<SEC-DOCUMENT>0001209191-21-014493.txt : 20210225
<SEC-HEADER>0001209191-21-014493.hdr.sgml : 20210225
<ACCEPTANCE-DATETIME>20210225192325
ACCESSION NUMBER:		0001209191-21-014493
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210223
FILED AS OF DATE:		20210225
DATE AS OF CHANGE:		20210225

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			COWARD D SCOTT
		CENTRAL INDEX KEY:			0001247296

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35092
		FILM NUMBER:		21682691

	MAIL ADDRESS:	
		STREET 1:		441 CHARMANY DRIVE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXACT SCIENCES CORP
		CENTRAL INDEX KEY:			0001124140
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				204782291
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		5505 ENDEAVOR LANE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719
		BUSINESS PHONE:		608-284-5700

	MAIL ADDRESS:	
		STREET 1:		5505 ENDEAVOR LANE
		CITY:			MADISON
		STATE:			WI
		ZIP:			53719

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXACT CORP
		DATE OF NAME CHANGE:	20000919
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
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<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
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        <issuerName>EXACT SCIENCES CORP</issuerName>
        <issuerTradingSymbol>EXAS</issuerTradingSymbol>
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            <rptOwnerName>COWARD D SCOTT</rptOwnerName>
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            <rptOwnerStreet1>C/O EXACT SCIENCES CORP.</rptOwnerStreet1>
            <rptOwnerStreet2>5505 ENDEAVOR LANE</rptOwnerStreet2>
            <rptOwnerCity>MADISON</rptOwnerCity>
            <rptOwnerState>WI</rptOwnerState>
            <rptOwnerZipCode>53719</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Administrative Officer</officerTitle>
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                <directOrIndirectOwnership>
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                <directOrIndirectOwnership>
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                <natureOfOwnership>
                    <value>Held in 401(k) Plan</value>
                </natureOfOwnership>
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        </nonDerivativeHolding>
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    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
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                    <value>12850</value>
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                <transactionPricePerShare>
                    <value>0.00</value>
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            </exerciseDate>
            <expirationDate>
                <footnoteId id="F7"/>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>12850</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
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                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
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                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
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                <value>21.68</value>
            </conversionOrExercisePrice>
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                <value>2021-02-23</value>
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                    <value>18750</value>
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                    <value>D</value>
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            <exerciseDate>
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            <expirationDate>
                <footnoteId id="F8"/>
            </expirationDate>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>18750</value>
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                    <value>0</value>
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    <footnotes>
        <footnote id="F1">Represents shares of common stock received upon vesting of a restricted stock unit award.</footnote>
        <footnote id="F2">Represents shares of common stock received upon exercise of a stock option award.</footnote>
        <footnote id="F3">The sales reported in this field were effected pursuant to a Rule 10b5-1 trading plan.</footnote>
        <footnote id="F4">Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units on February 23, 2021.</footnote>
        <footnote id="F5">In addition to the shares of Common Stock reported on this Form 4, which total 12,162 shares, Mr. Coward also holds, in the aggregate, an additional 72,757 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock.</footnote>
        <footnote id="F6">Each restricted stock unit represents a contingent right to receive one share of common stock.</footnote>
        <footnote id="F7">Represents a restricted stock unit award that partially vested on February 23, 2021. The restricted stock units vest in four equal annual installments beginning on February 23, 2018.</footnote>
        <footnote id="F8">These options vested and became exercisable in four equal annual installments beginning on February 23, 2018.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ D. Scott Coward by Mark R. Busch, attorney-in-fact</signatureName>
        <signatureDate>2021-02-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
