XML 41 R23.htm IDEA: XBRL DOCUMENT
v3.25.2

Insider Trading Arrangements | 3 Months Ended
--- | ---
Jun. 30, 2025 shares
Trading Arrangements, by Individual |
Material Terms of Trading Arrangement | During the quarter ended June 30, 2025, our directors and officers (as defined in Rule 16a-1(f) under the Exchange Act), or Section 16 officers and directors, adopted or terminated contracts, instructions or written plans for the purchase or sale of our securities as noted in the table below. * Contract, instruction or written plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act. ** "Non-Rule 10b5-1 trading arrangement" as defined in item 408(c) of Regulation S-K under the Exchange Act.
|  |  |  |  | Trading Arrangement |  |  |  |  |  |
| Action |  | Date |  | Rule 10b5-1* |  | Non-Rule 10b5-1** |  |  | Total Shares To Be Sold |  |  | Expiration Date
Frank Bennett, EVP, Chief Scientific Officer | Termination |  | May 6, 2025 |  | X |  |  |  |  | 104,079 |  |  | Upon the execution of all instructions included in the plan
Joseph Baroldi, EVP, Chief Business Officer | Adoption |  | May 2, 2025 |  | X |  |  |  |  | 87,874 |  |  | The earlier to occur of (i) August 3, 2026, and (ii) Upon the execution of all instructions provided in the plan
Patrick O' Neil, EVP, Chief Legal Officer and General Counsel | Adoption |  | May 2, 2025 |  | X |  |  |  |  | 237,477 |  |  | The earlier to occur of (i) August 3, 2026, and (ii) Upon the execution of all instructions provided in the plan
Eugene Schneider, EVP, Chief Clinical Development and Operations Officer | Adoption |  | May 2, 2025 |  | X |  |  |  |  | 38,756 |  |  | The earlier to occur of (i) August 3, 2026, and (ii) Upon the execution of all instructions provided in the plan
Richard Geary, EVP, Chief Development Officer | Adoption |  | May 6, 2025 |  | X |  |  |  |  | 220,870 |  |  | The earlier to occur of (i) July 31, 2026, and (ii) Upon the execution of all instructions provided in the plan
B. Lynne Parshall, Board Member | Adoption |  | May 6, 2025 |  | X |  |  |  |  | 41,993 |  |  | The earlier to occur of (i) May 31, 2026, and (ii) Upon the execution of all instructions provided in the plan
Frank Bennett, EVP, Chief Scientific Officer | Adoption |  | May 13, 2025 |  | X |  |  |  |  | 67,800 |  |  | The earlier to occur of (i) August 17, 2026, and (ii) Upon the execution of all instructions provided in the plan
Termination [Member] | Frank Bennett [Member] |
Trading Arrangements, by Individual |
Name | Frank Bennett
Title | Chief Scientific Officer
Rule 10b5-1 Arrangement Terminated | true
Non-Rule 10b5-1 Arrangement Terminated | true
Termination Date | May 6, 2025
Expiration Date | May 6, 2025
Aggregate Available | 104,079
Adoption [Member] | Frank Bennett [Member] |
Trading Arrangements, by Individual |
Name | Frank Bennett
Title | Chief Scientific Officer
Rule 10b5-1 Arrangement Adopted | true
Non-Rule 10b5-1 Arrangement Adopted | false
Adoption Date | May 13, 2025
Expiration Date | August 17, 2026
Arrangement Duration | 462 days
Aggregate Available | 67,800
Adoption [Member] | Joseph Baroldi [Member] |
Trading Arrangements, by Individual |
Name | Joseph Baroldi
Title | Chief Business Officer
Rule 10b5-1 Arrangement Adopted | true
Non-Rule 10b5-1 Arrangement Adopted | false
Adoption Date | May 2, 2025
Expiration Date | August 3, 2026
Arrangement Duration | 459 days
Aggregate Available | 87,874
Adoption [Member] | Patrick O' Neil [Member] |
Trading Arrangements, by Individual |
Name | Patrick O' Neil
Title | Chief Legal Officer and General Counsel
Rule 10b5-1 Arrangement Adopted | true
Non-Rule 10b5-1 Arrangement Adopted | false
Adoption Date | May 2, 2025
Expiration Date | August 3, 2026
Arrangement Duration | 459 days
Aggregate Available | 237,477
Adoption [Member] | Eugene Schneider [Member] |
Trading Arrangements, by Individual |
Name | Eugene Schneider
Title | Chief Clinical Development and Operations Officer
Rule 10b5-1 Arrangement Adopted | true
Non-Rule 10b5-1 Arrangement Adopted | false
Adoption Date | May 2, 2025
Expiration Date | August 3, 2026
Arrangement Duration | 459 days
Aggregate Available | 38,756
Adoption [Member] | Richard Geary [Member] |
Trading Arrangements, by Individual |
Name | Richard Geary
Title | Chief Development Officer
Rule 10b5-1 Arrangement Adopted | true
Non-Rule 10b5-1 Arrangement Adopted | false
Adoption Date | May 6, 2025
Expiration Date | July 31, 2026
Arrangement Duration | 452 days
Aggregate Available | 220,870
Adoption [Member] | B. Lynne Parshall [Member] |
Trading Arrangements, by Individual |
Name | B. Lynne Parshall
Title | Board Member
Rule 10b5-1 Arrangement Adopted | true
Non-Rule 10b5-1 Arrangement Adopted | false
Adoption Date | May 6, 2025
Expiration Date | May 31, 2026
Arrangement Duration | 391 days
Aggregate Available | 41,993

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 1 + Details
Name: | ecd_MtrlTermsOfTrdArrTextBlock
Namespace Prefix: | ecd_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 1 + Details
Name: | ecd_NonRule10b51ArrAdoptedFlag
Namespace Prefix: | ecd_
Data Type: | xbrli:booleanItemType
Balance Type: | na
Period Type: | duration

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 1 + Details
Name: | ecd_NonRule10b51ArrTrmntdFlag
Namespace Prefix: | ecd_
Data Type: | xbrli:booleanItemType
Balance Type: | na
Period Type: | duration

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 1 + Details
Name: | ecd_Rule10b51ArrAdoptedFlag
Namespace Prefix: | ecd_
Data Type: | xbrli:booleanItemType
Balance Type: | na
Period Type: | duration

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 1 + Details
Name: | ecd_Rule10b51ArrTrmntdFlag
Namespace Prefix: | ecd_
Data Type: | xbrli:booleanItemType
Balance Type: | na
Period Type: | duration

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 2 -Subparagraph A + Details
Name: | ecd_TradingArrByIndTable
Namespace Prefix: | ecd_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 2 -Subparagraph B + Details
Name: | ecd_TrdArrAdoptionDate
Namespace Prefix: | ecd_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 2 -Subparagraph C + Details
Name: | ecd_TrdArrDuration
Namespace Prefix: | ecd_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 2 -Subparagraph C + Details
Name: | ecd_TrdArrExpirationDate
Namespace Prefix: | ecd_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 2 -Subparagraph A + Details
Name: | ecd_TrdArrIndName
Namespace Prefix: | ecd_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 2 -Subparagraph A + Details
Name: | ecd_TrdArrIndTitle
Namespace Prefix: | ecd_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 2 -Subparagraph D + Details
Name: | ecd_TrdArrSecuritiesAggAvailAmt
Namespace Prefix: | ecd_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

X
- References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-K -Number 229 -Section 408 -Subsection a -Paragraph 2 -Subparagraph B + Details
Name: | ecd_TrdArrTerminationDate
Namespace Prefix: | ecd_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Details
Name: | ecd_TradingArrAxis=ions_TerminationMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | ecd_IndividualAxis=ions_FrankBennettMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | ecd_TradingArrAxis=ions_AdoptionMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | ecd_IndividualAxis=ions_JosephBaroldiMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | ecd_IndividualAxis=ions_PatrickONeilMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | ecd_IndividualAxis=ions_EugeneSchneiderMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | ecd_IndividualAxis=ions_RichardGearyMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | ecd_IndividualAxis=ions_BLynneParshallMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |