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MAYO LICENSE AGREEMENT (Details) - USD ($) |  | 3 Months Ended |
--- | --- | --- | ---
Jan. 31, 2016 | Mar. 31, 2016 | Mar. 31, 2015 | Feb. 28, 2015
Other Payments |  |  |  |
Charges incurred as part of the research collaboration |  | $ 10,126,000 | $ 6,571,000 |
Licensing Agreements | MAYO |  |  |  |
Warrants |  |  |  |
Value of common stock required to be issued upon commercial launch of second and third products | $ 200,000 |  |  |
Other Payments |  |  |  |
Charges incurred as part of the research collaboration |  | 1,000,000 | 500,000 |
Payments for research and development efforts |  | 1,000,000 | 1,200,000 |
Estimated liability for research and development efforts |  | 1,200,000 |  |
Amendments |  |  |  |
License fees payable in five annual installments |  |  |  | $ 5,000,000
License fee payments |  | 1,000,000 | $ 1,000,000 |
Licensing Agreements | MAYO | Sales Milestone Range One |  |  |  |
Warrants |  |  |  |
Amount agreed to be paid upon reaching the specified amount of net sales | 200,000 |  |  |
Net sales of a licensed product | 5,000,000 |  |  |
Licensing Agreements | MAYO | Sales Milestone Range Two |  |  |  |
Warrants |  |  |  |
Amount agreed to be paid upon reaching the specified amount of net sales | 750,000 |  |  |
Net sales of a licensed product | 20,000,000 |  |  |
Licensing Agreements | MAYO | Sales Milestone Range Three |  |  |  |
Warrants |  |  |  |
Amount agreed to be paid upon reaching the specified amount of net sales | 2,000,000 |  |  |
Net sales of a licensed product | $ 50,000,000 |  |  |
Licensing Agreements | MAYO | Minimum |  |  |  |
Warrants |  |  |  |
Royalty payments |  | $ 25,000 |  |

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 + Details
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