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Segment Information | 9 Months Ended
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Sep. 30, 2025
Segment Information [Abstract] |
Segment Information | 15. Segment Information We operate as a single operating segment, Ionis operations, focused on the research, development and commercialization of our RNA-targeted medicines to bring better futures to people with serious diseases. The CODM, our Chief Executive Officer, manages our company, reviews operating results, assesses performance and allocates resources on an aggregate basis using consolidated net income or loss as the key measure of segment profit or loss. As such, results of our operations are reported on a consolidated basis for purposes of management and segment reporting. Ionis operations derives its revenues from commercial and R&D revenue sources. Refer to Note 4, Revenues, for further details on our sources of revenue. The following table sets forth information on segment profit or loss, including significant segment expenses (in thousands):
| Three Months Ended |  | Nine Months Ended
| September 30, |  | September 30,
|  | 2025 |  |  |  | 2024 |  |  |  | 2025 |  |  |  | 2024 |
Revenue | $ | 156,719 |  |  | $ | 133,814 |  |  | $ | 740,381 |  |  | $ | 478,562 |
Less: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cost of sales |  | 2,193 |  |  |  | 912 |  |  |  | 7,097 |  |  |  | 6,815 |
Drug discovery |  | 28,412 |  |  |  | 25,790 |  |  |  | 85,656 |  |  |  | 80,652 |
Drug development |  | 120,828 |  |  |  | 132,201 |  |  |  | 351,463 |  |  |  | 392,151 |
Medical affairs |  | 8,874 |  |  |  | 5,511 |  |  |  | 22,342 |  |  |  | 17,279 |
Manufacturing and development chemistry |  | 15,790 |  |  |  | 14,087 |  |  |  | 51,616 |  |  |  | 39,723 |
R&D support |  | 23,092 |  |  |  | 20,052 |  |  |  | 64,252 |  |  |  | 59,065 |
Selling, general and administrative |  | 86,565 |  |  |  | 51,933 |  |  |  | 234,626 |  |  |  | 153,083 |
Other segment items (1) |  | (429 | ) |  |  | 23,808 |  |  |  | 75,322 |  |  |  | 79,342 |
Consolidated net loss | $ | (128,606 | ) |  | $ | (140,480 | ) |  | $ | (151,993 | ) |  | $ | (349,548 | )
(1) Other segment items include stock-based compensation expense, investment income, interest expense, gain or loss on investments, other income or expense and income tax expense or benefit.

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- Definition The entire disclosure for reporting segments including data and tables. 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