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Document and Entity Information
Nov. 11, 2025
Cover [Abstract]  
Document Type 8-K
Document Period End Date Nov. 11, 2025
Entity Registrant Name IONIS PHARMACEUTICALS, INC.
Entity Incorporation State Country Code DE
Entity File Number 000-19125
Entity Tax Identification Number 33-0336973
Entity Address Address Line 1 2855 Gazelle Court
Entity Address City Or Town Carlsbad
Entity Address State Or Province CA
Entity Address Postal Zip Code 92010
City Area Code 760
Local Phone Number 931-9200
Written Communications false
Soliciting Material false
Pre Commencement Tender Offer false
Pre Commencement Issuer Tender Offer false
Security 12b Title Common Stock, $.001 Par Value
Trading Symbol IONS
Security Exchange Name NASDAQ
Entity Emerging Growth Company false
Amendment Flag false
Entity Central Index Key 0000874015