    <SEC-DOCUMENT>0001104659-21-057561-index.html : 20210429
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    <ACCEPTANCE-DATETIME>20210429160717
    ACCESSION NUMBER:		0001104659-21-057561
    CONFORMED SUBMISSION TYPE:	DEFA14A
    PUBLIC DOCUMENT COUNT:		3
    FILED AS OF DATE:		20210429
    DATE AS OF CHANGE:		20210429

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			EXACT SCIENCES CORP
    		CENTRAL INDEX KEY:			0001124140
    		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
    		IRS NUMBER:				204782291
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEFA14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-35092
    		FILM NUMBER:		21870531

    	BUSINESS ADDRESS:
    		STREET 1:		5505 ENDEAVOR LANE
    		CITY:			MADISON
    		STATE:			WI
    		ZIP:			53719
    		BUSINESS PHONE:		608-284-5700

    	MAIL ADDRESS:
    		STREET 1:		5505 ENDEAVOR LANE
    		CITY:			MADISON
    		STATE:			WI
    		ZIP:			53719

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	EXACT CORP
    		DATE OF NAME CHANGE:	20000919
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEFA14A
    <SEQUENCE>1
    <FILENAME>tm212465d4_defa14a.htm
    <DESCRIPTION>DEFA14A
    <TEXT>
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    <SEQUENCE>2
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: tm212465d4_defa14aimg001.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>tm212465d4_defa14aimg002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: tm212465d4_defa14aimg002.jpg

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