<SEC-DOCUMENT>0001144204-17-008793-index.html : 20170214
<SEC-HEADER>0001144204-17-008793.hdr.sgml : 20170214
<ACCEPTANCE-DATETIME>20170214160443
ACCESSION NUMBER:		0001144204-17-008793
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20170214
DATE AS OF CHANGE:		20170214
GROUP MEMBERS:		DAVID E. SHAW

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXACT SCIENCES CORP
		CENTRAL INDEX KEY:			0001124140
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				204782291
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-62447
		FILM NUMBER:		17608579

	BUSINESS ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719
		BUSINESS PHONE:		608-284-5700

	MAIL ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXACT CORP
		DATE OF NAME CHANGE:	20000919

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			D. E. SHAW & CO, L.P.
		CENTRAL INDEX KEY:			0001009268
		IRS NUMBER:				133695715
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		1166 AVENUE OF THE AMERICAS
		STREET 2:		NINTH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
		BUSINESS PHONE:		2124780000

	MAIL ADDRESS:	
		STREET 1:		1166 AVENUE OF THE AMERICAS
		STREET 2:		NINTH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHAW D E & CO L P /NY/
		DATE OF NAME CHANGE:	19990421
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>v459172_sc13ga.htm
<DESCRIPTION>SC 13G/A
<TEXT>
Document 1 - file: v459172_sc13ga.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>v459172_ex1.htm
<DESCRIPTION>EXHIBIT 1
<TEXT>
Document 2 - file: v459172_ex1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>3
<FILENAME>v459172_ex2.htm
<DESCRIPTION>EXHIBIT 2
<TEXT>
Document 3 - file: v459172_ex2.htm

</DOCUMENT>
</SEC-DOCUMENT>