<SEC-DOCUMENT>0001140361-26-017637.txt : 20260429
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<ACCEPTANCE-DATETIME>20260429070032
ACCESSION NUMBER:		0001140361-26-017637
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		13
CONFORMED PERIOD OF REPORT:	20260429
ITEM INFORMATION:		Results of Operations and Financial Condition
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20260429
DATE AS OF CHANGE:		20260429

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		26910464

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
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      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>

      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold;">Washington, D.C.&#160; 20549</div>

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      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">PURSUANT TO SECTION 13 OR 15(d) OF THE</div>

      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">SECURITIES EXCHANGE ACT OF 1934</div>

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      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following
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              <div>Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</div>
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              <div>Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>

      <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">Securities registered pursuant to Section 12(b) of the Act:</div>

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              <div style="text-align: center; color: rgb(0, 0, 0);">Title of each class</div>
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              <div style="text-align: center; color: rgb(0, 0, 0);">Trading symbol</div>
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              <div style="text-align: center; color: rgb(0, 0, 0);">Name of each exchange on which registered</div>
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              <div style="text-align: center; color: rgb(0, 0, 0);">&#8220;<ix:nonNumeric name="dei:TradingSymbol" id="Fact_aedcc1b74a2644d29b33f833955191ca" contextRef="c20260429to20260429">IONS</ix:nonNumeric>&#8221;</div>
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      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"> <br/>
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      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (Section 230.405 of this
        chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (Section 240.12b-2 of this chapter).</div>

      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>

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              <div style="text-align: right;">Emerging growth company</div>
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    <td style="width: 8%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>

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      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>

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    <td style="width: 72pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Item 2.02</td>

    <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="font-weight: bold;">Results of Operations and Financial Condition.</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">On April 29, 2026, Ionis Pharmaceuticals, Inc. (the &#8220;<span style="font-weight: bold; font-style: italic;">Company</span>&#8221;) issued a press release announcing
        the Company&#8217;s financial results for the quarter ended March 31, 2026.&#160; In addition to disclosing results that are determined in accordance with Generally Accepted Accounting Principles (&#8220;<span style="font-weight: bold; font-style: italic;">GAAP</span>&#8221;),
        the Company also discloses pro forma or non-GAAP results of operations, which are adjusted from GAAP to exclude non-cash compensation expense related to equity awards and the related tax effects. The Company is presenting pro forma information
        excluding non-cash compensation expense related to equity awards and the related tax effects because the Company believes it better enables financial statement users to assess and compare its historical performance and project its future operating
        results and cash flows.&#160; A copy of the release is furnished with this report as an exhibit pursuant to &#8220;Item 2.02. Results of Operations and Financial Condition&#8221; of Form 8-K in accordance with SEC Release Nos. 33-8216 and 34-47583.</div>

      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">The information in this Current Report on Form 8-K and the Exhibit attached hereto shall not be deemed &#8220;filed&#8221; for purposes of Section 18 of the Securities
        Exchange Act of 1934 (the &#8220;<span style="font-weight: bold; font-style: italic;">Exchange Act</span>&#8221;) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act
        of 1933 or the Exchange Act, regardless of any general incorporation language in such filing.</div>

      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>

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    <td style="width: 72pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Item 9.01.</td>

    <td style="width: auto; vertical-align: top; text-align: justify; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="font-weight: bold;">Financial Statements and Exhibits.</div>
            </td>

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</table>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>

      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">(d) Exhibits.</div>

      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>

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              <div style="text-align: center; font-weight: bold;"><span style="text-decoration: underline;">Exhibit No.</span></div>
            </td>

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              <div style="text-align: left; font-weight: bold;"><span style="text-decoration: underline;">Description</span></div>
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  </tr>

  <tr>

    <td style="width: 12%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: center;"><a href="ef20071749_ex99-1.htm">99.1</a></div>
            </td>

    <td style="width: 88%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: left;">Press Release dated April 29, 2026.</div>
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    <td style="width: 12%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>

    <td style="width: 88%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>

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    <td style="width: 12%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: center;">104</div>
            </td>

    <td style="width: 88%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: left;">Cover Page Interactive Data File (embedded within the Inline XBRL document).</div>
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        </span></div>

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      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-variant: small-caps; font-weight: bold;">SIGNATURE</div>

      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>

      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman'; font-size: 10pt;">Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed
        on its behalf by the undersigned, thereunto duly authorized.</div>

      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>

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    <td style="width: 50%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>

    <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">
              <div style="text-align: justify; font-variant: small-caps; font-weight: bold;">Ionis Pharmaceuticals, Inc.</div>
            </td>

  </tr>

  <tr>

    <td style="width: 50%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>

    <td style="width: 3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>

    <td style="width: 47%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>

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    <td style="width: 50%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: justify;">Dated:&#160; April 29, 2026</div>
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    <td style="width: 3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: justify;">By:</div>
            </td>

    <td style="width: 47%; vertical-align: top; border-bottom: 2px solid black; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: justify;">/s/ Patrick R. O&#8217;Neil</div>
            </td>

  </tr>

  <tr>

    <td style="width: 50%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>

    <td style="width: 3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>

    <td style="width: 47%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: justify; font-variant: small-caps; font-weight: bold;">Patrick R. O&#8217;Neil</div>
            </td>

  </tr>

  <tr>

    <td style="width: 50%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>

    <td style="width: 3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>

    <td style="width: 47%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: justify;">Executive Vice President, Chief Legal Officer and General Counsel</div>
            </td>

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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>ef20071749_ex99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
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      <div style="text-align: right; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman';"> Exhibit 99.1</font></div>
      <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';"> <br>
        </font></div>
      <div style="text-align: left; font-size: 10pt; font-family: 'Times New Roman';"><img height="47" width="146" src="image0.jpg"></div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
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      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Ionis reports first quarter 2026 financial results and highlights progress on key programs</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: center; margin-left: 18pt; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">- TRYNGOLZA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174; </sup>(olezarsen) showed increasing demand in FCS driven by strong launch execution &#8211;</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: center; margin-left: 18pt; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;"><font style="font-size: 10pt; font-family: 'Times New Roman';">- Olezarsen sNDA accepted by the FDA for Priority Review; sHTG
          launch preparations on track &#8211;</font></div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: center; margin-left: 18pt; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">&#8211; Increasing annual TRYNGOLZA peak net sales guidance to &gt;$3B for sHTG &#8211;</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: center; margin-left: 18pt; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;"><font style="font-size: 10pt; font-family: 'Times New Roman';">- Zilganersen NDA for Alexander disease accepted for Priority
          Review, paving way for Ionis&#8217; first independent launch from leading neurology pipeline &#8211;</font></div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: center; margin-left: 18pt; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">- Strong first-quarter performance and outlook for the year supports improved 2026 financial guidance -</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">CARLSBAD, Calif., April 29, 2026</font><font style="font-size: 10pt; font-family: 'Times New Roman';"> &#8211; Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) (the &#8220;Company&#8221;) today reported financial results and provided key updates for the first quarter ended March 31, 2026.</font></div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">&#8220;Ionis&#8217; strong performance in the first quarter of 2026 underscores the strength of our commercial and R&amp;D engines. Our independent launches are increasingly
        contributing to revenue, driven by strong commercial execution, and we are on track for two additional groundbreaking independent launches in 2026 &#8212; olezarsen for severe hypertriglyceridemia, our first medicine for a broad patient population, and
        zilganersen for Alexander disease, the first launch from our leading neurology pipeline,&#8221; said Brett P. Monia, Ph.D., chief executive officer of Ionis. &#8220;In addition, we look forward to multiple key value-driving events this year, including results
        from pivotal Phase 3 partnered programs. These include presentation of positive bepirovirsen data in chronic hepatitis B next month at EASL, as well as results from the landmark pelacarsen Lp(a) HORIZON and eplontersen CARDIO-TTRansform
        cardiovascular outcomes trials later this year.&#8221;</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">1</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">First Quarter 2026 Summary Financial Results<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup>:</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <table align="center" cellspacing="0" cellpadding="0" border="0" style="width: 70%; color: #000000; font-family: 'Times New Roman'; font-size: 10pt; text-align: left;" id="za3c8253db11f47a1a75c5ad61e10b1e7" class="cfttable">

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            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 46%;">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top;" colspan="6">
              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">Three months</div>
              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">ended</div>
              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">March 31,</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
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            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; padding-bottom: 2px; width: 46%;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
              <div style="text-align: center;"> 2026</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftguttercell">&#160;</td>
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              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">2025</div>
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          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 46%;">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
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              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">(amounts in</div>
              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">millions)</div>
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            <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
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          <tr>
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              <div style="text-align: left;">Total revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>246</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>132</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 46%;">
              <div style="text-align: left;">Operating expenses</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
              <div>$</div>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>364</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>278</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 46%; background-color: rgb(204, 238, 255);">
              <div style="text-align: left;">Operating expenses on a non-GAAP basis</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>321</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>249</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 46%;">
              <div style="text-align: left;">Loss from operations</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>(118</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>(146</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 46%; background-color: rgb(204, 238, 255);">
              <div style="text-align: left;">Loss from operations on a non-GAAP basis</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>(75</div>
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              <div>Reconciliation of GAAP to non-GAAP basis contained later in this release.</div>
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              <div>Operating expenses for the quarter ended March 31, 2026 were in line with expectations and increased year over year primarily from investments related to the commercialization efforts for TRYNGOLZA and DAWNZERA as well as launch
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              <div>Cash and short-term investments were $1.9 billion as of March 31, 2026.&#160; The change in cash and short-term investments from year end 2025 was primarily related to the $633 million the Company used for the maturity of the 0% convertible
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              <div>Increasing annual olezarsen peak net sales guidance to &gt;$3 billion from &gt;$2 billion to reflect increasing confidence in the sHTG market opportunity for olezarsen</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">First Quarter 2026 Financial Results</div>
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              <div>Launch initiated in the European Union (EU) by Sobi</div>
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              <div>Olezarsen on track to launch this year as a transformational medicine for severe hypertriglyceridemia (sHTG), assuming approval</div>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">o</td>
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              <div>sNDA accepted by the FDA for Priority Review for the treatment of sHTG with a Prescription Drug User Fee Act (PDUFA) target action date of June 30, 2026</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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              <div>The European Medicines Agency (EMA) accepted an indication extension application in March for the treatment of adult patients with sHTG</div>
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              <div>DAWNZERA&#8482; (donidalorsen), the first and only RNA-targeted prophylactic therapy for hereditary angioedema (HAE) in patients 12 years of age and older</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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              <div>Generated U.S. net product sales of $16 million in the first quarter of 2026, an increase of 125% versus the fourth quarter of 2025</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">o</td>
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              <div>Launch initiated in the EU by Otsuka</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">o</td>
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              <div>Positive one-year results from OASISplus open-label extension cohort published in the<font style="font-style: italic;"> Journal of Asthma and Allergy</font></div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
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              <div>Zilganersen on track to launch this year as the first and only medicine to demonstrate clinically meaningful and disease-modifying benefit in children and adults with Alexander disease (AxD), assuming approval</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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            <td style="width: 36pt; font-size: 10pt; font-family: 'Times New Roman';"><br>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">o</td>
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              <div>New Drug Application (NDA) for AxD accepted by FDA for Priority Review with PDUFA target action date of September 22, 2026</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">o</td>
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              <div>Expanded access program (EAP) in U.S. underway</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">o</td>
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              <div>Positive additional results from the pivotal study presented at the American Academy of Neurology 2026 annual meeting</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Recent Highlights &#8211; Partnered Medicines</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
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              <div style="font-family: 'Times New Roman'; font-size: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">SPINRAZA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> (nusinersen) for the treatment of spinal muscular atrophy (SMA) generated global sales of $374
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">o</td>
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              <div>SPINRAZA high dose regimen approved and launched in the U.S. and EU</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;&#160; </div>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
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              <div style="font-family: 'Times New Roman'; font-size: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">WAINUA<sup style="font-family: 'Times New Roman'; vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> (eplontersen) (WAINZUA in EU) for the treatment of adults
                  with polyneuropathy of hereditary transthyretin-mediated amyloidosis (ATTRv-PN) generated global sales of $51 million in the first quarter of 2026, resulting in royalty revenue of $11 million</font></div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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            <td style="width: 36pt; font-size: 10pt; font-family: 'Times New Roman';"><br>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">o</td>
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              <div>Launches underway in numerous regions, including the EU and China; submissions in progress to expand WAINUA access globally</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z17b544b4dbdd446e8497ee265150acae" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 36pt; font-size: 10pt; font-family: 'Times New Roman';"><br>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">o</td>
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              <div>Phase 3 CARDIO-TTRansform study design and baseline characteristics to be presented at the Annual Congress of the Heart Failure Association of the ESC 2026</div>
            </td>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#8226;</td>
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              <div>Bepirovirsen, a potential first-in-class medicine for chronic hepatitis B (CHB), achieved the primary endpoint demonstrating a statistically significant and clinically meaningful functional cure rate in the B-Well 1 and B-Well 2 Phase 3
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">o</td>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">o</td>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">&#9632;</td>
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              <div>Accepted for regulatory review in EU, Japan, and China</div>
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      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">4</font></div>
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              <div style="text-align: center;">Three months ended</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
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            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
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            <td valign="bottom" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
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              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Revenue</div>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
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              <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt;">TRYNGOLZA sales, net</div>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
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              <div>27</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
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              <div>6</div>
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          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt;">DAWNZERA sales, net</div>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>16</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>-</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
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              <div style="text-align: left; text-indent: -7.2pt; margin-left: 43.2pt;">Total product sales, net</div>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>43</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>6</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">Royalty revenue:</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%; background-color: rgb(204, 238, 255);">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt;">SPINRAZA royalties</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>44</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>48</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt;">WAINUA royalties</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>11</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>9</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt;">Other royalties</div>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>3</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>7</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 43.2pt;">Total royalty revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>58</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>64</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%; background-color: rgb(204, 238, 255); padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">Other commercial revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>7</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>6</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 52.2pt; font-weight: bold;">Total commercial revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div style="font-weight: bold;">108</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div style="font-weight: bold;">76</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%; background-color: rgb(204, 238, 255);">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Research and development revenue:</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">Collaborative agreement revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>120</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>46</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">WAINUA joint development revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>18</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>10</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 52.2pt; font-weight: bold;">Total research and development revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div style="font-weight: bold;">138</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div style="font-weight: bold;">56</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 56%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 61.2pt; font-weight: bold;">Total revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div style="font-weight: bold;">$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div style="font-weight: bold;">246</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div style="font-weight: bold;">$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div style="font-weight: bold;">132</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>

      </table>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Commercial revenue for the first quarter ended March 31, 2026, increased 42%, compared to the same period in 2025. This increase was primarily driven by TRYNGOLZA and
        DAWNZERA product sales. Higher research and development revenue also contributed to the year-over-year revenue increase including approximately $95 million in milestone payments from multiple partnerships.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Operating Expenses</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Operating expenses for the first quarter ended March 31, 2026, were driven from investments primarily related to commercialization efforts for TRYNGOLZA and DAWNZERA
        as well as launch preparations for olezarsen in sHTG and zilganersen in Alexander disease.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Balance Sheet</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As of March 31, 2026, Ionis&#8217; cash, cash equivalents and short-term investments decreased to $1.9 billion, compared to $2.7 billion on December 31, 2025. At March 31,
        2026, Ionis had an escrow deposit of $633 million, which the Company used for the maturity of its 0% convertible notes due on April 1, 2026.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">5</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">2026 Financial Guidance</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Ionis improved its 2026 financial guidance to reflect the strong revenue performance experienced year-to-date and the Company&#8217;s outlook for the balance of 2026.
        Overall, the Company increased total revenue and decreased operating loss both by $75 million. The improvements were driven by Priority Review for TRYNGOLZA, strong first quarter R&amp;D revenue and the anticipated continued success of the
        Company&#8217;s ongoing commercial launches.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;" id="z2943a05206184a1983c9a44f0a54d80c" class="cfttable">

          <tr>
            <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
              <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Full Year 2026 Guidance</div>
            </td>
            <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">Previous</div>
              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">Guidance</div>
            </td>
            <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">New</div>
              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">Guidance</div>
            </td>
          </tr>
          <tr>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
              <div style="text-align: left;">Total Revenue</div>
            </td>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">$800-825 million</div>
            </td>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">$875-900 million</div>
            </td>
          </tr>
          <tr>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: left;">TRYNGOLZA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#160;</sup>product sales, net</div>
            </td>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: center;">NA</div>
            </td>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: center;">$100-110 million</div>
            </td>
          </tr>
          <tr>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
              <div style="text-align: left;">DAWNZERA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#160;</sup>product sales, net</div>
            </td>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">NA</div>
            </td>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">$110-120 million</div>
            </td>
          </tr>
          <tr>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: left;">Operating loss on a non-GAAP basis</div>
            </td>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: center;">$500-550 million</div>
            </td>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: center;">$425-475 million</div>
            </td>
          </tr>
          <tr>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
              <div style="text-align: left;">Cash, cash equivalents and short-term investments</div>
            </td>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">&gt;$1.6 billion</div>
            </td>
            <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">&gt;$1.6 billion</div>
            </td>
          </tr>

      </table>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Webcast and Other Updates</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Management will host a conference call and webcast to discuss Ionis&#8217; first quarter 2026 results at 8:30 a.m. Eastern time on Wednesday, April 29, 2026. Interested
        parties may access the webcast <u>here</u>. A webcast replay will be available for a limited time at the same address. To access the Company&#8217;s first quarter 2026 earnings slides click <u>here</u>.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Ionis&#8217; Marketed Medicines</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">INDICATION for TRYNGOLZA<sup style="font-family: 'Times New Roman'; vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#160;</sup>(olezarsen)</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">TRYNGOLZA<sup style="font-family: 'Times New Roman'; font-weight: bold; vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup><sup style="font-weight: bold; vertical-align: text-top; line-height: 1; font-size: smaller;">&#160;</sup>(olezarsen) was approved by the U.S. Food and
        Drug Administration as an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia syndrome (FCS).</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">IMPORTANT SAFETY INFORMATION</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">CONTRAINDICATIONS</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">TRYNGOLZA is contraindicated in patients with a history of serious hypersensitivity to TRYNGOLZA or any of the excipients in TRYNGOLZA. Hypersensitivity reactions
        requiring medical treatment have occurred.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">WARNINGS AND PRECAUTIONS</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Hypersensitivity Reactions</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Hypersensitivity reactions (including symptoms of bronchospasm, diffuse erythema, facial swelling, urticaria, chills and myalgias) have been reported in patients treated
        with TRYNGOLZA. Advise patients on the signs and symptoms of hypersensitivity reactions and instruct patients to promptly seek medical attention and discontinue use of TRYNGOLZA if hypersensitivity reactions occur.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">ADVERSE REACTIONS</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">The most common adverse reactions (incidence &gt;5% of TRYNGOLZA-treated patients and &gt;3% higher frequency than placebo) were injection site reactions, decreased
        platelet count and arthralgia.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Please see full <u>Prescribing Information</u> for TRYNGOLZA.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">6</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">INDICATION for DAWNZERA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">TM</sup> (donidalorsen)</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">DAWNZERA&#8482; (donidalorsen) was approved by the U.S. Food and Drug Administration for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adult and pediatric
        patients 12 years of age and older.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">IMPORTANT SAFETY INFORMATION</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">CONTRAINDICATIONS</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">DAWNZERA is contraindicated in patients with a history of serious hypersensitivity reactions, including anaphylaxis, to donidalorsen or any of the excipients in DAWNZERA.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">WARNINGS AND PRECAUTIONS</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Hypersensitivity Reactions</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Hypersensitivity reactions, including anaphylaxis, have been reported in patients treated with DAWNZERA. If signs and symptoms of serious hypersensitivity reactions
        occur, discontinue DAWNZERA and institute appropriate therapy.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">ADVERSE REACTIONS</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Most common adverse reactions (incidence &#8805; 5%) are injection site reactions, upper respiratory tract infection, urinary tract infection, and abdominal discomfort.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Please see full <u>Prescribing Information</u> for DAWNZERA.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">INDICATION for WAINUA<sup style="font-family: 'Times New Roman'; vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> (eplontersen)</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">WAINUA injection, for subcutaneous use, 45 mg is indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">IMPORTANT SAFETY INFORMATION for WAINUA</font><font style="font-size: 10pt; font-family: 'Times New Roman';"><sup style="font-family: 'Times New Roman'; font-weight: bold; vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;<font style="font-weight: bold;">(eplontersen)</font></font></div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">WARNINGS AND PRECAUTIONS</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Reduced Serum Vitamin A Levels and Recommended Supplementation </font><font style="font-size: 10pt; font-family: 'Times New Roman';">WAINUA leads to a decrease in serum vitamin A levels. Supplement with recommended daily allowance of vitamin A. Refer patient to an ophthalmologist if ocular symptoms suggestive of vitamin
          A deficiency occur.</font></div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">ADVERSE REACTIONS</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Most common adverse reactions (&#8805;9% in WAINUA-treated patients) were vitamin A decreased (15%) and vomiting (9%).</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">Please see link to <u>U.S. Full Prescribing Information</u> for WAINUA.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">For more information about SPINRAZA and QALSODY, visit <u>https://www.spinraza.com/</u> and <u>https://www.qalsody.com/</u>, respectively. QALSODY is approved under
        accelerated approval based on reduction in plasma neurofilament light chain (NfL) observed in patients treated with QALSODY. Continued approval may be contingent upon verification of clinical benefit in confirmatory trial(s).</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">7</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">About Ionis Pharmaceuticals, Inc.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">For three decades, Ionis has invented medicines that bring better futures to people with serious diseases. Ionis currently has marketed medicines and a leading
        pipeline in neurology, cardiometabolic disease and select areas of high patient need. As the pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies in addition to advancing new approaches in gene editing. A deep
        understanding of disease biology and industry-leading technology propels our work, coupled with a passion and urgency to deliver life-changing advances for patients. To learn more about Ionis, visit <u>Ionis.com</u> and follow us on <u>X
          (Twitter)</u><font style="color: rgb(0, 0, 255);"><u>,</u></font>&#160;<u>LinkedIn</u> and <u>Instagram</u>.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Ionis Forward-looking Statements</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">This press release includes forward-looking statements regarding Ionis&#8217; business, financial guidance and the therapeutic and commercial potential of our commercial
        medicines, additional medicines in development, technologies and our expectations regarding development and regulatory milestones. Any statement describing Ionis&#8217; goals, expectations, financial or other projections, intentions or beliefs is a
        forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties including those inherent in the process of discovering, developing and commercializing medicines that are safe
        and effective for use as human therapeutics, and in the endeavor of building a business around such medicines. Ionis&#8217; forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to
        differ materially from those expressed or implied by such forward-looking statements. Although Ionis&#8217; forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known
        by Ionis. Except as required by law, we undertake no obligation to update any forward-looking statements for any reason. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Ionis'
        programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended December 31, 2025, and most recent Form 10-Q, which are on file with the Securities and Exchange Commission. Copies of these and other documents are
        available from the Company.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">In this press release, unless the context requires otherwise, &#8220;Ionis,&#8221; &#8220;Company,&#8221; &#8220;we,&#8221; &#8220;our&#8221; and &#8220;us&#8221; all refer to Ionis Pharmaceuticals and its subsidiaries.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">IONIS<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> is a registered trademark of Ionis Pharmaceuticals, Inc. TRYNGOLZA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> is a registered trademark of Ionis Pharmaceuticals, Inc. DAWNZERA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">TM</sup>
        is a trademark of Ionis Pharmaceuticals, Inc. AKCEA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">TM</sup> is a trademark of Akcea Therapeutics, Inc. TEGSEDI<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">TM</sup> is a trademark of Akcea Therapeutics, Inc. WAYLIVRA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">TM</sup> is a trademark of Akcea Therapeutics, Inc. SPINRAZA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>
        and QALSODY<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174; </sup>are registered trademarks of Biogen. WAINUA<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174; </sup>is a registered trademark of the AstraZeneca group of companies.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Ionis Investor Contact:</div>
      <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">D. Wade Walke, Ph.D.</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"><u>IR@ionis.com</u></div>
      <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">760-603-2331</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Ionis Media Contact:</div>
      <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">Hayley Soffer</div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"><u>media@ionis.com</u></div>
      <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;">760-603-4679</div>
      <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman'; font-size: 10pt;"> <br>
      </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">8</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">IONIS PHARMACEUTICALS, INC.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">SELECTED FINANCIAL INFORMATION</div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Condensed Consolidated Statements of Operations</div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">(In Millions, Except Per Share Data)</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;" id="z320579bc44fa43fe877977cf0487955c" class="cfttable">

          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="6">
              <div style="text-align: center;">Three months ended</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="6">
              <div style="text-align: center;">March 31,</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
              <div style="text-align: center;"> 2026</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
              <div style="text-align: center;">2025</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="6">
              <div style="text-align: center;">(unaudited)</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Revenue:</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Commercial revenue:</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">Product sales, net</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>43</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>6</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">Royalty revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>58</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>64</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: rgb(204, 238, 255); padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">Other commercial revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>7</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>6</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt;">Total commercial revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>108</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>76</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Research and development revenue:</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">Collaborative agreement revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>120</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>46</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: rgb(204, 238, 255); padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">WAINUA joint development revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>18</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>10</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 34.2pt;">Total research and development revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>138</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>56</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">Total revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>246</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>132</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Expenses:</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Cost of sales</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>3</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>1</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Research, development and patent</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>210</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>201</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; width: 76%; padding-bottom: 2px; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman'; font-size: 10pt;">Selling, general and administrative</div>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>151</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>76</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">Total operating expenses</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>364</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>278</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Loss from operations</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>(118</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>(146</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Other income (expense):</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Interest expense related to the sale of future royalties</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>(17</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>(19</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: rgb(204, 238, 255); padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Other income, net</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>42</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>18</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Loss before income tax expense</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>(93</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>(147</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Income tax expense</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>-</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>-</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 4px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Net loss</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1" class="cftnumcell">
              <div>(93</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1" class="cftnumcell">
              <div>(147</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 4px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Basic and diluted net loss per share</div>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1" class="cftnumcell">
              <div>(0.56</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1" class="cftnumcell">
              <div>(0.93</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftfncell">
              <div>)</div>
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          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 4px; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Shares used in computing basic and diluted net loss per share</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>165</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>159</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>

      </table>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">9</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">IONIS PHARMACEUTICALS, INC.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Reconciliation of GAAP to Non-GAAP Basis:</div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Condensed Consolidated Operating Expenses, Loss From Operations, and Net Loss</div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">(In Millions)</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;" id="z2f8a6d7136874b7ca50a8ad8a690839a" class="cfttable">

          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="6">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top;" colspan="6">
              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">Three months ended</div>
              <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt;">March 31,</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
              <div style="text-align: center;"> 2026</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: center; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
              <div style="text-align: center;">2025</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; font-size: 10pt; font-family: 'Times New Roman';" colspan="6">
              <div style="text-align: center;">(unaudited)</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">As reported cost of sales according to GAAP</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>3</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>1</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Excluding compensation expense related to equity awards (1)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>-</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>-</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 4px; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Non-GAAP cost of sales</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>3</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>1</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">As reported research, development and patent expenses according to GAAP</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>210</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>201</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Excluding compensation expense related to equity awards</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>(25</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>(20</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: rgb(204, 238, 255); padding-bottom: 4px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Non-GAAP research, development and patent expenses</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>185</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>181</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">As reported selling, general and administrative expenses according to GAAP</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>151</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>76</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Excluding compensation expense related to equity awards</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>(18</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>(9</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 4px; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Non-GAAP selling, general and administrative expenses</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>133</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>67</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">As reported operating expenses according to GAAP</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>364</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>278</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Excluding compensation expense related to equity awards</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>(43</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>(29</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 4px; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Non-GAAP operating expenses</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>321</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>249</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">As reported loss from operations according to GAAP</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>(118</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>(146</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Excluding compensation expense related to equity awards</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>(43</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>(29</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 4px; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Non-GAAP loss from operations</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>(75</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>(117</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">As reported net loss according to GAAP</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>(93</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>(147</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Excluding compensation expense related to equity awards and related tax effects</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>(43</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
              <div>(29</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 4px; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Non-GAAP net loss</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>(50</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$&#160;</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>(118</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">
              <div>)</div>
            </td>
          </tr>

      </table>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <table cellspacing="0" cellpadding="0" id="z065f0e47131d4d1eb80a9444ce620668" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 18pt; font-size: 10pt; font-family: 'Times New Roman';"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman'; font-size: 10pt;">(1)</td>
            <td style="width: auto; vertical-align: top; text-align: left; font-size: 10pt; font-family: 'Times New Roman';">
              <div>Amounts appear as zero due to rounding in millions.</div>
            </td>
          </tr>

      </table>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">10</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;"><u>Reconciliation of GAAP to Non-GAAP Basis</u></div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="text-align: justify; font-family: 'Times New Roman'; font-size: 10pt;">As illustrated in the Selected Financial Information in this press release, non-GAAP operating expenses, non-GAAP loss from operations, and non-GAAP net loss were
        adjusted from GAAP to exclude compensation expense related to equity awards and the related tax effects. Compensation expense related to equity awards are non-cash. These measures are provided as supplementary information and are not a substitute
        for financial measures calculated in accordance with GAAP. Ionis reports these non-GAAP results to better enable financial statement users to assess and compare its historical performance and project its future operating results and cash flows.
        Further, the presentation of Ionis&#8217; non-GAAP results is consistent with how Ionis&#8217; management internally evaluates the performance of its operations.</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">11</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">IONIS PHARMACEUTICALS, INC.</div>
      <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">Condensed Consolidated Balance Sheets</div>
      <div style="text-align: center; margin-left: 1.5pt; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">(In Millions)</div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;" id="z684e62ba406949c480853feed94bad43" class="cfttable">

          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">
              <div style="text-align: center;">March 31,</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">
              <div style="text-align: center;">December 31,</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-bottom: #000000 solid 2px;" colspan="2">
              <div style="text-align: center;"> 2026</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-bottom: #000000 solid 2px;" colspan="2">
              <div style="text-align: center;">2025</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">
              <div style="text-align: center;">(unaudited)</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Assets:</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman';" colspan="2">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Cash, cash equivalents and short-term investments</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>1,919</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>2,677</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Escrow deposits</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>633</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>-</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Contracts receivable</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>74</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>66</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Other current assets</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>312</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>247</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Property, plant and equipment, net</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>142</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>123</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Right-of-use assets</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>235</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>239</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Other assets</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>135</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>172</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 4px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">Total assets</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1" class="cftnumcell">
              <div>3,450</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1" class="cftnumcell">
              <div>3,524</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 7.2pt;">Liabilities and stockholders&#8217; equity:</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Current portion of deferred contract revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>69</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>74</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">0% convertible senior notes due April 2026 &#8211; current</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>433</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>432</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Other current liabilities</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>215</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>277</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt; font-family: 'Times New Roman'; font-size: 10pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">0% convertible senior notes due 2030, net</font></div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>752</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>751</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">1.75% convertible senior notes due 2028, net</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>569</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>568</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Liability related to sale of future royalties, net</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>558</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>551</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Long-term lease liabilities</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>259</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>262</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Long-term obligations, less current portion</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>28</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
              <div>28</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Long-term deferred contract revenue</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>76</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>92</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 2px;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 16.2pt;">Total stockholders&#8217; equity</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>491</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
              <div>489</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; width: 76%; padding-bottom: 4px; background-color: #CCEEFF;">
              <div style="text-align: left; text-indent: -7.2pt; margin-left: 25.2pt;">Total liabilities and stockholders&#8217; equity</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
            </td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>3,450</div>
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            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div>$</div>
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            <td valign="bottom" style="font-size: 10pt; font-family: 'Times New Roman'; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div>3,524</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="font-size: 10pt; font-family: 'Times New Roman'; text-align: left; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>

      </table>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;">12</font></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Key 2026 Value Driving Events</font><font style="font-size: 10pt; font-family: 'Times New Roman';"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></font></div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';">&#160;</div>
      <div style="margin-left: 36pt;">
        <table cellspacing="0" cellpadding="0" border="0" id="z97ca32aa6fdf426ca340fa3e1f0d7033" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">

            <tr>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" colspan="5">
                <div style="text-align: left; font-weight: bold;">New Product Launches</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left; font-weight: bold;">Program</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left; font-weight: bold;">Indication</div>
              </td>
              <td style="width: 32%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-weight: bold;">Location</div>
              </td>
              <td style="width: 16%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">DAWNZERA</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">HAE</div>
              </td>
              <td style="width: 32%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">EU</div>
              </td>
              <td style="width: 16%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">Achieved</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Olezarsen</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">sHTG</div>
              </td>
              <td style="width: 32%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">U.S.</div>
              </td>
              <td style="width: 16%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">&#8226;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Zilganersen</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Alexander disease</div>
              </td>
              <td style="width: 32%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">U.S.</div>
              </td>
              <td style="width: 16%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">&#8226;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Bepirovirsen</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">CHB</div>
              </td>
              <td style="width: 32%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">U.S. &amp; Japan</div>
              </td>
              <td style="width: 16%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
                <div style="text-align: center;">&#8226;</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="margin-left: 36pt;">
        <table cellspacing="0" cellpadding="0" border="0" id="z232ce5d32bc94062bc1616039b54a700" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">

            <tr>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" colspan="6">
                <div style="text-align: left; font-weight: bold;">Regulatory Actions</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left; font-weight: bold;">Program</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left; font-weight: bold;">Indication</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left; font-weight: bold;">Regulatory Action</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; text-align: center; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Donidalorsen</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">HAE</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">EU approval decision</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">Achieved</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="2" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);" rowspan="2">
                <div style="text-align: left;">Olezarsen</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="2">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);" rowspan="2">
                <div style="text-align: left;">sHTG</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">U.S. approval decision</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">&#8226;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">EU submission</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">Achieved</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="2" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);" rowspan="2">
                <div style="text-align: left;">Zilganersen</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="2">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);" rowspan="2">
                <div style="text-align: left;">Alexander disease</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">U.S. submission</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">Achieved</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">U.S. approval decision</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">&#8226;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="2" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0);" rowspan="2">
                <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">Nusinersen</div>
                <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt;">(high dose)</div>
              </td>
              <td style="width: 1%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="2">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);" rowspan="2">
                <div style="text-align: left;">SMA</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">EU approval decision</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">Achieved</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">U.S. approval decision</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">Achieved</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Eplontersen</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">ATTR-CM</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Regulatory submission(s)</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">&#8226;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="2" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);" rowspan="2">
                <div style="text-align: left;">Bepirovirsen</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="2">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);" rowspan="2">
                <div style="text-align: left;">HBV</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Regulatory submission(s)</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">Achieved</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Regulatory decision(s)</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">&#8226;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Pelacarsen</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Lp(a)- CVD</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">U.S. submission</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
                <div style="text-align: center;">&#8226;</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="font-size: 10pt; font-family: 'Times New Roman';"><br>
      </div>
      <div style="margin-left: 36pt;">
        <table cellspacing="0" cellpadding="0" border="0" id="z03cd30adae1b417c9b389196202544b4" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">

            <tr>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" colspan="6">
                <div style="text-align: left; font-weight: bold;">Key Phase 3 Clinical Events</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left; font-weight: bold;">Program</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left; font-weight: bold;">Indication</div>
              </td>
              <td style="width: 1%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left; font-weight: bold;">Event</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Obudanersen</div>
              </td>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Angelman syndrome</div>
              </td>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Phase 3 enrollment completion</div>
              </td>
              <td style="width: 16.3%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">&#8226;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Bepirovirsen</div>
              </td>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">HBV</div>
              </td>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">B-Well data</div>
              </td>
              <td style="width: 16.3%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">Achieved</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Pelacarsen</div>
              </td>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Lp(a)-CVD</div>
              </td>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Lp(a) HORIZON data</div>
              </td>
              <td style="width: 16.3%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">&#8226;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
              <td style="width: 20%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">Eplontersen</div>
              </td>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 30%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">ATTR-CM</div>
              </td>
              <td style="width: 1%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
              <td style="width: 31%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
                <div style="text-align: left;">CARDIO-TTRansform data</div>
              </td>
              <td style="width: 16.3%; vertical-align: middle; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;">&#8226;</div>
              </td>
            </tr>
            <tr>
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              <td style="width: 20%; vertical-align: top; font-size: 10pt; font-family: 'Times New Roman'; border-top: 2px solid rgb(0, 0, 0);">
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  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" />
  <link:labelLink xlink:type="extended" xlink:role="http://www.xbrl.org/2003/role/link">
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    <link:label xlink:type="resource" xlink:label="dei_CoverAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_CoverAbstract" xml:lang="en-US" id="dei_CoverAbstract">Cover [Abstract]</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType" xlink:label="DocumentType" xlink:title="DocumentType" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentType" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentType" xml:lang="en-US" id="dei_DocumentType">Document Type</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="DocumentType" xlink:to="dei_DocumentType" xlink:title="label: DocumentType to dei_DocumentType" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications" xlink:label="WrittenCommunications" xlink:title="WrittenCommunications" />
    <link:label xlink:type="resource" xlink:label="dei_WrittenCommunications" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_WrittenCommunications" xml:lang="en-US" id="dei_WrittenCommunications">Written Communications</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="WrittenCommunications" xlink:to="dei_WrittenCommunications" xlink:title="label: WrittenCommunications to dei_WrittenCommunications" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial" xlink:label="SolicitingMaterial" xlink:title="SolicitingMaterial" />
    <link:label xlink:type="resource" xlink:label="dei_SolicitingMaterial" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_SolicitingMaterial" xml:lang="en-US" id="dei_SolicitingMaterial">Soliciting Material</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="SolicitingMaterial" xlink:to="dei_SolicitingMaterial" xlink:title="label: SolicitingMaterial to dei_SolicitingMaterial" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer" xlink:label="PreCommencementTenderOffer" xlink:title="PreCommencementTenderOffer" />
    <link:label xlink:type="resource" xlink:label="dei_PreCommencementTenderOffer" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_PreCommencementTenderOffer" xml:lang="en-US" id="dei_PreCommencementTenderOffer">Pre-commencement Tender Offer</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="PreCommencementTenderOffer" xlink:to="dei_PreCommencementTenderOffer" xlink:title="label: PreCommencementTenderOffer to dei_PreCommencementTenderOffer" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer" xlink:label="PreCommencementIssuerTenderOffer" xlink:title="PreCommencementIssuerTenderOffer" />
    <link:label xlink:type="resource" xlink:label="dei_PreCommencementIssuerTenderOffer" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_PreCommencementIssuerTenderOffer" xml:lang="en-US" id="dei_PreCommencementIssuerTenderOffer">Pre-commencement Issuer Tender Offer</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="PreCommencementIssuerTenderOffer" xlink:to="dei_PreCommencementIssuerTenderOffer" xlink:title="label: PreCommencementIssuerTenderOffer to dei_PreCommencementIssuerTenderOffer" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag" xlink:label="AmendmentFlag" xlink:title="AmendmentFlag" />
    <link:label xlink:type="resource" xlink:label="dei_AmendmentFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_AmendmentFlag" xml:lang="en-US" id="dei_AmendmentFlag">Amendment Flag</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="AmendmentFlag" xlink:to="dei_AmendmentFlag" xlink:title="label: AmendmentFlag to dei_AmendmentFlag" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalYearFocus" xlink:label="DocumentFiscalYearFocus" xlink:title="DocumentFiscalYearFocus" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentFiscalYearFocus" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentFiscalYearFocus" xml:lang="en-US" id="dei_DocumentFiscalYearFocus">Document Fiscal Year Focus</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="DocumentFiscalYearFocus" xlink:to="dei_DocumentFiscalYearFocus" xlink:title="label: DocumentFiscalYearFocus to dei_DocumentFiscalYearFocus" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="DocumentFiscalPeriodFocus" xlink:title="DocumentFiscalPeriodFocus" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentFiscalPeriodFocus" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentFiscalPeriodFocus" xml:lang="en-US" id="dei_DocumentFiscalPeriodFocus">Document Fiscal Period Focus</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="DocumentFiscalPeriodFocus" xlink:to="dei_DocumentFiscalPeriodFocus" xlink:title="label: DocumentFiscalPeriodFocus to dei_DocumentFiscalPeriodFocus" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate" xlink:label="DocumentPeriodEndDate" xlink:title="DocumentPeriodEndDate" />
    <link:label xlink:type="resource" xlink:label="dei_DocumentPeriodEndDate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_DocumentPeriodEndDate" xml:lang="en-US" id="dei_DocumentPeriodEndDate">Document Period End Date</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="DocumentPeriodEndDate" xlink:to="dei_DocumentPeriodEndDate" xlink:title="label: DocumentPeriodEndDate to dei_DocumentPeriodEndDate" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName" xlink:label="EntityRegistrantName" xlink:title="EntityRegistrantName" />
    <link:label xlink:type="resource" xlink:label="dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityRegistrantName" xml:lang="en-US" id="dei_EntityRegistrantName">Entity Registrant Name</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityRegistrantName" xlink:to="dei_EntityRegistrantName" xlink:title="label: EntityRegistrantName to dei_EntityRegistrantName" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey" xlink:label="EntityCentralIndexKey" xlink:title="EntityCentralIndexKey" />
    <link:label xlink:type="resource" xlink:label="dei_EntityCentralIndexKey" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityCentralIndexKey" xml:lang="en-US" id="dei_EntityCentralIndexKey">Entity Central Index Key</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityCentralIndexKey" xlink:to="dei_EntityCentralIndexKey" xlink:title="label: EntityCentralIndexKey to dei_EntityCentralIndexKey" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber" xlink:label="EntityFileNumber" xlink:title="EntityFileNumber" />
    <link:label xlink:type="resource" xlink:label="dei_EntityFileNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityFileNumber" xml:lang="en-US" id="dei_EntityFileNumber">Entity File Number</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityFileNumber" xlink:to="dei_EntityFileNumber" xlink:title="label: EntityFileNumber to dei_EntityFileNumber" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber" xlink:label="EntityTaxIdentificationNumber" xlink:title="EntityTaxIdentificationNumber" />
    <link:label xlink:type="resource" xlink:label="dei_EntityTaxIdentificationNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityTaxIdentificationNumber" xml:lang="en-US" id="dei_EntityTaxIdentificationNumber">Entity Tax Identification Number</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityTaxIdentificationNumber" xlink:to="dei_EntityTaxIdentificationNumber" xlink:title="label: EntityTaxIdentificationNumber to dei_EntityTaxIdentificationNumber" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="EntityIncorporationStateCountryCode" xlink:title="EntityIncorporationStateCountryCode" />
    <link:label xlink:type="resource" xlink:label="dei_EntityIncorporationStateCountryCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityIncorporationStateCountryCode" xml:lang="en-US" id="dei_EntityIncorporationStateCountryCode">Entity Incorporation, State or Country Code</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityIncorporationStateCountryCode" xlink:to="dei_EntityIncorporationStateCountryCode" xlink:title="label: EntityIncorporationStateCountryCode to dei_EntityIncorporationStateCountryCode" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany" xlink:label="EntityEmergingGrowthCompany" xlink:title="EntityEmergingGrowthCompany" />
    <link:label xlink:type="resource" xlink:label="dei_EntityEmergingGrowthCompany" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityEmergingGrowthCompany" xml:lang="en-US" id="dei_EntityEmergingGrowthCompany">Entity Emerging Growth Company</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1" xlink:label="EntityAddressAddressLine1" xlink:title="EntityAddressAddressLine1" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressAddressLine1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressAddressLine1" xml:lang="en-US" id="dei_EntityAddressAddressLine1">Entity Address, Address Line One</link:label>
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="EntityAddressAddressLine1" xlink:to="dei_EntityAddressAddressLine1" xlink:title="label: EntityAddressAddressLine1 to dei_EntityAddressAddressLine1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2" xlink:label="EntityAddressAddressLine2" xlink:title="EntityAddressAddressLine2" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressAddressLine2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressAddressLine2" xml:lang="en-US" id="dei_EntityAddressAddressLine2">Entity Address, Address Line Two</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine3" xlink:label="EntityAddressAddressLine3" xlink:title="EntityAddressAddressLine3" />
    <link:label xlink:type="resource" xlink:label="dei_EntityAddressAddressLine3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_EntityAddressAddressLine3" xml:lang="en-US" id="dei_EntityAddressAddressLine3">Entity Address, Address Line Three</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode" xlink:label="EntityAddressPostalZipCode" xlink:title="EntityAddressPostalZipCode" />
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode" xlink:label="CityAreaCode" xlink:title="CityAreaCode" />
    <link:label xlink:type="resource" xlink:label="dei_CityAreaCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_CityAreaCode" xml:lang="en-US" id="dei_CityAreaCode">City Area Code</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber" xlink:label="LocalPhoneNumber" xlink:title="LocalPhoneNumber" />
    <link:label xlink:type="resource" xlink:label="dei_LocalPhoneNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_LocalPhoneNumber" xml:lang="en-US" id="dei_LocalPhoneNumber">Local Phone Number</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol" xlink:label="TradingSymbol" xlink:title="TradingSymbol" />
    <link:label xlink:type="resource" xlink:label="dei_TradingSymbol" xlink:role="http://www.xbrl.org/2003/role/label" xlink:title="dei_TradingSymbol" xml:lang="en-US" id="dei_TradingSymbol">Trading Symbol</link:label>
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    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName" xlink:label="SecurityExchangeName" xlink:title="SecurityExchangeName" />
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  </link:labelLink>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.PRE
<SEQUENCE>5
<FILENAME>ions-20260429_pre.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii"?>
<!--Generated by Broadridge PROfile 26.3.2.5342 Broadridge-->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance">
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<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="include/report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
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<body>
<span style="display: none;">v3.26.1</span><table class="report" border="0" cellspacing="2" id="id2">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Document and Entity Information<br></strong></div></th>
<th class="th"><div>Apr. 29, 2026</div></th>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CoverAbstract', window );"><strong>Cover [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentType', window );">Document Type</a></td>
<td class="text">8-K<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_AmendmentFlag', window );">Amendment Flag</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentPeriodEndDate', window );">Document Period End Date</a></td>
<td class="text">Apr. 29,  2026<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityFileNumber', window );">Entity File Number</a></td>
<td class="text">000-19125<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityRegistrantName', window );">Entity Registrant Name</a></td>
<td class="text">IONIS PHARMACEUTICALS, INC.<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityCentralIndexKey', window );">Entity Central Index Key</a></td>
<td class="text">0000874015<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityIncorporationStateCountryCode', window );">Entity Incorporation, State or Country Code</a></td>
<td class="text">DE<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityTaxIdentificationNumber', window );">Entity Tax Identification Number</a></td>
<td class="text">33-0336973<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine1', window );">Entity Address, Address Line One</a></td>
<td class="text">2855 Gazelle Court<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressCityOrTown', window );">Entity Address, City or Town</a></td>
<td class="text">Carlsbad<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressStateOrProvince', window );">Entity Address, State or Province</a></td>
<td class="text">CA<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressPostalZipCode', window );">Entity Address, Postal Zip Code</a></td>
<td class="text">92010<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CityAreaCode', window );">City Area Code</a></td>
<td class="text">760<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_LocalPhoneNumber', window );">Local Phone Number</a></td>
<td class="text">931-9200<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Title of 12(b) Security</a></td>
<td class="text">Common Stock, $.001 Par Value<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">IONS<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NASDAQ<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityEmergingGrowthCompany', window );">Entity Emerging Growth Company</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_WrittenCommunications', window );">Written Communications</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SolicitingMaterial', window );">Soliciting Material</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementTenderOffer', window );">Pre-commencement Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementIssuerTenderOffer', window );">Pre-commencement Issuer Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
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<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_AmendmentFlag">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AmendmentFlag</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
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<td><strong> Balance Type:</strong></td>
<td>na</td>
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<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CityAreaCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Area code of city</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CityAreaCode</td>
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<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
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<td><strong> Balance Type:</strong></td>
<td>na</td>
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<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CoverAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Cover page.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CoverAbstract</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
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<td><strong> Balance Type:</strong></td>
<td>na</td>
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<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentPeriodEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period. The format of the date is YYYY-MM-DD.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentPeriodEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:dateItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentType">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentType</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:submissionTypeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 1 such as Attn, Building Name, Street Name</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressCityOrTown">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the City or Town</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressCityOrTown</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressPostalZipCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Code for the postal or zip code</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressPostalZipCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressStateOrProvince">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the state or province.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressStateOrProvince</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:stateOrProvinceItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCentralIndexKey">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCentralIndexKey</td>
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<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate if registrant meets the emerging growth company criteria.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityEmergingGrowthCompany</td>
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<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
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<td style="white-space:nowrap;">dei_EntityFileNumber</td>
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<td>duration</td>
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<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Two-character EDGAR code representing the state or country of incorporation.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityIncorporationStateCountryCode</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<td>dei:edgarStateCountryItemType</td>
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<td><strong> Balance Type:</strong></td>
<td>na</td>
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<td><strong> Period Type:</strong></td>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityRegistrantName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityRegistrantName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
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<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
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<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
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<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityTaxIdentificationNumber</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<td><strong> Balance Type:</strong></td>
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<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Local phone number for entity.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_LocalPhoneNumber</td>
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<td><strong> Balance Type:</strong></td>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementIssuerTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 13e<br> -Subsection 4c<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementIssuerTenderOffer</td>
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<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
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</table></div>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14d<br> -Subsection 2b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_Security12bTitle">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Title of a 12(b) registered security.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_Security12bTitle</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
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<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SecurityExchangeName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the Exchange on which a security is registered.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection d1-1<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SecurityExchangeName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<td>dei:edgarExchangeCodeItemType</td>
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<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
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<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SolicitingMaterial">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14a<br> -Subsection 12<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SolicitingMaterial</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<td><strong> Balance Type:</strong></td>
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<tr>
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<td>duration</td>
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<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Trading symbol of an instrument as listed on an exchange.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_TradingSymbol</td>
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<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Securities Act<br> -Number 230<br> -Section 425<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_WrittenCommunications</td>
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<td><strong> Balance Type:</strong></td>
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<tr>
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