<SEC-DOCUMENT>0001958244-25-004498.txt : 20251201
<SEC-HEADER>0001958244-25-004498.hdr.sgml : 20251201
<ACCEPTANCE-DATETIME>20251201181430
ACCESSION NUMBER:		0001958244-25-004498
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251201
DATE AS OF CHANGE:		20251201

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		251541071

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			WENDER JOSEPH H
		CENTRAL INDEX KEY:			0001073384
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
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    <ns2:headerData>
        <ns2:submissionType>144</ns2:submissionType>
        <ns2:filerInfo>
            <ns2:filer>
                <ns2:filerCredentials>
                    <ns2:cik>0001073384</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
                </ns2:filerCredentials>
            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



        </ns2:filerInfo>
    </ns2:headerData>
    <ns2:formData>
        <ns2:issuerInfo>
            <ns2:issuerCik>0000874015</ns2:issuerCik>
            <ns2:issuerName>Ionis Pharmaceuticals, Inc.</ns2:issuerName>
            <ns2:secFileNumber>000-19125</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>2855 Gazelle Court</com:street1>
                <com:city>Carlsbad</com:city>
                <com:stateOrCountry>CA</com:stateOrCountry>
                <com:zipCode>92010</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>1-760-931-9200</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Joseph Wender</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Director</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>14479</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>1187133.21</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>161974393</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>12/01/2025</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:acquiredDate>05/09/2024</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired upon option exercise</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>The Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>8680</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>05/09/2024</ns2:paymentDate>
            <ns2:natureOfPayment>Option exercise</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:acquiredDate>07/15/2022</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired as compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>The Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>5333</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>07/15/2022</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:acquiredDate>07/15/2022</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired as compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>The Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>466</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>07/15/2022</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Joseph H. Wender Trust Dtd 10/3/2000</ns2:name>
                <ns2:address>
                    <com:street1>2855 Gazelle Court</com:street1>
                    <com:city>Carlsbad</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>92010</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>09/02/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>5600</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>322174.16</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Joseph H. Wender Trust Dtd 10/3/2000</ns2:name>
                <ns2:address>
                    <com:street1>2855 Gazelle Court</com:street1>
                    <com:city>Carlsbad</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>92010</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>09/02/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>11200</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>616432.32</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Joseph H. Wender Trust Dtd 10/3/2000</ns2:name>
                <ns2:address>
                    <com:street1>2855 Gazelle Court</com:street1>
                    <com:city>Carlsbad</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>92010</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>09/03/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>11200</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>673548.96</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Joseph H. Wender Trust Dtd 10/3/2000</ns2:name>
                <ns2:address>
                    <com:street1>2855 Gazelle Court</com:street1>
                    <com:city>Carlsbad</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>92010</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>10/01/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>16800</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>1100384.88</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Joseph H. Wender Trust Dtd 10/3/2000</ns2:name>
                <ns2:address>
                    <com:street1>2855 Gazelle Court</com:street1>
                    <com:city>Carlsbad</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>92010</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>10/30/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>11200</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>820632.96</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Joseph H. Wender Trust Dtd 10/3/2000</ns2:name>
                <ns2:address>
                    <com:street1>2855 Gazelle Court</com:street1>
                    <com:city>Carlsbad</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>92010</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>10/30/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>5600</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>410022.48</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Joseph H. Wender Trust Dtd 10/3/2000</ns2:name>
                <ns2:address>
                    <com:street1>2855 Gazelle Court</com:street1>
                    <com:city>Carlsbad</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>92010</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>10/31/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>11200</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>841552.32</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Joseph H. Wender Trust Dtd 10/3/2000</ns2:name>
                <ns2:address>
                    <com:street1>2855 Gazelle Court</com:street1>
                    <com:city>Carlsbad</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>92010</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>12/01/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>5600</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>452711.84</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Joseph H. Wender Trust Dtd 10/3/2000</ns2:name>
                <ns2:address>
                    <com:street1>2855 Gazelle Court</com:street1>
                    <com:city>Carlsbad</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>92010</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>12/01/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>11200</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>904937.6</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:remarks>The sales of shares set forth herein are made in connection with a selling plan dated 12/26/2024, that is intended to comply with Rule 10b5-1(c). All shares to be sold by Joseph H. Wender Trust.</ns2:remarks>
        <ns2:noticeSignature>
            <ns2:noticeDate>12/01/2025</ns2:noticeDate>
            <ns2:planAdoptionDates>
                <ns2:planAdoptionDate>12/26/2024</ns2:planAdoptionDate>
            </ns2:planAdoptionDates>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of Joseph Wender</ns2:signature>
        </ns2:noticeSignature>
    </ns2:formData>
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</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
