<SEC-DOCUMENT>0001140361-25-022267.txt : 20250612
<SEC-HEADER>0001140361-25-022267.hdr.sgml : 20250612
<ACCEPTANCE-DATETIME>20250612090044
ACCESSION NUMBER:		0001140361-25-022267
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		14
CONFORMED PERIOD OF REPORT:	20250612
ITEM INFORMATION:		Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20250612
DATE AS OF CHANGE:		20250612

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		251041775

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>ef20050532_8k.htm
<DESCRIPTION>8-K
<TEXT>
<XBRL>
<?xml version='1.0' encoding='ASCII'?>
<html xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:srt="http://fasb.org/srt/2025" xmlns:ix="http://www.xbrl.org/2013/inlineXBRL" xmlns:ixt="http://www.xbrl.org/inlineXBRL/transformation/2020-02-12" xmlns:ixt-sec="http://www.sec.gov/inlineXBRL/transformation/2015-08-31" xmlns:us-gaap="http://fasb.org/us-gaap/2025" xmlns:dei="http://xbrl.sec.gov/dei/2025" xmlns:country="http://xbrl.sec.gov/country/2025" xmlns:currency="http://xbrl.sec.gov/currency/2025" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:utr="http://www.xbrl.org/2009/utr" xmlns:naics="http://xbrl.sec.gov/naics/2025" xmlns:sic="http://xbrl.sec.gov/sic/2025" xmlns:stpr="http://xbrl.sec.gov/stpr/2025" xmlns:exch="http://xbrl.sec.gov/exch/2025" xmlns:cef="http://xbrl.sec.gov/cef/2025" xmlns:cyd="http://xbrl.sec.gov/cyd/2025" xmlns:ions="http://ionis.com/20250612" xmlns="http://www.w3.org/1999/xhtml">
  <head>
    <title></title>
    <!-- Licensed to: Summit Financial
         Document created using Broadridge PROfile 25.5.1.5318
         Copyright 1995 - 2025 Broadridge -->
    <meta http-equiv="Content-Type" content="text/html"/>
</head>

<body style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; background-color: #ffffff;">
<div id="DSPFiXBRLHidden" style="display: none;"><ix:header><ix:hidden><ix:nonNumeric name="dei:AmendmentFlag" id="Fact_0bbd1fd2f4ff497487e7f3e17f3f73da" contextRef="c20250612to20250612" format="ixt:fixed-false">false</ix:nonNumeric><ix:nonNumeric name="dei:EntityCentralIndexKey" id="Fact_f420855766f9475ca30008d3ded17626" contextRef="c20250612to20250612">0000874015</ix:nonNumeric></ix:hidden><ix:references><link:schemaRef xlink:href="ions-20250612.xsd" xlink:type="simple"/></ix:references><ix:resources><xbrli:context id="c20250612to20250612"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000874015</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2025-06-12</xbrli:startDate><xbrli:endDate>2025-06-12</xbrli:endDate></xbrli:period></xbrli:context></ix:resources></ix:header></div>
<div style="line-height: initial;">
  <div>
    <div>
      <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"/>
      <div>
        <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>

        <div style="text-align: center; font-size: 12pt; font-weight: bold;">Washington, D.C.&#160; 20549</div>

        <div>&#160;</div>

        <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM <ix:nonNumeric name="dei:DocumentType" id="Fact_92f8574b374d4a929c0ec28331312b0a" contextRef="c20250612to20250612">8-K</ix:nonNumeric></div>

        <div>&#160;</div>

        <div style="text-align: center; font-weight: bold;">CURRENT REPORT</div>

        <div style="text-align: center; font-weight: bold;">PURSUANT TO SECTION 13 OR 15(d) OF THE</div>

        <div style="text-align: center; font-weight: bold;">SECURITIES EXCHANGE ACT OF 1934</div>

        <div>&#160;</div>

        <div style="text-align: center;">Date of report (Date of earliest event reported):&#160; <ix:nonNumeric name="dei:DocumentPeriodEndDate" id="Fact_9f59c43959044e1eb3cb6c659f54647a" contextRef="c20250612to20250612" format="ixt:date-monthname-day-year-en">June 12, 2025</ix:nonNumeric></div>

        <div>&#160;</div>

        <div style="text-align: center; font-size: 24pt; font-weight: bold;"><ix:nonNumeric name="dei:EntityRegistrantName" id="Fact_45f4069dda2441a9879e2740d50cc489" contextRef="c20250612to20250612">IONIS PHARMACEUTICALS, INC.</ix:nonNumeric><br/>
        </div>

        <div style="text-align: center;">(Exact Name of Registrant as Specified in Charter)</div>

        <div>&#160;</div>

        <div style="text-align: center; font-weight: bold;"><ix:nonNumeric name="dei:EntityIncorporationStateCountryCode" id="Fact_a1c60e3aa24b4e0b949ae5c1bc353ba9" contextRef="c20250612to20250612" format="ixt-sec:stateprovnameen">Delaware</ix:nonNumeric><br/>
        </div>

        <div style="text-align: center;">(State or Other Jurisdiction of Incorporation)</div>

        <div>&#160;</div>

        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000; border-spacing: 0;">


  <tr>

    <td style="width: 49%; vertical-align: top;">
                <div style="text-align: center; font-weight: bold;"><ix:nonNumeric name="dei:EntityFileNumber" id="Fact_d4ef9ac722d54c9b9f9e21ed216995c4" contextRef="c20250612to20250612">000-19125</ix:nonNumeric><br/>
                </div>
              </td>

    <td colspan="1" style="width: 2%; vertical-align: top;"><br/>
              </td>

    <td style="width: 49%; vertical-align: top;">
                <div style="text-align: center; font-weight: bold;"><ix:nonNumeric name="dei:EntityTaxIdentificationNumber" id="Fact_4a2719bdd8d241ed802b49d2bb3d59fb" contextRef="c20250612to20250612">33-0336973</ix:nonNumeric><br/>
                </div>
              </td>

  </tr>

  <tr>

    <td style="width: 49%; vertical-align: top;">
                <div style="text-align: center;">(Commission File No.)</div>
              </td>

    <td colspan="1" style="width: 2%; vertical-align: top;"><br/>
              </td>

    <td style="width: 49%; vertical-align: top;">
                <div style="text-align: center;">(IRS Employer Identification No.)</div>
              </td>

  </tr>


</table>
        <div><br/>
        </div>

        <div style="text-align: center; font-weight: bold;"><ix:nonNumeric name="dei:EntityAddressAddressLine1" id="Fact_ce17ea47e12948e8b128d4188d8871ff" contextRef="c20250612to20250612">2855 Gazelle Court</ix:nonNumeric><br/>
        </div>

        <div style="text-align: center; font-weight: bold;"><ix:nonNumeric name="dei:EntityAddressCityOrTown" id="Fact_c20e6548c6fe44c7acb6ab52ce1e2076" contextRef="c20250612to20250612">Carlsbad</ix:nonNumeric>, <ix:nonNumeric name="dei:EntityAddressStateOrProvince" id="Fact_c0081cdafa5c48c68b55608b2d4f7176" contextRef="c20250612to20250612">CA</ix:nonNumeric> <ix:nonNumeric name="dei:EntityAddressPostalZipCode" id="Fact_2cc1d1bc739846369729b826cf48a90f" contextRef="c20250612to20250612">92010</ix:nonNumeric></div>

        <div style="text-align: center;">(Address of Principal Executive Offices and Zip Code)</div>

        <div>&#160;</div>

        <div>
          <div style="text-align: center;">Registrant&#8217;s telephone number, including area code: <span style="font-weight: bold;">(<ix:nonNumeric name="dei:CityAreaCode" id="Fact_a5c9f01928a64cb29423707e5d238e33" contextRef="c20250612to20250612">760</ix:nonNumeric>) <ix:nonNumeric name="dei:LocalPhoneNumber" id="Fact_3e1d0c4645244147801f761b1b069548" contextRef="c20250612to20250612">931-9200</ix:nonNumeric></span></div>

          <div style="text-align: center;"><span style="font-weight: bold;"> <br/>
            </span></div>

          <div>
            <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; border: none; margin-left: auto; margin-right: auto;"/></div>

        </div>

        <div> <br/>
        </div>

        <div>Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:</div>

        <div> <br/>
        </div>

        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000; border-spacing: 0;" class="DSPFListTable">


  <tr>

    <td style="width: 18pt; vertical-align: top; color: #000000;"><ix:nonNumeric name="dei:WrittenCommunications" id="Fact_0f7db15e86724b5ea710169be85f732e" contextRef="c20250612to20250612" format="ixt-sec:boolballotbox">&#9744;</ix:nonNumeric></td>

    <td style="width: auto; vertical-align: top;">
                <div>Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</div>
              </td>

  </tr>


</table>
        <div style="text-indent: -18pt; margin-left: 18pt;"> <br/>
        </div>

        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000; border-spacing: 0;" class="DSPFListTable">


  <tr>

    <td style="width: 18pt; vertical-align: top; color: #000000;"><ix:nonNumeric name="dei:SolicitingMaterial" id="Fact_ad7a7c1fe596425393cf51d6dbf0d76d" contextRef="c20250612to20250612" format="ixt-sec:boolballotbox">&#9744;</ix:nonNumeric></td>

    <td style="width: auto; vertical-align: top;">
                <div>Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</div>
              </td>

  </tr>


</table>
        <div style="text-indent: -18pt; margin-left: 18pt;"> <br/>
        </div>

        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000; border-spacing: 0;" class="DSPFListTable">


  <tr>

    <td style="width: 18pt; vertical-align: top; color: #000000;"><ix:nonNumeric name="dei:PreCommencementTenderOffer" id="Fact_35bf4fdf6a054a0f9ae4f9cf047d5d28" contextRef="c20250612to20250612" format="ixt-sec:boolballotbox">&#9744;</ix:nonNumeric></td>

    <td style="width: auto; vertical-align: top;">
                <div>Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</div>
              </td>

  </tr>


</table>
        <div style="text-indent: -18pt; margin-left: 18pt;"> <br/>
        </div>

        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000; border-spacing: 0;" class="DSPFListTable">


  <tr>

    <td style="width: 18pt; vertical-align: top; color: #000000;"><ix:nonNumeric name="dei:PreCommencementIssuerTenderOffer" id="Fact_43c4c42b3197481d82c53e73a043344a" contextRef="c20250612to20250612" format="ixt-sec:boolballotbox">&#9744;</ix:nonNumeric></td>

    <td style="width: auto; vertical-align: top;">
                <div>Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</div>
              </td>

  </tr>


</table>
        <div>&#160;</div>

        <div style="color: #000000;">Securities registered pursuant to Section 12(b) of the Act:</div>

        <div><br/>
        </div>

        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000; border-spacing: 0;">


  <tr>

    <td style="width: 31.1%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: rgb(0, 0, 0);">Title of each class</div>
              </td>

    <td style="width: 4.7%; vertical-align: top;"><br/>
              </td>

    <td style="width: 17.22%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: rgb(0, 0, 0);">Trading symbol</div>
              </td>

    <td style="width: 4.57%; vertical-align: top;"><br/>
              </td>

    <td style="width: 42.41%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: rgb(0, 0, 0);">Name of each exchange on which registered</div>
              </td>

  </tr>

  <tr>

    <td style="width: 31.1%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);"><ix:nonNumeric name="dei:Security12bTitle" id="Fact_6fa6d1e5a84647049da890ff16d0a485" contextRef="c20250612to20250612">Common Stock, $.001 Par Value</ix:nonNumeric><br/>
                </div>
              </td>

    <td style="width: 4.7%; vertical-align: top;"><br/>
              </td>

    <td style="width: 17.22%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">&#8220;<ix:nonNumeric name="dei:TradingSymbol" id="Fact_50387bec36a7430ab101f0d1b22a4606" contextRef="c20250612to20250612">IONS</ix:nonNumeric>&#8221;</div>
              </td>

    <td style="width: 4.57%; vertical-align: top;"><br/>
              </td>

    <td style="width: 42.41%; vertical-align: top;">
                <div style="text-align: center; color: #000000;"><ix:nonNumeric name="dei:SecurityExchangeName" id="Fact_8b1f4582fc1a45dcaef27634644dda27" contextRef="c20250612to20250612" format="ixt-sec:exchnameen">The Nasdaq Stock Market, LLC</ix:nonNumeric><br/>
                </div>
              </td>

  </tr>


</table>
        <div style="text-align: justify;"> <br/>
        </div>

        <div style="text-align: justify;">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (Section 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of
          1934 (Section 240.12b-2 of this chapter).</div>

        <div style="text-align: center; text-indent: 288pt;">&#160;&#160;Emerging growth company&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160; &#160; <ix:nonNumeric name="dei:EntityEmergingGrowthCompany" id="Fact_736445dc7825414487cbfcd5392faf50" contextRef="c20250612to20250612" format="ixt-sec:boolballotbox">&#9744;</ix:nonNumeric></div>

        <div>&#160;</div>

        <div style="text-align: justify;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
          to Section 13(a) of the Exchange Act.<span style="color: rgb(0, 0, 0);"> &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#9744;</span></div>

        <div>&#160;</div>

        <div>
          <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"/> </div>

        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"/></div>

        </div>

        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000; border-spacing: 0;" class="DSPFListTable">


  <tr>

    <td style="width: 63pt; vertical-align: top; font-weight: bold;">Item 5.02</td>

    <td style="width: auto; vertical-align: top; text-align: justify;">
                <div style="font-weight: bold;">Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.</div>
              </td>

  </tr>


</table>
        <div>&#160;</div>

        <div style="text-align: justify;">(b)&#160; Retirement of Richard Geary Ph.D., executive vice president and chief development officer</div>

        <div><br/>
        </div>

        <div style="text-align: justify;">On June 12, 2025, Ionis Pharmaceuticals, Inc. (the &#8220;<span style="font-weight: bold; font-style: italic;">Company</span>&#8221;) issued a press release announcing that Richard Geary Ph.D., executive vice president and
          chief development officer, will retire effective January 2026. To support a seamless transition, the Company plans to engage Dr. Geary as a strategic consultant throughout 2026, and will file an amendment to this 8-K when the Company and Dr.
          Geary enter into the agreement for such services.</div>

        <div><br/>
        </div>

        <div style="text-align: justify;">(c)&#160; Appointment of Holly Kordasiewicz, Ph.D., to executive vice president and chief development officer</div>

        <div><br/>
        </div>

        <div style="text-align: justify;">On June 12, 2025, the Company issued a press release announcing that Holly Kordasiewicz, Ph.D., currently senior vice president, neurology, will succeed Dr. Richard Geary Ph.D. in the role of executive vice
          president and chief development officer beginning in January 2026.</div>

        <div><br/>
        </div>

        <div style="text-align: justify;">A copy of the release is attached as Exhibit 99.1 to this Current Report and incorporated herein by reference.</div>

        <div><br/>
        </div>

        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000; border-spacing: 0;" class="DSPFListTable">


  <tr>

    <td style="width: 63pt; vertical-align: top; font-weight: bold;">Item 9.01.</td>

    <td style="width: auto; vertical-align: top; text-align: justify;">
                <div style="font-weight: bold;">Financial Statements and Exhibits.</div>
              </td>

  </tr>


</table>
        <div><br/>
        </div>

        <div style="text-align: justify;">(d) Exhibits.</div>

        <div><br/>
        </div>

        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000; border-spacing: 0;">


  <tr>

    <td style="width: 15%; vertical-align: bottom;">
                <div style="text-align: center; font-weight: bold;"><span style="text-decoration: underline;">Exhibit No.</span></div>
              </td>

    <td style="width: 85%; vertical-align: bottom;">
                <div style="font-weight: bold;"><span style="text-decoration: underline;">Description</span></div>
              </td>

  </tr>

  <tr>

    <td style="width: 15%; vertical-align: top;">
                <div style="text-align: center;"><a href="ef20050532_ex99-1.htm">99.1</a></div>
              </td>

    <td style="width: 85%; vertical-align: top;">
                <div>Press Release dated June 12, 2025.</div>
              </td>

  </tr>

  <tr>

    <td rowspan="1" style="width: 15%; vertical-align: top;"><br/>
              </td>

    <td rowspan="1" style="width: 85%; vertical-align: top;"><br/>
              </td>

  </tr>

  <tr>

    <td rowspan="1" style="width: 15%; vertical-align: top; text-align: center;">104</td>

    <td rowspan="1" style="width: 85%; vertical-align: top;">
                <div>Cover Page Interactive Data File (embedded within the Inline XBRL document).</div>
              </td>

  </tr>


</table>
        <div style="text-align: justify;"> <br/>
        </div>

        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"/></div>

        </div>

        <div style="text-align: center; font-variant: small-caps; font-weight: bold;">SIGNATURE</div>

        <div>&#160;</div>

        <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly
          authorized.</div>

        <div>&#160;</div>

        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0); border-spacing: 0;">


  <tr>

    <td style="width: 50%; vertical-align: top;"><br/>
              </td>

    <td colspan="2" rowspan="1" style="vertical-align: top;">
                <div style="text-align: justify; font-variant: small-caps; font-weight: bold;">Ionis Pharmaceuticals, Inc.</div>
              </td>

  </tr>

  <tr>

    <td rowspan="1" style="width: 50%; vertical-align: top;">&#160;</td>

    <td colspan="2" rowspan="1" style="vertical-align: top;">&#160;</td>

  </tr>

  <tr>

    <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">
                <div style="text-align: justify;">Dated:&#160; June 12, 2025</div>
              </td>

    <td style="width: 3%; vertical-align: top; padding-bottom: 2px;">
                <div style="text-align: justify;">By:&#160;&#160;</div>
              </td>

    <td style="width: 47%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Patrick R. O&#8217;Neil</td>

  </tr>

  <tr>

    <td style="width: 50%; vertical-align: top;"><br/>
              </td>

    <td style="width: 3%; vertical-align: top;">
                <div style="text-align: justify; font-variant: small-caps; font-weight: bold;"><br/>
                </div>
              </td>

    <td style="width: 47%; vertical-align: top;">
                <div style="text-align: justify; font-variant: small-caps; font-weight: bold;">Patrick R. O&#8217;Neil</div>
              </td>

  </tr>

  <tr>

    <td style="width: 50%; vertical-align: top;"><br/>
              </td>

    <td style="width: 3%; vertical-align: top;">
                <div>
                  <div style="text-align: justify;"><br/>
                  </div>
                </div>
              </td>

    <td style="width: 47%; vertical-align: top;">
                <div>
                  <div style="text-align: justify;">Executive Vice President, Chief Legal </div>
                  <div style="text-align: justify;">Officer and General Counsel</div>
                </div>
              </td>

  </tr>


</table>
        <div>
          <div style="text-align: justify;"><br/>
          </div>

          <div style="text-align: justify;"><br/>
          </div>

        </div>

        <div>
          <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; border: none; margin-left: auto; margin-right: auto;"/></div>

      </div>

    </div>

  </div>

</div>
</body>
</html>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>ef20050532_ex99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Summit Financial
         Document created using Broadridge PROfile 25.5.1.5318
         Copyright 1995 - 2025 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000;">
  <font style="font-size: 10pt;"> </font>
  <div>
    <hr noshade="noshade" align="center" style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;">
    <div>
      <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold; font-size: 10pt;">Exhibit 99.1</div>
      <font style="font-size: 10pt;"><img src="image00002.jpg"></font>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"> <font style="font-size: 10pt;"><br>
        </font></div>
      <font style="font-size: 10pt;"> </font>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold; font-size: 10pt;">Ionis announces Dr. Richard Geary, chief development officer to retire; Dr. Holly Kordasiewicz to assume role in January 2026</div>
      <font style="font-size: 10pt;"> </font>
      <div><font style="font-size: 10pt;"><br>
        </font> </div>
      <font style="font-size: 10pt;"> </font>
      <div><font style="font-weight: bold; font-size: 10pt;">CARLSBAD, Calif., June 12, 2025</font><font style="font-size: 10pt;"> -- <u>Ionis Pharmaceuticals, Inc.</u> (Nasdaq: IONS) today announced that Richard Geary Ph.D., executive vice president and
          chief development officer, will retire effective January 2026 and that Holly Kordasiewicz, Ph.D., currently senior vice president, neurology, will succeed him in the role.</font></div>
      <font style="font-size: 10pt;"> </font>
      <div><font style="font-size: 10pt;"><br>
        </font> </div>
      <font style="font-size: 10pt;"> </font>
      <div style="font-size: 10pt;">&#8220;Richard has made tremendous contributions to Ionis over his 30-year tenure during which he spearheaded dozens of development programs and brought six innovative medicines through regulatory approvals, including
        TRYNGOLZA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">TM</sup>, our first independent commercial medicine. We thank him for his leadership and unwavering dedication to patients in need,&#8221; said Brett P. Monia, Ph.D.,
        chief executive officer, Ionis. &#8220;Holly is a deeply respected and innovative leader who will champion our vision to bring a steady cadence of transformational medicines to people in need and support Ionis&#8217; continued growth as a fully-integrated
        biotechnology company. Her broad experience across research and development, strong operational and management skills, and deep neurology expertise, position Holly to successfully guide our portfolio, which includes eight wholly owned neurology
        medicines in clinical development.&#8221;</div>
      <font style="font-size: 10pt;"> </font>
      <div><font style="font-size: 10pt;"><br>
        </font> </div>
      <font style="font-size: 10pt;"> </font>
      <div style="font-size: 10pt;">Dr. Kordasiewicz has 20 years of experience in research and development and joined Ionis in 2011. An expert in neurology drug development, she currently oversees Ionis&#8217; industry-leading neurology program, including
        medicines for Alexander disease, Angelman syndrome, Alzheimer&#8217;s disease, prion disease and multiple system atrophy. Dr. Kordasiewicz also played an integral role in the discovery and development of our Biogen-partnered programs QALSODY&#174; (tofersen)
        for a genetic form of amyotrophic lateral sclerosis and IONIS-MAPT<sub style="vertical-align: bottom; line-height: 1; font-size: smaller;">Rx</sub> (BIIB080), a promising Alzheimer&#8217;s disease medicine in Phase 2 development. Dr. Kordasiewicz holds a
        B.A. from SUNY-Geneseo and a Ph.D. in Neuroscience from the University of Minnesota. She completed postdoctoral work at the University of Minnesota and the University of California San Diego.</div>
      <font style="font-size: 10pt;"> </font>
      <div><font style="font-size: 10pt;"><br>
        </font> </div>
      <font style="font-size: 10pt;"> </font>
      <div style="font-size: 10pt;">Dr. Geary joined Ionis in 1995 and has been involved in nearly every aspect of discovery and development. Under Dr. Geary&#8217;s leadership, Ionis submitted more than 50 investigational new drug applications to regulatory
        agencies and achieved six FDA and EU approvals, including for TRYNGOLZA (olezarsen). Dr. Geary will serve as a strategic consultant to Ionis throughout 2026&#8203; to support a seamless transition.</div>
      <font style="font-size: 10pt;"> </font>
      <div><font style="font-size: 10pt;"><br>
        </font> </div>
      <font style="font-size: 10pt;"> </font>
      <div style="font-weight: bold; font-size: 10pt;">About Ionis Pharmaceuticals, Inc.</div>
      <font style="font-size: 10pt;"> </font>
      <div style="font-size: 10pt;">For three decades, Ionis has invented medicines that bring better futures to people with serious diseases. Ionis currently has six marketed medicines and a leading pipeline in neurology, cardiology and select areas of
        high patient need. As the pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies in addition to advancing new approaches in gene editing. A deep understanding of disease biology and industry-leading technology
        propels our work, coupled with a passion and urgency to deliver life-changing advances for patients. To learn more about Ionis, visit <u>Ionis.com</u><font style="color: rgb(0, 0, 255);">&#160;</font>and follow us on <u>X (Twitter)</u>,&#160;<u>LinkedIn</u><font style="color: rgb(0, 0, 255);">&#160;</font>and <u>Instagram</u>.</div>
      <font style="font-size: 10pt;"> </font>
      <div><font style="font-size: 10pt;"> <br>
        </font> </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <font style="font-size: 10pt;"><img src="image00002.jpg"></font>
      <div style="font-weight: bold;"> <font style="font-size: 10pt;"><br>
        </font> </div>
      <div style="font-weight: bold; font-size: 10pt;">Ionis Forward-looking Statements</div>
      <div style="font-weight: bold; font-size: 10pt;"> <br>
      </div>
      <div style="font-size: 10pt;">This press release includes forward-looking statements regarding Ionis' business and the therapeutic and commercial potential of our commercial medicines, additional medicines in development and technologies. Any
        statement describing Ionis' goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties
        including those inherent in the process of discovering, developing and commercializing medicines that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such medicines. Ionis' forward-looking
        statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Ionis' forward-looking statements
        reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Ionis. Except as required by law, we undertake no obligation to update any forward-looking statements for any reason. As a
        result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Ionis' programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended December 31, 2024, and most
        recent Form 10-Q, which are on file with the Securities and Exchange Commission. Copies of these and other documents are available from the Company.</div>
      <div style="font-size: 10pt;">In this press release, unless the context requires otherwise, "Ionis," "Company," "we," "our" and "us" all refer to Ionis Pharmaceuticals and its subsidiaries.</div>
      <div><font style="font-size: 10pt;"><br>
        </font> </div>
      <div style="font-size: 10pt;">Ionis Pharmaceuticals<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> and TRYNGOLZA&#8482; are trademarks of Ionis Pharmaceuticals, Inc. QALSODY&#174; is a registered trademark of Biogen.</div>
      <div><font style="font-size: 10pt;"><br>
        </font> </div>
      <div style="font-weight: bold; font-size: 10pt;">Ionis Investor Contact:</div>
      <div style="font-size: 10pt;">D. Wade Walke, Ph.D.</div>
      <div style="font-size: 10pt;"><u>IR@ionis.com</u><font style="color: #0000FF;">&#160;</font>760-603-2331</div>
      <div><font style="font-size: 10pt;"><br>
        </font> </div>
      <div style="font-weight: bold; font-size: 10pt;">Ionis Media Contact:</div>
      <div style="font-size: 10pt;">Hayley Soffer</div>
      <div style="font-size: 10pt;"><u>media@ionis.com</u><font style="color: #0000FF;">&#160;</font>760-603-4679</div>
      <div><font style="font-size: 10pt;"><br>
        </font> </div>
      <div style="text-align: center; font-size: 10pt;">###</div>
      <div><font style="font-size: 10pt;"><br>
        </font> </div>
      <div><font style="font-size: 10pt;"><br>
        </font> </div>
      <div>
        <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    </div>
  </div>
  <font style="font-size: 10pt;"> </font>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.SCH
<SEQUENCE>3
<FILENAME>ions-20250612.xsd
<DESCRIPTION>XBRL TAXONOMY EXTENSION SCHEMA
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii"?>
<!--Generated by Broadridge PROfile 25.5.1.5318 Broadridge-->
<xs:schema targetNamespace="http://ionis.com/20250612" elementFormDefault="qualified" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:ions="http://ionis.com/20250612" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:dei="http://xbrl.sec.gov/dei/2025" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:us-types="http://fasb.org/us-types/2025" xmlns:srt-types="http://fasb.org/srt-types/2025">
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xlink:type="simple" xlink:href="ions-20250612_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="ions-20250612_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:roleType roleURI="http://ionis.com/role/DocumentAndEntityInformation" id="DocumentAndEntityInformation">
        <link:definition>000100 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:import namespace="http://fasb.org/us-gaap/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/country/2025" schemaLocation="https://xbrl.sec.gov/country/2025/country-2025.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/currency/2025" schemaLocation="https://xbrl.sec.gov/currency/2025/currency-2025.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/exch/2025" schemaLocation="https://xbrl.sec.gov/exch/2025/exch-2025.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/naics/2025" schemaLocation="https://xbrl.sec.gov/naics/2025/naics-2025.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/sic/2025" schemaLocation="https://xbrl.sec.gov/sic/2025/sic-2025.xsd" />
  <xs:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xs:import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/stpr/2025" schemaLocation="https://xbrl.sec.gov/stpr/2025/stpr-2025.xsd" />
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xs:import namespace="http://www.xbrl.org/2004/ref" schemaLocation="http://www.xbrl.org/2004/ref-2004-08-10.xsd" />
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xs:import namespace="http://fasb.org/us-types/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-types-2025.xsd" />
  <xs:import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd" />
  <xs:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd" />
  <xs:import namespace="http://fasb.org/srt-types/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-types-2025.xsd" />
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd" />
</xs:schema>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.LAB
<SEQUENCE>4
<FILENAME>ions-20250612_lab.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION LABEL LINKBASE
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii"?>
<!--Generated by Broadridge PROfile 25.5.1.5318 Broadridge-->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance">
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" />
  <link:labelLink xlink:type="extended" xlink:role="http://www.xbrl.org/2003/role/link">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract" xlink:label="CoverAbstract" xlink:title="CoverAbstract" />
    <link:label xlink:type="resource" xlink:label="dei_CoverAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_CoverAbstract" xml:lang="en-US" id="dei_CoverAbstract">Cover [Abstract]</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="CoverAbstract" xlink:to="dei_CoverAbstract" xlink:title="label: CoverAbstract to dei_CoverAbstract" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType" xlink:label="DocumentType" xlink:title="DocumentType" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentType" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentType" xml:lang="en-US" id="dei_DocumentType">Document Type</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="DocumentType" xlink:to="dei_DocumentType" xlink:title="label: DocumentType to dei_DocumentType" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications" xlink:label="WrittenCommunications" xlink:title="WrittenCommunications" />
    <link:label xlink:type="resource" xlink:label="dei_WrittenCommunications" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_WrittenCommunications" xml:lang="en-US" id="dei_WrittenCommunications">Written Communications</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="WrittenCommunications" xlink:to="dei_WrittenCommunications" xlink:title="label: WrittenCommunications to dei_WrittenCommunications" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial" xlink:label="SolicitingMaterial" xlink:title="SolicitingMaterial" />
    <link:label xlink:type="resource" xlink:label="dei_SolicitingMaterial" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_SolicitingMaterial" xml:lang="en-US" id="dei_SolicitingMaterial">Soliciting Material</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="SolicitingMaterial" xlink:to="dei_SolicitingMaterial" xlink:title="label: SolicitingMaterial to dei_SolicitingMaterial" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer" xlink:label="PreCommencementTenderOffer" xlink:title="PreCommencementTenderOffer" />
    <link:label xlink:type="resource" xlink:label="dei_PreCommencementTenderOffer" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_PreCommencementTenderOffer" xml:lang="en-US" id="dei_PreCommencementTenderOffer">Pre-commencement Tender Offer</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="PreCommencementTenderOffer" xlink:to="dei_PreCommencementTenderOffer" xlink:title="label: PreCommencementTenderOffer to dei_PreCommencementTenderOffer" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer" xlink:label="PreCommencementIssuerTenderOffer" xlink:title="PreCommencementIssuerTenderOffer" />
    <link:label xlink:type="resource" xlink:label="dei_PreCommencementIssuerTenderOffer" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_PreCommencementIssuerTenderOffer" xml:lang="en-US" id="dei_PreCommencementIssuerTenderOffer">Pre-commencement Issuer Tender Offer</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="PreCommencementIssuerTenderOffer" xlink:to="dei_PreCommencementIssuerTenderOffer" xlink:title="label: PreCommencementIssuerTenderOffer to dei_PreCommencementIssuerTenderOffer" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag" xlink:label="AmendmentFlag" xlink:title="AmendmentFlag" />
    <link:label xlink:type="resource" xlink:label="dei_AmendmentFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_AmendmentFlag" xml:lang="en-US" id="dei_AmendmentFlag">Amendment Flag</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="AmendmentFlag" xlink:to="dei_AmendmentFlag" xlink:title="label: AmendmentFlag to dei_AmendmentFlag" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalYearFocus" xlink:label="DocumentFiscalYearFocus" xlink:title="DocumentFiscalYearFocus" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentFiscalYearFocus" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentFiscalYearFocus" xml:lang="en-US" id="dei_DocumentFiscalYearFocus">Document Fiscal Year Focus</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="DocumentFiscalYearFocus" xlink:to="dei_DocumentFiscalYearFocus" xlink:title="label: DocumentFiscalYearFocus to dei_DocumentFiscalYearFocus" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="DocumentFiscalPeriodFocus" xlink:title="DocumentFiscalPeriodFocus" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentFiscalPeriodFocus" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentFiscalPeriodFocus" xml:lang="en-US" id="dei_DocumentFiscalPeriodFocus">Document Fiscal Period Focus</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="DocumentFiscalPeriodFocus" xlink:to="dei_DocumentFiscalPeriodFocus" xlink:title="label: DocumentFiscalPeriodFocus to dei_DocumentFiscalPeriodFocus" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate" xlink:label="DocumentPeriodEndDate" xlink:title="DocumentPeriodEndDate" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentPeriodEndDate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentPeriodEndDate" xml:lang="en-US" id="dei_DocumentPeriodEndDate">Document Period End Date</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="DocumentPeriodEndDate" xlink:to="dei_DocumentPeriodEndDate" xlink:title="label: DocumentPeriodEndDate to dei_DocumentPeriodEndDate" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName" xlink:label="EntityRegistrantName" xlink:title="EntityRegistrantName" />
    <link:label xlink:type="resource" xlink:label="dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityRegistrantName" xml:lang="en-US" id="dei_EntityRegistrantName">Entity Registrant Name</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityRegistrantName" xlink:to="dei_EntityRegistrantName" xlink:title="label: EntityRegistrantName to dei_EntityRegistrantName" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey" xlink:label="EntityCentralIndexKey" xlink:title="EntityCentralIndexKey" />
    <link:label xlink:type="resource" xlink:label="dei_EntityCentralIndexKey" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityCentralIndexKey" xml:lang="en-US" id="dei_EntityCentralIndexKey">Entity Central Index Key</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityCentralIndexKey" xlink:to="dei_EntityCentralIndexKey" xlink:title="label: EntityCentralIndexKey to dei_EntityCentralIndexKey" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber" xlink:label="EntityFileNumber" xlink:title="EntityFileNumber" />
    <link:label xlink:type="resource" xlink:label="dei_EntityFileNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityFileNumber" xml:lang="en-US" id="dei_EntityFileNumber">Entity File Number</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityFileNumber" xlink:to="dei_EntityFileNumber" xlink:title="label: EntityFileNumber to dei_EntityFileNumber" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber" xlink:label="EntityTaxIdentificationNumber" xlink:title="EntityTaxIdentificationNumber" />
    <link:label xlink:type="resource" xlink:label="dei_EntityTaxIdentificationNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityTaxIdentificationNumber" xml:lang="en-US" id="dei_EntityTaxIdentificationNumber">Entity Tax Identification Number</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityTaxIdentificationNumber" xlink:to="dei_EntityTaxIdentificationNumber" xlink:title="label: EntityTaxIdentificationNumber to dei_EntityTaxIdentificationNumber" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="EntityIncorporationStateCountryCode" xlink:title="EntityIncorporationStateCountryCode" />
    <link:label xlink:type="resource" xlink:label="dei_EntityIncorporationStateCountryCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityIncorporationStateCountryCode" xml:lang="en-US" id="dei_EntityIncorporationStateCountryCode">Entity Incorporation, State or Country Code</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityIncorporationStateCountryCode" xlink:to="dei_EntityIncorporationStateCountryCode" xlink:title="label: EntityIncorporationStateCountryCode to dei_EntityIncorporationStateCountryCode" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany" xlink:label="EntityEmergingGrowthCompany" xlink:title="EntityEmergingGrowthCompany" />
    <link:label xlink:type="resource" xlink:label="dei_EntityEmergingGrowthCompany" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityEmergingGrowthCompany" xml:lang="en-US" id="dei_EntityEmergingGrowthCompany">Entity Emerging Growth Company</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityEmergingGrowthCompany" xlink:to="dei_EntityEmergingGrowthCompany" xlink:title="label: EntityEmergingGrowthCompany to dei_EntityEmergingGrowthCompany" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1" xlink:label="EntityAddressAddressLine1" xlink:title="EntityAddressAddressLine1" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressAddressLine1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressAddressLine1" xml:lang="en-US" id="dei_EntityAddressAddressLine1">Entity Address, Address Line One</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressAddressLine1" xlink:to="dei_EntityAddressAddressLine1" xlink:title="label: EntityAddressAddressLine1 to dei_EntityAddressAddressLine1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2" xlink:label="EntityAddressAddressLine2" xlink:title="EntityAddressAddressLine2" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressAddressLine2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressAddressLine2" xml:lang="en-US" id="dei_EntityAddressAddressLine2">Entity Address, Address Line Two</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressAddressLine2" xlink:to="dei_EntityAddressAddressLine2" xlink:title="label: EntityAddressAddressLine2 to dei_EntityAddressAddressLine2" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine3" xlink:label="EntityAddressAddressLine3" xlink:title="EntityAddressAddressLine3" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressAddressLine3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressAddressLine3" xml:lang="en-US" id="dei_EntityAddressAddressLine3">Entity Address, Address Line Three</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressAddressLine3" xlink:to="dei_EntityAddressAddressLine3" xlink:title="label: EntityAddressAddressLine3 to dei_EntityAddressAddressLine3" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown" xlink:label="EntityAddressCityOrTown" xlink:title="EntityAddressCityOrTown" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressCityOrTown" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressCityOrTown" xml:lang="en-US" id="dei_EntityAddressCityOrTown">Entity Address, City or Town</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressCityOrTown" xlink:to="dei_EntityAddressCityOrTown" xlink:title="label: EntityAddressCityOrTown to dei_EntityAddressCityOrTown" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince" xlink:label="EntityAddressStateOrProvince" xlink:title="EntityAddressStateOrProvince" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressStateOrProvince" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressStateOrProvince" xml:lang="en-US" id="dei_EntityAddressStateOrProvince">Entity Address, State or Province</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressStateOrProvince" xlink:to="dei_EntityAddressStateOrProvince" xlink:title="label: EntityAddressStateOrProvince to dei_EntityAddressStateOrProvince" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCountry" xlink:label="EntityAddressCountry" xlink:title="EntityAddressCountry" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressCountry" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressCountry" xml:lang="en-US" id="dei_EntityAddressCountry">Entity Address, Country</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressCountry" xlink:to="dei_EntityAddressCountry" xlink:title="label: EntityAddressCountry to dei_EntityAddressCountry" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode" xlink:label="EntityAddressPostalZipCode" xlink:title="EntityAddressPostalZipCode" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressPostalZipCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressPostalZipCode" xml:lang="en-US" id="dei_EntityAddressPostalZipCode">Entity Address, Postal Zip Code</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressPostalZipCode" xlink:to="dei_EntityAddressPostalZipCode" xlink:title="label: EntityAddressPostalZipCode to dei_EntityAddressPostalZipCode" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode" xlink:label="CityAreaCode" xlink:title="CityAreaCode" />
    <link:label xlink:type="resource" xlink:label="dei_CityAreaCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_CityAreaCode" xml:lang="en-US" id="dei_CityAreaCode">City Area Code</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="CityAreaCode" xlink:to="dei_CityAreaCode" xlink:title="label: CityAreaCode to dei_CityAreaCode" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber" xlink:label="LocalPhoneNumber" xlink:title="LocalPhoneNumber" />
    <link:label xlink:type="resource" xlink:label="dei_LocalPhoneNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_LocalPhoneNumber" xml:lang="en-US" id="dei_LocalPhoneNumber">Local Phone Number</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="LocalPhoneNumber" xlink:to="dei_LocalPhoneNumber" xlink:title="label: LocalPhoneNumber to dei_LocalPhoneNumber" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle" xlink:label="Security12bTitle" xlink:title="Security12bTitle" />
    <link:label xlink:type="resource" xlink:label="dei_Security12bTitle" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_Security12bTitle" xml:lang="en-US" id="dei_Security12bTitle">Title of 12(b) Security</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="Security12bTitle" xlink:to="dei_Security12bTitle" xlink:title="label: Security12bTitle to dei_Security12bTitle" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_NoTradingSymbolFlag" xlink:label="NoTradingSymbolFlag" xlink:title="NoTradingSymbolFlag" />
    <link:label xlink:type="resource" xlink:label="dei_NoTradingSymbolFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_NoTradingSymbolFlag" xml:lang="en-US" id="dei_NoTradingSymbolFlag">No Trading Symbol Flag</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="NoTradingSymbolFlag" xlink:to="dei_NoTradingSymbolFlag" xlink:title="label: NoTradingSymbolFlag to dei_NoTradingSymbolFlag" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol" xlink:label="TradingSymbol" xlink:title="TradingSymbol" />
    <link:label xlink:type="resource" xlink:label="dei_TradingSymbol" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_TradingSymbol" xml:lang="en-US" id="dei_TradingSymbol">Trading Symbol</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="TradingSymbol" xlink:to="dei_TradingSymbol" xlink:title="label: TradingSymbol to dei_TradingSymbol" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName" xlink:label="SecurityExchangeName" xlink:title="SecurityExchangeName" />
    <link:label xlink:type="resource" xlink:label="dei_SecurityExchangeName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_SecurityExchangeName" xml:lang="en-US" id="dei_SecurityExchangeName">Security Exchange Name</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="SecurityExchangeName" xlink:to="dei_SecurityExchangeName" xlink:title="label: SecurityExchangeName to dei_SecurityExchangeName" />
  </link:labelLink>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.PRE
<SEQUENCE>5
<FILENAME>ions-20250612_pre.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii"?>
<!--Generated by Broadridge PROfile 25.5.1.5318 Broadridge-->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance">
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" />
  <link:roleRef roleURI="http://ionis.com/role/DocumentAndEntityInformation" xlink:type="simple" xlink:href="ions-20250612.xsd#DocumentAndEntityInformation" />
  <link:presentationLink xlink:type="extended" xlink:role="http://ionis.com/role/DocumentAndEntityInformation">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract" xlink:label="CoverAbstract" xlink:title="CoverAbstract" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType" xlink:label="DocumentType" xlink:title="DocumentType" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="DocumentType" xlink:title="presentation: CoverAbstract to DocumentType" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag" xlink:label="AmendmentFlag" xlink:title="AmendmentFlag" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="AmendmentFlag" xlink:title="presentation: CoverAbstract to AmendmentFlag" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate" xlink:label="DocumentPeriodEndDate" xlink:title="DocumentPeriodEndDate" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="DocumentPeriodEndDate" xlink:title="presentation: CoverAbstract to DocumentPeriodEndDate" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalYearFocus" xlink:label="DocumentFiscalYearFocus" xlink:title="DocumentFiscalYearFocus" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="DocumentFiscalYearFocus" xlink:title="presentation: CoverAbstract to DocumentFiscalYearFocus" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="DocumentFiscalPeriodFocus" xlink:title="DocumentFiscalPeriodFocus" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="DocumentFiscalPeriodFocus" xlink:title="presentation: CoverAbstract to DocumentFiscalPeriodFocus" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber" xlink:label="EntityFileNumber" xlink:title="EntityFileNumber" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityFileNumber" xlink:title="presentation: CoverAbstract to EntityFileNumber" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName" xlink:label="EntityRegistrantName" xlink:title="EntityRegistrantName" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityRegistrantName" xlink:title="presentation: CoverAbstract to EntityRegistrantName" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey" xlink:label="EntityCentralIndexKey" xlink:title="EntityCentralIndexKey" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityCentralIndexKey" xlink:title="presentation: CoverAbstract to EntityCentralIndexKey" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="EntityIncorporationStateCountryCode" xlink:title="EntityIncorporationStateCountryCode" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityIncorporationStateCountryCode" xlink:title="presentation: CoverAbstract to EntityIncorporationStateCountryCode" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber" xlink:label="EntityTaxIdentificationNumber" xlink:title="EntityTaxIdentificationNumber" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityTaxIdentificationNumber" xlink:title="presentation: CoverAbstract to EntityTaxIdentificationNumber" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1" xlink:label="EntityAddressAddressLine1" xlink:title="EntityAddressAddressLine1" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityAddressAddressLine1" xlink:title="presentation: CoverAbstract to EntityAddressAddressLine1" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2" xlink:label="EntityAddressAddressLine2" xlink:title="EntityAddressAddressLine2" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityAddressAddressLine2" xlink:title="presentation: CoverAbstract to EntityAddressAddressLine2" order="11.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine3" xlink:label="EntityAddressAddressLine3" xlink:title="EntityAddressAddressLine3" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityAddressAddressLine3" xlink:title="presentation: CoverAbstract to EntityAddressAddressLine3" order="12.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown" xlink:label="EntityAddressCityOrTown" xlink:title="EntityAddressCityOrTown" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityAddressCityOrTown" xlink:title="presentation: CoverAbstract to EntityAddressCityOrTown" order="13.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince" xlink:label="EntityAddressStateOrProvince" xlink:title="EntityAddressStateOrProvince" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityAddressStateOrProvince" xlink:title="presentation: CoverAbstract to EntityAddressStateOrProvince" order="14.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCountry" xlink:label="EntityAddressCountry" xlink:title="EntityAddressCountry" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityAddressCountry" xlink:title="presentation: CoverAbstract to EntityAddressCountry" order="15.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode" xlink:label="EntityAddressPostalZipCode" xlink:title="EntityAddressPostalZipCode" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityAddressPostalZipCode" xlink:title="presentation: CoverAbstract to EntityAddressPostalZipCode" order="16.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode" xlink:label="CityAreaCode" xlink:title="CityAreaCode" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="CityAreaCode" xlink:title="presentation: CoverAbstract to CityAreaCode" order="17.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber" xlink:label="LocalPhoneNumber" xlink:title="LocalPhoneNumber" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="LocalPhoneNumber" xlink:title="presentation: CoverAbstract to LocalPhoneNumber" order="18.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle" xlink:label="Security12bTitle" xlink:title="Security12bTitle" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="Security12bTitle" xlink:title="presentation: CoverAbstract to Security12bTitle" order="19.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol" xlink:label="TradingSymbol" xlink:title="TradingSymbol" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="TradingSymbol" xlink:title="presentation: CoverAbstract to TradingSymbol" order="20.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_NoTradingSymbolFlag" xlink:label="NoTradingSymbolFlag" xlink:title="NoTradingSymbolFlag" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="NoTradingSymbolFlag" xlink:title="presentation: CoverAbstract to NoTradingSymbolFlag" order="21.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName" xlink:label="SecurityExchangeName" xlink:title="SecurityExchangeName" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="SecurityExchangeName" xlink:title="presentation: CoverAbstract to SecurityExchangeName" order="22.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany" xlink:label="EntityEmergingGrowthCompany" xlink:title="EntityEmergingGrowthCompany" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="EntityEmergingGrowthCompany" xlink:title="presentation: CoverAbstract to EntityEmergingGrowthCompany" order="23.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications" xlink:label="WrittenCommunications" xlink:title="WrittenCommunications" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="WrittenCommunications" xlink:title="presentation: CoverAbstract to WrittenCommunications" order="24.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial" xlink:label="SolicitingMaterial" xlink:title="SolicitingMaterial" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="SolicitingMaterial" xlink:title="presentation: CoverAbstract to SolicitingMaterial" order="25.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer" xlink:label="PreCommencementTenderOffer" xlink:title="PreCommencementTenderOffer" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="PreCommencementTenderOffer" xlink:title="presentation: CoverAbstract to PreCommencementTenderOffer" order="26.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer" xlink:label="PreCommencementIssuerTenderOffer" xlink:title="PreCommencementIssuerTenderOffer" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CoverAbstract" xlink:to="PreCommencementIssuerTenderOffer" xlink:title="presentation: CoverAbstract to PreCommencementIssuerTenderOffer" order="27.0" preferredLabel="http://www.xbrl.org/2003/role/label" />
  </link:presentationLink>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>image00002.jpg
<TEXT>
begin 644 image00002.jpg
M_]C_X  02D9)1@ ! 0$ 8 !@  #_VP!#  8$!08%! 8&!08'!P8("A *"@D)
M"A0.#PP0%Q08&!<4%A8:'24?&ALC'!86("P@(R8G*2HI&1\M,"TH,"4H*2C_
MVP!# 0<'!PH("A,*"A,H&A8:*"@H*"@H*"@H*"@H*"@H*"@H*"@H*"@H*"@H
M*"@H*"@H*"@H*"@H*"@H*"@H*"@H*"C_P  1"  T )H# 2(  A$! Q$!_\0
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
end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>8
<FILENAME>R1.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="include/report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.25.1</span><table class="report" border="0" cellspacing="2" id="id2">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Document and Entity Information<br></strong></div></th>
<th class="th"><div>Jun. 12, 2025</div></th>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CoverAbstract', window );"><strong>Cover [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentType', window );">Document Type</a></td>
<td class="text">8-K<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_AmendmentFlag', window );">Amendment Flag</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentPeriodEndDate', window );">Document Period End Date</a></td>
<td class="text">Jun. 12,  2025<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityFileNumber', window );">Entity File Number</a></td>
<td class="text">000-19125<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityRegistrantName', window );">Entity Registrant Name</a></td>
<td class="text">IONIS PHARMACEUTICALS, INC.<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityCentralIndexKey', window );">Entity Central Index Key</a></td>
<td class="text">0000874015<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityIncorporationStateCountryCode', window );">Entity Incorporation, State or Country Code</a></td>
<td class="text">DE<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityTaxIdentificationNumber', window );">Entity Tax Identification Number</a></td>
<td class="text">33-0336973<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine1', window );">Entity Address, Address Line One</a></td>
<td class="text">2855 Gazelle Court<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressCityOrTown', window );">Entity Address, City or Town</a></td>
<td class="text">Carlsbad<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressStateOrProvince', window );">Entity Address, State or Province</a></td>
<td class="text">CA<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressPostalZipCode', window );">Entity Address, Postal Zip Code</a></td>
<td class="text">92010<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CityAreaCode', window );">City Area Code</a></td>
<td class="text">760<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_LocalPhoneNumber', window );">Local Phone Number</a></td>
<td class="text">931-9200<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Title of 12(b) Security</a></td>
<td class="text">Common Stock, $.001 Par Value<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">IONS<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NASDAQ<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityEmergingGrowthCompany', window );">Entity Emerging Growth Company</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_WrittenCommunications', window );">Written Communications</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SolicitingMaterial', window );">Soliciting Material</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementTenderOffer', window );">Pre-commencement Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementIssuerTenderOffer', window );">Pre-commencement Issuer Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_AmendmentFlag">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AmendmentFlag</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CityAreaCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Area code of city</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CityAreaCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CoverAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Cover page.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CoverAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentPeriodEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period. The format of the date is YYYY-MM-DD.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentPeriodEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:dateItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentType">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentType</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:submissionTypeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 1 such as Attn, Building Name, Street Name</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressCityOrTown">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the City or Town</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressCityOrTown</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressPostalZipCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Code for the postal or zip code</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressPostalZipCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressStateOrProvince">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the state or province.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressStateOrProvince</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:stateOrProvinceItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCentralIndexKey">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCentralIndexKey</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:centralIndexKeyItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityEmergingGrowthCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate if registrant meets the emerging growth company criteria.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityEmergingGrowthCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityFileNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityFileNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:fileNumberItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityIncorporationStateCountryCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Two-character EDGAR code representing the state or country of incorporation.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityIncorporationStateCountryCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarStateCountryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityRegistrantName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityRegistrantName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityTaxIdentificationNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityTaxIdentificationNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:employerIdItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_LocalPhoneNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Local phone number for entity.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_LocalPhoneNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementIssuerTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 13e<br> -Subsection 4c<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementIssuerTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14d<br> -Subsection 2b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_Security12bTitle">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Title of a 12(b) registered security.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_Security12bTitle</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:securityTitleItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SecurityExchangeName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the Exchange on which a security is registered.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection d1-1<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SecurityExchangeName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarExchangeCodeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SolicitingMaterial">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14a<br> -Subsection 12<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SolicitingMaterial</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_TradingSymbol">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Trading symbol of an instrument as listed on an exchange.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_TradingSymbol</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:tradingSymbolItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_WrittenCommunications">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Securities Act<br> -Number 230<br> -Section 425<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_WrittenCommunications</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>9
<FILENAME>Show.js
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
// Edgar(tm) Renderer was created by staff of the U.S. Securities and Exchange Commission.  Data and content created by government employees within the scope of their employment are not subject to domestic copyright protection. 17 U.S.C. 105.
var Show={};Show.LastAR=null,Show.showAR=function(a,r,w){if(Show.LastAR)Show.hideAR();var e=a;while(e&&e.nodeName!='TABLE')e=e.nextSibling;if(!e||e.nodeName!='TABLE'){var ref=((window)?w.document:document).getElementById(r);if(ref){e=ref.cloneNode(!0);
e.removeAttribute('id');a.parentNode.appendChild(e)}}
if(e)e.style.display='block';Show.LastAR=e};Show.hideAR=function(){Show.LastAR.style.display='none'};Show.toggleNext=function(a){var e=a;while(e.nodeName!='DIV')e=e.nextSibling;if(!e.style){}else if(!e.style.display){}else{var d,p_;if(e.style.display=='none'){d='block';p='-'}else{d='none';p='+'}
e.style.display=d;if(a.textContent){a.textContent=p+a.textContent.substring(1)}else{a.innerText=p+a.innerText.substring(1)}}}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>10
<FILENAME>report.css
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
/* Updated 2009-11-04 */
/* v2.2.0.24 */

/* DefRef Styles */
.report table.authRefData{
	background-color: #def;
	border: 2px solid #2F4497;
	font-size: 1em;
	position: absolute;
}

.report table.authRefData a {
	display: block;
	font-weight: bold;
}

.report table.authRefData p {
	margin-top: 0px;
}

.report table.authRefData .hide {
	background-color: #2F4497;
	padding: 1px 3px 0px 0px;
	text-align: right;
}

.report table.authRefData .hide a:hover {
	background-color: #2F4497;
}

.report table.authRefData .body {
	height: 150px;
	overflow: auto;
	width: 400px;
}

.report table.authRefData table{
	font-size: 1em;
}

/* Report Styles */
.pl a, .pl a:visited {
	color: black;
	text-decoration: none;
}

/* table */
.report {
	background-color: white;
	border: 2px solid #acf;
	clear: both;
	color: black;
	font: normal 8pt Helvetica, Arial, san-serif;
	margin-bottom: 2em;
}

.report hr {
	border: 1px solid #acf;
}

/* Top labels */
.report th {
	background-color: #acf;
	color: black;
	font-weight: bold;
	text-align: center;
}

.report th.void	{
	background-color: transparent;
	color: #000000;
	font: bold 10pt Helvetica, Arial, san-serif;
	text-align: left;
}

.report .pl {
	text-align: left;
	vertical-align: top;
	white-space: normal;
	width: 200px;
	white-space: normal; /* word-wrap: break-word; */
}

.report td.pl a.a {
	cursor: pointer;
	display: block;
	width: 200px;
	overflow: hidden;
}

.report td.pl div.a {
	width: 200px;
}

.report td.pl a:hover {
	background-color: #ffc;
}

/* Header rows... */
.report tr.rh {
	background-color: #acf;
	color: black;
	font-weight: bold;
}

/* Calendars... */
.report .rc {
	background-color: #f0f0f0;
}

/* Even rows... */
.report .re, .report .reu {
	background-color: #def;
}

.report .reu td {
	border-bottom: 1px solid black;
}

/* Odd rows... */
.report .ro, .report .rou {
	background-color: white;
}

.report .rou td {
	border-bottom: 1px solid black;
}

.report .rou table td, .report .reu table td {
	border-bottom: 0px solid black;
}

/* styles for footnote marker */
.report .fn {
	white-space: nowrap;
}

/* styles for numeric types */
.report .num, .report .nump {
	text-align: right;
	white-space: nowrap;
}

.report .nump {
	padding-left: 2em;
}

.report .nump {
	padding: 0px 0.4em 0px 2em;
}

/* styles for text types */
.report .text {
	text-align: left;
	white-space: normal;
}

.report .text .big {
	margin-bottom: 1em;
	width: 17em;
}

.report .text .more {
	display: none;
}

.report .text .note {
	font-style: italic;
	font-weight: bold;
}

.report .text .small {
	width: 10em;
}

.report sup {
	font-style: italic;
}

.report .outerFootnotes {
	font-size: 1em;
}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>12
<FILENAME>FilingSummary.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<XML>
<?xml version='1.0' encoding='utf-8'?>
<FilingSummary>
  <Version>3.25.1</Version>
  <ProcessingTime/>
  <ReportFormat>html</ReportFormat>
  <ContextCount>1</ContextCount>
  <ElementCount>22</ElementCount>
  <EntityCount>1</EntityCount>
  <FootnotesReported>false</FootnotesReported>
  <SegmentCount>0</SegmentCount>
  <ScenarioCount>0</ScenarioCount>
  <TuplesReported>false</TuplesReported>
  <UnitCount>0</UnitCount>
  <MyReports>
    <Report instance="ef20050532_8k.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R1.htm</HtmlFileName>
      <LongName>000100 - Document - Document and Entity Information</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://ionis.com/role/DocumentAndEntityInformation</Role>
      <ShortName>Document and Entity Information</ShortName>
      <MenuCategory>Cover</MenuCategory>
      <Position>1</Position>
    </Report>
    <Report>
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <LongName>All Reports</LongName>
      <ReportType>Book</ReportType>
      <ShortName>All Reports</ShortName>
    </Report>
  </MyReports>
  <InputFiles>
    <File doctype="8-K" isOnlyDei="true" isUsgaap="true" original="ef20050532_8k.htm">ef20050532_8k.htm</File>
    <File>ions-20250612.xsd</File>
    <File>ions-20250612_lab.xml</File>
    <File>ions-20250612_pre.xml</File>
  </InputFiles>
  <SupplementalFiles/>
  <BaseTaxonomies>
    <BaseTaxonomy items="22">http://xbrl.sec.gov/dei/2025</BaseTaxonomy>
  </BaseTaxonomies>
  <HasPresentationLinkbase>true</HasPresentationLinkbase>
  <HasCalculationLinkbase>false</HasCalculationLinkbase>
</FilingSummary>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>JSON
<SEQUENCE>14
<FILENAME>MetaLinks.json
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
{
 "version": "2.2",
 "instance": {
  "ef20050532_8k.htm": {
   "nsprefix": "ions",
   "nsuri": "http://ionis.com/20250612",
   "dts": {
    "inline": {
     "local": [
      "ef20050532_8k.htm"
     ]
    },
    "schema": {
     "local": [
      "ions-20250612.xsd"
     ],
     "remote": [
      "http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xl-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xlink-2003-12-31.xsd",
      "http://www.xbrl.org/2004/ref-2004-08-10.xsd",
      "http://www.xbrl.org/2005/xbrldt-2005.xsd",
      "http://www.xbrl.org/2006/ref-2006-02-27.xsd",
      "http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd",
      "http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd",
      "http://www.xbrl.org/lrr/role/net-2009-12-16.xsd",
      "https://www.xbrl.org/2020/extensible-enumerations-2.0.xsd",
      "https://www.xbrl.org/dtr/type/2020-01-21/types.xsd",
      "https://www.xbrl.org/dtr/type/2024-01-31/types.xsd",
      "https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd",
      "https://xbrl.fasb.org/srt/2025/elts/srt-roles-2025.xsd",
      "https://xbrl.fasb.org/srt/2025/elts/srt-types-2025.xsd",
      "https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd",
      "https://xbrl.fasb.org/us-gaap/2025/elts/us-roles-2025.xsd",
      "https://xbrl.fasb.org/us-gaap/2025/elts/us-types-2025.xsd",
      "https://xbrl.sec.gov/country/2025/country-2025.xsd",
      "https://xbrl.sec.gov/currency/2025/currency-2025.xsd",
      "https://xbrl.sec.gov/dei/2025/dei-2025.xsd",
      "https://xbrl.sec.gov/exch/2025/exch-2025.xsd",
      "https://xbrl.sec.gov/naics/2025/naics-2025.xsd",
      "https://xbrl.sec.gov/sic/2025/sic-2025.xsd",
      "https://xbrl.sec.gov/stpr/2025/stpr-2025.xsd"
     ]
    },
    "labelLink": {
     "local": [
      "ions-20250612_lab.xml"
     ]
    },
    "presentationLink": {
     "local": [
      "ions-20250612_pre.xml"
     ]
    }
   },
   "keyStandard": 22,
   "keyCustom": 0,
   "axisStandard": 0,
   "axisCustom": 0,
   "memberStandard": 0,
   "memberCustom": 0,
   "hidden": {
    "total": 2,
    "http://xbrl.sec.gov/dei/2025": 2
   },
   "contextCount": 1,
   "entityCount": 1,
   "segmentCount": 0,
   "elementCount": 29,
   "unitCount": 0,
   "baseTaxonomies": {
    "http://xbrl.sec.gov/dei/2025": 22
   },
   "report": {
    "R1": {
     "role": "http://ionis.com/role/DocumentAndEntityInformation",
     "longName": "000100 - Document - Document and Entity Information",
     "shortName": "Document and Entity Information",
     "isDefault": "true",
     "groupType": "document",
     "subGroupType": "",
     "menuCat": "Cover",
     "order": "1",
     "firstAnchor": {
      "contextRef": "c20250612to20250612",
      "name": "dei:DocumentType",
      "unitRef": null,
      "xsiNil": "false",
      "lang": "en-US",
      "decimals": null,
      "ancestors": [
       "div",
       "div",
       "div",
       "div",
       "div",
       "body",
       "html"
      ],
      "reportCount": 1,
      "baseRef": "ef20050532_8k.htm",
      "first": true,
      "unique": true
     },
     "uniqueAnchor": {
      "contextRef": "c20250612to20250612",
      "name": "dei:DocumentType",
      "unitRef": null,
      "xsiNil": "false",
      "lang": "en-US",
      "decimals": null,
      "ancestors": [
       "div",
       "div",
       "div",
       "div",
       "div",
       "body",
       "html"
      ],
      "reportCount": 1,
      "baseRef": "ef20050532_8k.htm",
      "first": true,
      "unique": true
     }
    }
   },
   "tag": {
    "dei_AmendmentFlag": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "AmendmentFlag",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Amendment Flag",
        "documentation": "Boolean flag that is true when the XBRL content amends previously-filed or accepted submission."
       }
      }
     },
     "auth_ref": []
    },
    "dei_CityAreaCode": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "CityAreaCode",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "City Area Code",
        "documentation": "Area code of city"
       }
      }
     },
     "auth_ref": []
    },
    "dei_CoverAbstract": {
     "xbrltype": "stringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "CoverAbstract",
     "lang": {
      "en-us": {
       "role": {
        "label": "Cover [Abstract]",
        "documentation": "Cover page."
       }
      }
     },
     "auth_ref": []
    },
    "dei_DocumentFiscalPeriodFocus": {
     "xbrltype": "fiscalPeriodItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "DocumentFiscalPeriodFocus",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Document Fiscal Period Focus",
        "documentation": "Fiscal period values are FY, Q1, Q2, and Q3. 1st, 2nd and 3rd quarter 10-Q or 10-QT statements have value Q1, Q2, and Q3 respectively, with 10-K, 10-KT or other fiscal year statements having FY."
       }
      }
     },
     "auth_ref": []
    },
    "dei_DocumentFiscalYearFocus": {
     "xbrltype": "gYearItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "DocumentFiscalYearFocus",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Document Fiscal Year Focus",
        "documentation": "This is focus fiscal year of the document report in YYYY format. For a 2006 annual report, which may also provide financial information from prior periods, fiscal 2006 should be given as the fiscal year focus. Example: 2006."
       }
      }
     },
     "auth_ref": []
    },
    "dei_DocumentPeriodEndDate": {
     "xbrltype": "dateItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "DocumentPeriodEndDate",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Document Period End Date",
        "documentation": "For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period. The format of the date is YYYY-MM-DD."
       }
      }
     },
     "auth_ref": []
    },
    "dei_DocumentType": {
     "xbrltype": "submissionTypeItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "DocumentType",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Document Type",
        "documentation": "The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'."
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityAddressAddressLine1": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityAddressAddressLine1",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Address, Address Line One",
        "documentation": "Address Line 1 such as Attn, Building Name, Street Name"
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityAddressAddressLine2": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityAddressAddressLine2",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Address, Address Line Two",
        "documentation": "Address Line 2 such as Street or Suite number"
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityAddressAddressLine3": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityAddressAddressLine3",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Address, Address Line Three",
        "documentation": "Address Line 3 such as an Office Park"
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityAddressCityOrTown": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityAddressCityOrTown",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Address, City or Town",
        "documentation": "Name of the City or Town"
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityAddressCountry": {
     "xbrltype": "countryCodeItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityAddressCountry",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Address, Country",
        "documentation": "ISO 3166-1 alpha-2 country code."
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityAddressPostalZipCode": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityAddressPostalZipCode",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Address, Postal Zip Code",
        "documentation": "Code for the postal or zip code"
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityAddressStateOrProvince": {
     "xbrltype": "stateOrProvinceItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityAddressStateOrProvince",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Address, State or Province",
        "documentation": "Name of the state or province."
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityCentralIndexKey": {
     "xbrltype": "centralIndexKeyItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityCentralIndexKey",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Central Index Key",
        "documentation": "A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK."
       }
      }
     },
     "auth_ref": [
      "r1"
     ]
    },
    "dei_EntityEmergingGrowthCompany": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityEmergingGrowthCompany",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Emerging Growth Company",
        "documentation": "Indicate if registrant meets the emerging growth company criteria."
       }
      }
     },
     "auth_ref": [
      "r1"
     ]
    },
    "dei_EntityFileNumber": {
     "xbrltype": "fileNumberItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityFileNumber",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity File Number",
        "documentation": "Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen."
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityIncorporationStateCountryCode": {
     "xbrltype": "edgarStateCountryItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityIncorporationStateCountryCode",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Incorporation, State or Country Code",
        "documentation": "Two-character EDGAR code representing the state or country of incorporation."
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityRegistrantName": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityRegistrantName",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Registrant Name",
        "documentation": "The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC."
       }
      }
     },
     "auth_ref": [
      "r1"
     ]
    },
    "dei_EntityTaxIdentificationNumber": {
     "xbrltype": "employerIdItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityTaxIdentificationNumber",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Tax Identification Number",
        "documentation": "The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS."
       }
      }
     },
     "auth_ref": [
      "r1"
     ]
    },
    "dei_LocalPhoneNumber": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "LocalPhoneNumber",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Local Phone Number",
        "documentation": "Local phone number for entity."
       }
      }
     },
     "auth_ref": []
    },
    "dei_NoTradingSymbolFlag": {
     "xbrltype": "trueItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "NoTradingSymbolFlag",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "No Trading Symbol Flag",
        "documentation": "Boolean flag that is true only for a security having no trading symbol."
       }
      }
     },
     "auth_ref": []
    },
    "dei_PreCommencementIssuerTenderOffer": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "PreCommencementIssuerTenderOffer",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Pre-commencement Issuer Tender Offer",
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act."
       }
      }
     },
     "auth_ref": [
      "r3"
     ]
    },
    "dei_PreCommencementTenderOffer": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "PreCommencementTenderOffer",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Pre-commencement Tender Offer",
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act."
       }
      }
     },
     "auth_ref": [
      "r5"
     ]
    },
    "dei_Security12bTitle": {
     "xbrltype": "securityTitleItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "Security12bTitle",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Title of 12(b) Security",
        "documentation": "Title of a 12(b) registered security."
       }
      }
     },
     "auth_ref": [
      "r0"
     ]
    },
    "dei_SecurityExchangeName": {
     "xbrltype": "edgarExchangeCodeItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "SecurityExchangeName",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Security Exchange Name",
        "documentation": "Name of the Exchange on which a security is registered."
       }
      }
     },
     "auth_ref": [
      "r2"
     ]
    },
    "dei_SolicitingMaterial": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "SolicitingMaterial",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Soliciting Material",
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act."
       }
      }
     },
     "auth_ref": [
      "r4"
     ]
    },
    "dei_TradingSymbol": {
     "xbrltype": "tradingSymbolItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "TradingSymbol",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Trading Symbol",
        "documentation": "Trading symbol of an instrument as listed on an exchange."
       }
      }
     },
     "auth_ref": []
    },
    "dei_WrittenCommunications": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "WrittenCommunications",
     "presentation": [
      "http://ionis.com/role/DocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Written Communications",
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act."
       }
      }
     },
     "auth_ref": [
      "r6"
     ]
    }
   }
  }
 },
 "std_ref": {
  "r0": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "12",
   "Subsection": "b"
  },
  "r1": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "12",
   "Subsection": "b-2"
  },
  "r2": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "12",
   "Subsection": "d1-1"
  },
  "r3": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "13e",
   "Subsection": "4c"
  },
  "r4": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "14a",
   "Subsection": "12"
  },
  "r5": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "14d",
   "Subsection": "2b"
  },
  "r6": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Securities Act",
   "Number": "230",
   "Section": "425"
  }
 }
}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>ZIP
<SEQUENCE>15
<FILENAME>0001140361-25-022267-xbrl.zip
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
begin 644 0001140361-25-022267-xbrl.zip
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M;M<(C #2,E"];23&,C20F@:AD9Q;DYTM%NM!EJ-U#W7O;"N@RWIB600TJS7
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MQ]C_4:W-TY=EFQ)*H4ME'+9R!LP+C-!V/#,D!K8=2C +3;=K@7+9\ER8^X3
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MH2V_G0"0I5$[3]KU?/TA*=Q(GO=T\IY'RC%+B>!3V? X4IZ_P]2XI$^]J'2
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MU_>K3\O?Y:_R6Z@=^?EB]3GC;!(=_C]02P,$%     @ %4C,6K5OI$VY#
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MI@HNS<)ZHC:A!ZK-\7V0M7HWH6OI-&6V?KQC1)45E>;]PNQ02>*:<QENLUY
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MX63V0QJ:S_):(PI.J!@!U1?G$*WEDHJ$TC,?P'MFAG:CD+,E"W+X(L5QL:_
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M,3\@?G!^B(@_X@?:'_\'4$L! A0#%     @ %4C,6J>L>0R*$@  4UX  !$
M             ( !     &5F,C P-3 U,S)?.&LN:'1M4$L! A0#%     @
M%4C,6K5OI$VY#   )B@  !4              ( !N1(  &5F,C P-3 U,S)?
M97@Y.2TQ+FAT;5!+ 0(4 Q0    ( !5(S%KW[U)[00,  # /   1
M      "  :4?  !I;VYS+3(P,C4P-C$R+GAS9%!+ 0(4 Q0    ( !5(S%H?
MK^PS>P@  #!6   5              "  14C  !I;VYS+3(P,C4P-C$R7VQA
M8BYX;6Q02P$"% ,4    "  52,Q:YPW,K=@%  #K/@  %0
M@ '#*P  :6]N<RTR,#(U,#8Q,E]P<F4N>&UL4$L%!@     %  4 1P$  ,XQ
$      $!

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>16
<FILENAME>ef20050532_8k_htm.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<XML>
<?xml version="1.0" encoding="utf-8"?>
<xbrl
  xmlns="http://www.xbrl.org/2003/instance"
  xmlns:dei="http://xbrl.sec.gov/dei/2025"
  xmlns:link="http://www.xbrl.org/2003/linkbase"
  xmlns:xlink="http://www.w3.org/1999/xlink">
    <link:schemaRef xlink:href="ions-20250612.xsd" xlink:type="simple"/>
    <context id="c20250612to20250612">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000874015</identifier>
        </entity>
        <period>
            <startDate>2025-06-12</startDate>
            <endDate>2025-06-12</endDate>
        </period>
    </context>
    <dei:AmendmentFlag
      contextRef="c20250612to20250612"
      id="Fact_0bbd1fd2f4ff497487e7f3e17f3f73da">false</dei:AmendmentFlag>
    <dei:EntityCentralIndexKey
      contextRef="c20250612to20250612"
      id="Fact_f420855766f9475ca30008d3ded17626">0000874015</dei:EntityCentralIndexKey>
    <dei:DocumentType
      contextRef="c20250612to20250612"
      id="Fact_92f8574b374d4a929c0ec28331312b0a">8-K</dei:DocumentType>
    <dei:DocumentPeriodEndDate
      contextRef="c20250612to20250612"
      id="Fact_9f59c43959044e1eb3cb6c659f54647a">2025-06-12</dei:DocumentPeriodEndDate>
    <dei:EntityRegistrantName
      contextRef="c20250612to20250612"
      id="Fact_45f4069dda2441a9879e2740d50cc489">IONIS PHARMACEUTICALS, INC.</dei:EntityRegistrantName>
    <dei:EntityIncorporationStateCountryCode
      contextRef="c20250612to20250612"
      id="Fact_a1c60e3aa24b4e0b949ae5c1bc353ba9">DE</dei:EntityIncorporationStateCountryCode>
    <dei:EntityFileNumber
      contextRef="c20250612to20250612"
      id="Fact_d4ef9ac722d54c9b9f9e21ed216995c4">000-19125</dei:EntityFileNumber>
    <dei:EntityTaxIdentificationNumber
      contextRef="c20250612to20250612"
      id="Fact_4a2719bdd8d241ed802b49d2bb3d59fb">33-0336973</dei:EntityTaxIdentificationNumber>
    <dei:EntityAddressAddressLine1
      contextRef="c20250612to20250612"
      id="Fact_ce17ea47e12948e8b128d4188d8871ff">2855 Gazelle Court</dei:EntityAddressAddressLine1>
    <dei:EntityAddressCityOrTown
      contextRef="c20250612to20250612"
      id="Fact_c20e6548c6fe44c7acb6ab52ce1e2076">Carlsbad</dei:EntityAddressCityOrTown>
    <dei:EntityAddressStateOrProvince
      contextRef="c20250612to20250612"
      id="Fact_c0081cdafa5c48c68b55608b2d4f7176">CA</dei:EntityAddressStateOrProvince>
    <dei:EntityAddressPostalZipCode
      contextRef="c20250612to20250612"
      id="Fact_2cc1d1bc739846369729b826cf48a90f">92010</dei:EntityAddressPostalZipCode>
    <dei:CityAreaCode
      contextRef="c20250612to20250612"
      id="Fact_a5c9f01928a64cb29423707e5d238e33">760</dei:CityAreaCode>
    <dei:LocalPhoneNumber
      contextRef="c20250612to20250612"
      id="Fact_3e1d0c4645244147801f761b1b069548">931-9200</dei:LocalPhoneNumber>
    <dei:WrittenCommunications
      contextRef="c20250612to20250612"
      id="Fact_0f7db15e86724b5ea710169be85f732e">false</dei:WrittenCommunications>
    <dei:SolicitingMaterial
      contextRef="c20250612to20250612"
      id="Fact_ad7a7c1fe596425393cf51d6dbf0d76d">false</dei:SolicitingMaterial>
    <dei:PreCommencementTenderOffer
      contextRef="c20250612to20250612"
      id="Fact_35bf4fdf6a054a0f9ae4f9cf047d5d28">false</dei:PreCommencementTenderOffer>
    <dei:PreCommencementIssuerTenderOffer
      contextRef="c20250612to20250612"
      id="Fact_43c4c42b3197481d82c53e73a043344a">false</dei:PreCommencementIssuerTenderOffer>
    <dei:Security12bTitle
      contextRef="c20250612to20250612"
      id="Fact_6fa6d1e5a84647049da890ff16d0a485">Common Stock, $.001 Par Value</dei:Security12bTitle>
    <dei:TradingSymbol
      contextRef="c20250612to20250612"
      id="Fact_50387bec36a7430ab101f0d1b22a4606">IONS</dei:TradingSymbol>
    <dei:SecurityExchangeName
      contextRef="c20250612to20250612"
      id="Fact_8b1f4582fc1a45dcaef27634644dda27">NASDAQ</dei:SecurityExchangeName>
    <dei:EntityEmergingGrowthCompany
      contextRef="c20250612to20250612"
      id="Fact_736445dc7825414487cbfcd5392faf50">false</dei:EntityEmergingGrowthCompany>
</xbrl>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
