<SEC-DOCUMENT>0001209191-16-107904.txt : 20160311
<SEC-HEADER>0001209191-16-107904.hdr.sgml : 20160311
<ACCEPTANCE-DATETIME>20160311165916
ACCESSION NUMBER:		0001209191-16-107904
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20160226
FILED AS OF DATE:		20160311
DATE AS OF CHANGE:		20160311

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXACT SCIENCES CORP
		CENTRAL INDEX KEY:			0001124140
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				204782291
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719
		BUSINESS PHONE:		608-284-5700

	MAIL ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXACT CORP
		DATE OF NAME CHANGE:	20000919

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			COWARD D SCOTT
		CENTRAL INDEX KEY:			0001247296

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35092
		FILM NUMBER:		161501417

	MAIL ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719
</SEC-HEADER>
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<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
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    <periodOfReport>2016-02-26</periodOfReport>

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        <issuerName>EXACT SCIENCES CORP</issuerName>
        <issuerTradingSymbol>EXAS</issuerTradingSymbol>
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            <rptOwnerName>COWARD D SCOTT</rptOwnerName>
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            <rptOwnerStreet1>C/O EXACT SCIENCES CORP.</rptOwnerStreet1>
            <rptOwnerStreet2>441 CHARMANY DRIVE</rptOwnerStreet2>
            <rptOwnerCity>MADISON</rptOwnerCity>
            <rptOwnerState>WI</rptOwnerState>
            <rptOwnerZipCode>53719</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>SVP and General Counsel</officerTitle>
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    </reportingOwner>

    <nonDerivativeTable>
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                <value>Common Stock</value>
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            <transactionDate>
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            <deemedExecutionDate></deemedExecutionDate>
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            <transactionAmounts>
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                <sharesOwnedFollowingTransaction>
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            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
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                <natureOfOwnership>
                    <value>Held in 401(K) Account</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
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    <derivativeTable>
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            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
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            <conversionOrExercisePrice>
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            <transactionDate>
                <value>2016-02-26</value>
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                <transactionPricePerShare>
                    <value>0.00</value>
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                <transactionAcquiredDisposedCode>
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                <directOrIndirectOwnership>
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                <value>Restricted Stock Units</value>
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                    <value>18075</value>
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    <footnotes>
        <footnote id="F1">Represents shares of common stock received upon vesting of a restricted stock unit award.</footnote>
        <footnote id="F2">Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units on March 9, 2016.</footnote>
        <footnote id="F3">These options vest and become exercisable in four equal annual installments beginning on the first anniversary of the grant date.</footnote>
        <footnote id="F4">Each restricted stock unit represents a contingent right to receive one share of common stock.</footnote>
        <footnote id="F5">These restricted stock units vest in four equal annual installments beginning on the first anniversary of the grant date.</footnote>
        <footnote id="F6">Represents a restricted stock unit award granted on March 9, 2015 that partially vested on March 9, 2016. The restricted stock units vest in four equal annual installments beginning on March 9, 2016.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ D. Scott Coward by Mark R. Busch, attorney-in-fact</signatureName>
        <signatureDate>2016-03-11</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
