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Investments - Contract Maturity of Available-for-Sale Securities (Details) | 9 Months Ended
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Sep. 30, 2025
Investments [Abstract] |
Maximum contract maturity period, range 1 | 1 year
One year or less | 67.00%
Maximum contract maturity period, range 2 | 2 years
After one year but within two years | 29.00%
Maximum contract maturity period, range 3 | 3 years 6 months
After two years but within three and a half years | 4.00%
Total | 100.00%

X
- Definition The percentage of available-for-sale debt securities that mature beyond one year but within two years of the balance sheet date. + References No definition available. + Details
Name: | ions_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughTwoYearsPercentage
Namespace Prefix: | ions_
Data Type: | dtr:percentItemType
Balance Type: | na
Period Type: | instant

X
- Definition The percentage of available-for-sale debt securities that mature beyond two years but within three and one-half years of the balance sheet date. + References No definition available. + Details
Name: | ions_AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeAndOneHalfYearsPercentage
Namespace Prefix: | ions_
Data Type: | dtr:percentItemType
Balance Type: | na
Period Type: | instant

X
- Definition The aggregate percentage of all available-for-sale debt securities, regardless of maturity. + References No definition available. + Details
Name: | ions_AvailableForSaleSecuritiesDebtMaturitiesTotalPercentage
Namespace Prefix: | ions_
Data Type: | dtr:percentItemType
Balance Type: | na
Period Type: | instant

X
- Definition The percentage of available-for-sale debt securities that mature within one year of the balance sheet date. + References No definition available. + Details
Name: | ions_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearPercentage
Namespace Prefix: | ions_
Data Type: | dtr:percentItemType
Balance Type: | na
Period Type: | instant

X
- Definition The maximum contract maturity period for the first range of available-for-sale securities, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
Name: | ions_MaximumContractMaturityPeriodRange1
Namespace Prefix: | ions_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- Definition The maximum contract maturity period for the second range of available-for-sale securities, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
Name: | ions_MaximumContractMaturityPeriodRange2
Namespace Prefix: | ions_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- Definition The maximum contract maturity period for the third range of available-for-sale securities, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
Name: | ions_MaximumContractMaturityPeriodRange3
Namespace Prefix: | ions_
Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

X
- References No definition available. + Details
Name: | us-gaap_InvestmentsAbstract
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Period Type: | duration