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v3.21.2

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Cash flows from operating activities: |  |
Net loss | $ (375,014) | $ (405,273)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 64,267 | 53,345
Loss on disposal of property, plant and equipment | 928 | 930
Unrealized (gain) loss on equity investments | 1,937 | (1,183)
Deferred tax benefit | (248,716) | (6,161)
Stock-based compensation | 197,180 | 111,075
Post-combination expense for acceleration of unvested equity | 80,960 | 0
Realized gain on preferred stock investment | (30,500) | 0
Loss on settlement of convertible notes | 0 | 50,819
Amortization of deferred financing costs, convertible note debt discount and issuance costs, and other liabilities | 4,948 | 340
Amortization of premium on short-term investments | 3,265 | 1,040
Amortization of acquired intangible assets | 70,954 | 70,199
Intangible asset impairment charge | 20,210 | 209,666
Asset acquisition IPR&D expense | 85,337 | 0
Remeasurement of contingent consideration | 10,986 | 0
Non-cash lease expense | 18,347 | 11,041
Changes in assets and liabilities: |  |
Accounts receivable, net | (14,038) | (73,642)
Inventory, net | (1,091) | (18,472)
Operating lease liabilities | (11,834) | (6,135)
Accounts payable and accrued liabilities | 64,344 | (7,608)
Other assets and liabilities | (20,134) | 35,097
Net cash provided by (used in) operating activities | (77,664) | 25,078
Cash flows from investing activities: |  |
Purchases of marketable securities | (1,021,557) | (890,012)
Maturities and sales of marketable securities | 424,830 | 559,907
Purchases of property, plant and equipment | (76,374) | (48,371)
Business combination, net of cash acquired | (415,549) | (6,658)
Asset acquisition | (58,073) | 0
Investments in privately held companies | (13,555) | (10,610)
Other investing activities | (244) | 345
Net cash used in investing activities | (1,160,522) | (395,399)
Cash flows from financing activities: |  |
Proceeds from issuance of convertible notes, net | 0 | 1,125,547
Proceeds from exercise of common stock options | 13,372 | 15,408
Proceeds in connection with the Company’s employee stock purchase plan | 12,038 | 9,799
Payments on settlement of convertible notes | 0 | (150,054)
Other financing activities | (4,742) | (938)
Net cash provided by financing activities | 20,668 | 999,762
Net increase (decrease) in cash, cash equivalents and restricted cash | (1,217,518) | 629,441
Cash, cash equivalents and restricted cash, beginning of period | 1,491,594 | 177,528
Cash, cash equivalents and restricted cash, end of period | 274,076 | 806,969
Supplemental disclosure of non-cash investing and financing activities: |  |
Property, plant and equipment acquired but not paid | 21,110 | 7,209
Unrealized gain (loss) on available-for-sale investments, before tax | (563) | 1,159
Issuance of 162,606 and 136,559 shares of common stock to fund the Company’s 401(k) matching contribution for 2020 and 2019, respectively | 22,934 | 12,007
Issuance of 9,510,436 and 382,947 shares of common stock for business combinations and asset acquisition for 2021 and 2020, respectively | 1,270,918 | 28,847
Business combination contingent consideration liability | 350,348 | 0
Supplemental disclosure of cash flow information: |  |
Interest paid | $ 10,685 | $ 9,239

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