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Liability Related to Sale of Future Royalties - Liability Related to Sale of Future Royalties (Details) - Royalty Purchase Agreement [Member] $ in Thousands	9 Months Ended
	Sep. 30, 2025 USD ($)
Royalty Revenue Monetization [Abstract]
Liability related to sale of future royalties, net	$ 542,212
Royalty payments to Royalty Pharma	(38,478)
Interest expense related to sale of future royalties	54,964
Amortization of issuance costs related to sale of future royalties	458
Liability related to sale of future royalties, net	559,156
Liability related to sale of future royalties, net - Non-current	545,182
Other Current Liabilities [Member]
Royalty Revenue Monetization [Abstract]
Less: Current portion	$ (13,974)

X

- Definition

Amount of amortization expense attributable to the sale of future royalties.

+ References

No definition available.

+ Details

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X

- Definition

Amount of interest expense using the effective interest rate method related to the sale of future royalties.

+ References

No definition available.

+ Details

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X

- Definition

Amount, after accumulated amortization, of the unamortized liability related to the sale of future royalties, pursuant to a royalty purchase agreement, that the Company is entitled to receive under collaboration agreements with Biogen and Novartis. The balance will be amortized over the estimated life of the arrangement using the effective interest rate method.

+ References

No definition available.

+ Details

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X

- Definition

Amount, after accumulated amortization, of the unamortized liability related to the sale of future royalties, pursuant to a royalty purchase agreement, that the Company is entitled to receive under collaboration agreements with Biogen and Novartis. The balance will be amortized over the estimated life of the arrangement using the effective interest rate method. Used to reflect the current portion of the liability (due within one year or within the normal operating cycle if longer).

+ References

No definition available.

+ Details

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X

- Definition

Amount, after accumulated amortization, of the unamortized liability related to the sale of future royalties, pursuant to a royalty purchase agreement, that the Company is entitled to receive under collaboration agreements with Biogen and Novartis. The balance will be amortized over the estimated life of the arrangement using the effective interest rate method. Used to reflect the noncurrent portion of the liability (due after one year or beyond the operating cycle if longer).

+ References

No definition available.

+ Details

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Namespace Prefix:	ions_
Data Type:	xbrli:monetaryItemType
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X

- Definition

The amount of royalty payments made during the period under a royalty purchase agreement.

+ References

No definition available.

+ Details

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Namespace Prefix:	ions_
Data Type:	xbrli:monetaryItemType
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X

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 808
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479402/808-10-50-1

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