMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |