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v3.25.3

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2025 | Sep. 30, 2024
Operating activities: |  |
Net loss | $ (151,993) | $ (349,548)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 6,749 | 7,374
Amortization of right-of-use operating lease assets | 6,803 | 7,472
Amortization of other assets | 1,801 | 1,877
Amortization of discount on investments, net | (18,063) | (28,283)
Amortization of debt issuance costs | 4,940 | 5,016
Non-cash royalty revenue related to sale of royalties | (38,478) | (30,422)
Non-cash interest related to sale of future royalties | 54,964 | 54,330
Stock-based compensation expense | 90,554 | 94,052
Loss (gain) on investments, net | (9,437) | 320
Non-cash losses related to other assets | (3,643) | 1,009
Changes in operating assets and liabilities: |  |
Contracts receivable | 67,580 | 79,850
Inventories | (14,600) | (27)
Other current and long-term assets | (123,489) | (8,155)
Accounts payable | (29,116) | (19,215)
Income taxes | 67 | (2,110)
Accrued compensation | (12,595) | (27,169)
Accrued liabilities and other current liabilities | 87,683 | (28,661)
Deferred contract revenue | (50,601) | (142,518)
Net cash used in operating activities | (130,874) | (384,808)
Investing activities: |  |
Purchases of short-term investments | (1,126,595) | (1,519,227)
Proceeds from sale of short-term investments | 1,302,751 | 1,339,284
Purchases of property, plant and equipment | (30,152) | (19,783)
Acquisition of licenses and other assets, net | (4,275) | (2,514)
Net cash provided by (used in) investing activities | 141,729 | (202,240)
Financing activities: |  |
Proceeds from issuance of common stock through equity plans, net | 84,787 | 33,207
Proceeds from issuance of common stock in public offering, net | 0 | 489,093
Principal payments on mortgage debt | (123) | (126)
Net cash provided by financing activities | 84,664 | 522,174
Effects of exchange rates on cash | 745 | 213
Net increase (decrease) in cash and cash equivalents | 96,264 | (64,661)
Cash and cash equivalents at beginning of period | 242,077 | 399,266
Cash and cash equivalents at end of period | 338,341 | 334,605
Supplemental disclosures of cash flow information: |  |
Interest paid | 5,399 | 5,714
Income taxes paid (refunds received), net | (661) | 2,072
Supplemental disclosures of non-cash investing and financing activities: |  |
Right-of-use assets obtained in exchange for lease obligations | 86,939 | 0
Amounts accrued for capital and patent expenditures | $ 478 | $ 2,240

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